메뉴 건너뛰기




Volumn 14, Issue 2, 2004, Pages 156-162

Neural and psychological mechanisms underlying appetitive learning: Links to drug addiction

Author keywords

Acb; AcbC; CeA; Central nucleus of the amygdala; Conditioned stimulus; CS; DA; Dopamine; N methyl D aspartate; NMDA; Nucleus accumbens; Nucleus accumbens core subregion; PKA; Protein kinase A

Indexed keywords

DOPAMINE 1 RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 1842734671     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.conb.2004.03.004     Document Type: Review
Times cited : (199)

References (87)
  • 2
    • 84943255384 scopus 로고
    • Instrumental conditioning
    • Edited by Mackintosh NJ. London: Academic Press;
    • Dickinson A: Instrumental conditioning. In Animal Learning and Cognition. Edited by Mackintosh NJ. London: Academic Press; 1994:45-79.
    • (1994) Animal Learning and Cognition , pp. 45-79
    • Dickinson, A.1
  • 3
    • 0028006389 scopus 로고
    • Motivational control of goal-directed action
    • Dickinson A., Balleine B. Motivational control of goal-directed action. Anim Learn Behav. 22:1994;1-18.
    • (1994) Anim Learn Behav , vol.22 , pp. 1-18
    • Dickinson, A.1    Balleine, B.2
  • 4
    • 0001398415 scopus 로고
    • Instrumental performance following reinforcer devaluation depends upon incentive learning
    • Balleine B., Dickinson A. Instrumental performance following reinforcer devaluation depends upon incentive learning. Q J Exp Psychol B. 43:1991;279-296.
    • (1991) Q J Exp Psychol B , vol.43 , pp. 279-296
    • Balleine, B.1    Dickinson, A.2
  • 5
    • 0001878379 scopus 로고
    • Food for Tolman: Cognition and cathexis in concert
    • Edited by Archer T, Nilsson L-G. Hillsdale NJ: Erlbaum;
    • Garcia J: Food for Tolman: cognition and cathexis in concert. In Aversion, Avoidance and Anxiety. Edited by Archer T, Nilsson L-G. Hillsdale NJ: Erlbaum; 1989:45-85.
    • (1989) Aversion, Avoidance and Anxiety , pp. 45-85
    • Garcia, J.1
  • 6
    • 84946268134 scopus 로고
    • Variations in the sensitivity of instrumental responding to reinforcer devaluation
    • Adams C.D. Variations in the sensitivity of instrumental responding to reinforcer devaluation. Q J Exp Psychol B. 34:1982;77-98.
    • (1982) Q J Exp Psychol B , vol.34 , pp. 77-98
    • Adams, C.D.1
  • 7
    • 0036114221 scopus 로고    scopus 로고
    • Emotion and motivation: The role of the amygdala, ventral striatum, and prefrontal cortex
    • The authors present an extended review of the psychological processes that contribute to motivated behaviour in the rat, and the contribution of the amygdala, ventral striatum, and prefrontal cortex to instrumental responding.
    • Cardinal R.N., Parkinson J.A., Hall J., Everitt B.J. Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev. 26:2002;321-352 The authors present an extended review of the psychological processes that contribute to motivated behaviour in the rat, and the contribution of the amygdala, ventral striatum, and prefrontal cortex to instrumental responding.
    • (2002) Neurosci Biobehav Rev , vol.26 , pp. 321-352
    • Cardinal, R.N.1    Parkinson, J.A.2    Hall, J.3    Everitt, B.J.4
  • 8
    • 0026148681 scopus 로고
    • Modulation of taste affect by hunger, caloric satiety, and sensory-specific satiety in the rat
    • Berridge K.C. Modulation of taste affect by hunger, caloric satiety, and sensory-specific satiety in the rat. Appetite. 16:1991;103-120.
    • (1991) Appetite , vol.16 , pp. 103-120
    • Berridge, K.C.1
  • 9
    • 0034869625 scopus 로고    scopus 로고
    • The role of withdrawal in heroin addiction: Enhances reward or promotes avoidance?
    • Hutcheson D.M., Everitt B.J., Robbins T.W., Dickinson A. The role of withdrawal in heroin addiction: enhances reward or promotes avoidance? Nat Neurosci. 4:2001;943-947.
    • (2001) Nat Neurosci , vol.4 , pp. 943-947
    • Hutcheson, D.M.1    Everitt, B.J.2    Robbins, T.W.3    Dickinson, A.4
  • 10
    • 0026603102 scopus 로고
    • Pleasure: The common currency
    • Cabanac M. Pleasure: the common currency. J Theor Biol. 155:1992;173-200.
    • (1992) J Theor Biol , vol.155 , pp. 173-200
    • Cabanac, M.1
  • 12
    • 0034113857 scopus 로고    scopus 로고
    • Conditioned effects of environmental stimuli paired with smoked cocaine in humans
    • Foltin R.W., Haney M. Conditioned effects of environmental stimuli paired with smoked cocaine in humans. Psychopharmacology (Berl). 149:2000;24-33.
    • (2000) Psychopharmacology (Berl) , vol.149 , pp. 24-33
    • Foltin, R.W.1    Haney, M.2
  • 13
    • 0030726784 scopus 로고    scopus 로고
    • Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core
    • Kelley A.E., SmithRoe S.L., Holahan M.R. Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core. Proc Natl Acad Sci U S A. 94:1997;12174-12179.
    • (1997) Proc Natl Acad Sci U S a , vol.94 , pp. 12174-12179
    • Kelley, A.E.1    Smithroe, S.L.2    Holahan, M.R.3
  • 14
    • 0034667561 scopus 로고    scopus 로고
    • Coincident activation of NMDA and dopamine D1 receptors within the nucleus accumbens core is required for appetitive instrumental learning
    • Smith-Roe S.L., Kelley A.E. Coincident activation of NMDA and dopamine D1 receptors within the nucleus accumbens core is required for appetitive instrumental learning. J Neurosci. 20:2000;7737-7742.
    • (2000) J Neurosci , vol.20 , pp. 7737-7742
    • Smith-Roe, S.L.1    Kelley, A.E.2
  • 15
    • 0036353486 scopus 로고    scopus 로고
    • Appetitive instrumental learning is impaired by inhibition of cAMP-dependent protein kinase within the nucleus accumbens
    • Baldwin A.E., Sadeghian K., Holahan M.R., Kelley A.E. Appetitive instrumental learning is impaired by inhibition of cAMP-dependent protein kinase within the nucleus accumbens. Neurobiol Learn Mem. 77:2002;44-62.
    • (2002) Neurobiol Learn Mem , vol.77 , pp. 44-62
    • Baldwin, A.E.1    Sadeghian, K.2    Holahan, M.R.3    Kelley, A.E.4
  • 16
    • 0036897570 scopus 로고    scopus 로고
    • Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbens
    • The authors provide a demonstration that post-trial infusions of the protein synthesis inhibitor anisomycin into the AcbC disrupt consolidation of a recently learned instrumental response (lever-pressing for food), indicating a role for this structure in instrumental acquisition.
    • Hernandez P.J., Sadeghian K., Kelley A.E. Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbens. Nat Neurosci. 5:2002;1327-1331 The authors provide a demonstration that post-trial infusions of the protein synthesis inhibitor anisomycin into the AcbC disrupt consolidation of a recently learned instrumental response (lever-pressing for food), indicating a role for this structure in instrumental acquisition.
    • (2002) Nat Neurosci , vol.5 , pp. 1327-1331
    • Hernandez, P.J.1    Sadeghian, K.2    Kelley, A.E.3
  • 17
    • 0036236466 scopus 로고    scopus 로고
    • Effects of cytotoxic nucleus accumbens lesions on instrumental conditioning in rats
    • de Borchgrave R., Rawlins J.N., Dickinson A., Balleine B.W. Effects of cytotoxic nucleus accumbens lesions on instrumental conditioning in rats. Exp Brain Res. 144:2002;50-68.
    • (2002) Exp Brain Res , vol.144 , pp. 50-68
    • De Borchgrave, R.1    Rawlins, J.N.2    Dickinson, A.3    Balleine, B.W.4
  • 18
    • 0028589497 scopus 로고
    • Effects of ibotenic acid lesions of the nucleus accumbens on instrumental action
    • Balleine B., Killcross S. Effects of ibotenic acid lesions of the nucleus accumbens on instrumental action. Behav Brain Res. 65:1994;181-193.
    • (1994) Behav Brain Res , vol.65 , pp. 181-193
    • Balleine, B.1    Killcross, S.2
  • 20
    • 0034971066 scopus 로고    scopus 로고
    • Involvement of the central nucleus of the amygdala and nucleus accumbens core in mediating Pavlovian influences on instrumental behaviour
    • Hall J., Parkinson J.A., Connor T.M., Dickinson A., Everitt B.J. Involvement of the central nucleus of the amygdala and nucleus accumbens core in mediating Pavlovian influences on instrumental behaviour. Eur J Neurosci. 13:2001;1984-1992.
    • (2001) Eur J Neurosci , vol.13 , pp. 1984-1992
    • Hall, J.1    Parkinson, J.A.2    Connor, T.M.3    Dickinson, A.4    Everitt, B.J.5
  • 21
    • 0034331220 scopus 로고    scopus 로고
    • Intra-accumbens amphetamine increases the conditioned incentive salience of sucrose reward: Enhancement of reward 'wanting' without enhanced 'liking' or response reinforcement
    • Wyvell C.L., Berridge K.C. Intra-accumbens amphetamine increases the conditioned incentive salience of sucrose reward: enhancement of reward 'wanting' without enhanced 'liking' or response reinforcement. J Neurosci. 20:2000;8122-8130.
    • (2000) J Neurosci , vol.20 , pp. 8122-8130
    • Wyvell, C.L.1    Berridge, K.C.2
  • 22
    • 0035478395 scopus 로고    scopus 로고
    • Incentive sensitization by previous amphetamine exposure: Increased cue-triggered 'wanting' for sucrose reward
    • Wyvell C.L., Berridge K.C. Incentive sensitization by previous amphetamine exposure: increased cue-triggered 'wanting' for sucrose reward. J Neurosci. 21:2001;7831-7840.
    • (2001) J Neurosci , vol.21 , pp. 7831-7840
    • Wyvell, C.L.1    Berridge, K.C.2
  • 23
    • 0033913868 scopus 로고    scopus 로고
    • Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists
    • Dickinson A., Smith J., Mirenowicz J. Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists. Behav Neurosci. 114:2000;468-483.
    • (2000) Behav Neurosci , vol.114 , pp. 468-483
    • Dickinson, A.1    Smith, J.2    Mirenowicz, J.3
  • 24
    • 0033560090 scopus 로고    scopus 로고
    • Dissociation in effects of lesions of the nucleus accumbens core and shell on appetitive Pavlovian approach behavior and the potentiation of conditioned reinforcement and locomotor activity by d-amphetamine
    • Parkinson J.A., Olmstead M.C., Burns L.H., Robbins T.W., Everitt B.J. Dissociation in effects of lesions of the nucleus accumbens core and shell on appetitive Pavlovian approach behavior and the potentiation of conditioned reinforcement and locomotor activity by d-amphetamine. J Neurosci. 19:1999;2401-2411.
    • (1999) J Neurosci , vol.19 , pp. 2401-2411
    • Parkinson, J.A.1    Olmstead, M.C.2    Burns, L.H.3    Robbins, T.W.4    Everitt, B.J.5
  • 25
    • 0021720239 scopus 로고
    • Enhanced behavioural control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens
    • Taylor J.R., Robbins T.W. Enhanced behavioural control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens. Psychopharmacology (Berl). 84:1984;405-412.
    • (1984) Psychopharmacology (Berl) , vol.84 , pp. 405-412
    • Taylor, J.R.1    Robbins, T.W.2
  • 26
    • 0022495758 scopus 로고
    • 6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine
    • Taylor J.R., Robbins T.W. 6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine. Psychopharmacology (Berl). 90:1986;390-397.
    • (1986) Psychopharmacology (Berl) , vol.90 , pp. 390-397
    • Taylor, J.R.1    Robbins, T.W.2
  • 27
    • 0025874936 scopus 로고
    • Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens
    • Cador M., Taylor J.R., Robbins T.W. Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens. Psychopharmacology (Berl). 104:1991;377-385.
    • (1991) Psychopharmacology (Berl) , vol.104 , pp. 377-385
    • Cador, M.1    Taylor, J.R.2    Robbins, T.W.3
  • 28
    • 0037010742 scopus 로고    scopus 로고
    • Motivational views of reinforcement: Implications for understanding the behavioral functions of nucleus accumbens dopamine
    • The authors present an excellent review of the nature of 'reinforcement' and the contribution of Acb DA to motivated behaviour.
    • Salamone J.D., Correa M. Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine. Behav Brain Res. 137:2002;3-25 The authors present an excellent review of the nature of 'reinforcement' and the contribution of Acb DA to motivated behaviour.
    • (2002) Behav Brain Res , vol.137 , pp. 3-25
    • Salamone, J.D.1    Correa, M.2
  • 29
    • 0037382478 scopus 로고    scopus 로고
    • Nucleus accumbens dopamine and the regulation of effort in food-seeking behavior: Implications for studies of natural motivation, psychiatry, and drug abuse
    • Salamone J.D., Correa M., Mingote S.M., Weber S.M. Nucleus accumbens dopamine and the regulation of effort in food-seeking behavior: implications for studies of natural motivation, psychiatry, and drug abuse. J Pharmacol Exp Ther. 305:2003;1-8.
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 1-8
    • Salamone, J.D.1    Correa, M.2    Mingote, S.M.3    Weber, S.M.4
  • 30
    • 0014234914 scopus 로고
    • Auto-shaping of the pigeon's keypeck
    • Brown P.L., Jenkins H.M. Auto-shaping of the pigeon's keypeck. J Exp Anal Behav. 11:1968;1-8.
    • (1968) J Exp Anal Behav , vol.11 , pp. 1-8
    • Brown, P.L.1    Jenkins, H.M.2
  • 31
    • 0032767117 scopus 로고    scopus 로고
    • Selective excitotoxic lesions of the nucleus accumbens core and shell differentially affect aversive Pavlovian conditioning to discrete and contextual cues
    • Parkinson J.A., Robbins T.W., Everitt B.J. Selective excitotoxic lesions of the nucleus accumbens core and shell differentially affect aversive Pavlovian conditioning to discrete and contextual cues. Psychobiology. 27:1999;256-266.
    • (1999) Psychobiology , vol.27 , pp. 256-266
    • Parkinson, J.A.1    Robbins, T.W.2    Everitt, B.J.3
  • 32
    • 0034013103 scopus 로고    scopus 로고
    • Disconnection of the anterior cingulate cortex and nucleus accumbens core impairs Pavlovian approach behavior: Further evidence for limbic cortical-ventral striatopallidal systems
    • Parkinson J.A., Willoughby P.J., Robbins T.W., Everitt B.J. Disconnection of the anterior cingulate cortex and nucleus accumbens core impairs Pavlovian approach behavior: further evidence for limbic cortical-ventral striatopallidal systems. Behav Neurosci. 114:2000;42-63.
    • (2000) Behav Neurosci , vol.114 , pp. 42-63
    • Parkinson, J.A.1    Willoughby, P.J.2    Robbins, T.W.3    Everitt, B.J.4
  • 35
    • 0033959687 scopus 로고    scopus 로고
    • Dissociable roles of the central and basolateral amygdala in appetitive emotional learning
    • Parkinson J.A., Robbins T.W., Everitt B.J. Dissociable roles of the central and basolateral amygdala in appetitive emotional learning. Eur J Neurosci. 12:2000;405-413.
    • (2000) Eur J Neurosci , vol.12 , pp. 405-413
    • Parkinson, J.A.1    Robbins, T.W.2    Everitt, B.J.3
  • 36
    • 0035990451 scopus 로고    scopus 로고
    • Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats
    • •]) it is demonstrated that the CeA is involved in the learning, but not the performance, of a learned approach response to a CS that predicts an appetitive outcome, and that Acb DA contributes to both processes.
    • •]) it is demonstrated that the CeA is involved in the learning, but not the performance, of a learned approach response to a CS that predicts an appetitive outcome, and that Acb DA contributes to both processes.
    • (2002) Behav Neurosci , vol.116 , pp. 553-567
    • Cardinal, R.N.1    Parkinson, J.A.2    Lachenal, G.3    Halkerston, K.M.4    Rudarakanchana, N.5    Hall, J.6    Morrison, C.H.7    Howes, S.R.8    Robbins, T.W.9    Everitt, B.J.10
  • 37
    • 0242352382 scopus 로고    scopus 로고
    • Amygdalar control of the mesocorticolimbic dopamine system: Parallel pathways to motivated behavior
    • Phillips A.G., Ahn S., Howland J.G. Amygdalar control of the mesocorticolimbic dopamine system: parallel pathways to motivated behavior. Neurosci Biobehav Rev. 27:2003;543-554.
    • (2003) Neurosci Biobehav Rev , vol.27 , pp. 543-554
    • Phillips, A.G.1    Ahn, S.2    Howland, J.G.3
  • 38
    • 0035817882 scopus 로고    scopus 로고
    • A cellular mechanism of reward-related learning
    • Reynolds J.N., Hyland B.I., Wickens J.R. A cellular mechanism of reward-related learning. Nature. 413:2001;67-70.
    • (2001) Nature , vol.413 , pp. 67-70
    • Reynolds, J.N.1    Hyland, B.I.2    Wickens, J.R.3
  • 39
    • 0036592025 scopus 로고    scopus 로고
    • Dopamine-dependent plasticity of corticostriatal synapses
    • The authors present a review of empirical data and recent theoretical models of the manner in which cortical (presynaptic) and striatal (postsynaptic) activity contribute to altering the strength of corticostriatal synapses, and how this relationship is altered by DA.
    • Reynolds J.N., Wickens J.R. Dopamine-dependent plasticity of corticostriatal synapses. Neural Netw. 15:2002;507-521 The authors present a review of empirical data and recent theoretical models of the manner in which cortical (presynaptic) and striatal (postsynaptic) activity contribute to altering the strength of corticostriatal synapses, and how this relationship is altered by DA.
    • (2002) Neural Netw , vol.15 , pp. 507-521
    • Reynolds, J.N.1    Wickens, J.R.2
  • 40
    • 0036469371 scopus 로고    scopus 로고
    • Appetitive instrumental learning requires coincident activation of NMDA and dopamine D1 receptors within the medial prefrontal cortex
    • The authors found that infusion of the DA D1 receptor antagonist SCH-23390 and the NMDA-type glutamate receptor antagonist AP-5 synergistically disrupted acquisition of a simple lever-press instrumental response when infused into the rat medial prefrontal cortex before training. Infusion of a PKA inhibitor into the PFC similarly disrupted learning. Impairment of learning occurred at drug doses that did not impair performance of a previously learned response. No drug altered primary feeding or locomotor behaviour, although they did suppress rats' tendency to respond at the food alcove to collect reward; this may be a cause or a consequence of their impaired instrumental learning.
    • Baldwin A.E., Sadeghian K., Kelley A.E. Appetitive instrumental learning requires coincident activation of NMDA and dopamine D1 receptors within the medial prefrontal cortex. J Neurosci. 22:2002;1063-1071 The authors found that infusion of the DA D1 receptor antagonist SCH-23390 and the NMDA-type glutamate receptor antagonist AP-5 synergistically disrupted acquisition of a simple lever-press instrumental response when infused into the rat medial prefrontal cortex before training. Infusion of a PKA inhibitor into the PFC similarly disrupted learning. Impairment of learning occurred at drug doses that did not impair performance of a previously learned response. No drug altered primary feeding or locomotor behaviour, although they did suppress rats' tendency to respond at the food alcove to collect reward; this may be a cause or a consequence of their impaired instrumental learning.
    • (2002) J Neurosci , vol.22 , pp. 1063-1071
    • Baldwin, A.E.1    Sadeghian, K.2    Kelley, A.E.3
  • 41
    • 0031801210 scopus 로고    scopus 로고
    • Goal-directed instrumental action: Contingency and incentive learning and their cortical substrates
    • Balleine B.W., Dickinson A. Goal-directed instrumental action: contingency and incentive learning and their cortical substrates. Neuropharmacology. 37:1998;407-419.
    • (1998) Neuropharmacology , vol.37 , pp. 407-419
    • Balleine, B.W.1    Dickinson, A.2
  • 42
    • 0142250829 scopus 로고    scopus 로고
    • Hyperdopaminergic mutant mice have higher 'wanting' but not 'liking' for sweet rewards
    • Pecina S., Cagniard B., Berridge K.C., Aldridge J.W., Zhuang X. Hyperdopaminergic mutant mice have higher 'wanting' but not 'liking' for sweet rewards. J Neurosci. 23:2003;9395-9402.
    • (2003) J Neurosci , vol.23 , pp. 9395-9402
    • Pecina, S.1    Cagniard, B.2    Berridge, K.C.3    Aldridge, J.W.4    Zhuang, X.5
  • 43
    • 0030850372 scopus 로고    scopus 로고
    • Pimozide does not shift palatability: Separation of anhedonia from sensorimotor suppression by taste reactivity
    • Pecina S., Berridge K.C., Parker L.A. Pimozide does not shift palatability: separation of anhedonia from sensorimotor suppression by taste reactivity. Pharmacol Biochem Behav. 58:1997;801-811.
    • (1997) Pharmacol Biochem Behav , vol.58 , pp. 801-811
    • Pecina, S.1    Berridge, K.C.2    Parker, L.A.3
  • 44
    • 0032423613 scopus 로고    scopus 로고
    • What is the role of dopamine in reward: Hedonic impact, reward learning, or incentive salience?
    • Berridge K.C., Robinson T.E. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev. 28:1998;309-369.
    • (1998) Brain Res Brain Res Rev , vol.28 , pp. 309-369
    • Berridge, K.C.1    Robinson, T.E.2
  • 45
    • 0033964125 scopus 로고    scopus 로고
    • Measuring hedonic impact in animals and infants: Microstructure of affective taste reactivity patterns
    • Berridge K.C. Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns. Neurosci Biobehav Rev. 24:2000;173-198.
    • (2000) Neurosci Biobehav Rev , vol.24 , pp. 173-198
    • Berridge, K.C.1
  • 46
    • 0036582977 scopus 로고    scopus 로고
    • The neuroscience of natural rewards: Relevance to addictive drugs
    • Kelley A.E., Berridge K.C. The neuroscience of natural rewards: relevance to addictive drugs. J Neurosci. 22:2002;3306-3311.
    • (2002) J Neurosci , vol.22 , pp. 3306-3311
    • Kelley, A.E.1    Berridge, K.C.2
  • 48
    • 0141988771 scopus 로고    scopus 로고
    • Differential control over drug-seeking behavior by drug-associated conditioned reinforcers and discriminative stimuli predictive of drug availability
    • Di Ciano P., Everitt B.J. Differential control over drug-seeking behavior by drug-associated conditioned reinforcers and discriminative stimuli predictive of drug availability. Behav Neurosci. 117:2003;952-960.
    • (2003) Behav Neurosci , vol.117 , pp. 952-960
    • Di Ciano, P.1    Everitt, B.J.2
  • 49
    • 0034491760 scopus 로고    scopus 로고
    • Second-order schedules of drug reinforcement in rats and monkeys: Measurement of reinforcing efficacy and drug-seeking behaviour
    • Everitt B.J., Robbins T.W. Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour. Psychopharmacology (Berl). 153:2000;17-30.
    • (2000) Psychopharmacology (Berl) , vol.153 , pp. 17-30
    • Everitt, B.J.1    Robbins, T.W.2
  • 50
    • 0035098988 scopus 로고    scopus 로고
    • The effects of nucleus accumbens core and shell lesions on intravenous heroin self-administration and the acquisition of drug-seeking behaviour under a second-order schedule of heroin reinforcement
    • Hutcheson D.M., Parkinson J.A., Robbins T.W., Everitt B.J. The effects of nucleus accumbens core and shell lesions on intravenous heroin self-administration and the acquisition of drug-seeking behaviour under a second-order schedule of heroin reinforcement. Psychopharmacology (Berl). 153:2001;464-472.
    • (2001) Psychopharmacology (Berl) , vol.153 , pp. 464-472
    • Hutcheson, D.M.1    Parkinson, J.A.2    Robbins, T.W.3    Everitt, B.J.4
  • 51
    • 0034894089 scopus 로고    scopus 로고
    • Dissociable effects of antagonism of NMDA and AMPA/KA receptors in the nucleus accumbens core and shell on cocaine-seeking behavior
    • Di Ciano P., Everitt B.J. Dissociable effects of antagonism of NMDA and AMPA/KA receptors in the nucleus accumbens core and shell on cocaine-seeking behavior. Neuropsychopharmacology. 25:2001;341-360.
    • (2001) Neuropsychopharmacology , vol.25 , pp. 341-360
    • Di Ciano, P.1    Everitt, B.J.2
  • 52
    • 0025179967 scopus 로고
    • Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
    • Sokoloff P., Giros B., Martres M.P., Bouthenet M.L., Schwartz J.C. Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature. 347:1990;146-151.
    • (1990) Nature , vol.347 , pp. 146-151
    • Sokoloff, P.1    Giros, B.2    Martres, M.P.3    Bouthenet, M.L.4    Schwartz, J.C.5
  • 53
    • 0037310229 scopus 로고    scopus 로고
    • Attenuation of cue-controlled cocaine-seeking by a selective D3 dopamine receptor antagonist SB-277011-A
    • The authors provide a recent demonstration that the DA D3 receptor antagonist SB-277011-A suppresses cocaine seeking under a second-order schedule in rats, without affecting cocaine taking under a fixed-ratio-1 schedule, or food seeking on the same second-order schedule as used for cocaine. Such compounds may represent a pharmacological intervention that could be of use in drug addiction.
    • Di Ciano P., Underwood R.J., Hagan J.J., Everitt B.J. Attenuation of cue-controlled cocaine-seeking by a selective D3 dopamine receptor antagonist SB-277011-A. Neuropsychopharmacology. 28:2003;329-338 The authors provide a recent demonstration that the DA D3 receptor antagonist SB-277011-A suppresses cocaine seeking under a second-order schedule in rats, without affecting cocaine taking under a fixed-ratio-1 schedule, or food seeking on the same second-order schedule as used for cocaine. Such compounds may represent a pharmacological intervention that could be of use in drug addiction.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 329-338
    • Di Ciano, P.1    Underwood, R.J.2    Hagan, J.J.3    Everitt, B.J.4
  • 56
    • 0042092510 scopus 로고    scopus 로고
    • Cocaine-seeking behavior in response to drug-associated stimuli in rats: Involvement of D3 and D2 dopamine receptors
    • Cervo L., Carnovali F., Stark J.A., Mennini T. Cocaine-seeking behavior in response to drug-associated stimuli in rats: involvement of D3 and D2 dopamine receptors. Neuropsychopharmacology. 28:2003;1150-1159.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1150-1159
    • Cervo, L.1    Carnovali, F.2    Stark, J.A.3    Mennini, T.4
  • 57
    • 1842821992 scopus 로고    scopus 로고
    • Economic concepts in the behavioral study of addiction
    • Edited by Heather N, Vuchinich R. Oxford: Elsevier;
    • Rachlin H: Economic concepts in the behavioral study of addiction. In Choice, Behavioral Economics and Addiction. Edited by Heather N, Vuchinich R. Oxford: Elsevier; 2003:129-149.
    • (2003) Choice, Behavioral Economics and Addiction , pp. 129-149
    • Rachlin, H.1
  • 58
    • 0035283482 scopus 로고    scopus 로고
    • A behavioral economic analysis of polydrug abuse in alcoholics: Asymmetrical substitution of alcohol and cocaine
    • Petry N.M. A behavioral economic analysis of polydrug abuse in alcoholics: asymmetrical substitution of alcohol and cocaine. Drug Alcohol Depend. 62:2001;31-39.
    • (2001) Drug Alcohol Depend , vol.62 , pp. 31-39
    • Petry, N.M.1
  • 59
    • 0028933934 scopus 로고
    • The behavioral economics of concurrent drug reinforcers: A review and reanalysis of drug self-administration research
    • Bickel W.K., DeGrandpre R.J., Higgins S.T. The behavioral economics of concurrent drug reinforcers: a review and reanalysis of drug self-administration research. Psychopharmacology (Berl). 118:1995;250-259.
    • (1995) Psychopharmacology (Berl) , vol.118 , pp. 250-259
    • Bickel, W.K.1    Degrandpre, R.J.2    Higgins, S.T.3
  • 60
    • 0034564724 scopus 로고    scopus 로고
    • An economic approach to animal models of alcoholism
    • Heyman G.M. An economic approach to animal models of alcoholism. Alcohol Res Health. 24:2000;132-139.
    • (2000) Alcohol Res Health , vol.24 , pp. 132-139
    • Heyman, G.M.1
  • 61
    • 0037010770 scopus 로고    scopus 로고
    • Nucleus accumbens shell and core dopamine: Differential role in behavior and addiction
    • Di Chiara G. Nucleus accumbens shell and core dopamine: differential role in behavior and addiction. Behav Brain Res. 137:2002;75-114.
    • (2002) Behav Brain Res , vol.137 , pp. 75-114
    • Di Chiara, G.1
  • 62
    • 0037390212 scopus 로고    scopus 로고
    • Nucleus accumbens mu-opioids regulate intake of a high-fat diet via activation of a distributed brain network
    • The authors demonstrate that administration of a μ-opioid antagonist into the Acb markedly increases the intake of highly palatable high-fat foods in rats. Infusion of the γ-aminobutyric acid (GABA) agonist muscimol into the ventral tegmental area or lateral hypothalamus blocked this effect; indeed, infusion of muscimol into the lateral hypothalamus suppressed high-fat food intake in its own right, whereas muscimol increased fat intake when infused into the dorsomedial hypothalamus.
    • Will M.J., Franzblau E.B., Kelley A.E. Nucleus accumbens mu-opioids regulate intake of a high-fat diet via activation of a distributed brain network. J Neurosci. 23:2003;2882-2888 The authors demonstrate that administration of a μ-opioid antagonist into the Acb markedly increases the intake of highly palatable high-fat foods in rats. Infusion of the γ-aminobutyric acid (GABA) agonist muscimol into the ventral tegmental area or lateral hypothalamus blocked this effect; indeed, infusion of muscimol into the lateral hypothalamus suppressed high-fat food intake in its own right, whereas muscimol increased fat intake when infused into the dorsomedial hypothalamus.
    • (2003) J Neurosci , vol.23 , pp. 2882-2888
    • Will, M.J.1    Franzblau, E.B.2    Kelley, A.E.3
  • 63
    • 0036169799 scopus 로고    scopus 로고
    • Intake of saccharin, salt, and ethanol solutions is increased by infusion of a mu opioid agonist into the nucleus accumbens
    • Zhang M., Kelley A.E. Intake of saccharin, salt, and ethanol solutions is increased by infusion of a mu opioid agonist into the nucleus accumbens. Psychopharmacology (Berl). 159:2002;415-423.
    • (2002) Psychopharmacology (Berl) , vol.159 , pp. 415-423
    • Zhang, M.1    Kelley, A.E.2
  • 65
    • 0034638262 scopus 로고    scopus 로고
    • Enhanced intake of high-fat food following striatal mu-opioid stimulation: Microinjection mapping and fos expression
    • Zhang M., Kelley A.E. Enhanced intake of high-fat food following striatal mu-opioid stimulation: microinjection mapping and fos expression. Neuroscience. 99:2000;267-277.
    • (2000) Neuroscience , vol.99 , pp. 267-277
    • Zhang, M.1    Kelley, A.E.2
  • 66
    • 0031808940 scopus 로고    scopus 로고
    • Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens
    • Zhang M., Gosnell B.A., Kelley A.E. Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens. J Pharmacol Exp Ther. 285:1998;908-914.
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 908-914
    • Zhang, M.1    Gosnell, B.A.2    Kelley, A.E.3
  • 67
    • 0345257772 scopus 로고    scopus 로고
    • Restricted daily consumption of a highly palatable food (chocolate Ensure(R)) alters striatal enkephalin gene expression
    • Kelley A.E., Will M.J., Steininger T.L., Zhang M., Haber S.N. Restricted daily consumption of a highly palatable food (chocolate Ensure(R)) alters striatal enkephalin gene expression. Eur J Neurosci. 18:2003;2592-2598.
    • (2003) Eur J Neurosci , vol.18 , pp. 2592-2598
    • Kelley, A.E.1    Will, M.J.2    Steininger, T.L.3    Zhang, M.4    Haber, S.N.5
  • 68
    • 0027305458 scopus 로고
    • The neural basis of drug craving - An incentive-sensitization theory of addiction
    • Robinson T.E., Berridge K.C. The neural basis of drug craving - an incentive-sensitization theory of addiction. Brain Res Brain Res Rev. 18:1993;247-291.
    • (1993) Brain Res Brain Res Rev , vol.18 , pp. 247-291
    • Robinson, T.E.1    Berridge, K.C.2
  • 69
    • 0041922328 scopus 로고    scopus 로고
    • Repeated nicotine exposure enhances reward-related learning in the rat
    • Olausson P., Jentsch J.D., Taylor J.R. Repeated nicotine exposure enhances reward-related learning in the rat. Neuropsychopharmacology. 28:2003;1264-1271.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1264-1271
    • Olausson, P.1    Jentsch, J.D.2    Taylor, J.R.3
  • 70
    • 0344690192 scopus 로고    scopus 로고
    • Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization
    • Taylor J.R., Horger B.A. Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization. Psychopharmacology (Berl). 142:1999;31-40.
    • (1999) Psychopharmacology (Berl) , vol.142 , pp. 31-40
    • Taylor, J.R.1    Horger, B.A.2
  • 71
    • 0036615635 scopus 로고    scopus 로고
    • Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine
    • Vezina P., Lorrain D.S., Arnold G.M., Austin J.D., Suto N. Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine. J Neurosci. 22:2002;4654-4662.
    • (2002) J Neurosci , vol.22 , pp. 4654-4662
    • Vezina, P.1    Lorrain, D.S.2    Arnold, G.M.3    Austin, J.D.4    Suto, N.5
  • 73
    • 0035180797 scopus 로고    scopus 로고
    • Behavioral sensitization in humans
    • Sax K.W., Strakowski S.M. Behavioral sensitization in humans. J Addict Dis. 20:2001;55-65.
    • (2001) J Addict Dis , vol.20 , pp. 55-65
    • Sax, K.W.1    Strakowski, S.M.2
  • 74
    • 0033561459 scopus 로고    scopus 로고
    • Drug addiction: Bad habits add up
    • Robbins TW, Everitt BJ: Drug addiction: bad habits add up. [news] Nature 1999, 398:567-570.
    • (1999) [News] Nature , vol.398 , pp. 567-570
    • Robbins, T.W.1    Everitt, B.J.2
  • 76
    • 0036584948 scopus 로고    scopus 로고
    • Psychomotor stimulant addiction: A neural systems perspective
    • Everitt B.J., Wolf M.E. Psychomotor stimulant addiction: a neural systems perspective. J Neurosci. 22:2002;3312-3320.
    • (2002) J Neurosci , vol.22 , pp. 3312-3320
    • Everitt, B.J.1    Wolf, M.E.2
  • 77
    • 0030023451 scopus 로고    scopus 로고
    • Myths about the treatment of addiction
    • O'Brien C.P., McLellan A.T. Myths about the treatment of addiction. Lancet. 347:1996;237-240.
    • (1996) Lancet , vol.347 , pp. 237-240
    • O'Brien, C.P.1    McLellan, A.T.2
  • 79
    • 0141919652 scopus 로고    scopus 로고
    • Oral cocaine seeking by rats: Action or habit?
    • Miles F.J., Everitt B.J., Dickinson A. Oral cocaine seeking by rats: action or habit? Behav Neurosci. 117:2003;927-938.
    • (2003) Behav Neurosci , vol.117 , pp. 927-938
    • Miles, F.J.1    Everitt, B.J.2    Dickinson, A.3
  • 80
    • 0036777967 scopus 로고    scopus 로고
    • Alcohol seeking by rats: Action or habit?
    • The authors trained rats to respond on two levers for food pellets and 10% ethanol solution. Subsequently, either the food pellets or the ethanol was devalued by pairing it with illness induced by lithium chloride. When lever-pressing was subsequently tested (in extinction), rats pressed the pellet lever less if the pellets (but not the ethanol) had been devalued, indicating that responding for pellets was a goal-directed action. By contrast, the rate at which they pressed the ethanol lever was unaffected by devaluation of the reinforcer (although their consumption of the ethanol was reduced). This suggests that responding for ethanol was not a goal-directed action but a stimulus-response habit, whose performance was not controlled by the consequence of the action.
    • Dickinson A., Wood N., Smith J.W. Alcohol seeking by rats: action or habit? Q J Exp Psychol B. 55:2002;331-348 The authors trained rats to respond on two levers for food pellets and 10% ethanol solution. Subsequently, either the food pellets or the ethanol was devalued by pairing it with illness induced by lithium chloride. When lever-pressing was subsequently tested (in extinction), rats pressed the pellet lever less if the pellets (but not the ethanol) had been devalued, indicating that responding for pellets was a goal-directed action. By contrast, the rate at which they pressed the ethanol lever was unaffected by devaluation of the reinforcer (although their consumption of the ethanol was reduced). This suggests that responding for ethanol was not a goal-directed action but a stimulus-response habit, whose performance was not controlled by the consequence of the action.
    • (2002) Q J Exp Psychol B , vol.55 , pp. 331-348
    • Dickinson, A.1    Wood, N.2    Smith, J.W.3
  • 81
    • 0029972847 scopus 로고    scopus 로고
    • Inactivation of hippocampus or caudate nucleus with lidocaine differentially affects expression of place and response learning
    • Packard M.G., McGaugh J.L. Inactivation of hippocampus or caudate nucleus with lidocaine differentially affects expression of place and response learning. Neurobiol Learn Mem. 65:1996;65-72.
    • (1996) Neurobiol Learn Mem , vol.65 , pp. 65-72
    • Packard, M.G.1    McGaugh, J.L.2
  • 82
    • 0037101647 scopus 로고    scopus 로고
    • Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue
    • Ito R., Dalley J.W., Robbins T.W., Everitt B.J. Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue. J Neurosci. 22:2002;6247-6253.
    • (2002) J Neurosci , vol.22 , pp. 6247-6253
    • Ito, R.1    Dalley, J.W.2    Robbins, T.W.3    Everitt, B.J.4
  • 83
    • 0037382264 scopus 로고    scopus 로고
    • Coordination of actions and habits in the medial prefrontal cortex of rats
    • When rats learn to press a lever for food, their actions are initially goal directed and if the value of the reinforcer is subsequently altered, their responding is sensitive to this. Under certain conditions, extended training can render the response habitual and insensitive to reinforcer revaluation. In this study, rats were given either limited or extended training before receiving excitotoxic lesions of either prelimbic or infralimbic cortex. Following prelimbic lesions, rats' behaviour was habitual after only limited training, which suggests that they lacked their goal-directed system. This supports previous evidence demonstrating the necessity of this structure to perceive action-outcome contingencies and thus to execute goal-directed actions. Intriguingly, rats with infralimbic lesions maintained goal-directed responses even after responding had become habitual in sham-operated controls.
    • Killcross A.S., Coutureau E. Coordination of actions and habits in the medial prefrontal cortex of rats. Cereb Cortex. 13:2003;400-408 When rats learn to press a lever for food, their actions are initially goal directed and if the value of the reinforcer is subsequently altered, their responding is sensitive to this. Under certain conditions, extended training can render the response habitual and insensitive to reinforcer revaluation. In this study, rats were given either limited or extended training before receiving excitotoxic lesions of either prelimbic or infralimbic cortex. Following prelimbic lesions, rats' behaviour was habitual after only limited training, which suggests that they lacked their goal-directed system. This supports previous evidence demonstrating the necessity of this structure to perceive action-outcome contingencies and thus to execute goal-directed actions. Intriguingly, rats with infralimbic lesions maintained goal-directed responses even after responding had become habitual in sham-operated controls.
    • (2003) Cereb Cortex , vol.13 , pp. 400-408
    • Killcross, A.S.1    Coutureau, E.2
  • 84
    • 0242720412 scopus 로고    scopus 로고
    • Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naive healthy volunteers: Results from a large cohort
    • Abi-Dargham A., Kegeles L.S., Martinez D., Innis R.B., Laruelle M. Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naive healthy volunteers: results from a large cohort. Eur Neuropsychopharmacol. 13:2003;459-468.
    • (2003) Eur Neuropsychopharmacol , vol.13 , pp. 459-468
    • Abi-Dargham, A.1    Kegeles, L.S.2    Martinez, D.3    Innis, R.B.4    Laruelle, M.5
  • 85
    • 0036747883 scopus 로고    scopus 로고
    • Role of dopamine in drug reinforcement and addiction in humans: Results from imaging studies
    • Volkow N.D., Fowler J.S., Wang G.J. Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies. Behav Pharmacol. 13:2002;355-366.
    • (2002) Behav Pharmacol , vol.13 , pp. 355-366
    • Volkow, N.D.1    Fowler, J.S.2    Wang, G.J.3
  • 86
    • 1642580578 scopus 로고    scopus 로고
    • Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning
    • The authors demonstrate that instrumental responding in rats with lesions of the dorsolateral striatum continues to be sensitive to devaluation of the reinforcer (that is, their actions are goal directed) beyond the point at which normal rats' actions have become habitual and insensitive to such devaluation. This provides strong support for the long-held view that the dorsal striatum is critical for habit formation.
    • Yin H.H., Knowlton B.J., Balleine B.W. Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning. Eur J Neurosci. 19:2004;181-189 The authors demonstrate that instrumental responding in rats with lesions of the dorsolateral striatum continues to be sensitive to devaluation of the reinforcer (that is, their actions are goal directed) beyond the point at which normal rats' actions have become habitual and insensitive to such devaluation. This provides strong support for the long-held view that the dorsal striatum is critical for habit formation.
    • (2004) Eur J Neurosci , vol.19 , pp. 181-189
    • Yin, H.H.1    Knowlton, B.J.2    Balleine, B.W.3
  • 87
    • 0345256645 scopus 로고    scopus 로고
    • Inactivation of the infralimbic prefrontal cortex reinstates goal directed responding in overtrained rats
    • ••] by demonstrating that rats can be 'released' from habitual responding by inactivation of the infralimbic cortex; this structure may therefore act to inhibit goal directed action once a habit has been acquired.
    • ••] by demonstrating that rats can be 'released' from habitual responding by inactivation of the infralimbic cortex; this structure may therefore act to inhibit goal directed action once a habit has been acquired.
    • (2003) Behav Brain Res , vol.146 , pp. 167-174
    • Coutureau, E.1    Killcross, A.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.