-
2
-
-
84943388739
-
-
Katritzky A.R., and Rees C.W. (Eds), Pergamon, Oxford
-
Sundberg R.J. In: Katritzky A.R., and Rees C.W. (Eds). Pyrroles and Their Benzoderivatives: Synthesis and Applications. Comprehensive Heterocyclic Chemistry Vol. 4 (1984), Pergamon, Oxford 313-376
-
(1984)
Comprehensive Heterocyclic Chemistry
, vol.4
, pp. 313-376
-
-
Sundberg, R.J.1
-
4
-
-
33751532464
-
-
Thomas E.J. (Ed), George Thieme, Stuttgart, Germany Category 2, Chapter 10.13
-
Joule J.A. In: Thomas E.J. (Ed). Indole and its Derivatives. Science of Synthesis: Houben-Weyl Methods of Molecular Transformations Vol. 10 (2000), George Thieme, Stuttgart, Germany Category 2, Chapter 10.13
-
(2000)
Science of Synthesis: Houben-Weyl Methods of Molecular Transformations
, vol.10
-
-
Joule, J.A.1
-
5
-
-
0013614138
-
-
Houlihan W.J. (Ed), Wiley-Interscience, New York, NY
-
Brown R.K. In: Houlihan W.J. (Ed). Indoles (1972), Wiley-Interscience, New York, NY
-
(1972)
Indoles
-
-
Brown, R.K.1
-
6
-
-
0001426611
-
-
Katritzky A.R., Rees C.W., Scriven E.F.V., and Bird C.W. (Eds), Pergamon, Oxford
-
Sundberg R.J. In: Katritzky A.R., Rees C.W., Scriven E.F.V., and Bird C.W. (Eds). Comprehensive Heterocyclic Chemistry II Vol. 2 (1996), Pergamon, Oxford 119
-
(1996)
Comprehensive Heterocyclic Chemistry II
, vol.2
, pp. 119
-
-
Sundberg, R.J.1
-
7
-
-
0001275286
-
-
Katritzky A.R., Rees C.W., Scriven E.F.V., and Bird C.W. (Eds), Pergamon, Oxford
-
Gribble G.W. In: Katritzky A.R., Rees C.W., Scriven E.F.V., and Bird C.W. (Eds). Comprehensive Heterocyclic Chemistry II Vol. 2 (1996), Pergamon, Oxford 207
-
(1996)
Comprehensive Heterocyclic Chemistry II
, vol.2
, pp. 207
-
-
Gribble, G.W.1
-
8
-
-
33750442468
-
-
Sundberg R.J. (Ed), Academic, London
-
In: Sundberg R.J. (Ed). Indoles (1996), Academic, London
-
(1996)
Indoles
-
-
-
9
-
-
33750456099
-
-
For recent reviews on the synthesis of indoles, see:
-
-
-
-
14
-
-
0024239320
-
-
Evans B.E., Rittle K.E., Bock M.G., DiPardo R.M., Freidinger R.M., Whitter W.L., Lundell G.F., Verber D.F., Anderson P.S., Chang R.S.L., Lotti V.J., Cerino D.H., Chen T.B., Kling P.J., Kunkel K.A., Springer J.P., and Hirshfield J. J. Med. Chem. 31 (1988) 2235-2246
-
(1988)
J. Med. Chem.
, vol.31
, pp. 2235-2246
-
-
Evans, B.E.1
Rittle, K.E.2
Bock, M.G.3
DiPardo, R.M.4
Freidinger, R.M.5
Whitter, W.L.6
Lundell, G.F.7
Verber, D.F.8
Anderson, P.S.9
Chang, R.S.L.10
Lotti, V.J.11
Cerino, D.H.12
Chen, T.B.13
Kling, P.J.14
Kunkel, K.A.15
Springer, J.P.16
Hirshfield, J.17
-
19
-
-
33750430794
-
-
Kuethe J.T., Wong A., Qu C., Smitrovich J.H., Davies I.W., and Hughes D.L. J. Org. Chem. 70 (2005) 255-2567
-
(2005)
J. Org. Chem.
, vol.70
, pp. 255-2567
-
-
Kuethe, J.T.1
Wong, A.2
Qu, C.3
Smitrovich, J.H.4
Davies, I.W.5
Hughes, D.L.6
-
21
-
-
11144357557
-
-
Thoma G., Nuninger F., Schaefer M., Akyel K.G., Albert R., Beerli C., Bruns C., Francotte E., Luyten M., MacKenzie D., Oberer L., Streiff M.B., Wagner T., Walter H., Weckbecker G., and Zerwes H.-G. J. Med. Chem. 47 (2004) 1939-1955
-
(2004)
J. Med. Chem.
, vol.47
, pp. 1939-1955
-
-
Thoma, G.1
Nuninger, F.2
Schaefer, M.3
Akyel, K.G.4
Albert, R.5
Beerli, C.6
Bruns, C.7
Francotte, E.8
Luyten, M.9
MacKenzie, D.10
Oberer, L.11
Streiff, M.B.12
Wagner, T.13
Walter, H.14
Weckbecker, G.15
Zerwes, H.-G.16
-
22
-
-
1242307864
-
-
Kumar K., Michalik D., Castro I.G., Tillack A., Zapf A., Arlt M., Heinrich T., Boettcher H., and Beller M. Chem.-Eur. J. 10 (2004) 746-757
-
(2004)
Chem.-Eur. J.
, vol.10
, pp. 746-757
-
-
Kumar, K.1
Michalik, D.2
Castro, I.G.3
Tillack, A.4
Zapf, A.5
Arlt, M.6
Heinrich, T.7
Boettcher, H.8
Beller, M.9
-
23
-
-
1542404599
-
-
Palani A., Dugar S., Clader J.W., Greenlee W.J., Ruperto V., Duffy R.A., and Lachowicz J.E. Bioorg. Med. Chem. Lett. 14 (2004) 1791-1794
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 1791-1794
-
-
Palani, A.1
Dugar, S.2
Clader, J.W.3
Greenlee, W.J.4
Ruperto, V.5
Duffy, R.A.6
Lachowicz, J.E.7
-
24
-
-
0242286043
-
-
Kakefuda A., Watanabe T., Taguchi Y., Masuda N., Tanaka A., and Yanagisawa I. Chem. Pharm. Bull. 51 (2003) 390-398
-
(2003)
Chem. Pharm. Bull.
, vol.51
, pp. 390-398
-
-
Kakefuda, A.1
Watanabe, T.2
Taguchi, Y.3
Masuda, N.4
Tanaka, A.5
Yanagisawa, I.6
-
25
-
-
12444313031
-
-
Dai Y., Guo Y., Guo J., Pease L.J., Li J., Marcotte P.A., Glaser K.B., Tapang P., Albert D.H., Richardson P.L., Davidsen S.K., and Michaelides M.R. Bioorg. Med. Chem. Lett. 13 (2003) 1897-1901
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 1897-1901
-
-
Dai, Y.1
Guo, Y.2
Guo, J.3
Pease, L.J.4
Li, J.5
Marcotte, P.A.6
Glaser, K.B.7
Tapang, P.8
Albert, D.H.9
Richardson, P.L.10
Davidsen, S.K.11
Michaelides, M.R.12
-
26
-
-
12444323524
-
-
Mavunkel B.J., Chakravarty S., Perumattam J.J., Luedtke G.R., Liang X., Lim D., Xu Y.-J., Laney M., Liu D.Y., Schreiner G.F., Lewicki J.A., and Dugar S. Bioorg. Med. Chem. Lett. 13 (2003) 3087-3090
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 3087-3090
-
-
Mavunkel, B.J.1
Chakravarty, S.2
Perumattam, J.J.3
Luedtke, G.R.4
Liang, X.5
Lim, D.6
Xu, Y.-J.7
Laney, M.8
Liu, D.Y.9
Schreiner, G.F.10
Lewicki, J.A.11
Dugar, S.12
-
27
-
-
18244385530
-
-
Chollet A.-M., Diguarher T.L., Kucharczyk N., Loynel A., Bertrand M., Tucker G., Guilbaud N., Burbridge M., Pastoureau P., Fradin A., Sabatini M., Fauchère J.-L., and Casara P. Bioorg. Med. Chem. 10 (2002) 531-544
-
(2002)
Bioorg. Med. Chem.
, vol.10
, pp. 531-544
-
-
Chollet, A.-M.1
Diguarher, T.L.2
Kucharczyk, N.3
Loynel, A.4
Bertrand, M.5
Tucker, G.6
Guilbaud, N.7
Burbridge, M.8
Pastoureau, P.9
Fradin, A.10
Sabatini, M.11
Fauchère, J.-L.12
Casara, P.13
-
28
-
-
0037038322
-
-
Koch S.S.C., Thoresen L.H., Tikhe J.G., Maegley K.A., Almassy R.J., Li J., Yu X.-H., Zook S.E., Kumpf R.A., Zhang C., Boritzki T.J., Mansour R.N., Zhang K.E., Ekker A., Calabrese C.R., Curtin N.J., Kyle S., Thomas S.E., Wang L.-Z., Calvert A.H., Golding B.T., Griffin R.J., Newell D.R., Webber S.E., and Hostomsky Z. J. Med. Chem. 45 (2002) 4961-4974
-
(2002)
J. Med. Chem.
, vol.45
, pp. 4961-4974
-
-
Koch, S.S.C.1
Thoresen, L.H.2
Tikhe, J.G.3
Maegley, K.A.4
Almassy, R.J.5
Li, J.6
Yu, X.-H.7
Zook, S.E.8
Kumpf, R.A.9
Zhang, C.10
Boritzki, T.J.11
Mansour, R.N.12
Zhang, K.E.13
Ekker, A.14
Calabrese, C.R.15
Curtin, N.J.16
Kyle, S.17
Thomas, S.E.18
Wang, L.-Z.19
Calvert, A.H.20
Golding, B.T.21
Griffin, R.J.22
Newell, D.R.23
Webber, S.E.24
Hostomsky, Z.25
more..
-
29
-
-
0742286896
-
-
For a leading reference, see: and references cited therein
-
For a leading reference, see:. Kumar K., Zapf A., Michalik D., Tillack A., Heinrich T., Böttcher H., Arlt M., and Beller M. Org. Lett. 6 (2004) 7-10 and references cited therein
-
(2004)
Org. Lett.
, vol.6
, pp. 7-10
-
-
Kumar, K.1
Zapf, A.2
Michalik, D.3
Tillack, A.4
Heinrich, T.5
Böttcher, H.6
Arlt, M.7
Beller, M.8
-
33
-
-
33750472948
-
-
For leading references, see:
-
-
-
-
38
-
-
20444452906
-
-
Davies I.W., Smitrovich J.H., Sidler R., Qu C., Gresham V., and Bazaral C. Tetrahedron 61 (2005) 6425-6437
-
(2005)
Tetrahedron
, vol.61
, pp. 6425-6437
-
-
Davies, I.W.1
Smitrovich, J.H.2
Sidler, R.3
Qu, C.4
Gresham, V.5
Bazaral, C.6
-
39
-
-
33750459309
-
-
note
-
HPLC assay yield refers to quantitative HPLC analysis of the crude reaction mixture using an analytically pure standard.
-
-
-
-
40
-
-
33750486124
-
-
Isomeric isochromanones have reportedly been prepared by the reaction of 3 or its corresponding benzoic acid by reaction with DMF dimethyl acetal, see:
-
-
-
-
42
-
-
0026611418
-
-
Matsui T., Sugiura T., Nakai H., Iguchi S., Shigeoka S., Takada H., Odagaki Y., Nagao Y., Ushio Y., Ohmoto K., Iwamura H., Yamazaki S., Arai Y., and Kawamura M. J. Med. Chem. 35 (1992) 3307-3319
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3307-3319
-
-
Matsui, T.1
Sugiura, T.2
Nakai, H.3
Iguchi, S.4
Shigeoka, S.5
Takada, H.6
Odagaki, Y.7
Nagao, Y.8
Ushio, Y.9
Ohmoto, K.10
Iwamura, H.11
Yamazaki, S.12
Arai, Y.13
Kawamura, M.14
-
43
-
-
33750455399
-
-
Similar compounds of type 32 and 33 have been prepared in similar fashion by the reaction of 31 with NaOMe in MeOH or with piperadine at high temperatures, see:
-
-
-
-
50
-
-
33750490717
-
-
For a review on reductive cyclizations of aromatic nitrocompounds, see:
-
-
-
-
53
-
-
33750491872
-
-
For a discussion of mechanism including computational studies, see:
-
-
-
-
56
-
-
33750446230
-
-
Jacob, R. M. German Patent DE 828,695, 1950.
-
-
-
|