1H NMR study of the influence of hemin vinyl→methyl substitution on the interaction between the C-terminus and substrate and the "aging" of the heme oxygenase from Neisseria meningitidis: Induction of active site structural heterogeneity by a two-fold symmetric hemin

Biochemistry

Volumn 45, Issue 46, 2006, Pages 13875-13888

  Liu, Yangzhong ^a   Ma, Li Hua ^a   Zhang, Xuhong ^b   Yoshida, Tadashi ^b   Satterlee, James D ^c   La Mar, Gerd N ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b YAMAGATA UNIVERSITY   (Japan)

^c WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; HYDROGEN BONDS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SUBSTITUTION REACTIONS; SUBSTRATES;

H-BOND ACCEPTORS; N-TERMINAL SEQUENCING; OPTIMAL ORIENTATION;

ENZYME KINETICS;

2,4 DIMETHYLDEUTEROHEMIN; ALANINE; ARGININE; HEME OXYGENASE; HEMIN; HISTIDINE; METHYL GROUP; PHENYLALANINE; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVE SITE; ENZYME MODIFICATION; ENZYME SUBSTRATE; HYDROGEN BOND; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; BINDING SITE; CHEMISTRY; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION;

NEISSERIA MENINGITIDIS;

BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEME OXYGENASE (DECYCLIZING); HEMIN; HYDROGEN BONDING; NEISSERIA MENINGITIDIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 33751211886     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061747q     Document Type: Article

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