Solid-phase synthesis of α-substituted 3-bisarylthio N-hydroxy propionamides as specific MMP Inhibitors

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 3, 2002, Pages 531-544

  Chollet, Anne Marie ^a   Le Diguarher, Thierry ^a   Kucharczyk, Nathalie ^a   Loynel, Armelle ^a   Bertrand, Marc ^c   Tucker, Gordon ^b   Guilbaud, Nicolas ^b   Burbridge, Mike ^b   Pastoureau, Philippe ^b   Fradin, Armel ^b   Sabatini, Massimo ^b   Fauchère, Jean Luc ^a   Casara, Patrick ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 PHTHALIMIDOETHYL) 3 (3' CHLOROBIPHENYLTHIO)PROPIONIONAMIDE PROPIONIC ACID; 2 [2 (4 OXO 4H BENZO[D][2,3]TRIAZIN 3 YLETHYL)] 3 (4 PYRAZIN 2 YLPHENYLTHIO)PROPIONIC ACID; 2 [2 (4 OXO 4H BENZO[D][2,3]TRIAZIN 3 YLETHYL)] 3 (4 PYRIDIN 3 YLPHENYLTHIO)PROPIONIC ACID; 2 [2 (4 OXO 4H BENZO[D][2,3]TRIAZIN 3 YLETHYL)] 3 (4 PYRIMIDIN 5 YLPHENYLTHIO)PROPIONIC ACID; ITACONIC ACID; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; N HYDROXY 2 (2 X 1 AMINOCARBONYLETHYL) 3 (4' CHLOROBIPHENYLTHIO)PROPIONATE; N HYDROXY 2 (2 X ETHYL) 3 (4' CHLOROBIPHENYLTHIO)PROPIONATE; N HYDROXY 2 [2 (4 OXO 4H BENZO[D][2,3]TRIAZIN 3 YLETHYL)] 3 (4 PYRAZIN 2 YLPHENYLTHIO)PROPIONIONAMIDE; N HYDROXY 2 [2 (4 OXO 4H BENZO[D][2,3]TRIAZIN 3 YLETHYL)] 3 (4 PYRIDIN 3 YLPHENYLTHIO)PROPIONIONAMIDE; N HYDROXY 2 [2 (4 OXO 4H BENZO[D][2,3]TRIAZIN 3 YLETHYL)] 3 (4 PYRIMIDIN 5 YLPHENYLTHIO)PROPIONIONAMIDE; N HYDROXY 2 [2 (4 OXO 4H BENZO[D][2,3]TRIAZIN 3 YLETHYL)] 3 (4 THIEN 3 YLPHENYLTHIO)PROPIONIONAMIDE; N HYDROXY 2 [2 (4 OXO 4H BENZO[D][2,3]TRIAZIN 3 YLETHYL)] 3 (4' CHLOROBIPHENYL 4 THIO)PROPIONAMIDE; N HYDROXY 2 [2 (4 OXO 4H BENZO[D][2,3]TRIAZIN 3 YLETHYL)] 3 (BIPHENYL 4 THIO)PROPIONAMIDE; PROPIONAMIDE DERIVATIVE; UNCLASSIFIED DRUG; AMIDE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; PROPIONAMIDE; PROTEOGLYCAN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; SOLID; STRUCTURE ACTIVITY RELATION; ANIMAL; ARTICULAR CARTILAGE; COMBINATORIAL CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; MELANOMA; METABOLISM; METASTASIS; RABBIT; SYNTHESIS;

AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CARTILAGE, ARTICULAR; COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASES; MELANOMA; MICE; NEOPLASM METASTASIS; PROTEOGLYCANS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18244385530     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00311-X     Document Type: Article

References (30)