Precancerous hepatic nodules had significant levels of telomerase activity determined by sensitive quantitation using a hybridization protection assay

Cancer

Volumn 88, Issue 2, 2000, Pages 312-317

  Takaishi, Hideki ^a   Kitamoto, Mikiya ^a   Takahashi, Shoichi ^a   Aikata, Hiroshi ^a   Kawakami, Yoshiiku ^a   Nakanishi, Toshio ^a   Nakamura, Yasuhiro ^a   Shimamoto, Fumio ^a   Kajiyama, Goro ^a   Ide, Toshinori ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Dysplastic nodules; Hepatocellular carcinoma; Hybridization protection assay; Precancerous hepatic nodules; Telomerase

Indexed keywords

TELOMERASE;

ANALYTIC METHOD; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER NODULE; PRECANCER; PRIORITY JOURNAL; QUANTITATIVE ASSAY; TUMOR DIFFERENTIATION;

DNA PRIMERS; HUMANS; LIVER; LIVER NEOPLASMS; NUCLEIC ACID AMPLIFICATION TECHNIQUES; NUCLEIC ACID HYBRIDIZATION; PRECANCEROUS CONDITIONS; SENSITIVITY AND SPECIFICITY; TELOMERASE;

EID: 0034650779     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(20000115)88:2<312::AID-CNCR10>3.0.CO;2-R     Document Type: Article

References (18)

1. Greider CW, Blackburn EH. A telomeric sequence in the RNA of tetrahymena telomerase required for telomere repeat synthesis. Nature 1989;337:331-7.
2. Blackburn EH. Structure and function of telomeres. Nature 1991;350:569-73.
3. Morin GB. Recognition of a chromosome truncation site associated with alphathalassaemia by human telomerase. Nature 1991:353:454-6.
4. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266: 2011-5.
5. Wright WE, Shay JW, Piatyszek MA. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res 1995;23:3794-5.
6. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997;33:787-91.
7. Tahara H, Nakanishi T, Kitamoto M, Nakashio R, Shay JW, Tahara E, et al. Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas. Cancer Res 1995;55:2734-6.
8. Hiyama E, Kodama T, Shinbara K, Iwao T, Itoh M, Hiyama K, et al. Telomerase activity is detected in pancreatic cancer but not in benign tumors. Cancer Res 1997;57:326-31.
9. Nakashio R, Kitamoto M, Tahara H, Nakanishi T, Ide T, Kajiyama G. Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinoma. Int J Cancer 1997;74:141-7.
10. International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995;22:983-93.
11. Arakawa M, Kage M, Sugihara S, Nakashima T, Suenaga M, Okuda K. Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver. Observations in five cases. Gastroenterology 1986;91:198-208.
12. Nakanuma Y, Terada T, Terasaki S, Ueda K, Nonomura A, Kawahara E, et al. "Atypical adenomatous hyperplasia" in liver cirrhosis: low-grade hepatocellular carcinoma or borderline lesion? Histopathology 1990;17:27-35.
13. Eguchi A, Nakashima O, Okudaira S, Sugihara S, Kojiro M. Adenomatous hyperplasia in the vicinity of small hepatocellular carcinoma. Hepatology 1992;15:843-8.
14. Hytiroglou P, Kotoula V, Thung SN, Tsokos M, Fiel MI, Papadimitriou CS. Telomerase activity in precancerous hepatic nodules. Cancer 1998;82:1831-8.
15. Hirose M, Abe-Hashimoto J, Ogura K, Tahara H, Ide T, Yoshimura T. A rapid, useful and quantitative method to measure telomerase activity by hybridization protection assay connected with a telomeric repeat amplification protocol. J Cancer Res Clin Oncol 1997;123:337-44.
16. Kitamoto M, Ide T. Telomerase activity in precancerous hepatic nodules. Cancer 1999;85:245-6.
17. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954; 7:462-503.
18. Kondo F, Wada K, Nagato Y, Nakajima T, Kondo Y, Hirooka N, et al. Biopsy diagnosis of well-differentiated hepatocellular carcinoma based on new morphologic criteria. Hepatology 1989;9:751-5.