Solution 1H NMR investigation of the active site molecular and electronic structures of substrate-bound, cyanide-inhibited HmuO, a bacterial heme oxygenase from Corynebacterium diphtheriae

Journal of Biological Chemistry

Volumn 278, Issue 9, 2003, Pages 6651-6663

  Li, Yiming ^a   Syvitski, Ray T ^a   Chu, Grace C ^b,d   Ikeda Saito, Masao ^b,c   La Mar, Gerd N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TOHOKU UNIVERSITY   (Japan)

^d AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CATALYSIS; CRYSTAL STRUCTURE; HYDROGEN BONDS; IRON COMPOUNDS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

LIGANDS;

ENZYMES;

CYANIDE; HEME; HEME OXYGENASE; ASPARTIC ACID; BACTERIAL PROTEIN; HMUO PROTEIN, BACTERIA; HYDROGEN; LIGAND; PROTON; WATER;

ARTICLE; CATALYSIS; CORYNEBACTERIUM DIPHTHERIAE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HYDROGEN BOND; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; ANIMAL; BINDING SITE; CHEMISTRY; ENZYMOLOGY; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PROTEIN BINDING; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); CORYNEBACTERIUM; CORYNEBACTERIUM DIPHTHERIAE; MAMMALIA;

ANIMALS; ASPARTIC ACID; BACTERIAL PROTEINS; BINDING SITES; CATALYSIS; CORYNEBACTERIUM DIPHTHERIAE; CRYSTALLOGRAPHY, X-RAY; CYANIDES; HEME; HEME OXYGENASE (DECYCLIZING); HUMANS; HYDROGEN; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTONS; WATER;

EID: 0037470161     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211249200     Document Type: Article

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