Neurons and Astrocytes Respond to Prion Infection by Inducing Microglia Recruitment

Journal of Neuroscience

Volumn 24, Issue 3, 2004, Pages 620-627

  Marella, Mathieu ^a   Chabry, Joëlle ^a  

^a CNRS   (France)

Author keywords

Chemokines; Microglial cells; Neurotoxicity; Prion; Recruitment; Retina

Indexed keywords

AMYLOID PROTEIN; CHEMOKINE; CHEMOKINE RECEPTOR CCR5; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; PRION PROTEIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL COMMUNICATION; CELL FREE SYSTEM; CELL MIGRATION; CELL POPULATION; CONTROLLED STUDY; EMBRYO; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MICROGLIA; MOUSE; NERVE CELL CULTURE; NERVE CELL LESION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; RETINA CELL; SCRAPIE; UPREGULATION;

ANIMALS; ASTROCYTES; CELL COUNT; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENDOPEPTIDASE K; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; NEUROBLASTOMA; NEURONS; NITRITES; OPTIC NERVE; PRION DISEASES; PRPSC PROTEINS; RECEPTORS, CCR5; RETINA; SUBCELLULAR FRACTIONS;

EID: 0842284040     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4303-03.2004     Document Type: Article

References (38)

1. Baba M, Nishimura O, Kanzaki N, Okamoto M, Sawada H, Iizawa Y, Shiraishi M, Aramaki Y, Okonogi K, Ogawa Y, Meguro K, Fujino M (1999) A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc Natl Acad Sci USA 96:5698-5703.
2. Baker CA, Manuelidis L (2003) Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease. Proc Natl Acad Sci USA 100:675-679.
3. Baker CA, Lu ZY, Zaitsev I, Manuelidis L (1999) Microglial activation varies in different models of Creutzfeldt-Jakob disease. J Virol 73:5089-5097.
4. Betmouni S, Perry VH, Gordon JL (1996) Evidence for an early inflammatory response in the central nervous system of mice with scrapie. Neuroscience 74:1-5.
5. Brown DR (2001) Microglia and prion disease. Microsc Res Tech 54:71-80.
6. Brown DR, Schmidt B, Kretzschmar HA (1996) Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature 380:345-347.
7. Chabry J, Checler F, Vincent JP, Mazella J (1990) Colocalization of neurotensin receptors and of the neurotensin-degrading enzyme endopeptidase 24-16 in primary cultures of neurons. J Neurosci 10:3916-3921.
8. Chabry J, Ratsimanohatra C, Sponne I, Elena PP, Vincent JP, Pillot T (2003) In vivo and in vitro neurotoxicity of the human prion protein (PrP) fragment P118-135 independently of PrP expression. J Neurosci 23:462-469.
9. Chomczynski P, Sacchi W (1987) Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
10. Dandoy-Dron F, Guillo F, Benboudjema L, Deslys JP, Lasmezas C, Dormont D, Tovey MG, Dron M (1998) Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. J Biol Chem 273:7691-7697.
11. Ettaiche M, Pichot R, Vincent JP, Chabry J (2000) In vivo cytotoxicity of the prion protein fragment 106-126. J Biol Chem 275:36487-36490.
12. Fraser H (1982) Neuronal spread of scrapie agent and targeting of lesions within the retino-tectal pathway. Nature 295:149-150.
13. Giese A, Brown DR, Groschup MH, Feldmann C, Haist I, Kretzschmar HA (1998) Role of microglia in neuronal cell death in prion disease. Brain Pathol 8:449-457.
14. Giulian D, Chen J, Ngeman J, George J, Noponen M (1989) The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain. J Neurosci 9:4416-4429.
15. Giulian D, Haverkamp LJ, Li J, Karshin WL, Yu J, Tom D, Li X, Kirkpatrick JB (1995) Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain. Neurochem Int 27:119-137.
16. Guiroy DC, Wakayama I, Liberski PP, Gajdusek DC (1994) Relationship of microglia and scrapie amyloid-immunoreactive plaques in kuru, Creutzfeldt-Jakob disease and Gerstmann-Straussler syndrome. Acta Neuropathol (Berl) 87:526-530.
17. Hemmer K, Fransen L, Vanderstichele H, Vanmechelen E, Heuschling P (2001) An in vitro model for the study of microglia-induced neurodegeneration: involvement of nitric oxide and tumor necrosis factor-α. Neurochem Int 38:557-565.
18. Heppner FL, Prinz M, Aguzzi A (2001) Pathogenesis of prion diseases: possible implications of microglial cells. Prog Brain Res 132:737-750.
19. Hetz C, Russelakis-Carniero M, Maundrell K, Castilla J, Soto C (2003) Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J 22:5435-5445.
20. Johnstone M, Gearing AJ, Miller KM (1999) A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced. J Neuroimmunol 93:182-193.
21. Ju WK, Park KJ, Choi EK, Kim J, Carp RI, Wisniewski HM, Kim YS (1998) Expression of inducible nitric oxide synthase in the brains of scrapie-infected mice. J Neurovirol 4:445-450.
22. Le Y, Yazawa H, Gong W, Yu Z, Ferrans VJ, Murphy PM, Wang JM (2001) The neurotoxic prion peptide fragment PrP(106-126) is a chemotactic agonist for the G protein-coupled receptor formyl peptide receptor-like 1. J Immunol 166:1448-1451.
23. McHattie SJ, Brown DR, Bird MM (1999) Cellular uptake of the prion protein fragment PrP106-126 in vitro. J Neurocytol 28:149-159.
24. Merril CR, Goldman D, Sedman SA, Ebert MH (1981) Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins. Science 211:1437-1438.
25. Nishida N, Harris DA, Vilette D, Laude H, Frobert Y, Grassi J, Casanova D, Milhavet O, Lehmann S (2000) Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein. J Virol 74:320-325.
26. Prusiner SB, Groth DF, Bolton DC, Kent SB, Hood LE (1984) Purification and structural studies of a major scrapie prion protein. Cell 38:127-134.
27. Race RE, Priola SA, Bessen RA, Ernst D, Dockter J, Rall GF, Mucke L, Chesebro B, Oldstone MB (1995) Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent. Neuron 15:1183-1191.
28. Raeber AJ, Race RE, Brandner S, Priola SA, Sailer A, Bessen RA, Mucke L, Manson J, Aguzzi A, Oldstone MB, Weissmann C, Chesebro B (1997) Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. EMBO J 16:6057-6065.
29. Rezaie P, Lantos PL (2001) Microglia and the pathogenesis of spongiform encephalopathies. Brain Res Brain Res Rev 35:55-72.
30. Righi M, Mori L, De Libero G, Sironi M, Biondi A, Mantovani A, Donini SD, Ricciardi-Castagnoli P (1989) Monokine production by microglial cell clones. Eur J Immunol 19:1443-1448.
31. Russelakis-Carneiro M, Betmouni S, Perry VH (1999) Inflammatory response and retinal ganglion cell degeneration following intraocular injection of ME7. Neuropathol Appl Neurobiol 25:196-206.
32. Sailer A, Bueler H, Fischer M, Aguzzi A, Weissmann C (1994) No propagation of prions in mice devoid of PrP. Cell 77:967-968.
33. Sedgwick J, Ford A, Foulcher E, Airriess R (1998) Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts. J Immunol 160:5320-5330.
34. Streit WJ, Conde JR, Harrison JK (2001) Chemokines and Alzheimer's disease. Neurobiol Aging 22:909-913.
35. Tran PB, Miller RJ (2003) Chemokine receptors: signposts to brain development and disease. Nat Rev Neurosci 4:444-455.
36. Wilkinson PC (1998) Assays of leukocyte locomotion and chemotaxis. J Immunol Methods 216:139-153.
37. Williams A, Lucassen PJ, Ritchie D, Bruce M (1997) PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie. Exp Neurol 144:433-438.
38. Zlotnik A, Yoshie O (2000) Chemokines: a new classification system and their role in immunity. Immunity 12:121-127.