Palladium-Catalyzed Carbonylation of Haloindoles: No Need for Protecting Groups

Organic Letters

Volumn 6, Issue 1, 2004, Pages 7-10

  Kumar, Kamal ^a   Zapf, Alexander ^a   Michalik, Dirk ^a   Tillack, Annegret ^a   Heinrich, Timo ^a   Böttcher, Henning ^b   Arlt, Michael ^b   Beller, Matthias ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE DERIVATIVE; BROMINE DERIVATIVE; CARBOXYL GROUP; CARBOXYLIC ACID DERIVATIVE; HALIDE; INDOLE DERIVATIVE; PIPERAZINE DERIVATIVE;

ARTICLE; CARBONYLATION; CATALYSIS; PROTECTION; SYNTHESIS;

EID: 0742286896     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol035988r     Document Type: Article

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39. For other synthesis of 2-arylethylpiperazines and related molecules, see: (a) Akgun, H.; Hollstein, U.; Hurwite, L. J. Pharm. Sci. 1988, 17, 735 and references therein. (b) Pelletier, S. W. Chemistry of Alkaloids; Van Nostrand-Reinhold: New York, 1970. (c) Leake, C. D. The Amphetamines: Their Actions and Uses; Charles C. Thomas Co.: Springfield, IL, 1958. (d) Testa, B.; Salvesen, B. J. Pharm. Sci. 1980, 69, 497. (e) Laske, R.; Meindl, W.; Holler, E.; Schönenberger, H. Arch. Pharm. 1989, 322, 297, 847. (f) Glennon, R. A. ; Yousif, M. Y.; Ismaiel, A. M.; El-Ashmawy, M. B.; Herndon, J. L.; Fischer, J. B.; Server, A. C.; Howie, K. J. B. J. Med. Chem. 1991, 34, 3360.
40. For other synthesis of 2-arylethylpiperazines and related molecules, see: (a) Akgun, H.; Hollstein, U.; Hurwite, L. J. Pharm. Sci. 1988, 17, 735 and references therein. (b) Pelletier, S. W. Chemistry of Alkaloids; Van Nostrand-Reinhold: New York, 1970. (c) Leake, C. D. The Amphetamines: Their Actions and Uses; Charles C. Thomas Co.: Springfield, IL, 1958. (d) Testa, B.; Salvesen, B. J. Pharm. Sci. 1980, 69, 497. (e) Laske, R.; Meindl, W.; Holler, E.; Schönenberger, H. Arch. Pharm. 1989, 322, 297, 847. (f) Glennon, R. A. ; Yousif, M. Y.; Ismaiel, A. M.; El-Ashmawy, M. B.; Herndon, J. L.; Fischer, J. B.; Server, A. C.; Howie, K. J. B. J. Med. Chem. 1991, 34, 3360.
41. For other synthesis of 2-arylethylpiperazines and related molecules, see: (a) Akgun, H.; Hollstein, U.; Hurwite, L. J. Pharm. Sci. 1988, 17, 735 and references therein. (b) Pelletier, S. W. Chemistry of Alkaloids; Van Nostrand-Reinhold: New York, 1970. (c) Leake, C. D. The Amphetamines: Their Actions and Uses; Charles C. Thomas Co.: Springfield, IL, 1958. (d) Testa, B.; Salvesen, B. J. Pharm. Sci. 1980, 69, 497. (e) Laske, R.; Meindl, W.; Holler, E.; Schönenberger, H. Arch. Pharm. 1989, 322, 297, 847. (f) Glennon, R. A. ; Yousif, M. Y.; Ismaiel, A. M.; El-Ashmawy, M. B.; Herndon, J. L.; Fischer, J. B.; Server, A. C.; Howie, K. J. B. J. Med. Chem. 1991, 34, 3360.
42. For other synthesis of 2-arylethylpiperazines and related molecules, see: (a) Akgun, H.; Hollstein, U.; Hurwite, L. J. Pharm. Sci. 1988, 17, 735 and references therein. (b) Pelletier, S. W. Chemistry of Alkaloids; Van Nostrand-Reinhold: New York, 1970. (c) Leake, C. D. The Amphetamines: Their Actions and Uses; Charles C. Thomas Co.: Springfield, IL, 1958. (d) Testa, B.; Salvesen, B. J. Pharm. Sci. 1980, 69, 497. (e) Laske, R.; Meindl, W.; Holler, E.; Schönenberger, H. Arch. Pharm. 1989, 322, 297, 847. (f) Glennon, R. A. ; Yousif, M. Y.; Ismaiel, A. M.; El-Ashmawy, M. B.; Herndon, J. L.; Fischer, J. B.; Server, A. C.; Howie, K. J. B. J. Med. Chem. 1991, 34, 3360.
43. For other synthesis of 2-arylethylpiperazines and related molecules, see: (a) Akgun, H.; Hollstein, U.; Hurwite, L. J. Pharm. Sci. 1988, 17, 735 and references therein. (b) Pelletier, S. W. Chemistry of Alkaloids; Van Nostrand-Reinhold: New York, 1970. (c) Leake, C. D. The Amphetamines: Their Actions and Uses; Charles C. Thomas Co.: Springfield, IL, 1958. (d) Testa, B.; Salvesen, B. J. Pharm. Sci. 1980, 69, 497. (e) Laske, R.; Meindl, W.; Holler, E.; Schönenberger, H. Arch. Pharm. 1989, 322, 297, 847. (f) Glennon, R. A. ; Yousif, M. Y.; Ismaiel, A. M.; El-Ashmawy, M. B.; Herndon, J. L.; Fischer, J. B.; Server, A. C.; Howie, K. J. B. J. Med. Chem. 1991, 34, 3360.