The brain immune response in human prion diseases. Microglial activation and microglial disease. I. Sporadic Creutzfeldt-Jakob disease

Folia Neuropathologica

Volumn 44, Issue 3, 2006, Pages 202-213

  Szpak, Grazyna M ^a   Lewandowska, Eliza ^a   Lechowicz, Waldemar ^a   Wierzba Bobrowicz, Teresa ^a   Kulczycki, Jerzy ^a   Bertrand, Ewa ^a   Pasennik, Elzbieta ^a   Dymecki, Jerzy ^a  

^a INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Poland)

Author keywords

Activation microglia; Degeneration microglia; Human transmissible spongiform encephalopathy; Immunohistochemistry; Prion disease; PrP deposition; Sporadic Creutzfeldt Jakob disease

Indexed keywords

PRION PROTEIN;

ADULT; AGED; ARTICLE; AUTOPSY; BRAIN CORTEX; CELL ACTIVATION; CELL VACUOLE; CEREBELLUM CORTEX; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DISEASE COURSE; DISEASE TRANSMISSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LYMPHOCYTE HOMING; MICROGLIA; MORPHOLOGY; NERVE CELL DEGENERATION; PATHOGENESIS; PHENOTYPE; PRION DISEASE; SYMPTOMATOLOGY;

EID: 33750320504     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Aguzzi A, Miele G. Recent advantes in prion biology. Curr Opin Neurol 2004, 17: 337-342.
2. Aoki T, Kobayashi K, Isaki K. Microglial and astrocytic change in brains of 1999 Creutzfeldt-Jakob disease: an immunocytochemical and quantitative study. Clin Neuropathol 1999; 18: 51-60.
3. Aucouturier P, Carp RI, Carnaud C, Wiśniewski T. Short analytical review. Prion diseases and the immune system. Clinical Immunology 2000; 96: 79-85.
4. Baker ChA, Lu ZY, Zaitsev I, Manuelidis L. Microglial activation varies in different models of Creutzfeldt-Jakob disease. J Virol 1999; 73: 5089-5097.
5. Baker ChA, Martin D, Manuelidis L. Microglia from Creutzfeldt-Jakob disease - infected brains are infectious and show specific mRNA activation profiles. J Virol 2002; 76: 10905-10913.
6. Banati RB, Graeber MB. Surveillance, intervention and cytotoxicity: Is there a protective role of microglia? Developmental Neuroscience 1994; 16: 114-127.
7. Barcikowska M, Liberski PP, Boellaard JW, Brown P, Gajdusek DC, Budka H. Microglia is a component of the prion protein amyloid plaque in the Gerstmann-Sträussler-Scheinker syndrome. Acta Neuropathol 1993; 85: 623-627.
8. Bate C, Boshuizen RS, Langeveld JP, Williams A. Temporal and spatial relationship between the death of PrP-damaged neurons and microglial activation. Neuroreport 2002; 16: 1695-1700.
9. Bate C, Reid S, Williams A. Killing of prion-damaged neurons by microglia. Neuroreport 2001; 12: 2589-2594.
10. Becher B, Prat A, Antel JP. Brain-immune connection: Immunoregulatory properties of CNS-resident cells. Glia 2000; 29: 293-304.
11. Betmouni S, Perry VH, Gordon JL. Evidence for an early inflammatory response in the central nervous system of mice with scrapie. Neuroscience 1996; 74: 1-5.
12. Biernat W, Liberski PP, Guiroy DC, Yanagihara R, Gajdusek DC. Proliferating cell nuclear antigen immunohistochemistry in astrocytes in experimental Creutzfeldt-Jakob disease and human kuru, Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker syndrome. Neurodegeneration 1995; 4: 195-201.
13. Brown DR. Importance of glia to prion disease. Glia 2002; Suppl 1: S2.
14. Brown DR, Schmidt B, Kretzshmar HA. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature 1996; 380: 345-347.
15. Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Gullotta F, Haltia M, Hauw JJ, Iroside JW, Jellinger K. Neuropathological diagnostic criteria for Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). Brain Pathol 1995; 5: 459-466.
16. Budka H. Neuropathology of prion diseases. Brit Med Bull 2003; 66: 121-130.
17. vEitzen U, Egensperger R, Kösel S, Grasbon-Frodl EM, Imai Y, Bise K, Kohsaka S, Mehraein P, Graeber M. Microglia and the development of spongiform change in Creutzfeldt-Jakob disease. J Neuropathol Exp Neurol 1998; 57: 246-256.
18. Giese A, Kretzschmar HA. Prion-induced neuronal damage - the mechanisms of neuronal destruction in the subacute spongiform encephalopathies. Curr Top Microbiol Immunol 2001; 253: 203-217.
19. Haller NP, Heppner FL, Haas D, Nitsch R. Astrocytic factors deactivate antigen presenting cells that invade the CNS. Brain Pathol 1998; 8: 459-474.
20. Hanisch U-K. Microglia as a source and target of cytokines. Glia 2002; 40: 140-155.
21. Hepner FL, Aguzzi A. Recent developments in prion immunotherapy. Curr Opin Immunol 2004; 16: 594-598.
22. Ironside JW, Barrie C, McCardle L, Bell JE. Microglial cell reactions in human spongiform encephalopathies. Neuropathol Appl Neurobiol 1993; 19: 203.
23. Klatzo I, Gajdusek DC. Pathology of kuru. Lab Inves 1959; 8: 799-847.
24. Kovacs GG, Kalev O, Budka H. Contribution of neuropathology to the understanding of human prion disease. Folia Neuropathol 2004; suppl. A: 69-76.
25. Kovacs GG, Budka H. Aging, the brain and human prion disease. Exp Gerontology 2002; 37: 603-605.
26. Lewandowska E, Szpak GM, Kulczycki J, Lechowicz W, Wierzba-Bobrowicz T, Bertrand E, Pasennik E, Dymecki J. Creutzfeldt-Jakob disease-ultrastructural findings. Pol J Pathol 2002; 54, suppl.: 13-14.
27. Lewandowska E, Wierzba-Bobrowicz T, Kosno-Kruszewska E, Lechowicz W, Schmidt-Sidor B, Szpak GM, Bertrand E, Pasennik E, Gwiazda E. Ultrastructural evaluation of activated forms of microglia in human brain in selected neurological diseases (SSPE, Wilson's disease and Alzheimer's disease). Folia Neuropathol 2004; 42: 81-91.
28. Liberski PP, Brown P. Prion diseases: from transmission experiments to structural biology-still searching for the cause. Folia Neuropathol 2004; Suppl A: 15-32.
29. Liberski PP, Skłodowski B, Klimek A. Creutzfeldt-Jakob disease: Ultrastructural study of brain biopsy: Unusual interaction between astrocytes and oligo- and microglia. Folia Neuropathol 1995; 33: 85-92.
30. Marella M, Chabry J. Neurons and astrocytes respond to prion infections by inducing microglia recruitment. J Neurosci 2004; 24: 620-627.
31. Moresco RM, Messa C, Tagliavini F, et al. Creutzfeldt-Jakob disease: Activated microglia detected in vivo by molecular imaging. Meeting report of International Society of Neuropathology, XVI Congress in Turin, Italy 2003. Neuropathol Appl Neurobiol 2004; 30: 415.
32. Neumann H, Misgeld T, Matsumuro K, Wekerle H. Neutrophins inhibit MHC class II inducibility of microglia. Proc Natl Acad Sci 1998; 95: 5779-5784.
33. Prusiner SB. The prion diseases. Brain Pathol 1998; 8: 499-513.
34. sc. J Neuropathol Exp Neurol 2005; 64: 902-909.
35. sc in the same brain. Neurology 1999; 53: 2173-2176.
36. Raivich G, Bohatschek M, Kloss ChUA, Werner A, Jones LL, Kreutzberg GW. Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological functions. Brain Res Rev 1999; 30: 77-105.
37. Rezaie P, Trilo-Pazos G, Greenwood J, Everall IP, Male DK. Motility and ramification of human fetal microglia in culture. An investigation using time-lapse video microscopy and image analysis. Exp Cell Res 2002; 274: 68-82.
38. Sasaki A, Hirato J, Nakazato Y. Immunohistochemical study of microglia in the Creutzfeldt-Jakob diseased brain. Acta Neuropathol 1993; 86: 337-344.
39. Stence N, Waite M, Dailey ME. Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 2001; 33: 256-266.
40. Streit WJ. Microglia as neuroprotective immunocompetent cells of the CNS. Glia 2002; 40: 133-139.
41. Streit WJ, Sammons NW, Kuhns AJ, Sparks DL. Dystrophic microglia in the aging human brain. Glia 2004; 45: 208-212.
42. Szpak GM, Lechowicz W, Lewandowska E, Bertrand E, Wierzba-Bobrowicz T, Sobczyk W, Kulczycki I, Łojkowska W, Mendel P, Pasennik E, Stepień T, Lechowicz W. Microglial immune response in cerebral amyloid angiopathy in transmissible and non-transmissible cerebral amyloidoses. Folia Neuropathologica 2005; 43: 220-221.
43. Szpak GM, Lechowicz W, Lewandowska E, Bertrand E, Wierzba-Bobrowicz T, Gwiazda E, Dymecki J, Kulczycki J. Microglia activation stages in human brains affected by Creutzfeldt-Jakob disease. Glia 2002; Suppl. 1: S29.
44. Szpak GM, Lechowicz W, Lewandowska E, Bertrand E, Wierzba-Bobrowicz T, Gwiazda E, Schmidt-Sidor B, Kosno-Kruszewska E, Dymecki J. Interaction of microglia and neurons in CNS immune response to Amyotrophic Lateral Sclerosis. Glia 2002; Suppl. 1: S26.
45. Szpak GM, Lewandowska E, Lechowicz W, Bertrand E, Wierzba-Bobrowicz T, Gwiazda E, Pasennik E, Kosno-Kruszewska E, Lipczyńska-Łojkowska W, Bochyńska A, Fiszer U. Levy body variant of Alzheimer's disease and Alzheimers disease: a comparative immunohistochemical study. Folia Neuropathol 2001; 39: 63-71.
46. Szpak GM, Lechowicz W, Lewandowska E, Bertrand E, Wierzba-Bobrowicz T, Gwiazda E, Schmidt-Sidor B, Dymecki J. Neurons and microglia in central nervous system response on degenerative processes. Part I: Alzheimer's disease and Levy body variant of Alzheimer's disease. Quantitative study. Folia Neuropathol 2001; 39: 181-192.
47. Van Everbroeck B, Dewulf E, Pals Ph, Lubke U, Martin J-J, Cras P. The role of cytokines, astrocytes, microglia and apoptosis in Creutzfeldt-Jakob disease. Neurobiol Aging 2002; 23: 59-64.
48. Van Everbroeck B, Dobbeleir I, Be Waele M, De Leenheir E, Lubke U, Martin J-J, Cras P. Extracellular protein deposition correlates with glial activation and oxidative stress in Creutzfeldt-Jakob and Alzheimer's disease. Acta Neuropathol 2004; 108: 194-200.
49. Vilhardt F. Microglia: phagocyte and glia cell. IJBCB 2005; 37: 17-21.
50. Wierzba-Bobrowicz T, Lewandowska E, Kosno-Kruszewska E, Lechowicz W, Pasennik E, Schmidt-Sidor B. Degeneration of microglial cells in frontal and temporal lobes of chronic schizophrenics. Folia Neuropathol 2004; 42: 157-165.
51. Wierzba-Bobrowicz T, Gwiazda E, Kosno-Kruszewska E, Lewandowska E, Lechowicz W, Bertrand E, Szpak GM, Schmidt-Sidor B. Morphological analysis of active microglia-rod and ramified in human brains affected by some neurological diseases (SSPE, Alzheimer's disease and Wilson's disease). Folia Neuropathol 2002; 40: 125-131.
52. Wiliams AE, Lawson LJ, Perry VH, Fraser H. Characterization of the microglial response in murine scrapie. Neuropathol Appl Neurobiol 1994; 20: 45-55.