Myocardial hypertrophy in transgenic mice overexpressing human interleukin 1α

Journal of Cardiac Failure

Volumn 7, Issue 4, 2001, Pages 355-364

  Isoda, Kikuo ^a   Kamezawa, Yasuhiro ^a   Tada, Norihiro ^b   Sato, Masahiro ^a   Ohsuzu, Fumitaka ^a  

^a TOKAI UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytokines; Gene expression; Heart failure; Hypertrophy

Indexed keywords

ATRIAL NATRIURETIC FACTOR; CALCIUM CHANNEL; INTERLEUKIN 1; MYOSIN HEAVY CHAIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; LUNG EDEMA; LUNG WEIGHT; MICROSCOPY; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

EID: 0035654297     PISSN: 10719164     EISSN: None     Source Type: Journal    
DOI: 10.1054/jcaf.2001.28221     Document Type: Article

References (40)

1. Biology of interleukin 1
2. Interleukin-1: The first interleukin
3. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
4. Increased circulating cytokines in patients with myocarditis and cardiomyopathy
5. Biologic basis for interleukin-1 in disease
6. The role of nitric oxide in cardiac depression induced by interleukin-1 beta and tumour necrosis factor-alpha
7. Interleukin-1β modulates myocardial contraction via dexamethasone sensitive production of nitric oxide
8. Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte β-adrenergic responsiveness
9. Interleukin-1β inhibits phospholamban gene expression in cultured cardiomyocytes
10. Interleukin-1β modulates the growth and phenotype of neonatal rat cardiac myocytes
11. Inflammatory skin disease in transgenic mice that express high levels of interleukin 1α in basal epidermis
12. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis
13. Expression of collagenase and IL-1α in developing rat hearts
14. Efficient selection for high-expression transfectants with a novel eukaryotic vector
15. Production of transgenic mice
16. In vivo echocardiographic detection of enhanced left ventricular function in gene-targeted mice with phospholamban deficiency
17. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction
18. Differences in distribution of myocardial abnormalities in patients with obstructive and nonobstructive asymmetric septal hypertrophy
19. Proinflammatory consequences of transgenic Fas ligand expression in the heart
20. The effects of treatment with interleukin-1α on platelet recovery after high-dose carboplatin
21. Downregulation of renin gene expression by interleukin-1
22. A phase I trial of recombinant human interleukin-1β alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer
23. The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies
24. Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice
25. Cardiac-specific overexpression of tumor necrosis factor-alpha causes lethal myocarditis in transgenic mice
26. Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-α
27. Endotoxin and tumor necrosis factor induce interleukin-I gene expression in adult human vascular endothelial cells
28. Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein
29. Interleukin-1 represents a new modality for the activation of extracellular signal-related kinases/microtubule-associated protein-2 kinases
30. IL-1 activates two separate signal transduction pathways in T helper type II cells
31. BCL3 encodes a nuclear protein which can alter the subcellular location of NF-KB proteins
32. Interleukin-1 induces NFKB through its type I but not type II receptor in lymphocytes
33. In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-derived protein kinase and protein kinase C
34. IL-1 beta and IL-6 induce hyperplasia and hypertrophy of cultured guinea pig airway smooth muscle
35. Active myocarditis in the spectrum of acute dilated cardiomyopathies: Clinical features, histologic correlates and clinical outcome
36. Effects of immunosuppressive therapy in biopsy-proved myocarditis and borderline myocarditis on left ventricular function
37. The effects of interleukin 1 on myocardial function and metabolism
38. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes
39. 2+current by interleukin-1β in cultured rat ventricular myocytes
40. Increased expression of interleukin-1b and monocyte chemoattractant protein-1 in the hypertrophied and failing heart with pressure overload