S-glutathiolation of p21ras by peroxynitrite mediates endothelial insulin resistance caused by oxidized low-density lipoprotein

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 26, Issue 11, 2006, Pages 2454-2461

  Clavreul, Nicolas ^a   Bachschmid, Markus M ^a   Hou, Xiuyun ^a   Shi, Chaomei ^a   Idrizovic, Azra ^a   Ido, Yasuo ^a   Pimentel, David ^a   Cohen, Richard A ^a,b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Vascular Biology Unit X704   (United States)

Author keywords

Glutathione; Insulin resistance; Oxidized LDL; p21ras; Peroxynitrite; S glutathiolation

Indexed keywords

DIHYDRORHODAMINE; GLUTAREDOXIN; GLUTATHIONE DISULFIDE; HYDROETHIDINE; INSULIN; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MUTANT PROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZING AGENT; P21RAS PROTEIN; PEROXYNITRITE; PROTEIN DERIVATIVE; PROTEIN KINASE B; RHODAMINE; SERINE; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENETIC TRANSFECTION; INSULIN RESISTANCE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ALPROSTADIL; ANIMALS; AORTA; CATTLE; DINOPROSTONE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTATHIONE; GLUTATHIONE DISULFIDE; INSULIN; INSULIN RESISTANCE; LIPOPROTEINS, LDL; LYSOPHOSPHATIDYLCHOLINES; ONCOGENE PROTEIN P21(RAS); OXIDANTS; PEROXYNITROUS ACID; PHOSPHOPROTEINS; PHOSPHORYLATION; PROSTAGLANDINS E, SYNTHETIC; SIGNAL TRANSDUCTION;

EID: 33750217204     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000242791.28953.4c     Document Type: Article

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