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Volumn 42, Issue 8, 2006, Pages 478-481

New therapeutic options in Alzheimer's disease;Nuevas opciones terapéuticas en la enfermedad de Alzheimer

Author keywords

Alzheimer's disease; Ampakines; Cicloserine; Lithium; Memantine; Milacemide; Other non cholinergic treatments

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ALPHA TOCOPHEROL; AMPAKINE DERIVATIVE; BENZAMIDE DERIVATIVE; CYCLOSERINE; MEMANTINE; MILACEMIDE; N METHYL DEXTRO ASPARTIC ACID; SELEGILINE; UNCLASSIFIED DRUG; ACETAMIDE DERIVATIVE; ACETYLCHOLINE; AMINO ACID RECEPTOR BLOCKING AGENT; AMYLOID BETA PROTEIN; ANTIINFLAMMATORY AGENT; CHOLINESTERASE INHIBITOR; GLUTAMATE RECEPTOR; GLUTAMIC ACID; LITHIUM; MONOAMINE OXIDASE INHIBITOR;

EID: 33750134303     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.4208.2005218     Document Type: Review
Times cited : (2)

References (63)
  • 1
    • 0000428532 scopus 로고
    • 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists
    • Carlsson A, Lindquist M, Magnusson T. 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists. Nature 1957; 180: 1200.
    • (1957) Nature , vol.180 , pp. 1200
    • Carlsson, A.1    Lindquist, M.2    Magnusson, T.3
  • 2
    • 0000015266 scopus 로고
    • The occurrence, distribution and physiological role of catecholamines in the nervous system
    • Carlsson A. The occurrence, distribution and physiological role of catecholamines in the nervous system. Pharmacol Rev 1959; 11: 490-3.
    • (1959) Pharmacol Rev , vol.11 , pp. 490-493
    • Carlsson, A.1
  • 4
    • 0018924532 scopus 로고
    • The cholinergic system in old age and Alzheimer's disease
    • Perry EK. The cholinergic system in old age and Alzheimer's disease. Age Ageing 1980; 9: 1-8.
    • (1980) Age Ageing , vol.9 , pp. 1-8
    • Perry, E.K.1
  • 5
    • 0022645755 scopus 로고
    • The cholinergic hypothesis ten years on
    • Perry EK. The cholinergic hypothesis ten years on. Br Med Bull 1986; 42: 63-9.
    • (1986) Br Med Bull , vol.42 , pp. 63-69
    • Perry, E.K.1
  • 6
    • 0022457840 scopus 로고
    • Nicotinic acetylcholine binding sites in Alzheimer's disease
    • Whitehouse PJ, Martino AM, Antuono PG. Nicotinic acetylcholine binding sites in Alzheimer's disease. Brain Res 1986; 371: 146-51.
    • (1986) Brain Res , vol.371 , pp. 146-151
    • Whitehouse, P.J.1    Martino, A.M.2    Antuono, P.G.3
  • 7
    • 0022521048 scopus 로고
    • Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease
    • Palmer AM, Procter AW, Stratmann GC, Bowen DM. Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease. Neurosci Lett 1986; 66: 199-204.
    • (1986) Neurosci Lett , vol.66 , pp. 199-204
    • Palmer, A.M.1    Procter, A.W.2    Stratmann, G.C.3    Bowen, D.M.4
  • 8
    • 0023730447 scopus 로고
    • Cognitive deficits in olivopontocerebellar atrophy: Implications for the cholinergic hypothesis of Alzheimer's dementia
    • Kish SJ, El-Awar M, Schut L, Leach L, Oscar-Berman M, Freedman M. Cognitive deficits in olivopontocerebellar atrophy: implications for the cholinergic hypothesis of Alzheimer's dementia. Ann Neurol 1988; 24: 200-6.
    • (1988) Ann Neurol , vol.24 , pp. 200-206
    • Kish, S.J.1    El-Awar, M.2    Schut, L.3    Leach, L.4    Oscar-Berman, M.5    Freedman, M.6
  • 9
    • 0024464624 scopus 로고
    • Non-Alzheimer-type pattern of brain cholineacetyltransferase reduction in dominantly inherited olivopontocerebellar atrophy
    • Kish SJ, Robitaille Y, El-Awar M, Deck JH, Simmons J, Schut L, et al. Non-Alzheimer-type pattern of brain cholineacetyltransferase reduction in dominantly inherited olivopontocerebellar atrophy. Ann Neurol 1989; 26: 362-7.
    • (1989) Ann Neurol , vol.26 , pp. 362-367
    • Kish, S.J.1    Robitaille, Y.2    El-Awar, M.3    Deck, J.H.4    Simmons, J.5    Schut, L.6
  • 10
    • 0036156958 scopus 로고    scopus 로고
    • Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    • DeKosky ST, Ikonoomovic MD, Styren SD, Beckett L, Wieniewski S, Bennet A, et al. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol 2002; 51: 145-55.
    • (2002) Ann Neurol , vol.51 , pp. 145-155
    • DeKosky, S.T.1    Ikonoomovic, M.D.2    Styren, S.D.3    Beckett, L.4    Wieniewski, S.5    Bennet, A.6
  • 11
    • 0030976004 scopus 로고    scopus 로고
    • Cognitive enhancement therapy for Alzheimer's disease
    • Parnetti L, Senin U, Mecoci P. Cognitive enhancement therapy for Alzheimer's disease. Drugs 1997; 53: 752-68.
    • (1997) Drugs , vol.53 , pp. 752-768
    • Parnetti, L.1    Senin, U.2    Mecoci, P.3
  • 12
    • 0042020173 scopus 로고    scopus 로고
    • Treatment of Alzheimer's disease: Current status and new perspectives
    • Scarpini L, Scheltens P, Felman H. Treatment of Alzheimer's disease: current status and new perspectives. Lancet Neurol 2003; 2: 539-47.
    • (2003) Lancet Neurol , vol.2 , pp. 539-547
    • Scarpini, L.1    Scheltens, P.2    Felman, H.3
  • 13
    • 0027269660 scopus 로고
    • Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: Investigative and therapeutic perspective
    • Francis P, Sims N, Procter AW, Bowen D. Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: Investigative and therapeutic perspective. J Neurochem 1993; 60: 1589-601.
    • (1993) J Neurochem , vol.60 , pp. 1589-1601
    • Francis, P.1    Sims, N.2    Procter, A.W.3    Bowen, D.4
  • 14
    • 0028535113 scopus 로고
    • Anatomy and physiology of glutamate in the CNS
    • Greenamyre T, Porter R. Anatomy and physiology of glutamate in the CNS. Neurology 1994; 44 (Suppl 1): S7-13.
    • (1994) Neurology , vol.44 , Issue.SUPPL. 1
    • Greenamyre, T.1    Porter, R.2
  • 15
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurological disorders
    • Lipton S, Rosenberg P. Excitatory amino acids as a final common pathway for neurological disorders. N Engl J Med 1994; 330: 613-21.
    • (1994) N Engl J Med , vol.330 , pp. 613-621
    • Lipton, S.1    Rosenberg, P.2
  • 16
    • 0000004020 scopus 로고    scopus 로고
    • Glutamate and aspartate
    • Siegel G, Agranoff B, Albers R, Fisher S, Uhler M, eds, Philadelphia: Lippincott Williams & Wilkins;
    • Dingledine R, McBain C. Glutamate and aspartate. In Siegel G, Agranoff B, Albers R, Fisher S, Uhler M, eds. Basic neurochemistry. Philadelphia: Lippincott Williams & Wilkins; 2000. p. 316-33.
    • (2000) Basic neurochemistry , pp. 316-333
    • Dingledine, R.1    McBain, C.2
  • 17
    • 0025282045 scopus 로고
    • Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic?
    • Palmer AM, Gershon S. Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic? FASEB J 1990; 4: 2745-52.
    • (1990) FASEB J , vol.4 , pp. 2745-2752
    • Palmer, A.M.1    Gershon, S.2
  • 18
    • 0141483708 scopus 로고    scopus 로고
    • Glutamatergic systems in Alzheimer's disease
    • Francis PT. Glutamatergic systems in Alzheimer's disease. Int J Geriatr Psychiatry 2003; 18 (Suppl 1): S15-21.
    • (2003) Int J Geriatr Psychiatry , vol.18 , Issue.SUPPL. 1
    • Francis, P.T.1
  • 19
    • 0043172479 scopus 로고    scopus 로고
    • The glutamatergic system and Alzheimer's disease: Therapeutic implications
    • Butterfield DA, Pocernich CB. The glutamatergic system and Alzheimer's disease: therapeutic implications. CNS Drugs 2003; 17: 641-52.
    • (2003) CNS Drugs , vol.17 , pp. 641-652
    • Butterfield, D.A.1    Pocernich, C.B.2
  • 21
    • 0027363465 scopus 로고
    • Amino acid concentrations in cerebrospinal fluid and serum in Alzheimer's disease and vascular dementia
    • Martínez M, Frank A, Díez-Tejedor E, Hernanz A. Amino acid concentrations in cerebrospinal fluid and serum in Alzheimer's disease and vascular dementia. J Neural Transm [Parkinson Dis Sect] 1993; 6: 1-9.
    • (1993) J Neural Transm [Parkinson Dis Sect] , vol.6 , pp. 1-9
    • Martínez, M.1    Frank, A.2    Díez-Tejedor, E.3    Hernanz, A.4
  • 22
    • 0035957292 scopus 로고    scopus 로고
    • Antuono P, Jones J, Wang Y, Li JS. Decreased glutamate-glutamine in Alzheimer's disease detected in vivo with H.MRS at 0.5 T. Neurology 2001; 56: 737-42.
    • Antuono P, Jones J, Wang Y, Li JS. Decreased glutamate-glutamine in Alzheimer's disease detected in vivo with H.MRS at 0.5 T. Neurology 2001; 56: 737-42.
  • 23
    • 0037075624 scopus 로고    scopus 로고
    • Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease
    • Zenon M, Hansson O, Chen N, Leavitt B, Brundin P, Hayden MR, et al. Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron 2002; 33: 849-60.
    • (2002) Neuron , vol.33 , pp. 849-860
    • Zenon, M.1    Hansson, O.2    Chen, N.3    Leavitt, B.4    Brundin, P.5    Hayden, M.R.6
  • 26
    • 0028835455 scopus 로고
    • Cognitive and quantified electroencephalographic correlates of cycloserine treatment in Alzheimer's disease
    • Mohr E, Knott V, Sampson M, Wesnes K, Herting R, Mendis T. Cognitive and quantified electroencephalographic correlates of cycloserine treatment in Alzheimer's disease. Clin Neuropharmacol 1995; 18: 28-38.
    • (1995) Clin Neuropharmacol , vol.18 , pp. 28-38
    • Mohr, E.1    Knott, V.2    Sampson, M.3    Wesnes, K.4    Herting, R.5    Mendis, T.6
  • 28
    • 0033015134 scopus 로고    scopus 로고
    • Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment
    • Tsai GE, Falk WE, Gunther J, Coyle JT. Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment. Am J Psychiatry 1999; 156: 467-9.
    • (1999) Am J Psychiatry , vol.156 , pp. 467-469
    • Tsai, G.E.1    Falk, W.E.2    Gunther, J.3    Coyle, J.T.4
  • 29
    • 0026408120 scopus 로고    scopus 로고
    • Herting RL. Milacemide and other drugs active at glutamate NMDA receptors as potential treatment for dementia. Ann N Y Acad Sci 1991; 640: 237-40.
    • Herting RL. Milacemide and other drugs active at glutamate NMDA receptors as potential treatment for dementia. Ann N Y Acad Sci 1991; 640: 237-40.
  • 32
    • 0028061875 scopus 로고
    • Will a new type of drug make memory-making easier?
    • Service RF
    • Service RF. Will a new type of drug make memory-making easier? Science 1994; 266: 218-9.
    • (1994) Science , vol.266 , pp. 218-219
  • 33
    • 0032053963 scopus 로고    scopus 로고
    • Facilitative effects of the ampakine CX516 on short-term memory in rats: Correlations with hippocampal neuronal activity
    • Hampson RE, Rogers G, Lynch G, Deadwyler SA. Facilitative effects of the ampakine CX516 on short-term memory in rats: correlations with hippocampal neuronal activity. J Neurosci 1998; 18: 2748-63.
    • (1998) J Neurosci , vol.18 , pp. 2748-2763
    • Hampson, R.E.1    Rogers, G.2    Lynch, G.3    Deadwyler, S.A.4
  • 34
    • 0035077550 scopus 로고    scopus 로고
    • Member of the ampakine class of memory enhancers prolongs the single channel open time of reconstituted AMPA receptors
    • Suppiramaniam V, Bahr BA, Sinnarajah S, Owens K, Rogers G, Yilma S, et al. Member of the ampakine class of memory enhancers prolongs the single channel open time of reconstituted AMPA receptors. Synapse 2001; 40: 154-8.
    • (2001) Synapse , vol.40 , pp. 154-158
    • Suppiramaniam, V.1    Bahr, B.A.2    Sinnarajah, S.3    Owens, K.4    Rogers, G.5    Yilma, S.6
  • 35
    • 0141644275 scopus 로고    scopus 로고
    • Ampakines reduce methamphetamine-driven rotation and activate neocortex in a regionally selective fashion
    • Hess US, Whalen SP, Sandoval LM, Lynch G, Gall CM. Ampakines reduce methamphetamine-driven rotation and activate neocortex in a regionally selective fashion. Neuroscience 2003; 121: 509-21.
    • (2003) Neuroscience , vol.121 , pp. 509-521
    • Hess, U.S.1    Whalen, S.P.2    Sandoval, L.M.3    Lynch, G.4    Gall, C.M.5
  • 38
    • 0037345885 scopus 로고    scopus 로고
    • Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy
    • Hartmann S, Mobius HJ. Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy. Int Clin Psychopharmacol 2003; 18: 81-5.
    • (2003) Int Clin Psychopharmacol , vol.18 , pp. 81-85
    • Hartmann, S.1    Mobius, H.J.2
  • 39
    • 1642422286 scopus 로고    scopus 로고
    • Inhibition of human α7 nicotinic acetylcholine receptors by open channel blocker of NMDA receptors
    • Maskell P, Specter P, Newberry R, Bermúdez I. Inhibition of human α7 nicotinic acetylcholine receptors by open channel blocker of NMDA receptors. Br J Pharmacol 2003; 140: 1313-9.
    • (2003) Br J Pharmacol , vol.140 , pp. 1313-1319
    • Maskell, P.1    Specter, P.2    Newberry, R.3    Bermúdez, I.4
  • 42
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    • Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol 2000; 57: 1439-43.
    • (2000) Arch Neurol , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3    Celesia, G.G.4    Siegel, G.5
  • 43
    • 0034701238 scopus 로고    scopus 로고
    • The origins of Alzheimer disease: A is for amylod
    • Selkoe D. The origins of Alzheimer disease: A is for amylod. JAMA 2000; 283: 1615-7.
    • (2000) JAMA , vol.283 , pp. 1615-1617
    • Selkoe, D.1
  • 44
    • 0029892175 scopus 로고    scopus 로고
    • Cerebral amyloid deposition and diffuse plaques in normal aging: Evidence for presyntomatic and very mild Alzheimer's disease
    • Morris JC, Storandt M, McKeel DW Jr, Rubin EH, Price JL, Grant EA, et al. Cerebral amyloid deposition and diffuse plaques in normal aging: evidence for presyntomatic and very mild Alzheimer's disease. Neurology 1996; 46: 707-19.
    • (1996) Neurology , vol.46 , pp. 707-719
    • Morris, J.C.1    Storandt, M.2    McKeel Jr, D.W.3    Rubin, E.H.4    Price, J.L.5    Grant, E.A.6
  • 45
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • Naslund J, Haroutunian V, Mosh R, Davis KL, Davies P, Greengard P, et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 2000; 283: 1571-7.
    • (2000) JAMA , vol.283 , pp. 1571-1577
    • Naslund, J.1    Haroutunian, V.2    Mosh, R.3    Davis, K.L.4    Davies, P.5    Greengard, P.6
  • 46
    • 0033923118 scopus 로고    scopus 로고
    • Beta-peptide inmunization: A possible new treatment for Alzheimer disease
    • Schenk DB, Seubert P, Lieberburg I, Wallace J. Beta-peptide inmunization: a possible new treatment for Alzheimer disease. Arch Neurol 2000; 57: 934-6.
    • (2000) Arch Neurol , vol.57 , pp. 934-936
    • Schenk, D.B.1    Seubert, P.2    Lieberburg, I.3    Wallace, J.4
  • 47
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after inmunization with amyloid-beta peptide: A case report
    • Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO. Neuropathology of human Alzheimer disease after inmunization with amyloid-beta peptide: a case report. Nat Med 2003; 9: 448-52.
    • (2003) Nat Med , vol.9 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 48
    • 0035826771 scopus 로고    scopus 로고
    • Practice parameter: Management of dementia (and evidence-based review). Report of the quality standards subcommitte of the American Academy of Neurology
    • Doody RS, Stevens JC, Beck C, Dubinsky RM, Kaye JA, Gwyther L, et al. Practice parameter: management of dementia (and evidence-based review). Report of the quality standards subcommitte of the American Academy of Neurology. Neurology 2001; 56: 1154-66.
    • (2001) Neurology , vol.56 , pp. 1154-1166
    • Doody, R.S.1    Stevens, J.C.2    Beck, C.3    Dubinsky, R.M.4    Kaye, J.A.5    Gwyther, L.6
  • 50
    • 0038386058 scopus 로고    scopus 로고
    • WHIMS Investigators. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women. The Women's Health Initiative Memory Study: A randomized controlled trial
    • Shumaker SA, Legault C, Rapp SR, Thal L, Wallace RB, Ockene JK, et al, WHIMS Investigators. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women. The Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 2003; 289: 2651-62.
    • (2003) JAMA , vol.289 , pp. 2651-2662
    • Shumaker, S.A.1    Legault, C.2    Rapp, S.R.3    Thal, L.4    Wallace, R.B.5    Ockene, J.K.6
  • 51
    • 0034704547 scopus 로고    scopus 로고
    • Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: A randomized controlled trial. Alzheimer's Disease Cooperative Study
    • Mulnard RA, Cotman CW, Kawas C, Van Dyck CH, Sano M, Doody R, et al. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study. JAMA 2000; 283: 1007-15.
    • (2000) JAMA , vol.283 , pp. 1007-1015
    • Mulnard, R.A.1    Cotman, C.W.2    Kawas, C.3    Van Dyck, C.H.4    Sano, M.5    Doody, R.6
  • 52
    • 0031567583 scopus 로고    scopus 로고
    • Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons
    • Muñoz-Montano JR, Moreno FJ, Ávila J, Díaz-Nido J. Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons. FEBS Lett 1997; 411: 183-8.
    • (1997) FEBS Lett , vol.411 , pp. 183-188
    • Muñoz-Montano, J.R.1    Moreno, F.J.2    Ávila, J.3    Díaz-Nido, J.4
  • 53
    • 0036276050 scopus 로고    scopus 로고
    • Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease
    • Álvarez G, Muñoz-Montano JR, Satrústegui J, Ávila J, Bogóñez E, Díaz-Nido J. Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease. Bipolar Disord 2002; 4: 153-65.
    • (2002) Bipolar Disord , vol.4 , pp. 153-165
    • Álvarez, G.1    Muñoz-Montano, J.R.2    Satrústegui, J.3    Ávila, J.4    Bogóñez, E.5    Díaz-Nido, J.6
  • 54
    • 1542570268 scopus 로고    scopus 로고
    • Physiological roles of glycogen synthase kinase-3: Potential as a therapeutic target for diabetes and other disorders
    • Woodgett JR. Physiological roles of glycogen synthase kinase-3: potential as a therapeutic target for diabetes and other disorders. Curr Drug Targets Immune Endocr Metabol Disord 2003; 3: 281-90.
    • (2003) Curr Drug Targets Immune Endocr Metabol Disord , vol.3 , pp. 281-290
    • Woodgett, J.R.1
  • 55
    • 0037809277 scopus 로고    scopus 로고
    • Mental plaque removal
    • De Strooper B, Woogett J. Mental plaque removal. Nature 2003; 423: 392-3.
    • (2003) Nature , vol.423 , pp. 392-393
    • De Strooper, B.1    Woogett, J.2
  • 56
    • 0038187674 scopus 로고    scopus 로고
    • GSK-3 regulates production of Alzheimer's disease amyloid-β peptides
    • Phiel C, Wilson C, Lee V, Klein P. GSK-3 regulates production of Alzheimer's disease amyloid-β peptides. Nature 2003; 423: 435-8.
    • (2003) Nature , vol.423 , pp. 435-438
    • Phiel, C.1    Wilson, C.2    Lee, V.3    Klein, P.4
  • 58
    • 0036931742 scopus 로고    scopus 로고
    • Neuroprotective properties of valproate: Potential benefit for AD and tauopathies
    • Loy R, Tariot PN. Neuroprotective properties of valproate: potential benefit for AD and tauopathies. J Mol Neurosci 2002; 19: 303-7.
    • (2002) J Mol Neurosci , vol.19 , pp. 303-307
    • Loy, R.1    Tariot, P.N.2
  • 60
    • 0026551329 scopus 로고
    • Anti-inflamatory agents as a therapeutic approach to Alzheimer's disease
    • McGeer P, Rogers J. Anti-inflamatory agents as a therapeutic approach to Alzheimer's disease. Neurology 1992; 42: 447-8.
    • (1992) Neurology , vol.42 , pp. 447-448
    • McGeer, P.1    Rogers, J.2
  • 61
    • 0035829592 scopus 로고    scopus 로고
    • A subset of NSAIDS lower amyloidogenetic abeta 42 independently of cyclooxygenase activity
    • Weggen S, Eriksen J, Das P, Wang R, Sagi S, Pietrzik C, et al. A subset of NSAIDS lower amyloidogenetic abeta 42 independently of cyclooxygenase activity. Nature 2001; 414: 212-6.
    • (2001) Nature , vol.414 , pp. 212-216
    • Weggen, S.1    Eriksen, J.2    Das, P.3    Wang, R.4    Sagi, S.5    Pietrzik, C.6
  • 63
    • 0036667175 scopus 로고    scopus 로고
    • CX-516 Cortex pharmaceuticals
    • Danysz W. CX-516 Cortex pharmaceuticals. Curr Opin Investig Drugs 2002; 3: 1081-8.
    • (2002) Curr Opin Investig Drugs , vol.3 , pp. 1081-1088
    • Danysz, W.1


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