Hepatocarcinogenesis in human liver;A hepatokarcinogenezis folyamata humán májban

Magyar Onkologia

Volumn 50, Issue 2, 2006, Pages 107-113

  Nagy, Péter ^a   László, Viktória ^a   Schaff, Zsuzsa ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b II Sz Patológiai Intézet   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; HERMES ANTIGEN; PROTEIN P53; TUMOR MARKER;

CELL TRANSFORMATION; CHEMISTRY; DISEASE COURSE; GENE EXPRESSION PROFILING; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER TUMOR; PATHOLOGY; PRECANCER; PREDICTION AND FORECASTING; REVIEW;

ANTIGENS, CD44; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; PRECANCEROUS CONDITIONS; PREDICTIVE VALUE OF TESTS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33750105015     PISSN: 00250244     EISSN: 20600399     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Aihara T, Noguchi S, Sasaki Y, et al. Clonal analysis of precancerous lesion of hepatocellular carcinoma. Gastroenterology 111:455-461, 1996
2. Anthony PP, Vogel CL, Barker LF, et al. Liver cell dysplasia: A premalignant condition. J Clin Pathol 26:217- 223, 1973
3. Borzio M, Fargion S, Borzio F. Impact of large regenerative low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol 39:208-214, 2003
4. Burrel M, Lovet J M, Ayuso C, et al. MRI angiography is superior to helical CT for detection of HCC prior to liver transplantation: An explant correlation. Hepatology 38:1034-1042, 2003
5. Capurro M, Wanless IR, Sherman M, et al. Glypican 3: A novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology 125:89-97, 2003
6. Chuma M, Sakamoto M, Yamazaki K, et al. Expression profiling on multistage hepatocarcinogenesis: Identification of HSP70 as a molecular marker of early hepatocellular carcinoma. Hepatology 37:198-207, 2003
7. Deugnier YM, Charalambous P, Lequilleuc D, et al. Preneoplastic significance of hepatic iron-free foci in genetic haemochromatosis - A study of 185 patients. Hepatology 18:1363-1369, 1993
8. Endo K, Terada T. Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: Relationships with tumor grade, clinicopathologic parameters, p53 expression and patient survival. J Hepatol 32:78-84, 2000
9. Ferrel L. Liver pathology: Cirrhosis, hepatitis, and primary liver tumors. Update and diagnostic problems. Mod Pathol 13:679-704, 2000
10. Görög D, Regöly-Mérei L, Paku S, et al. Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma. World J Gastroenterol 11:5015-5018, 2005
11. Hollstein M, Sidransky D, Vogelstein B, et al. p53 mutations in human cancers. Science 253:49-53, 1991
12. Hsu JS, Jeng YM, Mao TL, et al. ®-catenin mutations are associated with a subset of low-stage hepatocellular carci- noma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 157:763-770, 2000
13. Hytiroglou P. Morphological changes of early human hepatocarcinogenesis. Semin Liver Dis 24:65-75, 2004
14. International working party. Terminology of nodular hepatocellular lesions. Hepatology 22:983-993, 1995
15. Ishikawa M, Yogita S, Miyake H, et al. Differential diagnosis of small hepatocellular carcinoma, and borderline lesions in therapeutical strategy. Hepato-gastroenterology 49:1591-1596, 2002
16. Kato K, Ozaki D, Zheng KF, et al. Characterization of hyperplastic foci observed in surgical specimens of hepatocellular carcinoma. Pathol Int 51:20-25, 2001
17. Kojiro M, Roskams T. Early hepatocellular carcinoma and dysplastic nodules Semin Liver Dis 25:133-141, 2005
18. Kondo Y, Kanai Y, Sakamoto M, et al. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis - A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 32:970-979, 2000
19. Krinsky GA, Lee VS, Nguyen MT, et al. Siderotic nodules in cirrhotic liver at MR imaging with explant correlation: No increased frequency of dysplastic nodules and hepatocellular carcinoma. Radiology 218:47-53, 2001
20. Lee JS, Chu IS, Heo J, et al. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology 40:667-676, 2004
21. Lee JS, Heo J, Libbrecht L, et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med 12:410-416, 2006
22. Lencioni R, Caramella D, Bartolozzi C, et al. Percutaneous ethanol injection therapy of adenomatous hyperplastic nodules in cirrhotic liver disease. Acta Radiol 35:138-142, 1994
23. Libbrecht L, Bielen D, Veslype C, et al. Focal lesions in cirrhotic explant livers: Pathological evaluation and accuracy of pretransplantation imaging examinations. Liver Transplant 8:749-761, 2002
24. Libbrecht L, Craninx M, Nevens F, et al. Predictive value of liver cell dysplasia for development of hepatocellular carcinoma of patients with non-cirrhotic and cirrhotic chronic viral hepatitis. Histopathology 39:66-73, 2001
25. Libbrecht L, Desmet V, Roskams T. Preneoplastic lesions in human hepatocarcinogenesis. Liver Internat 25:16-27, 2005
26. Libbrecht L, Desmet V, Van Damme B, et al. The expression of p16 in liver cell dysplasia in human cirrhotic liver. Eur J Cancer Prev 9:444, 2000
27. Libbrecht L, Desmet V, Van Damme B, et al. The immunohistochemical phenotype of dysplastic foci in human liver: Correlation with putative progenitor cells. J Hepatol 33:76-84, 2000
28. Lin CH, Hsieh SY, Sheen IS, et al. Genome-wide hypomethylation in hepatocellular carcinogenesis. Cancer Res 61:4238-4243, 2001
29. Liver cancer study group of Japan. Classification of Primary Liver Cancer. 2nd Ed Tokyo: KaneharaCo, 2004
30. Lódi C, Szabó E, Holczbauer A, et al. Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas. Mod Pathol 19:460-469, 2006
31. Marchio A, Terris B, Meddeb M, et al. Chromosomal abnormalities in liver cell dysplasia detected by comparative genomic hybridization. Mol Pathol 54:270-274, 2001
32. Moinzadeh P, Breuhahn K, Stutzer H, et al. Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade - results of an explorative CGH meta-analysis. Br J Cancer 92:935-941, 2005
33. Nakashima O, Sugihara S, Kage M, et al. Pathomorphologic characteristics of small hepatocellular carcinoma: A special reference to small hepatocellular carcinoma with indistinct margins. Hepatology 22:101-105, 1995
34. Nam SW, Park JY, Ramasamy A, et al. Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling. Hepatology 42:809-818, 2005
35. Orsatti G, Theise ND, Thung SN, et al. DNA image cytometric analysis of macroregenerative nodules (adenomatous hyperplasia) of the liver: Evidence in support of their preneoplastic nature. Hepatology 17:621-627, 1993
36. Paradis V, Bieche I, Dargere G, et al. Molecular profiling of hepatocellular carcinomas (HCC) using a large scale RTPCR approach: Determination of a molecular diagnostic index. Am J Pathol 173:733-741, 2003
37. Parkin M. Global cancer statistics in the year 2000. Lancet Oncol 2:533-543, 2001
38. Park YN, Chae KJ, Kim YB, et al. Apoptosis and proliferation in hepatocarcinogenesis related to cirrhosis. Cancer 92:2733-2738, 2001
39. Park YN, Yang CP, Fernandez GJ, et al. Neoangiogenesis and sinusoidal capillarization in dysplastic nodules of the liver. Am J Surg Pathol 22:656-662, 1998
40. Park WS, Cho YG, Kim CJ, et al. Hypermethylation of the RUNX3 gene in hepatocellular carcinoma. Exp Mol Med 37:276-281, 2005
41. Qin Y, Liu JY, Li B, et al. Association of low p16INK4a and p15INK4b mRNAs expression with their CpG islands methylation with human hepatocellular carcinogenesis. World J Gastroenterol 10:1276-1280, 2004
42. Roncalli M, Roz E, Coggi G, et al. The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: Implications for diagnosis and classification. Hepatology 30:1174-1178, 1999
43. Saito Y, Kanai Y, Nakagawa T, et al. Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. Int J Cancer 105:527-532, 2003
44. Saito Y, Kanai Y, Sakamoto M, et al. Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology 33:561-568, 2001
45. Saito Y, Kanai Y, Sakamoto M, et al. Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc Natl Acad Sci USA 99:10060-10065, 2002
46. Shuto T, Hirohashi K, Wakasa K, et al. Hyperplastic foci as a prognostic factor after resection of hepatocellular carcinoma. Hepato-Gastroenterology 46:2439-2441, 1999
47. Su Q, Benner A, Hofman WJ, et al. Human hepatic preneoplasia: Phenotypes and proliferation kinetics of foci and nodules of altered hepatocytes and their relationship to liver cell dysplasia. Virchows Arch 431:391-406, 1997
48. Takaishi H, Kitamoto M, Takahashi S, et al. Precancerous hepatic nodules had significant levels of telomerase activity determined by sensitive quantitation using a hybridization protection assay. Cancer 88:312-317, 2000
49. Tanji K, Bhagat G, Vu TH, et al. Mitochondrial DNA dysfunction in oncocytic hepatocytes. Liver Internat 23:397- 403, 2003
50. Tangkijvanich P, Anukulkarnkusol N, Suwangool P, et al. Clinical characteristics and prognosis of hepatocellular carcinoma: Analysis based on alpha-fetoprotein levels. J Clin Gastroenterol 31:301-308, 2000
51. Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 31:339-346, 2002
52. Thorgeirsson SS, Lee JS, Grisham JW. Molecular prognostication of liver cancer: End of the beginning. J Hepatol 44:798-805, 2006
53. Tiniakos DG, Brunt EM. Proliferative cell nuclear antigen and Ki-67 labeling in hepatocellular nodules: A comparative study. Liver 19:58-68, 1999
54. Uenishi T. Cytokeratin 19 expression in hepatocellular carcinoma predicts early postoperative recurrence. Cancer Sci 94:851-857, 2003
55. Yamada T, De Souza AT, Finkelstein S, et al. Loss of the gene encoding mannose 6-phosphate (IGF II receptor) is an early event in liver carcinogenesis Proc Natl Acad Sci USA 94:10351-10355, 1997
56. Yang B, Guo M, Herman JG, et al. Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol 163:1101-1107, 2003
57. Zhao M, Zimmermann A. Liver cell dysplasia: Reactivities for c-met protein, Rb protein, E-cadherin and transforming growth factor beta 1 in comparison with hepatocellular carcinoma. Histol Histopathol 13:657-670, 1998