A switch 3 point mutation in the α subunit of transducin yields a unique dominant-negative inhibitor

Journal of Biological Chemistry

Volumn 280, Issue 42, 2005, Pages 35696-35703

  Pereira, Ryan ^a   Cerione, Richard A ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; CONFORMATIONS; ENZYME INHIBITION; LIQUID CHROMATOGRAPHY; ORGANIC ACIDS; PROTEINS;

EFFECTOR ENZYMES; G PROTEIN-COUPLED SIGNALING; PHOSPHODIESTERASE; TRANSDUCIN;

MUTAGENESIS;

ALANINE; ALUMINUM FLUORIDE; ARGININE; CYCLIC GMP PHOSPHODIESTERASE; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; LYSINE; PROTEIN SUBUNIT; RHODOPSIN; TRANSDUCIN; TRANSDUCIN ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHIMERA; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; VERTEBRATE; VISION;

ALUMINUM COMPOUNDS; ANIMALS; ARGININE; CATALYSIS; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORIDES; GENES, DOMINANT; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTATION; NUCLEOTIDES; POINT MUTATION; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; RETINA; RHODOPSIN; SIGNAL TRANSDUCTION; SPECTROMETRY, FLUORESCENCE; TIME FACTORS; TRANSDUCIN; TRYPSIN;

VERTEBRATA;

EID: 27444441027     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504935200     Document Type: Article

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