Increased association of 7SK snRNA with Tat cofactor P-TEFb following activation of peripheral blood lymphocytes

AIDS

Volumn 17, Issue 17, 2003, Pages 2429-2436

  Haaland, Richard E ^a   Herrmann, Christine H ^a   Rice, Andrew P ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

7SK snRNA; P TEFb; Peripheral blood lymphocytes; Transcription elongation; Transcriptional latency

Indexed keywords

7SK SMALL NUCLEAR RNA; CYCLIN DEPENDENT KINASE 9; CYCLIN T1; P TEFB PROTEIN; PHYTOHEMAGGLUTININ; PROTEIN; SMALL NUCLEAR RNA; TRANSACTIVATOR PROTEIN; TRANSCRIPTION ELONGATION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL ISOLATION; COMPLEX FORMATION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LYMPHOCYTE ACTIVATION; NORTHERN BLOTTING; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSCRIPTION ELONGATION; TRANSCRIPTION LATENCY; TRANSCRIPTION REGULATION;

BLOTTING, NORTHERN; CYCLIN-DEPENDENT KINASE 9; CYCLINS; HELA CELLS; HUMANS; LYMPHOCYTE ACTIVATION; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PRECIPITIN TESTS; RNA, SMALL NUCLEAR; SOLUBILITY; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC;

EID: 1642366130     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200311210-00004     Document Type: Article

References (29)

1. Garber ME, Jones KA. HIV-1 Tat: coping with negative elongation factors. Curr Opin Immunol 1999, 11:460-465.
2. Karn J. Tackling Tat. J Mol Biol 1999, 293:235-254.
3. Taube R, Fujinaga K, Wimmer J, Barboric M, Peterlin BM. Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation. Virology 1999, 264:245-253.
4. Wei P, Garber ME, Fang SM, Fischer WH, Jones KA. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. 1998, Cell 92:451-462.
5. Fu TJ, Peng J, Lee G, Price DH, Flores O. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. J Biol Chem 1999, 274:34527-34530.
6. Peng J, Zhu Y, Milton JT, Price DH. Identification of multiple cyclin subunits of human P-TEFb. Genes Dev 1998, 12:755-762.
7. Price DH. P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II. Mol Cell Biol 2000, 20: 2629-2634.
8. Nguyen VT, Kiss T, Michels AA, Bensaude O. 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature 2001, 414:322-325.
9. Yang Z, Zhu Q, Luo K, Zhou Q. The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription. Nature 2001, 414:317-322.
10. Sano M, Abdellatif M, Oh H, Xie M, Bagella L, Giordano A, et al. Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Nat Med 2002, 8:1310-1317.
11. Herrmann CH, Carroll RG, Wei P, Jones KA, Rice AP. Tat-associated kinase, TAK, activity is regulated by distinct mechanims in peripheral blood lymphocytes and promonocytic cell lines. J Virol 1998, 72:9881-9888.
12. Yang X, Herrmann CH, Rice AP. The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function. J Virol 1996, 70:4576-4584.
13. Herrmann CH, Gold MO, Rice AP. Viral transactivators specifically target distinct cellular protein kinases that phosphorylate the RNA polymerase II C-terminal domain. Nucl Acids Res 1996, 24:501-508.
14. Herrmann CH, Rice AP. Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. J Virol 1995, 69:1612-1620.
15. Gupta S, Busch RK, Singh R, Reddy R. Characterization of U6 small nuclear RNA cap-specific antibodies. Identification of gamma-monomethyl-GTP cap structure in 7SK and several other human small RNAs. J Biol Chem 1990, 265: 19137-19142.
16. Kass S, Tyc K, Steitz JA, Sollner-Webb B. The U3 small nucleolar ribonucleoprotein functions in the first step of preribosomal RNA processing. Cell 1990, 60:897-908.
17. Herrmann CH, Mancini MA. The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions. J Cell Sci 2001, 114:1491-1503.
18. Riedl T, Egly JM. Phosphorylation in transcription: the CTD and more. Gene Expr 2000, 9:3-13.
19. Shatter AL, Rosenwald A, Hurt EM, Giltnane JM, Lam LT, Pickeral OK, et al. Signatures of the immune response. Immunity 2001, 15:375-385.
20. Yang X, Gold MO, Tang DN, Lewis DE, Aguilar-Cordova E, Rice AP, et al. TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines. Proc Natl Acad Sci USA 1997, 94:12331-12336.
21. Ghose R, Liou LY, Herrmann CH, Rice AP. Induction of TAK (cyclin T1/P-TEFb) in purified resting CD4(+) T lymphocytes by combination of cytokines. J Virol 2001, 75:11336-11343.
22. Garriga J, Peng J, Parreno M, Price DH, Henderson EE, Grana X. Upregulation of cyclin T1/CDK9 complexes during T cell activation. Oncogene 1998, 17:3093-3102.
23. Martin-Serrano J, Li K, Bieniasz PD. Cyclin T1 expression is mediated by a complex and constitutively active promoter and does not limit human immunodeficiency virus type 1 Tat function in unstimulated primary lymphocytes. J Virol 2002, 76: 208-219.
24. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993, 75:805-816.
25. Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM, et al. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 1994, 8:9-22.
26. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. p21 is a universal inhibitor of cyclin kinases. Nature 1993, 366:701-704.
27. Luo Y, Kurz J, MacAfee N, Krause MO. c-myc deregulation during transformation induction: involvement of 7SK RNA. J Cell Biochem 1997, 64:313-327.
28. Kwek KY, Murphy S, Furger A, Thomas B, O'Gorman W, Kimura H, et al. U1 snRNA associates with TFIIH and regulates transcriptional initiation. Nat Struct Biol 2002, 9:800-805.
29. Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, et al. MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription- dependent manner. Mol Cell Biol 2003, 23:4859-4869.