Facilitative effects of the ampakine CX516 on short-term memory in rats: Correlations with hippocampal neuronal activity

Journal of Neuroscience

Volumn 18, Issue 7, 1998, Pages 2748-2763

  Hampson, Robert E ^a   Rogers, Gary ^b   Lynch, Gary ^c   Deadwyler, Sam A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b Cortex Pharmaceutical ^*  (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AMPA receptors; Ampakine; Hippocampus; Learning; Memory; Neuron ensembles

Indexed keywords

6 QUINOXALINECARBOXYLIC ACID PIPERIDIDE; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ASSOCIATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG HALF LIFE; DRUG MECHANISM; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; LEARNING; MALE; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT TERM MEMORY;

EID: 0032053963     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-07-02748.1998     Document Type: Article

References (48)

1. Arai A, Lynch G (1992) Factors regulating the magnitude of long-term potentiation induced by theta pattern stimulation. Brain Res 598:173-184.
2. Arai A, Silberg J, Kessler M, Lynch G (1995) Effect of thiocyanate on AMPA receptor mediated responses in excised patches and hippocampal slices. Neuroscience 66:815-827.
3. Cahusac PMB, Miyashita Y, Rolls ET (1989) Responses of hippocampal formation neurons in the monkey related to delayed spatial response and object-place memory tasks. Behav Brain Res 33:229-240.
4. Cahusac PMB, Rolls ET, Miyashita Y, Niki H (1993) Modification of the responses of hippocampal neurons in the monkey during learning of a conditional spatial response task. Hippocampus 3:29-42.
5. Colombo M, Gross C (1994) Responses of inferotemporal cortex and hippocampal neurons during delayed matching to sample in monkeys (Macaca fascicularis). Behav Neurosci 108:443-455.
6. Deadwyler SA, Hampson RE (1995) Ensemble activity and behavior: what's the code? Science 270:1316-1318.
7. Deadwyler SA, Hampson RE (1997) The significance of neural ensemble codes during behavior and cognition. In: Annual review of neuroscience (Cowan WM, Shooter EM, Stevens CF, Thompson RF, eds). Palo Alto, CA: Annual Reviews.
8. Deadwyler SA, Bunn T, Hampson RE (1996a) Hippocampal ensemble activity during spatial delayed-nonmatch-to-sample performance in rats. J Neurosci 16:354-372.
9. Deadwyler SA, Byrd DR, Konstantopoulos JK, Evans GJO, Rogers G, Hampson RE (1996b) Enhancement of rat hippocampal ensemble activity by CX516 protects against errors in spatial DNMS. Soc Neurosci Abstr 22:1131.
10. Deadwyler SA, Rogers G, Lynch G, Hampson RE (1997) Facilitated encoding of task-relevant events in ensembles of hippocampal neurons by the ampakine CX516 (Cortex Pharmaceuticals). Soc Neurosci Abstr 23:509.
11. Dunnett SB (1989) Comparison of short-term memory deficits in animal models of aging using an operant delayed response task in rats. In: The biology of memory (Squire LR, Lindenlaub E, eds), pp 581-603. New York: FK Schattauer Verlag.
12. Eichenbaum H, Otto T, Cohen NJ (1994) Two functional components of the hippocampal memory system. Behav Brain Sci 17:449-518.
13. Fried I, MacDonald KA, Wilson CL (1997) Single neuron activity in human hippocampus and amygdala during recognition of faces and objects. Neuron 18:753-765.
14. Fox SE, Ranck Jr JB (1981) Electrophysiological characteristics of hippocampal complex-spike cells and theta cells. Exp Brain Res 41:399-410.
15. Fuster JM (1997) Network memory. Trends Neurosci 20:451-459.
16. Granger R, Whitson J, Larson J, Lynch G (1994) Non-hebbian properties of LTP enable high-capacity encoding of temporal sequences. Proc Natl Acad Sci USA 91:10104-10108.
17. Granger R, Deadwyler SA, Davis M, Moskovitz B, Kessler M, Rogers G, Lynch G (1996) Facilitation of glutamate receptors reverses an age-associated memory impairment in rats. Synapse 22:332-337.
18. Hampson RE, Deadwyler SA (1996a) Ensemble codes involving hippocampal neurons are at risk during delayed performance tests. Proc Natl Acad Sci USA 93:13487-13493.
19. Hampson RE, Deadwyler SA (1996b) LTP and LTD and the encoding of memory in small ensembles of hippocampal neurons. In: Long-term potentiation, Vol 3, Ed 3 (Baudry M, Davis J, eds), pp 199-214. Cambridge, MA: MIT.
20. Hampson RE, Kirby MT, Alexander KE, King VC, Deadwyler SA (1992) Functional significance of anatomic connections between CA1 and CA3 hippocampal cells during delayed match to sample behavior in the rat. Soc Neurosci Abstr 18:1065.
21. Hampson RE, Heyser CJ, Deadwyler SA (1993) Hippocampal cell firing correlates of delayed-match-to-sample performance in the rat. Behav Neurosci 107:715-739.
22. Hampson RE, Byrd DR, Deadwyler SA (1994) Population analyses reveal that rat hippocampus encodes both spatial and task-specific information during delayed-nonmatch-to-sample tasks. Soc Neurosci Abstr 20:430.
23. Hampson RE, Byrd DR, Konstantopoulos JK, Bunn T, Jarrard LE, Deadwyler SA (1995) Proactive interference and short-term memory during performance of a DNMS task in normal rats and rats with hippocampus removed. Soc Neurosci Abstr 21:1215.
24. Hampson RE, Rogers G, Lynch G, Deadwyler SA (1998) Facilitative effects of the ampakine CX516 on short-term memory in rats: enhancement of delayed-nonmatch-to-sample performance. J Neurosci 18:2740-2747.
25. Heyser CJ, Hampson RE, Deadwyler SA (1993) The effects of delta-9- THC on delayed match to sample performance in rats: alterations in short-term memory produced by changes in task specific firing of hippocampal neurons. J Pharmacol Exp Ther 264:294-307.
26. Larson J, Lieu T, Petchpradub V, LeDuc B, Ngo H, Rogers GA, Lynch G (1995) Facilitation of olfactory learning by a modulator of AMPA receptors. J Neurosci 15:8023-8030.
27. Lynch G, Baudry M (1991) Reevaluating the constraints on hypotheses regarding LTP expression. Hippocampus 1:9-14.
28. Lynch G, Granger R (1991) Serial steps in memory processing: possible clues from studies of plasticity in the olfactory-hippocampal circuit. In: olfaction as a model system for computational neuroscicnce (Eichenbaum H, Davis J, eds) Cambridge MA: MIT.
29. Lynch G, Kessler M, Rogers G, Ambros-Ingerson J, Granger R, Schehr RS (1996) Psychological effects of a drug that facilitates brain AMPA receptors. Int Clin Psychopharmacol 11:12-19.
30. McNaughton BL, O'Keefe J, Barnes CA (1983) The stereotrode: a new technique for simultaneous isolation of several single units in the central nervous system from multiple unit records. J Neurosci Methods 8:391-397.
31. Miller EK, Li L, Desimone RA (1991) Neural mechanism for working and recognition memory in inferior temporal cortex. Science 254:1377-1379.
32. Miller EK, Erickson CA, Desimone R (1996) Neural mechanisms of visual working memory in prefrontal cortex of the Macaque. J Neurosci 16:5154-5167.
33. Muller R (1996) A quarter of a century of place cells. Neuron 17:813-822.
34. Nishijo H, Ono T, Tamura R, Nakamura K (1993) Amygdala and hippocampal neuron responses related to recognition and memory in monkey. Prog Brain Res 95:339-357.
35. Otto T, Eichenbaum H (1992) Neuronal activity in the hippocampus during delayed non-match to sample performance in rats: evidence for hippocampal processing in recognition memory. Hippocampus 2:323-334.
36. Ono T, Nakamura K, Nishijo H, Eifuku S (1993) Monkey hippocampal neurons related to spatial and non-spatial functions. J Neurophysiol 70:1516-1529.
37. Partin K, Bowie D, Mayer ML (1995) Structural determinants of allosteric regulation in alternatively spliced AMPA receptors. Neuron 14:833-843.
38. Partin K, Fleck MW, Mayer ML (1996) AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate. J Neurosci 16:6634-6647.
39. Rogan MT, Staubli UV, LeDoux JE (1997) AMPA receptor facilitation accelerates fear learning without altering the level of conditioned fear acquired. J Neurosci 17:5928-5935.
40. Rogers GA (1997) XIII International Symposium on Radiopharmaceutical Chemistry, Uppsala, June.
41. Rolls ET, Cahusac PM, Feigenbaum JD, Miyashita Y (1993) Responses of single neurons in the hippocampus of the macaque related to recognition memory. Exp Brain Res 93:299-306.
42. Sakurai Y (1990) Hippocampal cells have behavioral correlates during the performance of an auditory working memory task in the rat. Behav Neurosci 104:253-263.
43. Squire LR (1992) Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol Rev 99:195-231.
44. Staubli U, Ferez Y, Xu F-B, Rogers G, Ingvar M, Stone-Elander S, Lynch G (1994a) Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo. Proc Natl Acad Sci USA 91:11158-11162.
45. Staubli U, Rogers G, Lynch G (1994b) Facilitation of glutamate receptors enhances memory. Proc Natl Acad Sci USA 91:777-781.
46. Watanabe T, Niki H (1985) Hippocampal unit activity and delayed response in the monkey. Brain Res 325:241-254.
47. Yeckel MF, Berger TW (1998) Spatial distribution of potentiated synapses in hippocampus: dependence on cellular mechanisms and network properties. J Neurosci 18:438-450.
48. Zola-Morgan S, Squire LR (1993) Neuroanatomy of memory. Annu Rev Neurosci 16:547-563.