Microglia and the development of spongiform change in Creutzfeldt-Jakob disease

Journal of Neuropathology and Experimental Neurology

Volumn 57, Issue 3, 1998, Pages 246-256

  Eitzen, Ulrich V ^a   Egensperger, Rupert ^b   Kösel, Siegfried ^a   Grasbon Frodl, Eva M ^a   Imai, Yoshinori ^c   Bise, Karl ^a   Kohsaka, Shinichi ^a,c   Mehraein, Parviz ^a   Graeber, Manuel B ^a,d  

^a UNIVERSITY OF MUNICH   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^d MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Computerized image analysis; MHC class II molecules; Microglial cytotoxicity; Neurodegeneration; Prion diseases.

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ADULT; AGED; ARTICLE; BRAIN CORTEX; BRAIN SPONGIOSIS; CELL VACUOLE; CLINICAL ARTICLE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; FEMALE; GRAY MATTER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MICROGLIA; NEUROPIL; PRIORITY JOURNAL;

EID: 0031942743     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199803000-00006     Document Type: Article

References (46)

1. Brown DR, Schmidt B, Kretzschmar HA. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature 1996;380:345-47
2. Chao CC, Hu S, Molitor TW, Shaskan EG, Peterson PK. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 1992;149:2736-41
3. Goodwin JL, Uemura E, Cunnick JE. Microglial release of nitric oxide by the syncrgistic action of beta-amyloid and IFN-gamma. Brain Res 1995;692:207-14
4. Colasanti M, Persichini T, Di Pucchio T, Gremo F, Lauro GM. Human ramified microglial cells produce nitric oxide upon Escherichia coli lipopolysaccharide and tumor necrosis factor alpha stimulation. Neurosci Lett 1995;200:144-46
5. Colton CA, Gilbert DL. Production of Superoxide anions by a CNS macrophage, the microglia. FEBS Lett 1987;223:284-88
6. Piani D, Frei K, Do KQ, Cuenod M, Fontana A. Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate. Neurosci Lett 1991;133:159-62
7. Banati RB, Rothe G, Valet G, Kreutzberg GW. Detection of lysosomal cysteine proteinases in microglia: Flow cytometric measurement and histochemical localization of cathepsin B and L. Glia 1993;7:183-91
8. Sawada M, Kondo N, Suzumura A, Marunouchi T. Production of tumor necrosis factor-alpha by microglia and astrocytes in culture. Brain Res 1989;491:394-97
9. Hetier E, Ayala J, Denefle P, et al. Brain macrophages synthesize interleukin-1 and interleukin-1 mRNAs in vitro. J Neurosci Res 1988;21:391-97
10. Woodroofe MN, Sarna GS, Wadhwa M, et al. Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: Evidence of a role for microglia in cytokine production. J Neuroimmunol 1991;33:227-36
11. Banati RB, Graeber MB. Surveillance, intervention and cytotoxicity: Is there a protective role of microglia? Dev Neurosci 1994;16:114-27
12. David S, Bouchard C, Tsatas O, Giftochristos N. Macrophages can modify the nonpermissive nature of the adult mammalian central nervous system. Neuron 1990;5:463-69
13. Rabchevsky AG, Streit WJ. Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth. J Neurosci Res 1997;47:34-48
14. Constam DB, Philipp J, Malipiero UV, ten Dijke P, Schachner M, Fontana A. Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia. J Immunol 1992;148:1404-10
15. Shimojo M, Nakajima K, Takei N, Hamanoue M, Kohsaka S. Production of basic fibroblast growth factor in cultured rat brain microglia. Neurosci Lett 1991;123:229-31
16. Chamak B, Dobbertin A, Mallat M. Immunohistochemical detection of thrombospondin in microglia in the developing rat brain. Neuroscience 1995;69:177-87
17. Nakajima K, Tsuzaki N, Shimojo M, Hamanoue M, Kohsaka S. Microglia isolated from rat brain secrete a urokinase-type plasminogen activator. Brain Res 1992;577:285-92
18. Nakajima K, Tsuzaki N, Nagata K, Takemoto N, Kohsaka S. Production and secretion of plasminogen in cultured rat brain microglia. FEBS Lett 1992;308:179-82
19. Mallat M, Houlgatte R, Brachet P, Prochiantz A. Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro. Dev Biol 1989;133:309-11
20. Elkabes S, DiCicco Bloom EM, Black IB. Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci 1996;16:2508-21
21. Sasaki A, Hirato J, Nakazato Y. Immunohistochemical study of microglia in the Creutzfeldt-Jakob diseased brain. Acta Neuropathol Berl 1993;86:337-44
22. Mühleisen H, Gehrmann J, Meyermann R. Reactive microglia in Creutzfeldt-Jakob disease. Neuropathol Appl Neurobiol 1995;21:505-17
23. Jeffrey M, Fraser JR, Halliday WG, Fowler N, Goodsir CM, Brown DA. Early unsuspected neuron and axon terminal loss in scrapie-infected mice revealed by morphometry and immunocytochemistry. Neuropathol Appl Neurobiol 1995;21:41-49
24. Graeber MB, Bise K, Mehraein P. CR3/43, a marker for activated human microglia: Application to diagnostic neuropathology. Neuropathol Appl Neurobiol 1994;20:406-8
25. Imai Y, Ibata I, Ito D, Ohsawa K, Kohsaka S. A novel gene ibal in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem Biophys Res Commun 1996;224:855-62
26. Masters CL, Richardson EPJ. Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease). The nature and progression of spongiform change. Brain 1978;101:333-44
27. Bell JE, Ironside JW. Neuropathology of spongiform encephalopathies in humans. Br Med Bull 1993;49:738-77
28. Budka H, Aguzzi A, Brown P, et al. Neuropathological diagnostic criteria for Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (Prion diseases). Brain Pathol 1995;5:459-66
29. MacDonald ST, Sutherland K, Ironside JW. Prion protein genotype and pathological phenotype studies in sporadic Creutzfeldt-Jakob disease. Neuropathol Appl Neurobiol 1996;22:285-92
30. Sutherland K, MacDonald ST, Ironside JW. Quantification and analysis of the neuropathological features of Creutzfeldt-Jakob disease. J Neurosci Methods 1996;64:123-32
31. Graeber MB. The microglial "sensor" of pathology. In: Ling EA, Tan CK, Tan CBC, eds. Topical issues in microglia research. Singapore: Singapore Neuroscience Association, 1996:237-53
32. DiPatre PL, Gelman BB. Microglial cell activation in aging and Alzheimer disease: Partial linkage with neurofibrillary tangle burden in the hippocampus. J Neuropathol Exp Neurol 1997;56:143-49
33. Ironside JW, Barrie C, McCardle I, Bell JE. Microglial cell reactions in human spongiform encephalopathies [abstract]. Neuropathol Appl Neurobiol 1993;19:203
34. McGeer PL, Itagaki S, McGeer EG. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol Berl 1988;76:550-57
35. Carpenter AF, Carpenter PW, Markesbery WR. Morphometric analysis of microglia in Alzheimer's disease. J Neuropathol Exp Neurol 1993;52:601-8
36. Graeber MB, Streit WJ, Kiefer R, Schoen SW, Kreutzberg GW. New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury. J Neuroimmunol 1990;27:121-32
37. Achim CL, Wiley CA. Expression of major histocompatibility complex antigens in the brains of patients with progressive multifocal leukoencephalopathy. J Neuropathol Exp Neurol 1992;51:257-63
38. De Simone R, Giampaolo A, Giometto B, et al. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions. J Neuropathol Exp Neurol 1995; 54:175-87
39. Lynch WP, Robertson SJ, Portis JL. Induction of focal spongiform neurodegeneration in developmentally resistant mice by implantation of murine retrovirus-infected microglia. J Virol 1995;69:1408-19
40. Williams A, Lucassen PJ, Ritchie D, Bruce M. PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie. Exp Neurol 1997;144:433-38
41. Forloni G, Angeretti N, Chiesa R, et al. Neurotoxicity of a prion protein fragment. Nature 1993;362:543-46
42. Brandner S, Isenmann S, Raeber A, et al. Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature 1996;379:339-43
43. Brown HR, Goller NL, Rudelli RD, et al. The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells. Acta Neuropathol Berl 1990;80:1-6
44. Bruce ME, McBride PA, Farquhar CF. Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie. Neurosci Lett 1989;102:1-6
45. Williams AE, Lawson LJ, Perry VH, Fraser H. Characterization of the microglial response in murine scrapie. Neuropathol Appl Neurobiol 1994;20:47-55
46. Lasmezas CI, Deslys JP, Robain O. Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein. Science 1997;275:402-5