Solution 1H, 15N NMR Spectroscopic Characterization of Substrate-Bound, Cyanide-Inhibited Human Heme Oxygenase: Water Occupation of the Distal Cavity

Journal of the American Chemical Society

Volumn 125, Issue 44, 2003, Pages 13392-13403

  Li, Yiming ^a   Syvitski, Ray T ^a   Auclair, Karine ^b,c   De Montellano, Paul Ortiz ^b   La Mar, Gerd N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; HYDROGEN BONDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTONS;

WATER RESONANCES;

ENZYMES;

AROMATIC COMPOUND; CYANIDE; HEME OXYGENASE; HYDROPEROXIDE; PHENYLALANINE; TRYPTOPHAN; WATER; NITROGEN; PROTON;

ARTICLE; CRYSTAL STRUCTURE; DIPOLE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROGEN BOND; IMMOBILIZATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; STEADY STATE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION; SOLUTION AND SOLUBILITY;

CYANIDES; HEME OXYGENASE (DECYCLIZING); HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTONS; SOLUTIONS; WATER;

EID: 0242330799     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja036176t     Document Type: Article

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