Hypermethylation of the RUNX3 gene in hepatocellular carcinoma

Experimental and Molecular Medicine

Volumn 37, Issue 4, 2005, Pages 276-281

  Park, Won Sang ^a   Cho, Yong Gu ^a   Kim, Chang Jae ^a   Song, Jae Hwi ^a   Lee, Youn Soo ^a   Kim, Su Young ^a   Nam, Suk Woo ^a   Lee, Sug Hyung ^a   Yoo, Nam Jin ^a   Lee, Jung Young ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

DNA methylation; Epigenesis, genetic; Genes, tumor suppressor; Liver neoplasms; Runx protein; Transforming growth factor

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; TRANSCRIPTION FACTOR RUNX3;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LIVER CELL CARCINOMA; MALE; METHYLATION; PARAMETER; PROMOTER REGION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

EID: 24944523611     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2005.37     Document Type: Article

References (28)

1. Alexandrow MG, Moses HL. Transforming growth factor beta 1 inhibits mouse keratinocytes late in G1 independent of effects on gene transcription. Cancer Res 1995;55:1452-7
2. Bae SC, Choi JK. Tumor suppressor activity of RUNX3. Oncogene 2004;23:4336-40
3. Bissell DM. Chronic liver injury, TGF-β and cancer. Exp Mol Med 2001;33:179-90
4. Cohen MM Jr. TGF beta/Smad signaling system and its pathologic correlates. Am J Med Genet 2003;116A:1-10
5. Goelz SE, Hamilton SR, Vogelstein B. Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biochem Biophys Res Commun 1985;130:118-26
6. Grunau C, Clark SJ, Rosenthal A. Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. Nucleic Acids Res 2001;29:e65-5
7. Kawate S, Ohwada S, Hamada K, Koyama T, Takenoshita S, Morishita Y, Hagiwara K. Mutational analysis of the Smad6 and Smad7 genes in hepatocellular carcinoma. Int J Mol Med 2001;8:49-52
8. Kawate S, Takenoshita S, Ohwada S, Mogi A, Fukusato T, Makita F, Kuwano H, Morishita Y. Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma. Int J Oncol 1999;14:127-31
9. Kim TY, Lee HJ, Hwang KS, Lee M, Kim JW, Bang YJ, Kang GH. Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma. Lab Invest 2004;84:479-84
10. Kloos DU, Choi C, Wingender E. The TGF-beta-Smad network: introducing bioinformatic tools. Trends Genet 2002; 18:96-103
11. Ku JL, Kang SB, Shin YK, Kang HC, Hong SH, Kim IJ, Shin JH, Han IO, Park JG. Promoter hypermethylation down-regulates RUNX3 gene expression in colorectal cancer cell lines. Oncogene 2004;23:6736-42
12. Lee JK, Kim MJ, Hong SP, Hong SD. Inactivation patterns of p16/INK4A in oral squamous cell carcinomas. Exp Mol Med 2004;36:165-71
13. Lee S, Lee HJ, Kim JH, Lee HS, Jang JJ, Kang GH. Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am J Pathol 2003;163:1371-78
14. Lehmann U, Hasemeier B, Lilischkis R, Kreipe H. Quantitative analysis of promoter hypermethylation in laser-microdissected archival specimens. Lab Invest 2001;81:635-7
15. Li QL, Ito K, Sakaura C, Fukamachi H, Inoue KI, Chi XZ, Lee KY, Nomura S, Lee CW, Man SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC, Ito Y. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 2002;109:113-24
16. Moustakas A, Pardali K, Gaal A, Heldin C. Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation. Immunol Lett 2002;82:85-91
17. Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, lsaacc WB, Cairns P, Nawroz H, Sidransky D, Casero RA, Meltzer PS, Hahn SA, Kern SE. DPC4 gene in various tumor types. Cancer Res 1996;56:2527-30
18. Shin HR, Jung KW, Won YJ, Park JG. 139 KCCR-affiliated Hospitals. 2002 annual report of the Korea central cancer registry: Based on registered data from 139 hospitals. Cancer Research and Treatment 2004;36:103-14
19. Tanaka K, Yanoshita R, Konishi M, Oshimura M, Maeda Y, Mori T, Miyaki M. Suppression of tumourigenicity in human colon carcinoma cells by introduction of normal chromosome 1p36 region. Oncogene 1993;8:2253-8
20. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 1999;96:8681-6
21. Toyota M, Issa JP. CpG island methylator phenotypes in aging and cancer. Semin Cancer Biol 1999;9:349-57
22. Wada M, Yazumi S, Takaishi S, Hasegawa K, Sawada M, Tanaka H, Ida H, Sakakura C, Ito K, Ito Y, Chiba T. Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines. Oncogene 2004;23:2401-7
23. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995;81:323-30
24. Weiser R. The transforming growth factor-beta signaling pathway in tumorigenesis. Curr Opin Oncol 2001;13:70-7
25. Weith A, Brodeur GM, Bruns GA, Matise TC, Mischke D, Nizetic D, Seidin MF, van Roy N, Vance J. Report of the second international workshop on human chromosome 1 mapping 1995. Cytogenet Cell Genet 1996;72:114-44
26. Xiao W-H, Liu W-W. Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma. World J Gastroenterol 2004;10:376-80
27. Zaidi SK, Sullivan AJ, Wijnen AJV, Stein JL, Stein GS, Lian JB. Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proc Natl Acad Sci USA 2002;99:8048-53
28. Zhang Y, Derynck R. Transcriptional regulation of the transforming growth factor-beta-inducible mouse germ line Ig alpha constant region gene by functional corporation of Smad, CREB, and AML family members. J Biol Chem 2000; 275:16979-85