Synthesis of novel KDR kinase inhibitors through catalytic reductive cyclization of o-nitrobenzylcarbonyl compounds

Journal of Organic Chemistry

Volumn 69, Issue 22, 2004, Pages 7761-7764

  Wong, Audrey ^a   Kuethe, Jeffrey T ^a   Davies, Ian W ^a   Hughes, David L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYME INHIBITION; ETHANOL; HYDROLYSIS; OPTIMIZATION; OXIDATION; REDUCTION; SYNTHESIS (CHEMICAL);

O-NITROBENZYLCARBONYL COMPOUNDS; PHENETHANOL; REDUCTIVE CYCLIZATION; SWERN-TYPE OXIDATION;

NITROGEN COMPOUNDS;

1 (2 METHOXYQUINOLIN 3 YL) 2 [5 [[4 (METHYLSULFONYL)PIPERAZIN 1 YL]METHYL] 2 NITROPHENYL]ETHANONE; 1H INDOL 2 YLQUINOLINE; 2 METHOXY 3 [5 [[4 (METHYLSULFONYL) 1 PIPERAZINYL]METHYL]1H INDOL 2 YL]QUINOLINE; 2 NITROBENZYLCARBONYL DERIVATIVE; 3 [5 [[4 (METHANESULFONYL) 1 PIPERAZINYL]METHYL]1H INDOL 2 YL]QUINOLIN 2(1H) ONE; ANTINEOPLASTIC AGENT; CARBONYL DERIVATIVE; NICKEL; NITROBENZENE DERIVATIVE; PHENETHYL ALCOHOL; PROTEIN TYROSINE KINASE INHIBITOR; QUINOLINE DERIVATIVE; TYROSINE KINASE KDR INHIBITOR; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CATALYST; CHEMICAL MODIFICATION; CHEMICAL REACTION; CYCLIZATION; DRUG HYDROLYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; POLYMERIZATION; PROCESS OPTIMIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REDUCTION; REPRODUCIBILITY; SWERN OXIDATION; TECHNIQUE;

CATALYSIS; CYCLIZATION; ENZYME INHIBITORS; MOLECULAR STRUCTURE; NITROBENZENES; NITROPHENOLS; OXIDATION-REDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 6344263852     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo048843m     Document Type: Article

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