A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B

British Journal of Pharmacology

Volumn 134, Issue 8, 2001, Pages 1647-1654

  Seebohm, G ^a   Lerche, C ^a   Pusch, M ^b   Steinmeyer, K ^a   Bruggemann A ^a   Busch, A E ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b CNR   (Italy)

Author keywords

293B; IsK; K channel; KCNE1; KCNQ1; MinK; Trans 6 cyano 4 (N ethylsulfonyl N methylamino) 3 hydroxy 2,2 dimethyl chromane

Indexed keywords

6 CYANO 4 (N ETHYLSULFONYL N METHYLAMINO) 3 HYDROXY 2,2 DIMETHYLCHROMANE; CHROMAN DERIVATIVE; CHROMANOL 293B; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CHANNEL GATING; DRUG MECHANISM; ENANTIOMER; KINETICS; NONHUMAN; PRIORITY JOURNAL; STEREOSPECIFICITY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BINDING SITES; CHROMANS; ELECTROPHYSIOLOGY; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; ION CHANNEL GATING; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; KINETICS; MEMBRANE POTENTIALS; OOCYTES; PATCH-CLAMP TECHNIQUES; PERFUSION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; STEREOISOMERISM; SULFONAMIDES; THERMODYNAMICS; XENOPUS;

EID: 0035678117     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704421     Document Type: Article

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