Do regulatory t-cells play a role in AIDS pathogenesis?

AIDS Reviews

Volumn 8, Issue 3, 2006, Pages 141-147

  Boasso, Adriano ^a   Vaccari, Monica ^a   Nilsson, Jakob ^b   Shearer, Gene M ^a   Andersson, Jan ^b   Cecchinato, Valentina ^a   Chougnet, Jakob ^c   Franchini, Genovetta ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Antiviral immunomodulatory; HIV; Immune regulatory; Immune response; Regulatory T cell; T cell

Indexed keywords

1 METHYLTRYPTOPHAN; ANTIRETROVIRUS AGENT; CD40 LIGAND MONOCLONAL ANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; IMMUNOGLOBULIN; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIGEN SPECIFICITY; ANTIVIRAL ACTIVITY; CD25+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; DRUG MECHANISM; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; IMMUNOREGULATION; IMMUNOTHERAPY; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; LYMPHOCYTE FUNCTION; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW;

ACQUIRED IMMUNODEFICIENCY SYNDROME; DRUG DESIGN; HIV; HUMANS; IMMUNOLOGIC FACTORS; T-LYMPHOCYTES, REGULATORY;

EID: 33750364462     PISSN: 11396121     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (63)

1. regs and immune control. J Clin Invest 2004;114:1209-17.
2. Gavin M, Rudensky A. Control of immune homeostasis by naturally arising regulatory CD4+ T-cells. Curr Opin Immunol 2003;15:690-6.
3. Nishimura E, Sakihama T, Setoguchi R, Tanaka K, Sakaguchi S. Induction of anti gen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells. Int Immunol 2004;16: 1189-201.
4. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunologic tolerance to self and nonself. Nat Immunol 2005;6:345-52.
5. Uraushihara K, Kanai T, Ko K, et al. Regulation of murine inflammatory bowel disease by CID25+ and CID25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells. J Immunol 2003;171:708-16.
6. Seddiki N, Santner-Nanan B, Martinson J, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006;203:1693-1700.
7. Ramsdell F. Foxp3 and natural regulatory T cells: key to a cell lineage? Immunity 2003;19:165-8.
8. Fontenot J, Gavin M, Rudensky A. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-6.
9. Hori S, Sakaguchi S. Foxp3: a critical regulator of the development and function of regulatory T cells. Microbes Infect 2004;6:745-51.
10. Wu Y, Borde M, Heissmeyer V, et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006; 126:375-87.
11. Birebent B, Lorho R, Lechartier H, et al. Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression. Eur J Immunol 2004;34:3485-96.
12. Walker M, Kasprowicz D, Gersuk V, et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25-T cells. J Clin Invest 2003;112:1437-43.
13. Fallarino F, Grohmann U, Hwang K, et al. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol 2003;4:1206-12.
14. Munn D, Sharma M, Mellor A. Ligation of B7-1/B7-2 by human CD4+ T-cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. J Immunol 2004;172:4100-10.
15. Mellor A, Munn D. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004;4:762-74.
16. Green E, Gorelik L, McGregor C, Tran E, Flavell R. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Nat] Acad Sci USA 2003;100:10878-83.
17. Huber S, Schramm C, Lehr H, et al. Cutting edge: TGF-β signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T-cells. J Immunol 2004; 173: 6526-31.
18. Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198:1875-86.
19. Maggi E, Cosmi L, Liotta F, Romagnani P, Romagnani S, Annunziato F. Thymic regulatory T cells. Autoimmun Rev 2005;4:579-86.
20. Chattopadhyay S, Chakraborty, N, Mukherji B. Regulatory T cells and tumor immunity. Cancer Immunol Immunother 2005;54:1153-61.
21. Rouse B, Suvas S. Regulatory cells and infectious agents: detentes cordiale and contraire. J Immunol 2004;173:2211-5.
22. Oswald-Richter K, Grill S, Shariat N, et al. HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. PLoS Biol 2004;2:E198.
23. Aandahl E, Michaelsson J, Moretto W, Hecht F, Nixon D. Human CD4+ CD25+ regulatory T cells control T-cell responses to HIV and CMV antigens. J Virol 2004;78:2454-9.
24. Kinter A, Hennessey M, Bell A, et al. CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med 2004;200:331-43.
25. Eggena M, Barugahare B, Jones N, et al. Depletion of regulatory T cells in HIV infection is associated with immune activation. J Immunol 2005;174:4407-14.
26. Kornfeld C, Ploquin M, Pandrea I, et al. Anti-inflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS. J Clin Invest 2005;115:1082-91.
27. Andersson J, Boasso A, Nilsson J, et al. The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. J Immunol 2005;174:3143-7.
28. Nilsson J, Boasso A, Velilla P, et al. HIV-1 driven regulatory T cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. Blood 2006 [Epub ahead of print],
29. Epple H, Loddenkemper C, Kunkel D, et al. Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood 2006 [Epub ahead of print].
30. Estes J, Li Q, Reynolds M, et al. Premature induction of an immunosuppressive regulatory T-cell response during acute SIV Infection. J Infect Dis 2006;193:703-12.
31. Bernard N, Chernoff D, Tsoukas C. Effect of splenectomy on T-cell subsets and plasma HIV viral titers in HIV-infected patients. J Hum Virol 1998;1:338-45.
32. Brenchley J, Schacker T, Ruff L. et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004;200:749-59.
33. Guadalupe M, Reay E, Sankaran S, et al. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary HIV-1 infection and substantial delay in restoration following HAART. J Virol 2003; 77:11708-17.
34. Li Q, Duan L, Estes J, et al. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 2005;434:1148-52.
35. Mattapallil J, Douek D, Hill B, Nishimura Y, Martin M, Roederer M. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 2005;434:1093-7.
36. Shen A, Zink M, Mankowski J, et al. Resting CD4+ T lymphocytes but not thymocytes provide a latent viral reservoir in a SIV-Macaca nemestrina model of HIV-1-infected patients on HAART. J Virol 2003;77:4938-49.
37. Veazey R, DeMaria M, Chalifoux L, et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 1998;280:427-31.
38. Vahlenkamp T, Tompkins M, Tompkins W. Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4+CD25+ T regulatory cells. J Immunol 2004;172:4752-761.
39. Weiss L, Donkova-Petrini V, Caccavelli L, Balbo M, Carbonneil C, Levy Y. HIV-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients. Blood 2004;104:3249-56.
40. Hryniewicz A, Boasso A, Edghill-Smith Y, et al. CTLA-4 blockade decreases TGFβ, indolamine 2,3- dioxygenase, and viral RNA expression in tissues of SIVmac251-infected macaques. Blood 2006 [Epub ahead of print].
41. Garber D, Silvestri G, Barry A, et al. Blockade of T cell co-stimulation reveals interrelated actions of CD4+ and CD8+ T cells in control of SIV replication. J Clin Invest 2004;113:836-45.
42. Boasso A, Herbeuval J, Hardy A, Winkler C, Shearer G. Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells. Blood 2005;105:1574-81.
43. Grohmann U, Orabona C, Fallarino F, et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 2002;3:1097-01.
44. Potula R, Poluektova L, Knipe B, et al. Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis. Blood 2005; 106:2382-90.
45. Casseb J, Benard G, Saito R, et al. The value of the lymphocyte proliferation test with phytohemagglutinin in the immune evaluation of Brazilian HIV-infected patients. J Investig Allergol Clin Immunol 1995;5:347-9
46. Hofmann B, Nishanian P, Baldwin R, Insixiengmay P, Nel A, Fahey J. HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism. J Immunol 1990;145: 3699-705.
47. Janossy G, Borthwick N, Lomnitzer R, et al. Lymphocyte activation in HIV-1 infection. Predominant proliferative defects among CD45RO+ cells of the CD4 and CD8 lineages. Aids 1993;7:613-24.
48. Clerici M, Stocks N, Zajac R, et al. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, HIV-seropositive patients. Independence of CD4+ cell numbers and clinical staging. J Clin Invest 1989;84:1892-99.
49. Shearer G, Clerici M. In vitro analysis of cell-mediated immunity: clinical relevance. Clin Chem 1994;40:2162-5.
50. MacDonald A, Duffy M, Brady M, et al. CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in HCV-infected persons. J Infect Dis 2002;185:720-7.
51. Raghavan S, Suri-Payer E, Holmgren J. Antigen-specific in vitro suppression of murine Helicobacter pylori-reactive immunopathologic T cells by CD4CD25 regulatory T cells. Scand J Immunol 2004;60:82-8.
52. Suffia I, Reckling S, Piccirillo C, Goldszmid R, Belkaid Y. Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. J Exp Med 2006;203:777-88.
53. Blansfield J, Beck K, Tran K, et al. Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. J Immunother 2005;28:593-8.
54. Maker A, Attia P, Rosenberg S. Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade. J Immunol 2005;175:7746-54.
55. Maker A, Phan G, Attia P, et al. Tumor regression and autoimmunity in patients treated with CTL-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann Surg Oncol 2005;12:1005-16.
56. Maker A, Yang J, Sherry R, et al. Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma. J Immunother 2006;29:455-63.
57. Phan G, Yang J, Sherry R, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA 2003;100:8372-7.
58. Robinson M, Chan C, Yang J, et al. Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis. J Immunother 2004;27:478-9.
59. Grant R, Naif H, Thuruthyil S, et al. Induction of indoleamine 2,3-dioxygenase in primary human macrophages by HIV-1. Redox Rep 2000;5:105-7.
60. Grant R, Naif H, Thuruthyil S, et al. Induction of indolamine 2,3-dioxygenase in primary human macrophages by HIV-1 is strain dependent. J Virol 2000;74:4110-5.
61. Day C, Kaufmann D, Kiepiela P, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006 [Epub ahead of print].
62. Nocentini G, Riccardi C. GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily. Eur J Immunol 2005;35:1016-22.
63. Trautmann L, Janbazian L, Chomont N, et al. Upregulation of PD-1 expression on HIV-specific CD8+ T-cells leads to reversible immune dysfunction. Nat Med 2006 [Epub ahead of print].