메뉴 건너뛰기




Volumn 19, Issue 1, 1999, Pages 58-68

Proliferating cell nuclear antigen and Ki-67 labeling in hepatocellular nodules: A comparative study

Author keywords

Dysplastic; Markers; Nodules; Proliferation

Indexed keywords

CYCLINE; KI 67 ANTIGEN;

EID: 0032945836     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1478-3231.1999.tb00011.x     Document Type: Article
Times cited : (42)

References (46)
  • 1
    • 0027198036 scopus 로고
    • A clinicopathologic study of adenomatous hyperplasia of the liver in 209 consecutive cirrhotic livers examined by autopsy
    • TERADA T, TERASAKI S, NAKANUMA Y. A clinicopathologic study of adenomatous hyperplasia of the liver in 209 consecutive cirrhotic livers examined by autopsy. Cancer 1993; 72: 1551-6.
    • (1993) Cancer , vol.72 , pp. 1551-1556
    • Terada, T.1    Terasaki, S.2    Nakanuma, Y.3
  • 2
    • 0022474895 scopus 로고
    • Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver: Observations in five cases
    • ARAKAWA M, KAGE M, SUGIHARA S, et al. Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver: observations in five cases. Gastroenterology 1986; 91: 198-208.
    • (1986) Gastroenterology , vol.91 , pp. 198-208
    • Arakawa, M.1    Kage, M.2    Sugihara, S.3
  • 3
    • 0028233123 scopus 로고
    • Frequent occurrence of hepatocellular carcinoma in cirrhotic livers after surgical resection of atypical adenomatous hyperplasia (borderline hepatocellular lesion): A follow-up study
    • KAJI K, TERADA T, NAKANUMA Y. Frequent occurrence of hepatocellular carcinoma in cirrhotic livers after surgical resection of atypical adenomatous hyperplasia (borderline hepatocellular lesion): a follow-up study. Am J Gastroenterol 1994; 89: 903-8.
    • (1994) Am J Gastroenterol , vol.89 , pp. 903-908
    • Kaji, K.1    Terada, T.2    Nakanuma, Y.3
  • 4
    • 0027470188 scopus 로고
    • Adenomatous hyperplasia of the liver as a precancerous lesion
    • NAKANUMA Y, TERADA T, UEDA K, et al. Adenomatous hyperplasia of the liver as a precancerous lesion. Liver 1993; 13: 1-9.
    • (1993) Liver , vol.13 , pp. 1-9
    • Nakanuma, Y.1    Terada, T.2    Ueda, K.3
  • 5
    • 0025155659 scopus 로고
    • Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma
    • TAKAYAMA T, MAKUUCHI M, HIROHASHI S, et al. Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 1990; 336: 1150-3.
    • (1990) Lancet , vol.336 , pp. 1150-1153
    • Takayama, T.1    Makuuchi, M.2    Hirohashi, S.3
  • 6
    • 0025369798 scopus 로고
    • 'Atypical adenomatous hyperplasia' in liver cirrhosis: Low-grade hepato-cellular carcinoma or borderline lesion?
    • NAKANUMA Y, TERADA T, TERASKI S, et al. 'Atypical adenomatous hyperplasia' in liver cirrhosis: low-grade hepato-cellular carcinoma or borderline lesion? Histopathology 1990; 17: 27-35.
    • (1990) Histopathology , vol.17 , pp. 27-35
    • Nakanuma, Y.1    Terada, T.2    Teraski, S.3
  • 7
    • 0029111660 scopus 로고
    • Adenomatous hyperplasia in cirrhotic livers: Histological evaluation, cellular density, and proliferative activity of 35 macronodular lesions in the cirrhotic expiants of 10 adult French patients
    • LEBAIL B, BELLEANNEE G, BERNARD P H, et al. Adenomatous hyperplasia in cirrhotic livers: histological evaluation, cellular density, and proliferative activity of 35 macronodular lesions in the cirrhotic expiants of 10 adult French patients. Hum Pathol 1995; 26: 897-906.
    • (1995) Hum Pathol , vol.26 , pp. 897-906
    • Lebail, B.1    Belleannee, G.2    Bernard, P.H.3
  • 9
    • 0029810226 scopus 로고    scopus 로고
    • Adult cirrhotic liver explants: Precancerous lesions and undetected small hepatocellular carcinoma
    • MION F, GROZEL L, BOILLOT O, et al. Adult cirrhotic liver explants: precancerous lesions and undetected small hepatocellular carcinoma. Gastroenterology 1996; 111: 1587-92.
    • (1996) Gastroenterology , vol.111 , pp. 1587-1592
    • Mion, F.1    Grozel, L.2    Boillot, O.3
  • 10
    • 0026697979 scopus 로고
    • Macroregenerative nodules and hepatocellular carcinoma in 44 sequential adult liver explants with cirrhosis
    • THEISE N D, SCHWARTZ M, MILLER C, THUNG S N. Macroregenerative nodules and hepatocellular carcinoma in 44 sequential adult liver explants with cirrhosis. Hepatology 1992; 16: 949-55.
    • (1992) Hepatology , vol.16 , pp. 949-955
    • Theise, N.D.1    Schwartz, M.2    Miller, C.3    Thung, S.N.4
  • 11
    • 0026452895 scopus 로고
    • Incidence and diagnostic features of macroregenerative nodules vs. small hepatocellular carcinoma in cirrhotic livers
    • FERRELL L, WRIGHT T, LAKE J, et al. Incidence and diagnostic features of macroregenerative nodules vs. small hepatocellular carcinoma in cirrhotic livers. Hepatology 1992; 16: 1372-1381.
    • (1992) Hepatology , vol.16 , pp. 1372-1381
    • Ferrell, L.1    Wright, T.2    Lake, J.3
  • 12
    • 0028898433 scopus 로고
    • Macroregenerative nodules in a series of adult cirrhotic liver explants: Issues in classification and nomenclature
    • HYTIROGLOU P, THEISE N D, SCHWARTZ M, et al. Macroregenerative nodules in a series of adult cirrhotic liver explants: issues in classification and nomenclature. Hepatology 1995; 21: 703-8
    • (1995) Hepatology , vol.21 , pp. 703-708
    • Hytiroglou, P.1    Theise, N.D.2    Schwartz, M.3
  • 13
    • 0029155354 scopus 로고
    • Terminology of nodular hepatocellular lesions
    • International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995; 22: 983-93.
    • (1995) Hepatology , vol.22 , pp. 983-993
  • 14
    • 0023869660 scopus 로고
    • Macroregenerative nodule of the liver. A clinicopathologic study of 345 autopsy cases of chronic liver disease
    • FURUYA K, NAKAMURA H, YAMAMOTO Y, et al. Macroregenerative nodule of the liver. A clinicopathologic study of 345 autopsy cases of chronic liver disease. Cancer 1988; 61: 99-105.
    • (1988) Cancer , vol.61 , pp. 99-105
    • Furuya, K.1    Nakamura, H.2    Yamamoto, Y.3
  • 15
    • 0027269648 scopus 로고
    • Histopathological and morphometric analysis of atypical adenomatous hyperplasia of human cirrhotic livers
    • TERADA T, UEDA K, NAKANUMA Y. Histopathological and morphometric analysis of atypical adenomatous hyperplasia of human cirrhotic livers. Vichows Archiv-A, Path Anat and Histopath 1993; 422: 381-8.
    • (1993) Vichows Archiv-A, Path Anat and Histopath , vol.422 , pp. 381-388
    • Terada, T.1    Ueda, K.2    Nakanuma, Y.3
  • 16
    • 0026632756 scopus 로고
    • Cell proliferative activity in adenomatous hyperplasia of the liver and small hepatocellular carcinoma. An immunohistochemical study demonstrating proliferating cell nuclear antigen
    • TERADA T, NAKANUMA Y. Cell proliferative activity in adenomatous hyperplasia of the liver and small hepatocellular carcinoma. An immunohistochemical study demonstrating proliferating cell nuclear antigen. Cancer 1992; 70: 591-8.
    • (1992) Cancer , vol.70 , pp. 591-598
    • Terada, T.1    Nakanuma, Y.2
  • 17
    • 0026027904 scopus 로고
    • Early stages of multistep hepatocarcinogenesis: Adenomatous hyperplasia and early hepatocellular carcinoma
    • SAKAMOTO M, HIROHASHI S, SHIMOSATO Y. Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol 1991; 22: 172-8.
    • (1991) Hum Pathol , vol.22 , pp. 172-178
    • Sakamoto, M.1    Hirohashi, S.2    Shimosato, Y.3
  • 18
    • 0026520315 scopus 로고
    • Adenomatous hyperplasia in the vicinity of small hepatocellular carcinoma
    • EQUCHI A, NAKASHIMA O, OKUDAIRA S, et al. Adenomatous hyperplasia in the vicinity of small hepatocellular carcinoma. Hepatology 1992; 15: 843-8.
    • (1992) Hepatology , vol.15 , pp. 843-848
    • Equchi, A.1    Nakashima, O.2    Okudaira, S.3
  • 19
    • 0027367008 scopus 로고
    • Proposal for standardized criteria for the diagnosis of benign, borderline, and malignant hepatocellular lesions arising in chronic advanced liver disease
    • FERRELL L D, CRAWFORD J M, DHILLON A P, et al. Proposal for standardized criteria for the diagnosis of benign, borderline, and malignant hepatocellular lesions arising in chronic advanced liver disease. Am J Surg Pathol 1993; 17; 1113-23.
    • (1993) Am J Surg Pathol , vol.17 , pp. 1113-1123
    • Ferrell, L.D.1    Crawford, J.M.2    Dhillon, A.P.3
  • 20
    • 0020632394 scopus 로고
    • Morphologic studies of the liver cell dysplasia
    • WATANABE S, OKITA K, HARADA T, et al. Morphologic studies of the liver cell dysplasia. Cancer 1983; 51: 2197-205.
    • (1983) Cancer , vol.51 , pp. 2197-2205
    • Watanabe, S.1    Okita, K.2    Harada, T.3
  • 21
    • 0015598739 scopus 로고
    • Liver cell dysplasia: A premalignant condition
    • ANTHONY P P, VOGEL C L, BARKER L F. Liver cell dysplasia: a premalignant condition. J Clin Pathol 1973; 26: 217-23.
    • (1973) J Clin Pathol , vol.26 , pp. 217-223
    • Anthony, P.P.1    Vogel, C.L.2    Barker, L.F.3
  • 22
    • 0029871986 scopus 로고    scopus 로고
    • Low proliferative activity in macroregenerative nodules: Evidence for an alternate hypothesis concerning human hepatocarcinogenesis
    • THEISE N D, MARCELIN K, GOLDFISCHER M, et al. Low proliferative activity in macroregenerative nodules: evidence for an alternate hypothesis concerning human hepatocarcinogenesis. Liver 1996; 16: 134-9.
    • (1996) Liver , vol.16 , pp. 134-139
    • Theise, N.D.1    Marcelin, K.2    Goldfischer, M.3
  • 23
    • 0027999653 scopus 로고
    • Clonal analysis of regenerative nodules in hepatitis C-virus induced liver cirrhosis
    • AIHARA T, NOGUCHI S, SASAKI Y, et al. Clonal analysis of regenerative nodules in hepatitis C-virus induced liver cirrhosis. Gastroenterology 1994; 107: 1805-11.
    • (1994) Gastroenterology , vol.107 , pp. 1805-1811
    • Aihara, T.1    Noguchi, S.2    Sasaki, Y.3
  • 24
    • 0027051417 scopus 로고
    • Clonal growth of hepatitis B virus - Integrated hepatocytes in cirrhotic liver nodules
    • YASUI H, HINO O, OHTAKE K, et al. Clonal growth of hepatitis B virus - integrated hepatocytes in cirrhotic liver nodules. Cancer Res 1992; 52: 6810-4.
    • (1992) Cancer Res , vol.52 , pp. 6810-6814
    • Yasui, H.1    Hino, O.2    Ohtake, K.3
  • 25
    • 0024203946 scopus 로고
    • Clonal origin of atypical adenomatous hyperplasia and clonal identity with hepatocellular carcinoma
    • TSUDA H, HIROHASHI S, SHIMOSATO Y, et al. Clonal origin of atypical adenomatous hyperplasia and clonal identity with hepatocellular carcinoma. Gastroenterolgy 1988; 95: 1664-6.
    • (1988) Gastroenterolgy , vol.95 , pp. 1664-1666
    • Tsuda, H.1    Hirohashi, S.2    Shimosato, Y.3
  • 26
    • 0027513261 scopus 로고
    • DNA image cytometric analysis of macroregenerative nodule (adenomatous hyperplasia) of the liver: Evidence in support of their preneoplastic nature
    • ORSATTI G, THEISE N, THUNG S N, PARONETTO F. DNA image cytometric analysis of macroregenerative nodule (adenomatous hyperplasia) of the liver: evidence in support of their preneoplastic nature. Hepatology 1993; 17: 621-7.
    • (1993) Hepatology , vol.17 , pp. 621-627
    • Orsatti, G.1    Theise, N.2    Thung, S.N.3    Paronetto, F.4
  • 27
    • 0028144250 scopus 로고
    • Nucleolar organizer regions in small nodular lesions representing early stages of human hepatocarcinogenesis
    • AOKI K, SAKAMOTO S, HIROHASHI S. Nucleolar organizer regions in small nodular lesions representing early stages of human hepatocarcinogenesis. Cancer 1994; 73: 289-93.
    • (1994) Cancer , vol.73 , pp. 289-293
    • Aoki, K.1    Sakamoto, S.2    Hirohashi, S.3
  • 28
    • 0025000244 scopus 로고
    • Identification and fine structure of proliferating hepatocytes in malignant and non-malignant liver diseases by use of a monoclonal antibody against DNA polymerase alpha
    • SEKI S, SAKAGUCHI H, KAWAKITA N, et al. Identification and fine structure of proliferating hepatocytes in malignant and non-malignant liver diseases by use of a monoclonal antibody against DNA polymerase alpha. Hum Pathol 1990; 21: 1020-30.
    • (1990) Hum Pathol , vol.21 , pp. 1020-1030
    • Seki, S.1    Sakaguchi, H.2    Kawakita, N.3
  • 29
    • 0030000639 scopus 로고    scopus 로고
    • Cytometric measurement of cell proliferation in echo-guided biopsies from focal lesions of the liver
    • FACCIOLI S, CHIECO P, GRAMANTIERI L, et al. Cytometric measurement of cell proliferation in echo-guided biopsies from focal lesions of the liver. Mod Pathol 1996; 9: 120-5.
    • (1996) Mod Pathol , vol.9 , pp. 120-125
    • Faccioli, S.1    Chieco, P.2    Gramantieri, L.3
  • 30
    • 0027429671 scopus 로고
    • Proliferating cell nuclear antigen in hepatocellular carcinoma and small cell liver dysplasia
    • ADACHI E, HASHIMOTO H, TSUNEYOSHI M. Proliferating cell nuclear antigen in hepatocellular carcinoma and small cell liver dysplasia. Cancer 1993; 72: 2902-9.
    • (1993) Cancer , vol.72 , pp. 2902-2909
    • Adachi, E.1    Hashimoto, H.2    Tsuneyoshi, M.3
  • 31
    • 0028273916 scopus 로고
    • Three types of liver cell dysplasia (LCD) in small cirrhotic nodules are distinguished by karyometry and PCNA labeling, and their features resemble distinct grades of hepatocellular carcinoma
    • ZHAO M, ZHANG N X, Du Z Y, LAISUE J A, et al. Three types of liver cell dysplasia (LCD) in small cirrhotic nodules are distinguished by karyometry and PCNA labeling, and their features resemble distinct grades of hepatocellular carcinoma. Histol Histopathol 1994; 9: 73-83.
    • (1994) Histol Histopathol , vol.9 , pp. 73-83
    • Zhao, M.1    Zhang, N.X.2    Du, Z.Y.3    Laisue, J.A.4
  • 32
    • 0026691205 scopus 로고
    • Liver cell dysplasia: A DNA aneuploid lesion with distinct morphologic features
    • THOMAS R M, BERMAN J J, YETTER R A, et al. Liver cell dysplasia: A DNA aneuploid lesion with distinct morphologic features. Hum Pathol 1992; 23: 496-503.
    • (1992) Hum Pathol , vol.23 , pp. 496-503
    • Thomas, R.M.1    Berman, J.J.2    Yetter, R.A.3
  • 33
    • 0028492109 scopus 로고
    • Comparative image cytometric DNA ploidy of liver cell dysplasia and hepatocellular carcinoma
    • RUBIN E, DEROSE P B, COHEN C. Comparative image cytometric DNA ploidy of liver cell dysplasia and hepatocellular carcinoma. Mod Pathol 1994; 7: 677-80.
    • (1994) Mod Pathol , vol.7 , pp. 677-680
    • Rubin, E.1    Derose, P.B.2    Cohen, C.3
  • 34
    • 15844411099 scopus 로고    scopus 로고
    • Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis
    • GANNE-CARRIE N, CHASTANG C, CHAPEL F, et al. Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis. Hepatology 1996; 23: 1112-8.
    • (1996) Hepatology , vol.23 , pp. 1112-1118
    • Ganne-Carrie, N.1    Chastang, C.2    Chapel, F.3
  • 35
    • 0028958050 scopus 로고
    • Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: A prospective study
    • BORZIO M, BRUNO S, RONCALLI M, et al. Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: a prospective study. Gastroenterology 1995; 108: 812-7.
    • (1995) Gastroenterology , vol.108 , pp. 812-817
    • Borzio, M.1    Bruno, S.2    Roncalli, M.3
  • 36
    • 0030663989 scopus 로고    scopus 로고
    • Large cell change (liver cell dysplasia) and hepatocellular carcinoma in cirrhosis: Matched case - Control study, pathological analysis, and pathogenetic hypothesis
    • LEE R G, TSAMANDAS A C, DEMETRIS A J. Large cell change (liver cell dysplasia) and hepatocellular carcinoma in cirrhosis: matched case - control study, pathological analysis, and pathogenetic hypothesis. Hepatology 1997; 26: 1415-22.
    • (1997) Hepatology , vol.26 , pp. 1415-1422
    • Lee, R.G.1    Tsamandas, A.C.2    Demetris, A.J.3
  • 37
    • 0030935587 scopus 로고    scopus 로고
    • Large-cell change of hepatocytes in cirrhosis may represent a reaction to prolonged cholestasis
    • NATAJARAN S, THEISE N D, THUNG S, et al. Large-cell change of hepatocytes in cirrhosis may represent a reaction to prolonged cholestasis. Am J Surg Pathol 1997; 21: 312-8.
    • (1997) Am J Surg Pathol , vol.21 , pp. 312-318
    • Natajaran, S.1    Theise, N.D.2    Thung, S.3
  • 38
    • 0026008188 scopus 로고
    • Hepatocellular carcinoma within siderotic regenerative nodules; appearance as a nodule within a nodule on MR images
    • MITCHELL D G, RUBIN R, SIEGELMAN E, BURK D L, et al. Hepatocellular carcinoma within siderotic regenerative nodules; appearance as a nodule within a nodule on MR images. Radiology 1991; 178: 101-3.
    • (1991) Radiology , vol.178 , pp. 101-103
    • Mitchell, D.G.1    Rubin, R.2    Siegelman, E.3    Burk, D.L.4
  • 39
    • 0024437670 scopus 로고
    • Adenomatous hyperplastic nodules in the cirrhotic liver: Differentiation from hepatocellular carcinoma with MR imaging
    • MATSUI O, KADOYA M, KAMEYAMA T et al. Adenomatous hyperplastic nodules in the cirrhotic liver: differentiation from hepatocellular carcinoma with MR imaging. Radiology 1989; 173: 123-6.
    • (1989) Radiology , vol.173 , pp. 123-126
    • Matsui, O.1    Kadoya, M.2    Kameyama, T.3
  • 40
    • 0000258908 scopus 로고
    • Evaluation of cell proliferation antibodies reactive in paraffin sections
    • KELLEHER L, MAGEE H M, DERVAN P A. Evaluation of cell proliferation antibodies reactive in paraffin sections. Applied Immunohistochemistry 1994; 28: 164-70.
    • (1994) Applied Immunohistochemistry , vol.28 , pp. 164-170
    • Kelleher, L.1    Magee, H.M.2    Dervan, P.A.3
  • 41
    • 0027253140 scopus 로고
    • The relevance of antibody concentration to the immunohistochemical quantification of cell proliferation-associated antigens
    • MCCORMICK D, YU C, HOBBS C, HALL P A. The relevance of antibody concentration to the immunohistochemical quantification of cell proliferation-associated antigens. Histopathology 1993; 22: 543-7.
    • (1993) Histopathology , vol.22 , pp. 543-547
    • Mccormick, D.1    Yu, C.2    Hobbs, C.3    Hall, P.A.4
  • 42
    • 0026619053 scopus 로고
    • The complexities of proliferating cell nuclear antigen
    • MCCORMICK D, HALL P A. The complexities of proliferating cell nuclear antigen. Histopathology 1992; 21: 591-4.
    • (1992) Histopathology , vol.21 , pp. 591-594
    • Mccormick, D.1    Hall, P.A.2
  • 43
    • 0028057922 scopus 로고
    • Clinicopathologic conferences
    • SCHAFFNER F, THUNG S N. Clinicopathologic conferences. Hepatology 1994; 19: 534-7.
    • (1994) Hepatology , vol.19 , pp. 534-537
    • Schaffner, F.1    Thung, S.N.2
  • 44
    • 0029687579 scopus 로고    scopus 로고
    • Thoughts on the development of hepatocellular carcinoma in cirrhotic and non-cirrhotic livers
    • Editorial
    • SNOVER D. Thoughts on the development of hepatocellular carcinoma in cirrhotic and non-cirrhotic livers. Editorial. Am J Clin Pathol 1996; 105: 3-5.
    • (1996) Am J Clin Pathol , vol.105 , pp. 3-5
    • Snover, D.1
  • 45
    • 0028832622 scopus 로고
    • Small hepatocellular carcinoma of single nodular type: A specific reference to its surrounding cancerous area undetected radiologically and macroscopically
    • MAEDA T, TAKENAKA K. ADACHI E, et al. Small hepatocellular carcinoma of single nodular type: a specific reference to its surrounding cancerous area undetected radiologically and macroscopically. J Surg Oncol 1995; 60: 75-9.
    • (1995) J Surg Oncol , vol.60 , pp. 75-79
    • Maeda, T.1    Takenaka, K.2    Adachi, E.3
  • 46
    • 0027500840 scopus 로고
    • Preneoplastic significance of hepatic iron free foci in genetic hemochromatosis: A study of 185 patients
    • DEUGNIER YM, CHARALAMBOUS P. LEQUILLENC D, et al. Preneoplastic significance of hepatic iron free foci in genetic hemochromatosis: A study of 185 patients. Hepatology 1993; 18: 1363-9.
    • (1993) Hepatology , vol.18 , pp. 1363-1369
    • Deugnier, Y.M.1    Charalambous, P.2    Lequillenc, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.