Non-random allelic losses at 3p, 11p and 13q during HPV-mediated immortalization and concomitant loss of terminal differentiation of human keratinocytes

International Journal of Cancer

Volumn 76, Issue 3, 1998, Pages 412-417

  Steenbergen, Renske D M ^a   Hermsen, Mario A J A ^a   Walboomers, Jan M M ^a   Meijer, Gerrit A ^a   Baak, Jan P A ^a   Meijer, Chris J L M ^a   Snijders, Peter J F ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CHROMOSOME 11P; CHROMOSOME 13Q; CHROMOSOME 3P; CONTROLLED STUDY; GENE LOSS; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA; VIRUS CARCINOGENESIS; VIRUS DNA CELL DNA INTERACTION; WART VIRUS;

ALLELES; CELL DIFFERENTIATION; CELL TRANSFORMATION, VIRAL; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 13; CHROMOSOMES, HUMAN, PAIR 3; HUMANS; KERATINOCYTES; LOSS OF HETEROZYGOSITY; PAPILLOMAVIRIDAE; TUMOR CELLS, CULTURED;

EID: 0031776841     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980504)76:3<412::AID-IJC20>3.0.CO;2-B     Document Type: Article

References (20)

1. BARRETT, J.C., ANNAB, L.A., ALCORTA, D., PRESTON, G., VOJTA, P. and YIN, Y., Cellular senescence and cancer. Cold Spring Harbor Symp. quant. Biol., 59, 411-118 (1994).
2. CHEN, T.M., PECORARO, G. and DEFENDU V., Genetic analysis of in vitro progression of human papillomavirus-transfected human cervical cells. Cancer Res., 53, 1167-1171 (1993).
3. COONEY, K.A., WETZEL, J.C., MERAJVER, S.D., MACOSKA, J.A., SINGLETON, T.P. and WOJNO, K.J., Distinct regions of allelic loss on 13q in prostate cancer. Cancer Res., 56, 1142-1145 (1996).
4. Du MANOIR, S., SCHROCK, E., BENTZ, M., SPEICHER, M.R., Joos, S., RIED, T., LICHTER, P. and CREMER, T., Quantitative analysis of comparative genomic hybridization. Cytometry, 19, 27-41 (1995).
5. HERMSEN, M.A.J.A., JOENJE, H., ARWERT, F., BRAAKHUIS, B.J.M., BAAK, J.P.P., WESTERVELD, A. and SLATER, R., Assessment of chromosomal gains and losses in oral squamous cell carcinoma by comparative genomic hybridization. Oral Oncology 33, 414-418 (1997).
6. HESELMEYER, K., SCHROCK, E., Du MANOIR, S., BLEGEN, H., SHAH, K., STEINBECK, R., AUER, G. and RIED, T., Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix. Proc. nat. Acad. Sci. (Wash.), 93, 479-484 (1996).
7. MULLOKANDOV, M.R., KHOLODILOV, N.G., ATKIN, N.B., BURK, R.D., JOHNSON, A.B. and KLINGER, H.P., Genomic alterations in cervical carcinoma: losses of chromosome heterozygosity and human papilloma virus tumor status. Cancer Res., 56, 197-205 (1996).
8. ODA, D., BIGLER, L., MAO, E. and DISTECHE, C.M., Chromosomal abnormalities in HPV-16-immortalized oral epithelial cells. Carcinogenesis, 17, 2003-2008 (1996).
9. OHMURA, H., TAHARA, H., SUZUKI, M., IDE, T., SHIMIZU, M., YOSHIDA, M.A., TAHARA, E., SHAY, J.W., BARRETT, J.C. and OSHIMURA, M., Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Jpn. J. Cancer Res., 86, 899-904 (1995).
10. REZNIKOFF, C.A., BELAIR, C., SAVELIEVA, E., ZHAI, Y., PFEIFER, K., YEAGER, T., THOMPSON, K.J., DE VRIES, S., BINDLEY, C., NEWTON, M.A., SEKHON, G. and WALDMAN, F., Long-term genome stability and minimal genotypic and phenotypic alterations in HPV 16 E7-, but not E6-, immortalized human uroepithelial cells. Genes Develop., 8, 2227-2240 (1994).
11. RODRIGUEZ, E., SREEKANTAIAH, C. and CHAGANTI, R.S., Genetic changes in epithelial solid neoplasia. [ReviewJ. Cancer Res., 54, 3398-3406 (1994).
12. SAVELIEVA, E., BELAIR, C.D., NEWTON, M.A., DE VRIES, S., GRAY, J.W., WALDMAN, F. and REZNIKOFF, C.A., 20q gain associates with immortalization: 20q13.2 amplification correlates with genome instability in human papil lorn a virus 16 E7 transformed human uroepithelial cells. Oncogene, 14, 551-560 (1997).
13. SEAGON, S. and DURST, M., Genetic analysis of an in vitro model system for human papillomavirus type 16-associated tumorigenesis. Cancer Res., 54, 5593-5598 (1994).
14. SMITS, P.H.M., SMITS, H.L., JEBBINK, M.F. and TER SCHEGGET, J., The short arm of chromosome 11 likely is involved in the regulation of human papillomavirus type 16 early enhancer/promoter and in the suppression of the transforming activity of the viral DNA. Virology, 176, 158-165 (1990).
15. SNIJDERS, P.J.F., VAN DEN BRULE, A.J.C., MEIJER, C.J.L.M and WALBOOMERS, J.M.M., Papillomaviruses and cancer of the upper digestive and respiratory tracts, Curr. Top. Microbiol. Immunol., 186, 177-198 (1994).
16. SOLINAS-TOLDO, S., DURST, M. and LICHTER, P., Specific chromosomal imbalances in human papillomavirus-transfected cells during progression toward immortality. Proc. nat. Acad. Sci. (Wash.), 94, 3854-3859 (1997).
17. STANLEY, M. and SARKAR, S., Genetic changes in cervical carcinoma. Papillomavirus Rep., 5, 141-147 (1994).
18. STEENBERGEN., R.D.M., PARKER, J.N., ISERN, S., SNIJDERS, P.J.F., WALBOOMERS, J.M.M., MEIJER, C.J.L.M., BROKER, T.R. and CHOW, L.T., Viral E6/E7 transcription in the basal layer of organotypic cultures without apparent p21cipl protein expression precedes immortalization of HPV 16 and 18 transfected human keratinocytes. J. Virol., 72, 749-757 (1998).
19. STEENBERGEN, R.D.M., WALBOOMERS, J.M.M., MEIJER, C.J.L.M., VAN DER RAAIJ-HELMER, E.M.H., PARKER, J.N., CHOW, L.T., BROKER, T.R. and SNIJDERS, P.J.F., Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: activation of telomerase and allele losses at 3p. 10p, llq and/or 18q. Oncogene, 13, 1249-1257 (1996).
20. ZUR HAUSEN, H., Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types. In: H. Zur Hausen (ed.), Human pathogenic papillomaviruses, pp. 131-156, Springer, Heidelberg (1994).