Antibody microarrays: Current status and key technological advances

OMICS A Journal of Integrative Biology

Volumn 10, Issue 3, 2006, Pages 411-427

  Wingren, Christer ^a   Borrebaeck, Carl A K ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEOME; REAGENT;

ANTIBODY MICROARRAY; ANTIBODY SPECIFICITY; BIOMEDICINE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; RESEARCH; REVIEW; TECHNIQUE; TECHNOLOGY;

ANIMALS; ANTIBODIES; HUMANS; MOLECULAR PROBES; PROTEIN ARRAY ANALYSIS;

EID: 33750959353     PISSN: 15362310     EISSN: None     Source Type: Journal    
DOI: 10.1089/omi.2006.10.411     Document Type: Review

References (132)

1. ADKINS, J.N., VARNUM, S.M., AUBERRY, K.J., et al. (2002). Toward a human blood serum proteome. Mol Cell Proteomics 1, 947-955.
2. ANDERSON, N.L., POLANSKI, M., PIEPER, R., GATLIN, T., TIRUMALAI, R.S., CONRADS, T.P. et al. (2004). The human plasma proteome: a non-redundant list developed by combination of four separate sources. Mol Cell Proteomics 3, 311-326.
3. ANGENENDT, P., GLOKLER, J., MURPHY, D., et al. (2002). Toward optimized antibody microarrays: a comparison of current microarray support materials. Anal Biochem 309, 253-260.
4. ANGENENDT, P., GLOKLER, J., SOBEK, J., et al. (2003). Next generation of protein microarray support materials: evaluation for protein and antibody microarray applications. J Chromatogr A 1009, 97-104.
5. ANGENENDT, P., NYARSIK, L., SZAFLARSKI, W., et al. (2004a). Cell-free protein expression and functional assay in nanowell chip format. Anal Chem 76, 1844-1849.
6. ANGENENDT, P., WILDE, J., KIJANKA, G., et al. (2004b). Seeing better through MIST: evaluation of monoclonal recombinant antibody fragments on microarrays. Anal Chem 76, 2916-2921.
7. ANGENENDT, P. (2005). Progress in protein and antibody microarray technologies. Drug Discov Today 10, 503-511.
8. ANGENENDT, P., LEHRACH, H., KREUTZBERGER, J., et al. (2005). Subnanoliter enzymatic assays on microarrays. Proteomics 5, 420-425.
9. ARNTZ, Y., SEELIG, J.D., LANG, H.P., et al. (2003). Label-free protein assay based on a nanomechanical cantilever array. Nanotechnology 14, 86-90.
10. BACKMANN, N., ZAHND, C., HUBER, F., et al. (2005). A label-free immunosensor array using single-chain antibody fragments. Proc Natl Acad Sci USA 102, 14587-14592.
11. BEATOR, J. (2002). From protein microarrays to cytokine detection chips. Biotech International Dec, 20-22.
12. BELOV, L., DE LA VEGA, O., DOS REMEDIOS, C.G., et al. (2001). Immunophenotyping of leukemias using a cluster of differentiation antibody microarray. Cancer Research 61, 4483-4489.
13. BELOV, L., HUANG, P., BARBER, N., et al. (2003). Identification of repertoires of surface antigens on leukemias using an antibody microarray. Proteomics 3, 2147-2154.
14. BINZ, H.K., AMSTUTZ, P., KOHL, A., et al. (2004). High-affinity binders selected from designed ankyrin repeat protein libraries. Nat Biotechnol 22, 575-582.
15. BLANK, K., LANKENAU, A., MAI, T., et al. (2004). Double-chip protein arrays: force-based multiplex sandwich immunoassays with increased specificity. Anal Bioanal Chem 379, 974-981.
16. BOCK, C., COLEMAN, M., COLLINS, B., et al. (2004). Photoaptamer arrays applied to multiplexed proteomic analysis. Proteomics 4, 609-618.
17. BORREBAECK, C.A.K. (2000). Antibodies in diagnostics-from immunoassays to protein chips. Immunol Today 21, 379-382.
18. BORREBAECK, C.A.K., EKSTRÖM, S., MALMBORG-HAGER, A.C., et al. (2001). Protein chips based on recombinant antibody fragments: a highly sensitive approach as detected by mass spectrometry. Biotechniques 30, 1126-1132.
19. BORREBAECK, C.A.K. (2006). Antibody microarray based oncoproteomics. Exp Opin Biol In press.
20. BRUCKBAUER, A., ZHOU, D., KANG, D.J., et al. (2004). An addressable antibody nanoarray produced on a nanostructured surface. J Am Chem Soc 126, 6508-6509.
21. CHENG, M.M.C., CUDA, G., BUNIMOVICH, Y.L., et al. (2005). Nanotechnologies for biomolecular detection and medical diagnostics. Curr Opin Chem Biol 10, 1-9.
22. CHOI, Y.S.C., PACK, S.P., and YOO, Y.J. (2005). Development of a protein microarray using a sequence-specific DNA binding domain on DNA chip surface. Biochem Biophys Res Commun 329, 1315-1319.
23. DAHLIN, A., ZACH, M., RINDZEVICIUS, T., et al. (2005). Localized surface plasmon resonance sensing of lipid-membrane-mediated biorecognition events. J Am Chem Soc 127, 5043-5048.
24. DELEHANTY, J.B., SCAFFER, K.M., and LIN, B. (2004). Transfected cell microarrays for the expression of membrane-displayed single-chain antibodies. Anal Chem 76, 7323-7328.
25. DEMERS, L.M., GINGER, D.S., PARK, S.J., et al. (2002). Direct patterning of modified oligonucleotides on metals and insulators by dip-pen litography. Science 296, 1836-1838.
26. DEXLIN, L., INGVARSSON, J., JÖNSSON, M., et al. (2006). Membrane protein profiling of intact cells using recombinant antibody microarrays. Submitted.
27. DUTTA, P., TIPPLE, C.A., LAVRIK, N.V., et al. (2003). Enantioselective sensors based on antibody-mediated nanomechanics. Anal Chem 75, 2342-2348.
28. ELLMARK, P., BELOV, L., HUNAG, P., et al. (2006a). Multiplex detection of surface molecules on colorectal cancers. Proteomics. 6, 1791-1802.
29. ELLMARK, P., INGVARSSON, J., CARLSSON, A., et al. (2006b). Protein expression profiling of normal and malignant stomach tissue using recombiant antibody microarrays. Submitted.
30. ESPINA, V., WOODHOUSE, B.C., WULFKUHLE, I., et al. (2004). Protein microarray detection strategies: focus on direct detection technologies. L Immunol Methods 290, 121-133.
31. FINNSKOG, D., RESSINE, A., LAURELL, T., et al. (2004). Integrated protein microchip assay with dual fluorescent- and MALDi read-out. J Proteome Res 3, 988-994.
32. FINNSKOG, D., JARAS, K., RESSINE, A., et al. (2006). High-speed biomarker identification utilizing silicon nanovial arrays and MALDI-TOF mass spectrometry. Electrophoresis 27, 1093-1103.
33. FREDRIKSSON, S., GULLBERG, M., JARVIUS, J., et al. (2002). Protein detection using proximity-dependent DNA ligation assay. Nat Biotechnol 20, 473-477.
34. GAO, W.M., KUICK, R., ORCHEKOWSKI, R.P., et al. (2005). Distinctive serum protein profiles involving abunsant proteins in lung cancer patients based upon antibody microarray analysis. BMC Cancer 5, 110-119.
35. GAVIN, I.M., KUKHTIN, A., GLESNE, D., et al. (2005). Analysis of protein interaction and function with a 3-dimensional MALDI-MS protein array. Biotechnicues 39, 99-107.
36. GHATNEKAR-NILSSON, S., DEXLIN, L., WINGREN, C., et al. (2006). Design of atto-vial based antibody arrays for proteome analsyis using a guided wave sensor. Submitted.
37. GILBERT, I., MAI, T., GILBERT, I., et al. (2003). A force-based protein biochip. Proc Natl Acad Sci USA 100, 11356-11360.
38. GILBERT, I., SCHIFFMANN, S., RUBENWOLF, S., et al. (2004). Double chip protein arrays using recombinant single-chain Fv antibody fragments. Proteomics 4, 1417-1420.
39. GUILLEAUME, B., BUNESS, A., SCHMIDT, C., et al. (2005). Systematic comparison of surface coatings for protein microarrays. Proteomics 5, 4705-4712.
40. HAAB, B.B., DUNHAM, M.J., and BROWN, P.O. (2001). Protein microarrays for highly parallel detection and quantification of specific proteins and antibodies in complex solutions. Genome biology 2, 1-22.
41. HAAB, B.B. (2003). Methods and applications of antibody microarrays in cancer research. Proteomics 3, 2116-2122.
42. HAAB, B.B., GEIERSTANGER, B.H., MICHAILIDIS, G., et al. (2005). Immunoassay and antibody microarray analysis of the HUPOplasma proteome project reference speciemnes: Systematic variation between sample types and calibration of mass spectrometry data. Proteomics 5, 3278-3291.
43. HAMELINCK, D., ZHOU, H., LI, L., et al. (2005). Optimized normalization for antibody microarrays and application to serum protein profiling. Mol Cell Proteomics 4, 773-784.
44. HANASH, S. (2003). Disease proteomics. Nature 13, 226-232.
45. HE, M., and TAUSSIG, M.J. (2001). Single step expression of protein arrays from DNA by cell-free expression and in situ immobilization (PISA method). Nucleic Acid Research 29, E73-3.
46. HEIDARI, B., MAXIMOV, I., SARWE, E.L., et al. (1999). Large scale nanolitography using nanoimprint litography. J Vac Sci Techn B 17, 2961-2964.
47. HOFF, J.D., CHENG, L.J., MEYHÖFER, E., et al. (2004). Nanoscale protein patterning by imprint litography. Nanoletters. (2004). 4, 853-858.
48. INGVARSSON, J., LINDSTEDT, M., BORREBAECK, C.A.K., et al. (2006a). One-step fractionation of complex proteomes enables detection of low abundant analytes using antibody-based microarrays. J Proteome Res 5, 170-176.
49. INGVARSSON, J., LARSSON, J., SJOHOLM, L., et al. (2006b). Design of recombinant antibody microarrays for serum protein profiling (submitted).
50. JANG, J.H., and HANASH, S. (2003). Profiling of the cell surface proteome. Proteomics 3, 1947-1954.
51. JI, H.F., YANG, X., ZHANG, J., et al. (2004). Molecular recognition of biowarfare agents using micromechanical sensors. Expert Rev Mol Diagnostics 47, 859-866.
52. KINGSMORE, S.F., and PATEL, D.D. (2003). Multiplexed protein profiling in antibody-based microarrays by rolling circle amplification. Curr Opin Biotechnol 14, 74-81.
53. KINGSMORE, S.F. (2006). Multiplexed protein measurement: technologies and applications of protein and antibody arrays. Nature Rew Drug Discov 5, 310-320.
54. KIYONAKA, S., SADA, K., YOSHIMURA, L, et al. (2004). Semi-wet peptide/protein array using supramolecular hydrogel. Nature Materials 3, 58-64.
55. KLENIN, K.V., KUSNEZOW, W., and LANGOWSKI, J. (2005). Kinetics of protein binding on solid-phase immunoassays: theory. J Chem Phys 122, 214715.
56. KNAPPIK, A., GE, L., HONEGGER, A., et al. (2000). Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular concensus frameworks and CDRs randomized with trinucleotides. J Mol Biol 296, 57-86.
57. KNEZEVIC, V., LEETHANAKUL, C., BICHSEL, V.E., et al. (2001). Proteomic profiling of the cancer microenvironment by antibody arrays. Proteomics 1, 1271-1278.
58. KO, I.K., KATO, K., and IWATA, H. (2005a). Antibody microarray for correlating cell phenotype with surface marker. Biomaterials 26, 687-696.
59. KO, I.K., KATO, K., and IWATA, H. (2005b). Parallel analysis of multiple surface markers expressed on rat neural stem cells using antibody microarrays. Biomaterials 26, 4882-4891.
60. KUSNEZOW, W., and HOHEISEL, J.D. (2002). Antibody microarrays: promises and problems. Biotechniques 33, 14-23.
61. KUSNEZOW, W., and HOHEISEL, J.D. (2003). Solid supports for microarray immunoassays. J Mol Recognit 16, 165-176.
62. KUSNEZOW, W., SYAGAILO, Y.V., RUFFER, S., et al. (2005). Kinetics of antigen binding to antibody-microspots: strong limitation by mass transport to the surface. Proteomics 6, 794-803.
63. KUSNEZOW, W., SYAGAILO, Y.V., GOYCHUK, I., et al. (2006). Antibody microarrays: the crucial impact of mass transport on assay kinetics and sensitivity. Exp Rew Mol Diagnos 6, 111-124.
64. LARSSON, C., BRAMFELDT, H., WINGREN, C., et al. (2005). Gravimetric antigen detection utilizing antibody-modified lipid bilayers. Anal Biochem 345, 72-80.
65. LIAN, W., LITHERLAND, S.A., BADRANE, H., et al. (2004). Ultrasensitive detection of biomolecules with fluorescent dye-doped nanoparticles. Anal Biochem 334, 135-144.
66. LIOTTA, L.A., and PETRICOIN, E.F. (2006). Serum peptidome for cancer detection: spinning biological trash into diagnostic gold. J Clin Invest 116, 26-30.
67. LUEKING A., CAHILL, D.J., and MULLNER, S. (2005). Protein biochips: a new and versatile patform technology for molecular medicine. Drug Discov Today 10, 789-794.
68. LYNCH, M., MOSHER, C., HUFF, J., et al. (2004). Functional protein nanoarrays for biomarker profiling. Proteomics 4, 1695-1702.
69. MACBEATH, G., and SCHREIBER, S.L. (2000). Printing proteins as microarrays for high-throughput function determination. Science 289, 1760-1763.
70. MACBEATH, G. (2002). Protein microarrays and proteomics. Nature Genetics 32, 526-532.
71. MILLER, J.C., ZHOU, H., KWEKE, L.J., et al. (2003). Antibody microarray profiling of human prostate cancer sera: antibody screening and identification of potential biomarkers. Proteomics 3, 56-63.
72. MITCHELL, P. (2002). A perspective on protein microarrays. Nat Biotechnol 20, 225-229.
73. NEVES-PETERSEN, M.T., SNABE, T., KLITGAARD, S., et al. (2006). Photonic activation of disulfide bridges achieves oriented protein immobilization on biosensor surfaces. Protein Science 15, 343-351.
74. NILSSON, P., PAAVILAINEN, L., LARSSON, K., et al. (2005). Proteomics 5, 4327-4337.
75. OLLE, E.W., SREEKUMAR, A., WARNER, R.L., et al. (2005). Development of internally controlled antibody microarray. Mol Cell Proteomics 4, 1664-1672.
76. ORCHRKOWSKI, R., HAMELINKC, D., LI, L., et al. (2005). Antibody microarray profiling reveals individual and combined serum protein signatures associated with pancreatic cancer. Cancer Res 65, 11193-11202.
77. PAVLICKOVA, P., KNAPPIK, A., KAMBHAMPATI, D., et al. (2003). Microarray of recombinant antibodies using a streptavidin sensor self-assembled onto a gold layer. Biotechniques 34, 124-130.
78. PAVLICKOVA, P., SCHNEIDER, E.M., and HUG, H. (2004). Advances in recombinant antibody microarrays. Clin Chim Acta 343, 17-35.
79. PAWLAK, M., SCHICK, E., BOPP, M.A., et al. (2003). Zeptosen's protein microarrays: a novel high performance microarray platform for low abundance protein analysis. Proteomics 2, 383-393.
80. PERLEE, L.T., CHRISTIANSEN, I., DONDERO, R., et al. (2004). Development and standardization of multiplexed antibody microarrays for use in quantitative proteomics. Proteome Science 2, 1-9.
81. PELUSO, P., WILSON, D.S., DO, D., et al. (2003). Optimizing antibody immobilization strategies for the construction of protein microarrays. Anal Biochem 312, 113-124.
82. PHIZICKY, E., BASTIAENS, P.I.H., ZHU, H., et al. (2004). Protein analysis on a proteomic scale. Nature 422, 208-215.
83. PIEPER, R., GATLIN, C., MAKUSKY, A.J., et al. (2003). The human serum proteome: Display of nearly 3700 chromatographically separated protein spots on two-dimensional electrophoresis gels and identification of 325 distinct proteins. Proteomics 3, 1345-1364.
84. POETZ, O., SCHWENK, M.S., KRAMER, S., et al. (2004). Protein microarrays: catching the proteome. Mech Ageing Dev 126, 161-170.
85. RAMACHANDRAN, N., HAINSWORTH, E., BHULLAR, B., et al. (2004). Self-assembling protein microarrays. Science 305, 86-90.
86. RAMACHANDRAN, N., LARSON, D.N., STARK, P.R.H., et al. (2005). Emerging tools for real-time label-free detection of interactions on functional protein microarrays. FEBS J 272, 5412-5425.
87. RENBERG, B., SHIROYAMA, I., ENGFELDT, T., et al. (2005). Affibody protein capture microarrays: synthesis and evaluation of random and directed immobilization of affibody molecules. Anal Biochem 341, 334-343.
88. RESSINE, A., EKSTRÖM, S., MARKO-VARGA, G., et al. (2003). Macro-/nanoporous silicon as a support for high-performance protein microarrays. Anal Chem 75, 6968-6974.
89. RESSINE, A., FINNSKOG, D., MALM, J., et al. (2005). Macro/nano-structured silicon as solid support for antibody arrays. Surface design, reproducibility, and assay characteristics enabling discovery of kallikrein gene products for prostate disease diagnostics. Nanobiotechnology 1, 93-104.
90. RUBINA, A.Y., DEMENTIEVA, E.I., STOMAKHIN, A.A., et al. (2003). Hydrogel-based protein microchips: manufacturing, properties, and applications. Biotechniques 34, 1008-1014, 1016-1020, 1022.
91. RUIZ-TAYLOR, L.A., MARTIN, T.L., ZAUGG, F.G., et al. (2001). Monolayers of derivatized poly(L-lysine)-grafted poly(ethyleneglycol) on metal oxides as a class of biomolecular interfaces. Proc Natl Acad Sci USA 98, 852-857.
92. SANCHEZ-CARBAYO, M., SOCCI, N.D., LOZANO, J.J., et al. (2006). Am J Pathol 168, 93-103.
93. SCHULTE, I., TAMMEN, H., SELLE, H., et al. (2005). Peptides in body fluids and tissues as markers of disease. Expert Rev Mol Diagn. 5, 145-157.
94. SCHWEITZER, B., WILTSHIRE, S., LAMBERT, I., et al. (2000). Immunoassays with rolling circle DNA amplification: a versatile platform for ultrasensitive antigen detection. Proc Natl Acad Sci USA 97, 10113-10119.
95. SCHWEITZER, B., ROBERTS, S., GRIMWADE, B., et al. (2002). Multiplexed protein profiling on microarrays by rolling-circle amplification. Nature Biotechnol 20, 359-365.
96. SCRIVENER, E., BARRY, R., PLATT, A., et al. (2003). Peptidomics: a new approach to affinity protein microarrays. Proteomics 3, 122-128.
97. SERVICE, R.F. (2001). Searching for recepies for protein chips. Science 294, 2080-2082.
98. SHEN, Z., STRYKER, G.A., MERNAUGH, R.L., et al. (2005). Single-chain fragment variable antibody piezoimmunosensors. Anal Chem 77, 797-805.
99. SHERIDAN, C. (2005). Protein chip companies turn to biomarkers. Nat Biotechnol 23, 3-4.
100. SONG, S.P., LIN, B., HU, J., et al. (2004). Simultaneous multianalysis for tumour markers by antibody fragments microarray system. Anal Chimica Acta 510, 147-152.
101. SREEKUMAR, A., NYATI, M.K., VARAMBALLY, S., et al. (2001). Profiling of cancer cells using protein microarrays: discovery of novel radiation-regulated proteins. Cancer Research 61, 7585-7593.
102. STAMOU, D., DUSCHL, C., DELMARCHE, E., et al. (2003). Self-assembled microarrays of attoliter molecular vessels. Angew Chem 42, 5580-5583.
103. STAUDT, L.M. (2002). Gene expression profiling of lymphoid malignacies. Annu Rev Med 53, 303-318.
104. STEINHAUER, C., WINGREN, C., MALMBORG-HAGER, A., and BORREBAECK, C.A.K. (2002). Single framework recombinant antibody fragments designed for protein chip applications. Biotechniques 33, 38-45.
105. STEINHAUER, C., RESSINE, A., MARKO-VARGA, G., et al. (2005). Biocompatability of surfaces for microarrays based on recombinant antibody fragments. Anal Biochem 341, 204-213.
106. STILLMAN, B.A., and TONKINSON, J.L. (2000). FAST slides: a novel surface for microarrays. Biotechniques 29, 630-635.
107. 2 template. Chem Biol Chem 4, 339-343.
108. SZODORAY, P., ALEX, P., BRUN, J.G., et al. (2004). Circulating cytokines in primary sjögren's syndrome determined by a multiplex cytokine array system. Scand J Immunol 59, 592-599.
109. SÖDERLIND, E., STRANDBERG, L., JIRHOLT, P., et al. (2000). Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries. Nat Biotechnol 18, 852-856.
110. TIRUMALAI, R.S., CHAN, K.C., PRIETO, D.A., et al. (2003). Characterisation of the low molecular weight human serum proteome. Mol Cell Proteomics 2, 1096-1103.
111. TOMIZAKI, T.Y., USUI, K., and MIHARA H. (2005). Protein-detecting microarrays: current accomplishments and requirements. ChemBioChem 6, 782-799.
112. TOMPSON, M., CHERAN, L.E., ZHANG, M., et al. (2005). Label-free detection of nucleic acid and protein microarrays for scanning Kelvin nanoprobe. Biosensors and Bioelectronics 20, 1471-1481.
113. USUI-AOKI, K., SHIMADA, K., NAGANO, M., et al. (2005). A novel approach to protein expression profiling using antibody microarrays combined with surface plasmon resonance technology. Proteomics. 5, 2396-2401.
114. WACKER, R., and NIEMEYER, C.M. (2004). DDI-uFIA-a readily configurable microarray-fluorescence immunoassay based on DNA-directed immobilization of proteins. ChemBioChem 5, 453-459.
115. WACKER, R., SCHRÖDER, H.S., and NIEMEYER, C.M. (2004). Performance of antibody microarrays fabricated by either DNA-directed immobilization, direct spotting, or streptavidin-biotin attachment: a comparative study. Anal Biochem 330, 281-287.
116. WANG, C.C., HUANG, R.P., SOMMER, M., et al. (2002). Array-based multiplexed screening and quantitation of human cytokines and chemokines. J Proteome Res 1, 337-343.
117. WARREN E.N., ELMS, P.J., PARKER, C.E., et al. (2004). Development of a protein chip: a MS-based method for quantitation of protein expression and modification levels using an immunoaffinity approach. Anal Chem 76, 4082-4092.
118. WEEKS, B.L., CAMARERO, J., NOY, A., et al. (2003). A microcantilever- based pathogen detector. Scanning 25, 297-299.
119. WILKINS, M.R., APPEL, R.D., VAN EYK, J.E., et al. (2006). Guidelines for the next ten years of proteomics. Proteomics 6, 4-8.
120. WILSON, D.S., and NOCK, S. (2003). Recent developments in protein microarray technology. Angew Chem 42, 494-500.
121. WINGREN, C., and BORREBAECK, C.A.K. (2005). Antibody-based microarrays: From focused assays to proteome-scale analysis. In Bioarrays: From Basics to Diagnostics. Appasani, K., ed. (Humana Press, Totowa, NJ).
122. WINGREN, C., and BORREBAECK, C.A.K. (2004). High-throughput proteomics using antibody microarrays. Expert Rev Proteomics 1, 355-364.
123. WINGREN, C., INGVARSSON, J., LINDSTEDT, M., et al. (2003). Recombinant antibody microarrays-a viable option? Nat Biotechnol 21, 223.
124. WINGREN, C., MONTELTUS, L., and BORREBAECK, C.A.K. (2004). Mega-dense nanoarrays-the challenge of novel antibody array formats. In Protein Microarrays. M. Schena, S. Weaver, eds. (Jones and Bartlett Publishers, Sudbury, UK). pp. 339-352.
125. WINGREN, C., STEINHAUER, C., INGVARSSON, J., et al. (2005). Microarrays based on affinity-tagged single-chain Fv antibodies: sensitive detection of analyte in complex proteomes. Proteomics 5, 1281-1291.
126. WINGREN, C., and BORREBAECK, C.A.K. (2006). Recombiant antibody microarrays; key technological issues. Screening Trend Drug Discov 2, 13-15.
127. WINGREN, C., INGVARSSON, J., DEXLIN, L., et al. (2006). Design of recombinant antibody microarrays for complex proteome analysiss: choice of sample labeling-tag and solid support. Submitted.
128. ZHOU, H., BOUWMAN, K., SCHOTANUS, M., et al. (2004). Two-color, rolling circle amplification on antibody microarrays for sensitive multiplexed serum-protein measurements. Genome Biology 5, R28.
129. YANAGIDA, M. (2002). Functional proteomics: current achievements. J Chromatogr B 771, 89-106.
130. ZHU, H., BILGIN, M., BANGHAM, R., et al. (2001). Global analysis of protein activities using proteome chips. Science 293, 2101-2105.
131. ZHU, H., and SNYDE, R.M. (2003). Protein chip technology. Curr Opin Chem Biol 7, 55-63.
132. ZHU, H., BILGIN, M., and SNYDER, M. (2003). Proteomics. Annu Rev Biochem 72, 783-812.