Mixed Regioselectivity in the Arg-177 Mutants of Corynebacterium diphtheriae Heme Oxygenase as a Consequence of in-Plane Heme Disorder

Biochemistry

Volumn 43, Issue 18, 2004, Pages 5222-5238

  Zeng, Yuhong ^a   Deshmukh, Rahul ^c   Caignan, Gregori A ^a   Bunce, Richard A ^b   Rivera, Mario ^a   Wilks, Angela ^c  

^a UNIVERSITY OF KANSAS   (United States)

^b OKLAHOMA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CARBON; ENZYMES; HYDROGEN BONDS; OXIDATION;

DISTAL POCKET; MUTANTS; REGIOSELECTIVITY;

BIOCHEMISTRY;

BILIVERDIN; CARBON; HEME; HEME OXYGENASE; HEME OXYGENASE 1; HEME PROPIONATE; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CORRELATION ANALYSIS; CORYNEBACTERIUM DIPHTHERIAE; ELECTRICITY; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME SPECIFICITY; HYDROGEN BOND; HYDROXYLATION; ISOMER; MUTANT; NONHUMAN; OPTICAL RESOLUTION; OPTICAL ROTATION; OXIDATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; BACTERIAL PROTEINS; BINDING SITES; CATALYSIS; CORYNEBACTERIUM DIPHTHERIAE; ELECTROSTATICS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HYDROGEN BONDING; ISOMERISM; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; RATS; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); CORYNEBACTERIUM; CORYNEBACTERIUM DIPHTHERIAE; UNCULTURED ACTINOMYCETE;

EID: 2442444243     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035970o     Document Type: Article

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