메뉴 건너뛰기




Volumn 1, Issue 2, 2005, Pages 263-273

Mechanisms of Cardiac Hypertrophy

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 1 ADRENERGIC RECEPTOR; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; CALCINEURIN; CALCINEURIN INHIBITOR; CALSEQUESTRIN; CYCLOSPORIN; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LOSARTAN; PHOSPHODIESTERASE III; PHOSPHOLAMBAN; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; SYNAPTOPHYSIN; TSUKUBAENOLIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 33751184396     PISSN: 15517136     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hfc.2005.03.006     Document Type: Review
Times cited : (17)

References (129)
  • 1
    • 3242774502 scopus 로고    scopus 로고
    • Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence
    • Selvetella G., Hirsch E., Notte A., et al. Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence. Cardiovasc Res 63 (2004) 373-380
    • (2004) Cardiovasc Res , vol.63 , pp. 373-380
    • Selvetella, G.1    Hirsch, E.2    Notte, A.3
  • 2
    • 0002537440 scopus 로고    scopus 로고
    • Cardiac hypertrophy: the good, the bad and the ugly
    • Frey N., and Olson E.N. Cardiac hypertrophy: the good, the bad and the ugly. Annu Rev Physiol 65 (2003) 45-79
    • (2003) Annu Rev Physiol , vol.65 , pp. 45-79
    • Frey, N.1    Olson, E.N.2
  • 3
    • 0141793051 scopus 로고    scopus 로고
    • Molecular interplay between mechanical and humoral signaling in cardiac hypertrophy
    • Tarone G., and Lembo G. Molecular interplay between mechanical and humoral signaling in cardiac hypertrophy. Trends Mol Med 9 (2003) 376-382
    • (2003) Trends Mol Med , vol.9 , pp. 376-382
    • Tarone, G.1    Lembo, G.2
  • 4
    • 0037462474 scopus 로고    scopus 로고
    • Sensing stretch is fundamental
    • Epstein N.D., and Davis J.S. Sensing stretch is fundamental. Cell 112 (2003) 147-150
    • (2003) Cell , vol.112 , pp. 147-150
    • Epstein, N.D.1    Davis, J.S.2
  • 5
    • 0030969371 scopus 로고    scopus 로고
    • The cellular and molecular response of cardiac myocytes to mechanical stress
    • Sadoshima J., and Izumo S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol 59 (1997) 551-571
    • (1997) Annu Rev Physiol , vol.59 , pp. 551-571
    • Sadoshima, J.1    Izumo, S.2
  • 6
    • 0034055761 scopus 로고    scopus 로고
    • Form follows function: how muscle shape is regulated by work
    • Russel B., Motlagh D., and Ashley W.W. Form follows function: how muscle shape is regulated by work. J Appl Physiol 88 (2000) 1127-1132
    • (2000) J Appl Physiol , vol.88 , pp. 1127-1132
    • Russel, B.1    Motlagh, D.2    Ashley, W.W.3
  • 7
    • 0042337388 scopus 로고    scopus 로고
    • Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy
    • Urbanek K., Quaini F., Tasca G., et al. Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci USA 100 (2003) 10440-10445
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10440-10445
    • Urbanek, K.1    Quaini, F.2    Tasca, G.3
  • 8
    • 0037991449 scopus 로고    scopus 로고
    • Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy
    • Lips D.J., De Windt L.J., van Kraaij J.W., et al. Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy. Eur Heart J 24 (2003) 883-896
    • (2003) Eur Heart J , vol.24 , pp. 883-896
    • Lips, D.J.1    De Windt, L.J.2    van Kraaij, J.W.3
  • 9
    • 0026100997 scopus 로고
    • Specific alterations in the distribution of extracellular matrix components within rat myocardium during the development of pressure overload
    • Contard F., Koteliansky V., Marotte F., et al. Specific alterations in the distribution of extracellular matrix components within rat myocardium during the development of pressure overload. Lab Invest 64 (1991) 65-75
    • (1991) Lab Invest , vol.64 , pp. 65-75
    • Contard, F.1    Koteliansky, V.2    Marotte, F.3
  • 10
    • 0035051054 scopus 로고    scopus 로고
    • Cytoplasmic signaling pathways that regulate cardiac hypertrophy
    • Molkentin J.D., and Dorn II G. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu Rev Physiol 63 (2001) 391-426
    • (2001) Annu Rev Physiol , vol.63 , pp. 391-426
    • Molkentin, J.D.1    Dorn II, G.2
  • 12
    • 0037378337 scopus 로고    scopus 로고
    • Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus
    • Morisco C., Sadoshima J., Trimarco B., et al. Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus. Am J Physiol Heart Circ Physiol 284 4 (2003) H1043-H1047
    • (2003) Am J Physiol Heart Circ Physiol , vol.284 , Issue.4
    • Morisco, C.1    Sadoshima, J.2    Trimarco, B.3
  • 13
    • 0025280867 scopus 로고
    • Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study
    • Levy D., Garrison R.J., Savage D.D., et al. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 322 (1990) 1561-1566
    • (1990) N Engl J Med , vol.322 , pp. 1561-1566
    • Levy, D.1    Garrison, R.J.2    Savage, D.D.3
  • 14
    • 0022507205 scopus 로고
    • Value of echocardiographic measurement of left ventricular mass in predicting cardiovascular morbid events in hypertensive men
    • Casale P.N., Devereux R.B., Milner M., et al. Value of echocardiographic measurement of left ventricular mass in predicting cardiovascular morbid events in hypertensive men. Ann Intern Med 105 (1986) 173-178
    • (1986) Ann Intern Med , vol.105 , pp. 173-178
    • Casale, P.N.1    Devereux, R.B.2    Milner, M.3
  • 15
    • 0026092229 scopus 로고
    • Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension
    • Koren M.J., Devereux R.B., Casale P.N., et al. Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med 114 (1991) 345-352
    • (1991) Ann Intern Med , vol.114 , pp. 345-352
    • Koren, M.J.1    Devereux, R.B.2    Casale, P.N.3
  • 16
    • 0035089266 scopus 로고    scopus 로고
    • Prognostic implications of left ventricular hypertrophy
    • Vakili B.A., Okin P.M., and Devereux R.B. Prognostic implications of left ventricular hypertrophy. Am Heart J 141 (2001) 334-341
    • (2001) Am Heart J , vol.141 , pp. 334-341
    • Vakili, B.A.1    Okin, P.M.2    Devereux, R.B.3
  • 17
    • 0028008455 scopus 로고
    • Prognostic value of left ventricular mass in uncomplicated acute myocardial infarction and one-vessel coronary artery disease
    • Bolognese L., Dellavesa P., Rossi L., et al. Prognostic value of left ventricular mass in uncomplicated acute myocardial infarction and one-vessel coronary artery disease. Am J Cardiol 73 (1994) 1-5
    • (1994) Am J Cardiol , vol.73 , pp. 1-5
    • Bolognese, L.1    Dellavesa, P.2    Rossi, L.3
  • 18
    • 0035797832 scopus 로고    scopus 로고
    • Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril
    • Mathew J., Sleight P., Lonn E., et al. Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril. Circulation 104 (2001) 1615-1621
    • (2001) Circulation , vol.104 , pp. 1615-1621
    • Mathew, J.1    Sleight, P.2    Lonn, E.3
  • 19
    • 0031963796 scopus 로고    scopus 로고
    • Prognostic significance of serial changes in left ventricular mass in essential hypertension
    • Verdecchia P., Schillaci G., Borgioni C., et al. Prognostic significance of serial changes in left ventricular mass in essential hypertension. Circulation 97 (1998) 48-54
    • (1998) Circulation , vol.97 , pp. 48-54
    • Verdecchia, P.1    Schillaci, G.2    Borgioni, C.3
  • 21
    • 0026092229 scopus 로고
    • Relation of left vetricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension
    • Koren M.J., Devereux R.B., Casale P.N., et al. Relation of left vetricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med 114 (1991) 345-350
    • (1991) Ann Intern Med , vol.114 , pp. 345-350
    • Koren, M.J.1    Devereux, R.B.2    Casale, P.N.3
  • 22
    • 0023690274 scopus 로고
    • Relation of concentric left ventricular hypertrophy and extracardiac target organ damage to supranormal left ventricular performance in established essential hypertension
    • Blade J., Devereux R.B., Herrold E.M., et al. Relation of concentric left ventricular hypertrophy and extracardiac target organ damage to supranormal left ventricular performance in established essential hypertension. Am J Cardiol 62 (1988) 246-252
    • (1988) Am J Cardiol , vol.62 , pp. 246-252
    • Blade, J.1    Devereux, R.B.2    Herrold, E.M.3
  • 23
    • 0037493197 scopus 로고    scopus 로고
    • Left ventricular hypertrophy is associated with asymptomatic cerebral damage in hypertensive patients
    • Selvetella G., Notte A., Maffei A., et al. Left ventricular hypertrophy is associated with asymptomatic cerebral damage in hypertensive patients. Stroke 34 (2003) 1766-1770
    • (2003) Stroke , vol.34 , pp. 1766-1770
    • Selvetella, G.1    Notte, A.2    Maffei, A.3
  • 24
    • 0036785954 scopus 로고    scopus 로고
    • Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy
    • Kemi O.J., Loennechen J.P., Wisloff U., et al. Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy. J Appl Physiol 93 (2002) 1301-1309
    • (2002) J Appl Physiol , vol.93 , pp. 1301-1309
    • Kemi, O.J.1    Loennechen, J.P.2    Wisloff, U.3
  • 25
    • 0034123657 scopus 로고    scopus 로고
    • Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways
    • Ruwlof C., and van der Laarse A. Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways. Cardiovasc Res 47 (2000) 23-37
    • (2000) Cardiovasc Res , vol.47 , pp. 23-37
    • Ruwlof, C.1    van der Laarse, A.2
  • 26
    • 0035338924 scopus 로고    scopus 로고
    • Cardiac mechanotransduction: from sensing to disease and treatment
    • Tavi P., Laine M., Weckstrom M., et al. Cardiac mechanotransduction: from sensing to disease and treatment. Trends Pharmacol Sci 22 (2001) 254-260
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 254-260
    • Tavi, P.1    Laine, M.2    Weckstrom, M.3
  • 27
    • 0030933063 scopus 로고    scopus 로고
    • MLP deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyophathy, and heart failure
    • Arber S., Hunter J.J., Ross Jr. J., et al. MLP deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyophathy, and heart failure. Cell 88 (1997) 393-403
    • (1997) Cell , vol.88 , pp. 393-403
    • Arber, S.1    Hunter, J.J.2    Ross Jr., J.3
  • 28
    • 0036843301 scopus 로고    scopus 로고
    • Role of integrins in endothelial mechanosensing of shear stress
    • Shyy J.Y.-J., and Chien S. Role of integrins in endothelial mechanosensing of shear stress. Cir Res 91 (2002) 769-775
    • (2002) Cir Res , vol.91 , pp. 769-775
    • Shyy, J.Y.-J.1    Chien, S.2
  • 29
    • 0031283019 scopus 로고    scopus 로고
    • Muscle β1D integrin reinforces the cytoskeleton-matrix link: modulation of integrin adhesive function by alternative splicing
    • Belkin A.M., Retta S.F., Pletjushkina O.Y., et al. Muscle β1D integrin reinforces the cytoskeleton-matrix link: modulation of integrin adhesive function by alternative splicing. J Cell Biol 139 (1997) 1583-1595
    • (1997) J Cell Biol , vol.139 , pp. 1583-1595
    • Belkin, A.M.1    Retta, S.F.2    Pletjushkina, O.Y.3
  • 30
    • 0034730790 scopus 로고    scopus 로고
    • Early activation of the multicomponent signaling complex associated with focal adhesion kinase induced by pressure overload in the rat heart
    • Franchini K.G., Torsoni A.S., Soares P.H., et al. Early activation of the multicomponent signaling complex associated with focal adhesion kinase induced by pressure overload in the rat heart. Circ Res 87 (2000) 558-565
    • (2000) Circ Res , vol.87 , pp. 558-565
    • Franchini, K.G.1    Torsoni, A.S.2    Soares, P.H.3
  • 31
    • 0034634653 scopus 로고    scopus 로고
    • Integrin activation and focal complex formation in cardiac hypertrophy
    • Laser M., Willey C.D., Jiang W., et al. Integrin activation and focal complex formation in cardiac hypertrophy. J Biol Chem 275 (2000) 35624-35630
    • (2000) J Biol Chem , vol.275 , pp. 35624-35630
    • Laser, M.1    Willey, C.D.2    Jiang, W.3
  • 32
    • 0012151543 scopus 로고    scopus 로고
    • Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle
    • Babbitt C.J., Shai S.Y., Harpf A.E., et al. Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle. Histochem Cell Biol 118 (2002) 431-439
    • (2002) Histochem Cell Biol , vol.118 , pp. 431-439
    • Babbitt, C.J.1    Shai, S.Y.2    Harpf, A.E.3
  • 33
    • 18244394595 scopus 로고    scopus 로고
    • Integrins play a critical role in mechanical stress-induced p38 MAPK activation
    • Aikawa R., Nagai T., Kudoh S., et al. Integrins play a critical role in mechanical stress-induced p38 MAPK activation. Hypertension 39 (2002) 233-238
    • (2002) Hypertension , vol.39 , pp. 233-238
    • Aikawa, R.1    Nagai, T.2    Kudoh, S.3
  • 34
    • 0037040839 scopus 로고    scopus 로고
    • Cardiac myocyte-specific excision of the β1 integrin gene results in myocardial fibrosis and cardiac failure
    • Shai S.Y., Harpf A.E., Babbitt C.J., et al. Cardiac myocyte-specific excision of the β1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res 90 (2002) 458-464
    • (2002) Circ Res , vol.90 , pp. 458-464
    • Shai, S.Y.1    Harpf, A.E.2    Babbitt, C.J.3
  • 35
    • 0035108354 scopus 로고    scopus 로고
    • Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance
    • Keller R.S., Shai S.Y., Babbitt C.J., et al. Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance. Am J Pathol 158 (2001) 1079-1090
    • (2001) Am J Pathol , vol.158 , pp. 1079-1090
    • Keller, R.S.1    Shai, S.Y.2    Babbitt, C.J.3
  • 36
    • 0032879692 scopus 로고    scopus 로고
    • Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain
    • Brancaccio M., Guazzone S., Menini N., et al. Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain. J Biol Chem 274 (1999) 29282-29288
    • (1999) J Biol Chem , vol.274 , pp. 29282-29288
    • Brancaccio, M.1    Guazzone, S.2    Menini, N.3
  • 37
    • 0037236642 scopus 로고    scopus 로고
    • Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload
    • Brancaccio M., Fratta L., Notte A., et al. Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med 9 (2003) 68-75
    • (2003) Nat Med , vol.9 , pp. 68-75
    • Brancaccio, M.1    Fratta, L.2    Notte, A.3
  • 38
    • 20344399430 scopus 로고    scopus 로고
    • Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload
    • in press
    • De Acetis M., Notte A., Accornero F., et al. Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload. Circ Res (2005) in press
    • (2005) Circ Res
    • De Acetis, M.1    Notte, A.2    Accornero, F.3
  • 39
    • 0034857217 scopus 로고    scopus 로고
    • Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure overload cardiac hypertrophy
    • Rapacciuolo A., Esposito G., Caron K., et al. Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure overload cardiac hypertrophy. J Am Coll Card 38 (2001) 876-882
    • (2001) J Am Coll Card , vol.38 , pp. 876-882
    • Rapacciuolo, A.1    Esposito, G.2    Caron, K.3
  • 40
    • 0037046072 scopus 로고    scopus 로고
    • Cardiovascular influences of alpha1b-adrenergic receptor defect in mice
    • Vecchione C., Fratta L., Rizzoni D., et al. Cardiovascular influences of alpha1b-adrenergic receptor defect in mice. Circulation 105 (2002) 1700-1707
    • (2002) Circulation , vol.105 , pp. 1700-1707
    • Vecchione, C.1    Fratta, L.2    Rizzoni, D.3
  • 42
    • 0031686860 scopus 로고    scopus 로고
    • Physiological consequences of β-adrenergic receptor disruption
    • Rohrer D.K. Physiological consequences of β-adrenergic receptor disruption. J Mol Med 76 (1998) 764-772
    • (1998) J Mol Med , vol.76 , pp. 764-772
    • Rohrer, D.K.1
  • 43
    • 0036952122 scopus 로고    scopus 로고
    • Adrenergic pathways and left ventricular remodeling
    • Dorn II G.W. Adrenergic pathways and left ventricular remodeling. J Card Fail 8 6 Suppl (2002) S370-S373
    • (2002) J Card Fail , vol.8 , Issue.6 SUPPL
    • Dorn II, G.W.1
  • 44
    • 0033535942 scopus 로고    scopus 로고
    • Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice
    • Engelhardt S., Hein L., Wiesmann F., et al. Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. Proc Natl Acad Sci USA 96 (1999) 7059-7064
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7059-7064
    • Engelhardt, S.1    Hein, L.2    Wiesmann, F.3
  • 45
    • 0029912925 scopus 로고    scopus 로고
    • Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression
    • Iwase M., Bishop S.P., Uechi M., et al. Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression. Circ Res 78 (1996) 517-524
    • (1996) Circ Res , vol.78 , pp. 517-524
    • Iwase, M.1    Bishop, S.P.2    Uechi, M.3
  • 46
    • 0028987631 scopus 로고
    • Overexpression of Gs alpha protein in the hearts of transgenic mice
    • Gaudin C., Ishikawa Y., and Wight D.C. Overexpression of Gs alpha protein in the hearts of transgenic mice. J Clin Invest 95 (1995) 1676-1683
    • (1995) J Clin Invest , vol.95 , pp. 1676-1683
    • Gaudin, C.1    Ishikawa, Y.2    Wight, D.C.3
  • 47
    • 0021194420 scopus 로고
    • Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure
    • Cohn J.N., Levine T.B., Olivari M.T., et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 311 (1984) 819-823
    • (1984) N Engl J Med , vol.311 , pp. 819-823
    • Cohn, J.N.1    Levine, T.B.2    Olivari, M.T.3
  • 48
    • 0019982539 scopus 로고
    • Decreased catecholamine sensitivity and beta adrenergic receptor density in failing human hearts
    • Bristow M.R., Ginsburg R., Minobe W., et al. Decreased catecholamine sensitivity and beta adrenergic receptor density in failing human hearts. N Engl J Med 307 (1982) 205-211
    • (1982) N Engl J Med , vol.307 , pp. 205-211
    • Bristow, M.R.1    Ginsburg, R.2    Minobe, W.3
  • 49
    • 0032499733 scopus 로고    scopus 로고
    • Expression of a beta-adrenergic receptor kinase I inhibitor prevents the development of heart failure in gene-targeted mice
    • Rochman H.A., Chien K.R., Choi D.J., et al. Expression of a beta-adrenergic receptor kinase I inhibitor prevents the development of heart failure in gene-targeted mice. Proc Natl Acad Sci USA 95 (1998) 7000-7005
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7000-7005
    • Rochman, H.A.1    Chien, K.R.2    Choi, D.J.3
  • 50
    • 0027497584 scopus 로고
    • Altered expression of beta-adrenergic receptor kinase and beta1 adrenergic receptors in the failing human heart
    • Ungerer M., Bohm M., Elce J.S., et al. Altered expression of beta-adrenergic receptor kinase and beta1 adrenergic receptors in the failing human heart. Circulation 87 (1993) 454-463
    • (1993) Circulation , vol.87 , pp. 454-463
    • Ungerer, M.1    Bohm, M.2    Elce, J.S.3
  • 51
    • 0029937949 scopus 로고    scopus 로고
    • The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. US Carvedilol Heart Failure Study group
    • Packer M., Bristow M.R., Cohn J.N., et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. US Carvedilol Heart Failure Study group. N Engl J Med 334 (1996) 1349-1355
    • (1996) N Engl J Med , vol.334 , pp. 1349-1355
    • Packer, M.1    Bristow, M.R.2    Cohn, J.N.3
  • 52
    • 0033549290 scopus 로고    scopus 로고
    • Effect of metoprolol CR/XL in chronic heart failure: metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)
    • Effect of metoprolol CR/XL in chronic heart failure: metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 353 (1999) 2001-2007
    • (1999) Lancet , vol.353 , pp. 2001-2007
  • 53
    • 0033577969 scopus 로고    scopus 로고
    • Role of the rennin-angiotensin system in cardiac hypertrophy
    • Yamazaki T., Komuro I., and Yazaki Y. Role of the rennin-angiotensin system in cardiac hypertrophy. Am J Cardiol 83 (1999) 53H-57H
    • (1999) Am J Cardiol , vol.83
    • Yamazaki, T.1    Komuro, I.2    Yazaki, Y.3
  • 54
    • 0025688895 scopus 로고
    • Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation
    • Schunkert H., Dzau V.J., Tang S.S., et al. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation. J Clin Invest 86 (1990) 1913-1920
    • (1990) J Clin Invest , vol.86 , pp. 1913-1920
    • Schunkert, H.1    Dzau, V.J.2    Tang, S.S.3
  • 55
    • 0033824138 scopus 로고    scopus 로고
    • International union of pharmacology. XXIII. The angiotensin II receptors
    • De Gasparo M., Catt K.J., Inagami T., et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 52 (2000) 415-472
    • (2000) Pharmacol Rev , vol.52 , pp. 415-472
    • De Gasparo, M.1    Catt, K.J.2    Inagami, T.3
  • 56
    • 0030610246 scopus 로고    scopus 로고
    • Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produce a lethal phenotype associated with myocite hyperplasia and heart block
    • Hein L., Stevens M.E., Barsh G.S., et al. Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produce a lethal phenotype associated with myocite hyperplasia and heart block. PNAS USA 94 (1997) 6391-6396
    • (1997) PNAS USA , vol.94 , pp. 6391-6396
    • Hein, L.1    Stevens, M.E.2    Barsh, G.S.3
  • 57
    • 0032546640 scopus 로고    scopus 로고
    • Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice
    • Harada K., Komuro I., Shiojima I., et al. Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice. Circulation 97 (1998) 1952-1959
    • (1998) Circulation , vol.97 , pp. 1952-1959
    • Harada, K.1    Komuro, I.2    Shiojima, I.3
  • 58
    • 0033770450 scopus 로고    scopus 로고
    • Important role of angiotensin II-mediated c-Jun NH2-terminal kinase activation in cardiac hypertrophy in hypertensive rats
    • Izumi Y., Kim S., Zhan Y., et al. Important role of angiotensin II-mediated c-Jun NH2-terminal kinase activation in cardiac hypertrophy in hypertensive rats. Hypertension 36 (2000) 511-519
    • (2000) Hypertension , vol.36 , pp. 511-519
    • Izumi, Y.1    Kim, S.2    Zhan, Y.3
  • 59
    • 0035902572 scopus 로고    scopus 로고
    • Angiotensin II type receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension
    • Ichihara S., Senbonmatsu T., Price Jr. E., et al. Angiotensin II type receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation 104 (2001) 346-351
    • (2001) Circulation , vol.104 , pp. 346-351
    • Ichihara, S.1    Senbonmatsu, T.2    Price Jr., E.3
  • 60
    • 0033837996 scopus 로고    scopus 로고
    • Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargment during in vivo pressure overload
    • Senbonmatsu T., Ichihara S., Price Jr. E., et al. Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargment during in vivo pressure overload. J Clin Invest 106 (2000) R25-R29
    • (2000) J Clin Invest , vol.106
    • Senbonmatsu, T.1    Ichihara, S.2    Price Jr., E.3
  • 61
    • 0034601761 scopus 로고    scopus 로고
    • Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodelling after aortic banding in mice
    • Akishita M., Iwai M., Wu L., et al. Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodelling after aortic banding in mice. Circulation 102 (2000) 1684-1689
    • (2000) Circulation , vol.102 , pp. 1684-1689
    • Akishita, M.1    Iwai, M.2    Wu, L.3
  • 62
    • 0026785561 scopus 로고
    • Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions
    • SOLVD
    • SOLVD. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med 327 (1992) 685-691
    • (1992) N Engl J Med , vol.327 , pp. 685-691
  • 63
    • 0026786643 scopus 로고
    • Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators
    • Pfeffer M.A., Braunwald E., Moye L.A., et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med 327 (1992) 669-677
    • (1992) N Engl J Med , vol.327 , pp. 669-677
    • Pfeffer, M.A.1    Braunwald, E.2    Moye, L.A.3
  • 64
    • 0034612118 scopus 로고    scopus 로고
    • Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial-the Losartan heart failure survival study ELITE II
    • Pitt B., Poole-Wilson P.A., Segal R., et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial-the Losartan heart failure survival study ELITE II. Lancet 355 (2000) 1582-1587
    • (2000) Lancet , vol.355 , pp. 1582-1587
    • Pitt, B.1    Poole-Wilson, P.A.2    Segal, R.3
  • 65
    • 0028175961 scopus 로고
    • Angiotensin receptor regulates cardiac hypertrophy and transforming growth factor-beta1 expression
    • Everett A.D., Tufro-McReddie A., Fisher A., et al. Angiotensin receptor regulates cardiac hypertrophy and transforming growth factor-beta1 expression. Hypertension 23 (1994) 587-592
    • (1994) Hypertension , vol.23 , pp. 587-592
    • Everett, A.D.1    Tufro-McReddie, A.2    Fisher, A.3
  • 66
    • 0024247175 scopus 로고
    • Structural vs contractile protein remodelling and myocardial stiffness in hypertrophied rat left ventricle
    • Jalil J.E., Doering C.W., Janicki J.S., et al. Structural vs contractile protein remodelling and myocardial stiffness in hypertrophied rat left ventricle. J Mol Cell Cardiol 20 (1988) 1179-1187
    • (1988) J Mol Cell Cardiol , vol.20 , pp. 1179-1187
    • Jalil, J.E.1    Doering, C.W.2    Janicki, J.S.3
  • 67
    • 0024410697 scopus 로고
    • Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle
    • Jalil J.E., Doering C.W., Janicki J.S., et al. Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. Circ Res 64 (1989) 1041-1050
    • (1989) Circ Res , vol.64 , pp. 1041-1050
    • Jalil, J.E.1    Doering, C.W.2    Janicki, J.S.3
  • 68
    • 0028182649 scopus 로고
    • Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload
    • Ito H., Hiroe M., Hirata Y., et al. Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload. Circulation 89 (1994) 2198-2203
    • (1994) Circulation , vol.89 , pp. 2198-2203
    • Ito, H.1    Hiroe, M.2    Hirata, Y.3
  • 69
    • 0029019736 scopus 로고
    • Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertrophy
    • Arai M., Yoguchi A., Iso T., et al. Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertrophy. Am J Physiol 268 (1995) H2084-H2091
    • (1995) Am J Physiol , vol.268
    • Arai, M.1    Yoguchi, A.2    Iso, T.3
  • 70
    • 0030869579 scopus 로고    scopus 로고
    • Atrial and pulmonary endothelin mRNA is increased in a canine model of chronic low cardiac output
    • Wie C.M., Clavell A.L., and Burnett J.C. Atrial and pulmonary endothelin mRNA is increased in a canine model of chronic low cardiac output. Am J Physiol 273 (1997) R838-R844
    • (1997) Am J Physiol , vol.273
    • Wie, C.M.1    Clavell, A.L.2    Burnett, J.C.3
  • 71
    • 0031059114 scopus 로고    scopus 로고
    • Increased cardiac expression in endothelin 1 mRNA in ischemic heart failure in rats
    • Tonnessen T., Christensen G., Oie E., et al. Increased cardiac expression in endothelin 1 mRNA in ischemic heart failure in rats. Cardiovasc Res 33 (1999) 601-610
    • (1999) Cardiovasc Res , vol.33 , pp. 601-610
    • Tonnessen, T.1    Christensen, G.2    Oie, E.3
  • 72
    • 0028299163 scopus 로고
    • Endothelin in human congestive heart failure
    • Wei C.M., Lerman A., Rodeheffer R.J., et al. Endothelin in human congestive heart failure. Circulation 89 (1994) 1580-1586
    • (1994) Circulation , vol.89 , pp. 1580-1586
    • Wei, C.M.1    Lerman, A.2    Rodeheffer, R.J.3
  • 73
    • 0035654297 scopus 로고    scopus 로고
    • Myocardial hypertrophy in transgenic mice overexpressing human interleukin 1α
    • Isoda K., Kamezawa Y., Tada N., et al. Myocardial hypertrophy in transgenic mice overexpressing human interleukin 1α. J Card Fail 7 (2001) 355-364
    • (2001) J Card Fail , vol.7 , pp. 355-364
    • Isoda, K.1    Kamezawa, Y.2    Tada, N.3
  • 74
    • 0033574574 scopus 로고    scopus 로고
    • Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress
    • Hirota H., Chen J., Betz U.A., et al. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell 97 (1999) 189-198
    • (1999) Cell , vol.97 , pp. 189-198
    • Hirota, H.1    Chen, J.2    Betz, U.A.3
  • 75
    • 0035933775 scopus 로고    scopus 로고
    • gp130 plays a critical role in pressure overload-induced cardiac hypertrophy
    • Uozumi H., Hiroi Y., Zou Y., et al. gp130 plays a critical role in pressure overload-induced cardiac hypertrophy. J Biol Chem 276 (2001) 23115-23119
    • (2001) J Biol Chem , vol.276 , pp. 23115-23119
    • Uozumi, H.1    Hiroi, Y.2    Zou, Y.3
  • 76
    • 0032748024 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 mediates pressure-induced hypertrophic response
    • Schultz J.E., Witt S.A., Nieman M.L., et al. Fibroblast growth factor-2 mediates pressure-induced hypertrophic response. J Clin Invest 104 (1999) 709-719
    • (1999) J Clin Invest , vol.104 , pp. 709-719
    • Schultz, J.E.1    Witt, S.A.2    Nieman, M.L.3
  • 77
    • 0035661066 scopus 로고    scopus 로고
    • Dilated cardiomyopathy and impaired cardiac hypertrophic response to angiotensin II in mice lacking FGF-2
    • Pellieux C., Foletti A., Peduto G., et al. Dilated cardiomyopathy and impaired cardiac hypertrophic response to angiotensin II in mice lacking FGF-2. J Clin Invest 108 (2001) 1843-1851
    • (2001) J Clin Invest , vol.108 , pp. 1843-1851
    • Pellieux, C.1    Foletti, A.2    Peduto, G.3
  • 78
    • 0030914008 scopus 로고    scopus 로고
    • Tissue repair and angiotensin II generated at sites of healing
    • Weber K.T., Sun Y., Katwa L.C., et al. Tissue repair and angiotensin II generated at sites of healing. Basic Res Cardiol 92 (1997) 75-78
    • (1997) Basic Res Cardiol , vol.92 , pp. 75-78
    • Weber, K.T.1    Sun, Y.2    Katwa, L.C.3
  • 79
    • 0029117828 scopus 로고
    • Tumor necrosis factor solubile receptors in patients with various degrees of congestive heart failure
    • Ferrari R., Bachetti T., Confortini R., et al. Tumor necrosis factor solubile receptors in patients with various degrees of congestive heart failure. Circulation 92 (1995) 1479-1486
    • (1995) Circulation , vol.92 , pp. 1479-1486
    • Ferrari, R.1    Bachetti, T.2    Confortini, R.3
  • 80
    • 0029670957 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and tumor necrosis factor receptors in the failing human heart
    • Torre-Amione G., Kapadia S., Lee J., et al. Tumor necrosis factor alpha and tumor necrosis factor receptors in the failing human heart. Circulation 93 (1996) 704-711
    • (1996) Circulation , vol.93 , pp. 704-711
    • Torre-Amione, G.1    Kapadia, S.2    Lee, J.3
  • 81
    • 0028171632 scopus 로고
    • Increased circulating cytokines in patients withmyocarditis and cardiomyopathy
    • Matsumori A., Yamada T., Suzuki H., et al. Increased circulating cytokines in patients withmyocarditis and cardiomyopathy. Br Heart J 72 (1994) 561-566
    • (1994) Br Heart J , vol.72 , pp. 561-566
    • Matsumori, A.1    Yamada, T.2    Suzuki, H.3
  • 82
    • 0034705270 scopus 로고    scopus 로고
    • Calcineurin signalling and muscle remodelling
    • Olson E.N., and Williams R.S. Calcineurin signalling and muscle remodelling. Cell 101 (2000) 689-692
    • (2000) Cell , vol.101 , pp. 689-692
    • Olson, E.N.1    Williams, R.S.2
  • 83
    • 0036162159 scopus 로고    scopus 로고
    • Old and new tools to dissect calcineurin's role in pressure-overload cardiac hypertrophy
    • Zhang W. Old and new tools to dissect calcineurin's role in pressure-overload cardiac hypertrophy. Cardiovasc Res 53 (2002) 294-303
    • (2002) Cardiovasc Res , vol.53 , pp. 294-303
    • Zhang, W.1
  • 84
    • 0032540267 scopus 로고    scopus 로고
    • A calcineurin-dependent trascriptional pathway for cardiac hypertrophy
    • Molkentin J.D., Lu J.R., Antos C.L., et al. A calcineurin-dependent trascriptional pathway for cardiac hypertrophy. Cell 93 (1998) 215-228
    • (1998) Cell , vol.93 , pp. 215-228
    • Molkentin, J.D.1    Lu, J.R.2    Antos, C.L.3
  • 85
    • 0035853110 scopus 로고    scopus 로고
    • Myocite-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo
    • Rothermel B.A., McKinsey T.A., Vega R.B., et al. Myocite-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. Proc Natl Acad Sci USA 98 (2001) 3328-3333
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3328-3333
    • Rothermel, B.A.1    McKinsey, T.A.2    Vega, R.B.3
  • 86
    • 0034739555 scopus 로고    scopus 로고
    • Calcineurin inhibitor attenuates left ventricular hypertrophy, leading to prevention of heart failure in hypertensive rats
    • Sakata Y., Masuyama T., Yamamoto K., et al. Calcineurin inhibitor attenuates left ventricular hypertrophy, leading to prevention of heart failure in hypertensive rats. Circulation 102 (2000) 2269-2275
    • (2000) Circulation , vol.102 , pp. 2269-2275
    • Sakata, Y.1    Masuyama, T.2    Yamamoto, K.3
  • 87
    • 0033515643 scopus 로고    scopus 로고
    • Cyclosporine attenuates pressure overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure
    • Meguro T., Hong C., Asai K., et al. Cyclosporine attenuates pressure overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure. Circ Res 84 (1999) 735-740
    • (1999) Circ Res , vol.84 , pp. 735-740
    • Meguro, T.1    Hong, C.2    Asai, K.3
  • 88
    • 0034625078 scopus 로고    scopus 로고
    • Calcineurin is activated in rat hearts with physiological left ventricular hypertrophy induced by voluntary exercise training
    • Eto Y., Yonekura K., Sonoda M., et al. Calcineurin is activated in rat hearts with physiological left ventricular hypertrophy induced by voluntary exercise training. Circulation 101 (2000) 2134-2137
    • (2000) Circulation , vol.101 , pp. 2134-2137
    • Eto, Y.1    Yonekura, K.2    Sonoda, M.3
  • 89
    • 0347320747 scopus 로고    scopus 로고
    • Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy
    • Wilkins B.J., Dai Y.S., Bueno O.F., et al. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res 94 (2004) 110-118
    • (2004) Circ Res , vol.94 , pp. 110-118
    • Wilkins, B.J.1    Dai, Y.S.2    Bueno, O.F.3
  • 90
    • 0032554670 scopus 로고    scopus 로고
    • Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice
    • Sakata Y., Hoit B.D., Liggett S.B., et al. Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. Circulation 97 (1998) 1488-1495
    • (1998) Circulation , vol.97 , pp. 1488-1495
    • Sakata, Y.1    Hoit, B.D.2    Liggett, S.B.3
  • 91
    • 0036143851 scopus 로고    scopus 로고
    • Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress
    • Esposito G., Rapacciuolo A., Naga Prasad S.V., et al. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation 105 (2002) 85-92
    • (2002) Circulation , vol.105 , pp. 85-92
    • Esposito, G.1    Rapacciuolo, A.2    Naga Prasad, S.V.3
  • 92
    • 0035952644 scopus 로고    scopus 로고
    • G-proteins in growth and apoptosis: lessons from the heart
    • Adams J.W., and Brown J.H. G-proteins in growth and apoptosis: lessons from the heart. Oncogene 20 (2001) 1626-1634
    • (2001) Oncogene , vol.20 , pp. 1626-1634
    • Adams, J.W.1    Brown, J.H.2
  • 93
    • 0037012652 scopus 로고    scopus 로고
    • Dual actions of the Galpha(q) agonist Pasteurella multocida toxin to promote cardiomyocyte hypertrophy and enhance apoptosis susceptibility
    • Sabri A., Wilson B.A., and Steinberg S.F. Dual actions of the Galpha(q) agonist Pasteurella multocida toxin to promote cardiomyocyte hypertrophy and enhance apoptosis susceptibility. Circ Res 90 (2002) 850-857
    • (2002) Circ Res , vol.90 , pp. 850-857
    • Sabri, A.1    Wilson, B.A.2    Steinberg, S.F.3
  • 94
    • 0035941418 scopus 로고    scopus 로고
    • Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase A
    • Antos C.L., Frey N., Marx S.O., et al. Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase A. Circ Res 89 (2001) 997-1004
    • (2001) Circ Res , vol.89 , pp. 997-1004
    • Antos, C.L.1    Frey, N.2    Marx, S.O.3
  • 95
    • 0033866027 scopus 로고    scopus 로고
    • Increase in G(i alpha) protein accompanies progression of post-infarction remodeling in hypertensive cardiomyopathy
    • Kouchi I., Zolk O., Jockenhovel F., et al. Increase in G(i alpha) protein accompanies progression of post-infarction remodeling in hypertensive cardiomyopathy. Hypertension 36 (2000) 42-47
    • (2000) Hypertension , vol.36 , pp. 42-47
    • Kouchi, I.1    Zolk, O.2    Jockenhovel, F.3
  • 96
    • 0033515118 scopus 로고    scopus 로고
    • Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy
    • Zou Y., Komuro I., Yamazaki T., et al. Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy. J Biol Chem 274 14 (1999) 9760-9770
    • (1999) J Biol Chem , vol.274 , Issue.14 , pp. 9760-9770
    • Zou, Y.1    Komuro, I.2    Yamazaki, T.3
  • 97
    • 0026557823 scopus 로고
    • Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure
    • Eschenhagen T., Mende U., Nose M., et al. Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure. Circ Res 70 (1992) 688-696
    • (1992) Circ Res , vol.70 , pp. 688-696
    • Eschenhagen, T.1    Mende, U.2    Nose, M.3
  • 98
    • 0023052241 scopus 로고
    • Studies and perspectives of protein kinase C
    • Nishizuka Y. Studies and perspectives of protein kinase C. Science 233 4761 (1986) 305-312
    • (1986) Science , vol.233 , Issue.4761 , pp. 305-312
    • Nishizuka, Y.1
  • 99
    • 1642388834 scopus 로고    scopus 로고
    • PKC-α regulates cardiac contractility and propensity toward heart failure
    • Braz J.C., Gregory K., Pathak A., et al. PKC-α regulates cardiac contractility and propensity toward heart failure. Nat Med 10 (2004) 248-254
    • (2004) Nat Med , vol.10 , pp. 248-254
    • Braz, J.C.1    Gregory, K.2    Pathak, A.3
  • 100
    • 0032910168 scopus 로고    scopus 로고
    • Organization and regulation of mitogen-activated protein kinase signalling pathways
    • Garrington T.P., and Johnson G.L. Organization and regulation of mitogen-activated protein kinase signalling pathways. Curr Opin Cell Biol 11 (1999) 211-218
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 211-218
    • Garrington, T.P.1    Johnson, G.L.2
  • 101
    • 0034383952 scopus 로고    scopus 로고
    • The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
    • Bueno O.F., De Windt L.J., Tymitz K.M., et al. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J 19 (2000) 6341-6350
    • (2000) EMBO J , vol.19 , pp. 6341-6350
    • Bueno, O.F.1    De Windt, L.J.2    Tymitz, K.M.3
  • 102
    • 0035355360 scopus 로고    scopus 로고
    • Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy
    • Nicol R.L., Frey N., Pearson G., et al. Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy. EMBO J 20 (2001) 2757-2767
    • (2001) EMBO J , vol.20 , pp. 2757-2767
    • Nicol, R.L.1    Frey, N.2    Pearson, G.3
  • 103
    • 0032563677 scopus 로고    scopus 로고
    • 'Stress-responsive' mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen activated protein kinases) in the myocardium
    • Sugden P.H., and Clerk A. 'Stress-responsive' mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen activated protein kinases) in the myocardium. Circ Res 24 (1998) 345-352
    • (1998) Circ Res , vol.24 , pp. 345-352
    • Sugden, P.H.1    Clerk, A.2
  • 104
    • 0032572534 scopus 로고    scopus 로고
    • Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein coupled receptor agonists,endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy?
    • Clerk A., Michael A., and Sudgen P.H. Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein coupled receptor agonists,endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy?. J Cell Biol 142 (1998) 523-535
    • (1998) J Cell Biol , vol.142 , pp. 523-535
    • Clerk, A.1    Michael, A.2    Sudgen, P.H.3
  • 105
    • 0034105968 scopus 로고    scopus 로고
    • TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice
    • Zhang D., Gaussin V., Taffet G.E., et al. TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice. Nat Med 6 (2000) 556-563
    • (2000) Nat Med , vol.6 , pp. 556-563
    • Zhang, D.1    Gaussin, V.2    Taffet, G.E.3
  • 106
    • 0035845631 scopus 로고    scopus 로고
    • Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction
    • Behr T.M., Nerurkar S.S., Nelson A.H., et al. Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction. Circulation 104 (2001) 1292-1298
    • (2001) Circulation , vol.104 , pp. 1292-1298
    • Behr, T.M.1    Nerurkar, S.S.2    Nelson, A.H.3
  • 107
    • 0037133571 scopus 로고    scopus 로고
    • MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq
    • Minamino T., Yujiri T., Terada N., et al. MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq. Proc Natl Acad Sci USA 99 (2002) 3866-3871
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3866-3871
    • Minamino, T.1    Yujiri, T.2    Terada, N.3
  • 108
    • 0036074371 scopus 로고    scopus 로고
    • The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
    • Sadoshima J., Montagne O., Wang Q., et al. The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J Clin Invest 110 (2002) 271-279
    • (2002) J Clin Invest , vol.110 , pp. 271-279
    • Sadoshima, J.1    Montagne, O.2    Wang, Q.3
  • 109
    • 0037125980 scopus 로고    scopus 로고
    • Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice
    • Condorelli G., Drusco A., Stassi G., et al. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci USA 99 (2002) 12333-12338
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12333-12338
    • Condorelli, G.1    Drusco, A.2    Stassi, G.3
  • 110
    • 0034213075 scopus 로고    scopus 로고
    • The conserved phosphoinositide 3-kinase pathway determines heart size in mice
    • Shioi T., Kang P.M., Douglas P.S., et al. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J 19 (2000) 2537-2548
    • (2000) EMBO J , vol.19 , pp. 2537-2548
    • Shioi, T.1    Kang, P.M.2    Douglas, P.S.3
  • 111
    • 0037151104 scopus 로고    scopus 로고
    • Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
    • Matsui T., Li L., Wu J.C., et al. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem 277 25 (2002) 22896-22901
    • (2002) J Biol Chem , vol.277 , Issue.25 , pp. 22896-22901
    • Matsui, T.1    Li, L.2    Wu, J.C.3
  • 112
    • 18644372367 scopus 로고    scopus 로고
    • Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
    • Crackower M.A., Oudit G.Y., Kozieradzki I., et al. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 110 (2002) 737-749
    • (2002) Cell , vol.110 , pp. 737-749
    • Crackower, M.A.1    Oudit, G.Y.2    Kozieradzki, I.3
  • 113
    • 0042750799 scopus 로고    scopus 로고
    • Akt and PI3-kinase signaling in cardiomyocyte hypertrophy and survival
    • Matsui T., Nagoshi T., and Rosenzweig A. Akt and PI3-kinase signaling in cardiomyocyte hypertrophy and survival. Cell Cycle 2 (2003) 220-223
    • (2003) Cell Cycle , vol.2 , pp. 220-223
    • Matsui, T.1    Nagoshi, T.2    Rosenzweig, A.3
  • 114
    • 0037357698 scopus 로고    scopus 로고
    • Regulation of cardiac myocyte cell death
    • Clerk A., Cole S.M., Cullingford T.E., et al. Regulation of cardiac myocyte cell death. Pharmacol Ther 97 (2003) 223-261
    • (2003) Pharmacol Ther , vol.97 , pp. 223-261
    • Clerk, A.1    Cole, S.M.2    Cullingford, T.E.3
  • 115
  • 116
    • 0142027759 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
    • McMullen J.R., Shioi T., Zhang L., et al. Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci USA 100 (2003) 12355-12360
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12355-12360
    • McMullen, J.R.1    Shioi, T.2    Zhang, L.3
  • 117
    • 0035477020 scopus 로고    scopus 로고
    • GSK3 takes centre stage more than 20 years after its discovery
    • Frame S., and Cohen P. GSK3 takes centre stage more than 20 years after its discovery. Biochem J 359 (2001) 1-16
    • (2001) Biochem J , vol.359 , pp. 1-16
    • Frame, S.1    Cohen, P.2
  • 118
    • 0032489431 scopus 로고    scopus 로고
    • Solution structure of the core NFATC1/DNA complex
    • Zhou P., Sun L.J., Dotsch V., et al. Solution structure of the core NFATC1/DNA complex. Cell 92 (1998) 687-696
    • (1998) Cell , vol.92 , pp. 687-696
    • Zhou, P.1    Sun, L.J.2    Dotsch, V.3
  • 119
    • 0034597147 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy
    • Haq S., Choukroun G., Kang Z.B., et al. Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy. J Cell Biol 151 (2000) 117-130
    • (2000) J Cell Biol , vol.151 , pp. 117-130
    • Haq, S.1    Choukroun, G.2    Kang, Z.B.3
  • 120
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross D.A., Alessi D.R., Cohen P., et al. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378 (1995) 785-789
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3
  • 121
    • 0037154168 scopus 로고    scopus 로고
    • Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo
    • Antos C.L., McKinsey T.A., Frey N., et al. Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci USA 99 (2002) 907-912
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 907-912
    • Antos, C.L.1    McKinsey, T.A.2    Frey, N.3
  • 122
    • 0036172127 scopus 로고    scopus 로고
    • Fas receptor signaling inhibits glycogen synthase kinase 3 beta and induces cardiac hypertrophy following pressure overload
    • Badorff C., Ruetten H., Mueller S., et al. Fas receptor signaling inhibits glycogen synthase kinase 3 beta and induces cardiac hypertrophy following pressure overload. J Clin Invest 109 (2002) 373-381
    • (2002) J Clin Invest , vol.109 , pp. 373-381
    • Badorff, C.1    Ruetten, H.2    Mueller, S.3
  • 123
    • 4344714889 scopus 로고    scopus 로고
    • PI3Kγ modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects
    • Patrucco E., Notte A., Barberis L., et al. PI3Kγ modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118 (2004) 1-20
    • (2004) Cell , vol.118 , pp. 1-20
    • Patrucco, E.1    Notte, A.2    Barberis, L.3
  • 124
  • 125
    • 0038464639 scopus 로고    scopus 로고
    • Phospholamban: a crucial regulator of cardiac contractility
    • MacLennan D.H., and Kranias E.G. Phospholamban: a crucial regulator of cardiac contractility. Nat Reviews 4 (2003) 566-577
    • (2003) Nat Reviews , vol.4 , pp. 566-577
    • MacLennan, D.H.1    Kranias, E.G.2
  • 126
    • 0033615645 scopus 로고    scopus 로고
    • Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy
    • Minamisawa S., Hoshijima M., Chu G., et al. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell 99 (1999) 313-322
    • (1999) Cell , vol.99 , pp. 313-322
    • Minamisawa, S.1    Hoshijima, M.2    Chu, G.3
  • 127
    • 1542409908 scopus 로고    scopus 로고
    • Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation
    • Engelhardt S., Hein L., Dyachenkow V., et al. Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation. Circulation 109 (2004) 1154-1160
    • (2004) Circulation , vol.109 , pp. 1154-1160
    • Engelhardt, S.1    Hein, L.2    Dyachenkow, V.3
  • 128
    • 0035937762 scopus 로고    scopus 로고
    • Rescue of contractile parameters and myocite hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation
    • Sato Y., Kiriazis H., Yatani A., et al. Rescue of contractile parameters and myocite hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation. J Biol Chem 276 (2001) 9392-9399
    • (2001) J Biol Chem , vol.276 , pp. 9392-9399
    • Sato, Y.1    Kiriazis, H.2    Yatani, A.3
  • 129
    • 0035048223 scopus 로고    scopus 로고
    • Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy
    • Freeman K., Lerman I., Kranias E.G., et al. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. J Clin Invest 107 (2001) 967-974
    • (2001) J Clin Invest , vol.107 , pp. 967-974
    • Freeman, K.1    Lerman, I.2    Kranias, E.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.