-
1
-
-
0038275890
-
Study of the structural dynamics of the E coli 70S ribosome using real-space refinement
-
Gao H, Sengupta J, Valle M, Korostelev A, Eswar N, et al. (2003) Study of the structural dynamics of the E coli 70S ribosome using real-space refinement. Cell 113: 789-801.
-
(2003)
Cell
, vol.113
, pp. 789-801
-
-
Gao, H.1
Sengupta, J.2
Valle, M.3
Korostelev, A.4
Eswar, N.5
-
3
-
-
0042238051
-
Complete atomic model of the bacterial flagellar filament by electron cryomicroscopy
-
Yonekura K, Maki-Yonekura S, Namba K (2003) Complete atomic model of the bacterial flagellar filament by electron cryomicroscopy. Nature 424: 643-650.
-
(2003)
Nature
, vol.424
, pp. 643-650
-
-
Yonekura, K.1
Maki-Yonekura, S.2
Namba, K.3
-
4
-
-
10344262047
-
Molecular model for a complete clathrin lattice from electron cryomicroscopy
-
Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, et al. (2004) Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature 432: 573-579.
-
(2004)
Nature
, vol.432
, pp. 573-579
-
-
Fotin, A.1
Cheng, Y.2
Sliz, P.3
Grigorieff, N.4
Harrison, S.C.5
-
5
-
-
31844435708
-
Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus
-
Jiang W, Chang J, Jakana J, Weigele P, King J, et al. (2006) Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus. Nature 439: 612-616.
-
(2006)
Nature
, vol.439
, pp. 612-616
-
-
Jiang, W.1
Chang, J.2
Jakana, J.3
Weigele, P.4
King, J.5
-
6
-
-
0035906702
-
Bridging the information gap: Computational tools for intermediate resolution structure interpretation
-
Jiang W, Baker ML, Ludtke SJ, Chiu W (2001) Bridging the information gap: Computational tools for intermediate resolution structure interpretation. J Mol Biol 308: 1033-1044.
-
(2001)
J Mol Biol
, vol.308
, pp. 1033-1044
-
-
Jiang, W.1
Baker, M.L.2
Ludtke, S.J.3
Chiu, W.4
-
7
-
-
0041507094
-
A structural-informatics approach for mining beta-sheets: Locating sheets in intermediate-resolution density maps
-
Kong Y, Ma J (2003) A structural-informatics approach for mining beta-sheets: Locating sheets in intermediate-resolution density maps. J Mol Biol 332: 399-413.
-
(2003)
J Mol Biol
, vol.332
, pp. 399-413
-
-
Kong, Y.1
Ma, J.2
-
8
-
-
2342538953
-
A structural-informatics approach for tracing beta-sheets: Building pseudo-C(alpha) traces for beta-strands in intermediate-resolution density maps
-
Kong Y, Zhang X, Baker TS, Ma J (2004) A structural-informatics approach for tracing beta-sheets: Building pseudo-C(alpha) traces for beta-strands in intermediate-resolution density maps. J Mol Biol 339: 117-130.
-
(2004)
J Mol Biol
, vol.339
, pp. 117-130
-
-
Kong, Y.1
Zhang, X.2
Baker, T.S.3
Ma, J.4
-
9
-
-
0032779888
-
Quantitative fitting of atomic models into observed densities derived by electron microscopy
-
Volkmann N, Hanein D (1999) Quantitative fitting of atomic models into observed densities derived by electron microscopy. J Struct Biol 125: 176-184.
-
(1999)
J Struct Biol
, vol.125
, pp. 176-184
-
-
Volkmann, N.1
Hanein, D.2
-
10
-
-
0032780181
-
Situs: A package for docking crystal structures into low-resolution maps from electron microscopy
-
Wriggers W, Milligan RA, McCammon JA (1999) Situs: A package for docking crystal structures into low-resolution maps from electron microscopy. J Struct Biol 125: 185-195.
-
(1999)
J Struct Biol
, vol.125
, pp. 185-195
-
-
Wriggers, W.1
Milligan, R.A.2
McCammon, J.A.3
-
11
-
-
0033780164
-
Fitting atomic models into electron-microscopy maps
-
Rossmann MG (2000) Fitting atomic models into electron-microscopy maps. Acta Crystallogr D Biol Crystallogr 56: 1341-1349.
-
(2000)
Acta Crystallogr D Biol Crystallogr
, vol.56
, pp. 1341-1349
-
-
Rossmann, M.G.1
-
12
-
-
0035783170
-
Real space refinement of acto-myosin structures from sectioned muscle
-
Chen LF, Blanc E, Chapman MS, Taylor KA (2001) Real space refinement of acto-myosin structures from sectioned muscle. J Struct Biol 133: 221-232.
-
(2001)
J Struct Biol
, vol.133
, pp. 221-232
-
-
Chen, L.F.1
Blanc, E.2
Chapman, M.S.3
Taylor, K.A.4
-
13
-
-
4344716056
-
Normal mode based flexible fitting of high-resolution structure into low-resolution experimental data from cryo-EM
-
Tama F, Miyashita O, Brooks CL III (2004) Normal mode based flexible fitting of high-resolution structure into low-resolution experimental data from cryo-EM. J Struct Biol 147: 315-326.
-
(2004)
J Struct Biol
, vol.147
, pp. 315-326
-
-
Tama, F.1
Miyashita, O.2
Brooks III, C.L.3
-
14
-
-
12844256969
-
Structural characterization of components of protein assemblies by comparative modeling and electron cryo-microscopy
-
Topf M, Baker ML, John B, Chiu W, Sali A (2005) Structural characterization of components of protein assemblies by comparative modeling and electron cryo-microscopy. J Struct Biol 149: 191-203.
-
(2005)
J Struct Biol
, vol.149
, pp. 191-203
-
-
Topf, M.1
Baker, M.L.2
John, B.3
Chiu, W.4
Sali, A.5
-
15
-
-
33645075435
-
Refinement of protein structures by iterative comparative modeling and cryoEM density fitting
-
Topf M, Baker ML, Marti-Renom MA, Chiu W, Sali A (2006) Refinement of protein structures by iterative comparative modeling and cryoEM density fitting. J Mol Biol 357: 1655-1668.
-
(2006)
J Mol Biol
, vol.357
, pp. 1655-1668
-
-
Topf, M.1
Baker, M.L.2
Marti-Renom, M.A.3
Chiu, W.4
Sali, A.5
-
16
-
-
20444484434
-
A decade of CASP: Progress, bottlenecks and prognosis in protein structure prediction
-
Moult J (2005) A decade of CASP: Progress, bottlenecks and prognosis in protein structure prediction. Curr Opin Struct Biol 15: 285-289.
-
(2005)
Curr Opin Struct Biol
, vol.15
, pp. 285-289
-
-
Moult, J.1
-
17
-
-
0027490731
-
Recognition of errors in three-dimensional structures of proteins
-
Sippl MJ (1993) Recognition of errors in three-dimensional structures of proteins. Proteins 17: 355-362.
-
(1993)
Proteins
, vol.17
, pp. 355-362
-
-
Sippl, M.J.1
-
19
-
-
0000314691
-
Herpes simplex viruses
-
Fields BN, Knipe DM, Howley PM, Griffin DE, editors. Philadelphia: Lippincott Williams & Wilkins
-
Whitley RJ (1997) Herpes simplex viruses. In: Fields BN, Knipe DM, Howley PM, Griffin DE, editors. Fields' virology. 3rd edition. Philadelphia: Lippincott Williams & Wilkins. pp. 2297-2342.
-
(1997)
Fields' Virology. 3rd Edition
, pp. 2297-2342
-
-
Whitley, R.J.1
-
20
-
-
0036176083
-
Origins of human virus diversity
-
Sharp PM (2002) Origins of human virus diversity. Cell 108: 305-312.
-
(2002)
Cell
, vol.108
, pp. 305-312
-
-
Sharp, P.M.1
-
21
-
-
0001860050
-
Herpesvirus capsid assembly and envelopment
-
Chiu W, Burnett RM, Garcia R, editors. New York: Oxford University Press
-
Steven AC, Spear PG (1997) Herpesvirus capsid assembly and envelopment. In: Chiu W, Burnett RM, Garcia R, editors. Structural biology of viruses. New York: Oxford University Press. pp. 312-351.
-
(1997)
Structural Biology of Viruses
, pp. 312-351
-
-
Steven, A.C.1
Spear, P.G.2
-
22
-
-
0028804828
-
Assembly of VP26 in herpes simplex virus-1 inferred from structures of wild-type and recombinant capsids
-
Zhou ZH, He J, Jakana J, Tatman JD, Rixon FJ, et al. (1995) Assembly of VP26 in herpes simplex virus-1 inferred from structures of wild-type and recombinant capsids. Nat Struct Biol 2: 1026-1030.
-
(1995)
Nat Struct Biol
, vol.2
, pp. 1026-1030
-
-
Zhou, Z.H.1
He, J.2
Jakana, J.3
Tatman, J.D.4
Rixon, F.J.5
-
23
-
-
0027291013
-
Structure of the herpes simplex virus capsid. Molecular composition of the pentons and the triplexes
-
Newcomb WW, Trus BL, Booy FP, Steven AC, Wall JS, et al. (1993) Structure of the herpes simplex virus capsid. Molecular composition of the pentons and the triplexes. J Mol Biol 232: 499-511.
-
(1993)
J Mol Biol
, vol.232
, pp. 499-511
-
-
Newcomb, W.W.1
Trus, B.L.2
Booy, F.P.3
Steven, A.C.4
Wall, J.S.5
-
24
-
-
0028256487
-
Assembly of herpes simplex virus type 1 capsids using a panel of recombinant baculoviruses
-
Tatman JD, Preston VG, Nicholson P, Elliott RM, Rixon FJ (1994) Assembly of herpes simplex virus type 1 capsids using a panel of recombinant baculoviruses. J Gen Virol 75 (Part 5): 1101-1113.
-
(1994)
J Gen Virol
, vol.75
, Issue.PART 5
, pp. 1101-1113
-
-
Tatman, J.D.1
Preston, V.G.2
Nicholson, P.3
Elliott, R.M.4
Rixon, F.J.5
-
25
-
-
0028345731
-
Assembly of herpes simplex virus (HSV) intermediate capsids in insect cells infected with recombinant baculoviruses expressing HSV capsid proteins
-
Thomsen DR, Roof LL, Homa FL (1994) Assembly of herpes simplex virus (HSV) intermediate capsids in insect cells infected with recombinant baculoviruses expressing HSV capsid proteins. J Virol 68: 2442-2457.
-
(1994)
J Virol
, vol.68
, pp. 2442-2457
-
-
Thomsen, D.R.1
Roof, L.L.2
Homa, F.L.3
-
26
-
-
0041347832
-
Architecture of the herpes simplex virus major capsid protein derived from structural bioinformatics
-
Baker ML, Jiang W, Bowman BR, Zhou ZH, Quiocho FA, et al. (2003) Architecture of the herpes simplex virus major capsid protein derived from structural bioinformatics. J Mol Biol 331: 447-456.
-
(2003)
J Mol Biol
, vol.331
, pp. 447-456
-
-
Baker, M.L.1
Jiang, W.2
Bowman, B.R.3
Zhou, Z.H.4
Quiocho, F.A.5
-
27
-
-
0037450631
-
Structure of the herpesvirus major capsid protein
-
Bowman BR, Chiu W, Quiocho FA, Baker ML, Rixon FJ (2003) Structure of the herpesvirus major capsid protein. EMBO J 22: 757-765.
-
(2003)
EMBO J
, vol.22
, pp. 757-765
-
-
Bowman, B.R.1
Chiu, W.2
Quiocho, F.A.3
Baker, M.L.4
Rixon, F.J.5
-
28
-
-
27744487093
-
Common ancestry of herpesviruses and tailed DNA bacteriophages
-
Baker ML, Jiang W, Rixon FJ, Chiu W (2005) Common ancestry of herpesviruses and tailed DNA bacteriophages. J Virol 79: 14967-14970.
-
(2005)
J Virol
, vol.79
, pp. 14967-14970
-
-
Baker, M.L.1
Jiang, W.2
Rixon, F.J.3
Chiu, W.4
-
29
-
-
0030774226
-
Hexon-only binding of VP26 reflects differences between the hexon and penton conformations of VP5, the major capsid protein of herpes simplex virus
-
Wingfield PT, Stahl SJ, Thomsen DR, Homa FL, Booy FP, et al. (1997) Hexon-only binding of VP26 reflects differences between the hexon and penton conformations of VP5, the major capsid protein of herpes simplex virus. J Virol 71: 8955-8961.
-
(1997)
J Virol
, vol.71
, pp. 8955-8961
-
-
Wingfield, P.T.1
Stahl, S.J.2
Thomsen, D.R.3
Homa, F.L.4
Booy, F.P.5
-
30
-
-
0029840591
-
Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins
-
Rixon FJ, Addison C, McGregor A, Macnab SJ, Nicholson P, et al. (1996) Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins. J Gen Virol 77 (Part 9): 2251-2260.
-
(1996)
J Gen Virol
, vol.77
, Issue.PART 9
, pp. 2251-2260
-
-
Rixon, F.J.1
Addison, C.2
McGregor, A.3
Macnab, S.J.4
Nicholson, P.5
-
31
-
-
17344386043
-
Herpes simplex virus type 1 VP26 is not essential for replication in cell culture but influences production of infectious virus in the nervous system of infected mice
-
Desai P, DeLuca NA, Person S (1998) Herpes simplex virus type 1 VP26 is not essential for replication in cell culture but influences production of infectious virus in the nervous system of infected mice. Virology 247: 115-124.
-
(1998)
Virology
, vol.247
, pp. 115-124
-
-
Desai, P.1
DeLuca, N.A.2
Person, S.3
-
32
-
-
0037213596
-
Residues of VP26 of herpes simplex virus type 1 that are required for its interaction with capsids
-
Desai P, Akpa JC, Person S (2003) Residues of VP26 of herpes simplex virus type 1 that are required for its interaction with capsids. J Virol 77: 391-404.
-
(2003)
J Virol
, vol.77
, pp. 391-404
-
-
Desai, P.1
Akpa, J.C.2
Person, S.3
-
33
-
-
0033152857
-
The crystal structure of the human hepatitis B virus capsid
-
Wynne SA, Crowther RA, Leslie AG (1999) The crystal structure of the human hepatitis B virus capsid. Mol Cell 3: 771-780.
-
(1999)
Mol Cell
, vol.3
, pp. 771-780
-
-
Wynne, S.A.1
Crowther, R.A.2
Leslie, A.G.3
-
34
-
-
1842409555
-
Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy
-
Böttcher B, Wynne SA, Crowther RA (1997) Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy. Nature 386: 88-91.
-
(1997)
Nature
, vol.386
, pp. 88-91
-
-
Böttcher, B.1
Wynne, S.A.2
Crowther, R.A.3
-
35
-
-
0030937751
-
Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryoelectron microscopy
-
Conway JF, Cheng N, Zlotnick A, Steven AC, Wingfield PT, et al. (1997) Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryoelectron microscopy. Nature 386: 91-94.
-
(1997)
Nature
, vol.386
, pp. 91-94
-
-
Conway, J.F.1
Cheng, N.2
Zlotnick, A.3
Steven, A.C.4
Wingfield, P.T.5
-
36
-
-
4444221565
-
UCSF Chimera - A visualization system for exploratory research and analysis
-
Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, et al. (2004) UCSF Chimera - A visualization system for exploratory research and analysis. J Comput Chem 25: 1605-1612.
-
(2004)
J Comput Chem
, vol.25
, pp. 1605-1612
-
-
Pettersen, E.F.1
Goddard, T.D.2
Huang, C.C.3
Couch, G.S.4
Greenblatt, D.M.5
-
37
-
-
0042622381
-
LGA: A method for finding 3D similarities in protein structures
-
Zemla A (2003) LGA: A method for finding 3D similarities in protein structures. Nucleic Acids Res 31: 3370-3374.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 3370-3374
-
-
Zemla, A.1
-
38
-
-
0028871926
-
Dali: A network tool for protein structure comparison
-
Holm L, Sander C (1995) Dali: A network tool for protein structure comparison. Trends in Biochem Sci 20: 478-480.
-
(1995)
Trends in Biochem Sci
, vol.20
, pp. 478-480
-
-
Holm, L.1
Sander, C.2
-
39
-
-
0030841589
-
Detecting folding motifs and similarities in protein structures
-
Kleywegt GJ, Jones TA (1997) Detecting folding motifs and similarities in protein structures. Methods Enzymol 277: 525-545.
-
(1997)
Methods Enzymol
, vol.277
, pp. 525-545
-
-
Kleywegt, G.J.1
Jones, T.A.2
-
40
-
-
0034608018
-
Seeing the herpesvirus capsid at 8.5 Å
-
Zhou ZH, Dougherty M, Jakana J, Chiu W, Jing H, et al. (2000) Seeing the herpesvirus capsid at 8.5 Å. Science 288: 877-880.
-
(2000)
Science
, vol.288
, pp. 877-880
-
-
Zhou, Z.H.1
Dougherty, M.2
Jakana, J.3
Chiu, W.4
Jing, H.5
-
41
-
-
0035162989
-
The pattern of tegument-capsid interaction in the herpes simplex virus type 1 virion is not influenced by the small hexon-associated protein VP26
-
Chen DH, Jakana J, McNab D, Mitchell J, Zhou ZH, et al. (2001) The pattern of tegument-capsid interaction in the herpes simplex virus type 1 virion is not influenced by the small hexon-associated protein VP26. J Virol 75: 11863-11867.
-
(2001)
J Virol
, vol.75
, pp. 11863-11867
-
-
Chen, D.H.1
Jakana, J.2
McNab, D.3
Mitchell, J.4
Zhou, Z.H.5
-
42
-
-
0028783737
-
Herpes simplex virus capsids assembled in insect cells infected with recombinant baculoviruses: Structural authenticity and localization of VP26
-
Trus BL, Homa FL, Booy FP, Newcomb WW, Thomsen DR, et al. (1995) Herpes simplex virus capsids assembled in insect cells infected with recombinant baculoviruses: Structural authenticity and localization of VP26. J Virol 69: 7362-7366.
-
(1995)
J Virol
, vol.69
, pp. 7362-7366
-
-
Trus, B.L.1
Homa, F.L.2
Booy, F.P.3
Newcomb, W.W.4
Thomsen, D.R.5
-
44
-
-
14844325731
-
Electron cryomicroscopy of biological machines at subnanometer resolution
-
Chiu W, Baker ML, Jiang W, Dougherty M, Schmid MF (2005) Electron cryomicroscopy of biological machines at subnanometer resolution. Structure 13: 363-372.
-
(2005)
Structure
, vol.13
, pp. 363-372
-
-
Chiu, W.1
Baker, M.L.2
Jiang, W.3
Dougherty, M.4
Schmid, M.F.5
-
45
-
-
4744344736
-
Structure determination of macromolecular assemblies by single-particle analysis of cryo-electron micrographs
-
Orlova EV, Saibil HR (2004) Structure determination of macromolecular assemblies by single-particle analysis of cryo-electron micrographs. Curr Opin Struct Biol 14: 584-590.
-
(2004)
Curr Opin Struct Biol
, vol.14
, pp. 584-590
-
-
Orlova, E.V.1
Saibil, H.R.2
-
46
-
-
0036382958
-
Exploring global distortions of biological macromolecules and assemblies from low-resolution structural information and elastic network theory
-
Tama F, Wriggers W, Brooks CL III (2002) Exploring global distortions of biological macromolecules and assemblies from low-resolution structural information and elastic network theory. J Mol Biol 321: 297-305.
-
(2002)
J Mol Biol
, vol.321
, pp. 297-305
-
-
Tama, F.1
Wriggers, W.2
Brooks III, C.L.3
-
47
-
-
0033377664
-
EMAN: Semiautomated software for high-resolution single-particle reconstructions
-
Ludtke SJ, Baldwin PR, Chiu W (1999) EMAN: Semiautomated software for high-resolution single-particle reconstructions. J Struct Biol 128: 82-97.
-
(1999)
J Struct Biol
, vol.128
, pp. 82-97
-
-
Ludtke, S.J.1
Baldwin, P.R.2
Chiu, W.3
-
48
-
-
0032530578
-
Clustering of low-energy conformations near the native structures of small proteins
-
Shortle D, Simons KT, Baker D (1998) Clustering of low-energy conformations near the native structures of small proteins. Proc Natl Acad Sci U S A 95: 11158-11162.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 11158-11162
-
-
Shortle, D.1
Simons, K.T.2
Baker, D.3
-
49
-
-
9144257886
-
The Pfam protein families database
-
Bateman A, Coin L, Durbin R, Finn RD, Hollich V, et al. (2004) The Pfam protein families database. Nucleic Acids Res 32: D138-D141.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Bateman, A.1
Coin, L.2
Durbin, R.3
Finn, R.D.4
Hollich, V.5
-
50
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
-
Altschul SF, Madden TL, Zhang J, Lipman DJ, Schäffer AA, et al. (1997) Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Zhang, J.3
Lipman, D.J.4
Schäffer, A.A.5
-
51
-
-
0023989064
-
Improved tools for biological sequence comparison
-
Pearson WR, Lipman DJ (1988) Improved tools for biological sequence comparison. Proc Natl Acad Sci U S A 85: 2444-2448.
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, pp. 2444-2448
-
-
Pearson, W.R.1
Lipman, D.J.2
-
52
-
-
0032420333
-
JPred: A consensus secondary structure prediction server
-
Cuff JA, Clamp ME, Siddiqui AS, Finlay M, Barton GJ (1998) JPred: A consensus secondary structure prediction server. Bioinformatics 14: 892-893.
-
(1998)
Bioinformatics
, vol.14
, pp. 892-893
-
-
Cuff, J.A.1
Clamp, M.E.2
Siddiqui, A.S.3
Finlay, M.4
Barton, G.J.5
-
53
-
-
0034044314
-
The PSIPRED protein structure prediction server
-
McGuffin LJ, Bryson K, Jones DT (2000) The PSIPRED protein structure prediction server. Bioinformatics 16: 404-405.
-
(2000)
Bioinformatics
, vol.16
, pp. 404-405
-
-
McGuffin, L.J.1
Bryson, K.2
Jones, D.T.3
-
54
-
-
0030931336
-
Seventy-five percent accuracy in protein secondary structure prediction
-
Frishman D, Argos P (1997) Seventy-five percent accuracy in protein secondary structure prediction. Proteins 27: 329-335.
-
(1997)
Proteins
, vol.27
, pp. 329-335
-
-
Frishman, D.1
Argos, P.2
-
55
-
-
0028158628
-
PHD - An automatic mail server for protein secondary structure prediction
-
Rost B, Sander C, Schneider R (1994) PHD - An automatic mail server for protein secondary structure prediction. Comput Appl Biosci 10: 53-60.
-
(1994)
Comput Appl Biosci
, vol.10
, pp. 53-60
-
-
Rost, B.1
Sander, C.2
Schneider, R.3
-
56
-
-
0033369033
-
Exploiting the past and the future in protein secondary structure prediction
-
Baldi P, Brunak S, Frasconi P, Soda G, Pollastri G (1999) Exploiting the past and the future in protein secondary structure prediction. Bioinformatics 15: 937-946.
-
(1999)
Bioinformatics
, vol.15
, pp. 937-946
-
-
Baldi, P.1
Brunak, S.2
Frasconi, P.3
Soda, G.4
Pollastri, G.5
|