The Ras-Raf relationship: An unfinished puzzle

Advances in Enzyme Regulation

Volumn 41, Issue 1, 2001, Pages 261-267

  Kerkhoff, Eugen ^a   Rapp, Ulf R ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; P65PAK PROTEIN; PHOSPHATIDIC ACID; PHOSPHATIDYLSERINE; PHOSPHOTRANSFERASE; PROTEIN CDC42; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASES; PROTO ONCOGENE PROTEINS C RAF; RAF PROTEIN; RAS PROTEIN;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL DIVISION; CELL MEMBRANE; CELLULAR DISTRIBUTION; CYTOSOL; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MODEL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN TERTIARY STRUCTURE; REGULATORY MECHANISM; STRUCTURE ANALYSIS;

ANIMALIA;

EID: 0034989234     PISSN: 00652571     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0065-2571(00)00023-6     Document Type: Short Survey

References (30)

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2. Cell cycle targets of Ras/Raf signalling
3. Role of Raf-1 serine/threonine kinase in growth factor signal transduction
4. Raf meets Ras: Completing the framework of a signal transduction pathway
5. Mutational activation of c-raf-1 and the definition of the minimal transforming sequence
6. Definition of the human Raf amino-terminal regulatory region by deletion mutagenesis
7. Expression of Raf oncogenes activates the PEA1 transcription factor motif
8. The Raf C1 Cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activation
9. How Ras related proteins talk to their effectors
10. The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf-1 in complex with Rap1A and a GTP analogue
11. Signalling and subcellular targeting by membrane-binding domains
12. The solution structure of the Raf-1 cysteine-rich domain, a novel Ras and phospholipid binding site
13. Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase
14. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
15. Activation of Raf as a result of recruitment to the plasma membrane
16. Isolation of a new protein factor required for activation of Raf-1 by Ha-Ras: Partial purification from rat brain cytosols
17. The complexity of Raf-1 regulation
18. Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester
19. Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells
20. The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras
21. Physical association with Ras enhances activation of membrane bound raf (RafCAAX)
22. Mutational analysis of Raf-1 cysteine rich domain: Requirement for a cluster of basic aminoacids for interaction with phosphatidylserine
23. Structural basis of Rab effector specifity: Crystal structure of the small G protein Rab3A complexed with the effector domain of Rabphilin-3A
24. p21-activated protein kinase: A crucial component of morphological signalling?
25. Structure of Cdc42 bound to the GTPase binding domain of PAK1
26. Structure of PAK in an autoinhibited conformation reveals a multistage activation switch
27. Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization
28. Oligomerization activates c-Raf-1 through a Ras-dependent mechanism
29. Formation of the Ras dimer is essential for Raf-activation
30. Normal and oncogenic p21-Ras proteins bind to the aminoterminal regulatory domain of c-Raf-1