Crucial role of NO and endothelium-derived hyperpolarizing factor in human sustained conduit artery flow-mediated dilatation

Hypertension

Volumn 48, Issue 6, 2006, Pages 1088-1094

  Bellien, Jeremy ^a   Iacob, Michele ^a   Gutierrez, Laurence ^a   Isabelle, Marc ^a   Lahary, Agnes ^a   Thuillez, Christian ^a   Joannides, Robinson ^a  

^a ROUEN UNIVERSITY HOSPITAL   (France)

Author keywords

Conduit arteries; Cytochrome P450; Endothelium; Endothelium derived hyperpolarizing factor; Flow mediated dilatation; Nitric oxide

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CYTOCHROME P450; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; FLUCONAZOLE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; SODIUM CHLORIDE; TETRYLAMMONIUM CHLORIDE;

ADULT; ARTERY DIAMETER; ARTICLE; BLOOD FLOW; CALCULATION; CONTROLLED STUDY; DOPPLER FLOWMETRY; HEATING; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RADIAL ARTERY; SHEAR STRESS; SKIN; VASODILATATION;

ADULT; BIOLOGICAL FACTORS; BLOOD FLOW VELOCITY; ENZYME INHIBITORS; HUMANS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RADIAL ARTERY; REGIONAL BLOOD FLOW; SHEAR STRENGTH; VASODILATION;

EID: 33751087770     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000246672.72188.bd     Document Type: Article

References (40)

1. Pohl U, Holtz J, Busse R, Bassenge E. Crucial role of endothelium in the vasodilatator response to increased flow in vivo. Hypertension. 1986;8:37-44.
2. Joannides R, Haefeli W, Linder L, Richard V, Bakkali ELH, Thuillez C, Lüscher T. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation. 1995;91:1314-1319.
3. Lieberman EH, Gerhard MD, Uehata A, Selwyn AP, Ganz P, Yeung AC, Creager MA. Flow-induced vasodilation of the human brachial artery is impaired in patients <40 years of age with coronary artery disease. Am J Cardiol. 1996;78:1210-1214.
4. Doshi SN, Naka KK, Payne N, Jones CJ, Ashton M, Lewis MJ, Goodfellow J. Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide. Clin Sci (Lond). 2001;101:629-635.
5. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R. International Brachial Artery Reactivity Task Force. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002;39:257-265.
6. Quyyumi AA. Prognostic value of endothelial function. Am J Cardiol. 2003;91:19H-24H.
7. Mullen MJ, Kharbanda RK, Cross J, Donald AE, Taylor M, Vallance P, Deanfield JE, MacAllister RJ. Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo. Relevance to endothelial dysfunction in hypercholesterolemia. Circ Res. 2001;88:145-151.
8. Dube S, Canty JM Jr. Shear-stress-induced vasodilatation in porcine coronary conduit arteries is independent of nitric oxide release. Am J Physiol Heart Circ Physiol. 2001;280:H2581-H2590.
9. Shiode N, Morishima N, Nakayama K, Yamagata T, Matsuura H, Kajiyama G. Flow-mediated vasodilation of human epicardial coronary arteries: effect of inhibition of nitric oxide synthesis. J Am Coll Cardiol. 1996;27:304-310.
10. MacGuire JJ, Ding H, Triggle CR. Endothelium-derived relaxing factors: a focus on endothelium-derived hyperpolarizing factor(s). Can J Physiol Pharmacol. 2001;79:443-470.
11. Huang A, Sun D, Jacobson A, Carroll MA, Falck JR, Kaley G. Epoxyeicosatrienoic acids are released to mediate shear stress-dependent hyperpolarization of arteriolar smooth muscle. Circ Res. 2005;96:376-383.
12. Miura H, Wachtel RE, Liu Y, Loberiza FR, Saito T, Miura M, Gutterman DD. Flow-induced dilation of human coronary arterioles. Important role of Ca2+-activated K+ channels. Circulation. 2001;103:1992-1998.
13. Halcox JP, Narayanan S, Cramer-Joyce L, Mincemoyer R, Quyyumi AA. Characterization of endothelium-derived hyperpolarizing factor in the human forearm microcirculation. Am J Physiol Heart Circ Physiol. 2001;280:H2470-H2477.
14. Passauer J, Bussemaker E, Lassig G, Pistrosch F, Fauler J, Gross P, Fleming I. Baseline blood flow and bradykinin-induced vasodilator responses in the human forearm are insensitive to the cytochrome P450 2C9 (CYP2C9) inhibitor sulphaphenazole. Clin Sci (Lond). 2003;105:513-518.
15. Fichtlscherer S, Dimmeler S, Breuer S, Busse R, Zeiher AM, Fleming I. Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease. Circulation. 2004;109:178-183.
16. Hillig T, Krustrup P, Fleming I, Osada T, Saltin B, Hellsten Y. Cytochrome P450 2C9 plays an important role in the regulation of exercise-induced skeletal muscle blood flow and oxygen uptake in humans. J Physiol. 2003;546:307-314.
17. Archer SL, Gragasin FS, Wu X, Wang S, McMurtry S, Kim DH, Platonov M, Koshal A, Hashimoto K, Campbell WB, Falck JR, Michelakis ED. Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12- epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels. Circulation. 2003;107:769-776.
18. Bellien J, Joannides R, Iacob I, Arnaud P, Thuillez C. Evidence for a basal release of a cytochrome-related endothelium-derived hyperpolarizing factor in the radial artery in humans. Am J Physiol Heart Circ Physiol. 2006;290:H1347-H1352.
19. Joannides R, Costentin A, Iacob M, Compagnon P, Lahary A, Thuillez C. Influence of vascular dimension on gender difference in flow-dependent dilatation of peripheral conduit arteries. Am J Physiol Heart Circ Physiol. 2002;82:H1262-H1269.
20. Inokuchi K, Hirooka Y, Shimokawa H, Sakai K, Kishi T, Ito K, Kimura Y, Takeshita A. Role of endothelium-derived hyperpolarizing factor in human forearm circulation. Hypertension. 2003;42:919-924.
21. Langton PD, Nelson MT, Huang Y, Standen NB. Block of calcium-activated potassium channels in mammalian arterial myocytes by tetraethylammonium ions. Am J Physiol. 1991;60:H927-H934.
22. Venkatakrishnan K, von Moltke LL, Greenblatt DJ. Effects of the antifungal agents on oxidative drug metabolism: clinical relevance. Clin Pharmacokinet. 2000;38:111-180.
23. Hoobler SW, Malton SD, Ballantine HT, Cohen S, Nelight RB, Peet MM, Lyons RH. Studies on vasomotor tone. I. The effect of the tetraethylammonium ion on the peripheral blood flow of normal subjects. J Clin Invest. 1949;28:638-647.
24. Joannides R, Richard V, Haefeli WE, Linder L, Lüscher TF, Thuillez C. Role of basal and stimulated release of nitric oxide in the regulation of radial artery diameter in humans. Hypertension. 1995;26:327-331.
25. Heavey DJ, Barrow SE, Hickling NE, Ritter JM. Aspirin causes short-lived inhibition of bradykinin-stimulated prostacyclin production in man. Nature. 1985;318:186-188.
26. Detry JM, Brengelmann GL, Rowell LB, Wyss C. Skin and muscle components of forearm blood flow in directly heated resting man. J Appl Physiol. 1972;32:506-511.
27. Kellogg DL, Liu Y, Kosiba IF, O'Donnell D. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol. 1999;86:1185-1190.
28. Fleming I, Michaelis UR, Bredenkotter D, Fisslthaler B, Dehghani F, Brandes RP, Busse R. Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circ Res. 2001;88:44-51.
29. Moncada S, Rees DD, Schulz R, Palmer RM. Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc Natl Acad Sci U S A. 1991;88:2166-2170.
30. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 1989;2:997-1000.
31. Tentolouris C, Tousoulis D, Crake T, Katsimaglis G, Stefanadis C, Davies G, Toutouzas P. Inhibition of nitric oxide synthesis in human epicardial coronary arteries and stenoses in relation to serum lipid level. Atherosclerosis. 1999;147:285-291.
32. Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, Cohen RA. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature. 1994;368:850-853.
33. Takamura Y, Shimokawa H, Zhao H, Igarashi H, Egashira K, Takeshita A. Important role of endothelium-derived hyperpolarizing factor in shear stress-induced endothelium-dependent relaxations in the rat mesenteric artery. J Cardiovasc Pharmacol. 1999;34:381-387.
34. Alvarez J, Montero M, Garcia-Sancho J. High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992;267:11789-11793.
35. Hamilton CA, Williams R, Pathi V, Berg G, McArthur K, McPhaden AR, Reid JL, Dominiczak AF. Pharmacological characterization of endothelium-dependent relaxation in human radial artery: comparison with internal thoracic artery. Cardiovasc Res. 1999;42:214-223.
36. Bauersachs J, Popp R, Hecker M, Sauer E, Fleming I, Busse R. Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation. 1996;94:3341-3347.
37. Urakami-Harasawa L, Shimokawa H, Nakashima M, Egashira K, Takeshita A. Importance of endothelium-derived hyperpolarizing factor in human arteries. J Clin Invest. 1997;100:2793-2799.
38. Fleming I. Cytochrome P450 epoxygenase as EDHF synthase(s). Pharmacol Res. 2004;49:525-533.
39. Chrissobolis S, Sobey CG. Inwardly rectifying potassium channels in the regulation of vascular tone. Curr Drug Targets. 2003;4:281-289.
40. Larsen BT, Gutterman DD, Hatoum OA. Emerging role of epoxyeicosatrienoic acids in coronary vascular function. Eur J Clin Invest. 2006;36:293-300.