Depression and anxiety in Parkinson's disease: Possible effect of genetic variation in the serotonin transporter

Journal of Geriatric Psychiatry and Neurology

Volumn 12, Issue 2, 1999, Pages 49-52

  Menza, Matthew A ^a   Palermo, Brandon ^b   DiPaola, Rocco ^a   Sage, Jacob I ^a   Ricketts, Michael H ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN; SEROTONIN TRANSPORTER;

AGED; ALLELE; ANXIETY NEUROSIS; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; DEPRESSION; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAMILTON SCALE; HUMAN; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; PROMOTER REGION; RISK FACTOR; SYNAPSE;

AGED; ALLELES; ANXIETY; CARRIER PROTEINS; DEPRESSION; FEMALE; GENES, REGULATOR; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; PARKINSON DISEASE; RISK FACTORS; SEROTONIN; VARIATION (GENETICS);

EID: 0032846350     PISSN: 08919887     EISSN: None     Source Type: Journal    
DOI: 10.1177/089198879901200202     Document Type: Article

References (33)

1. Cummings JL. Depression and Parkinson's disease. Am J Psychiatry 1992; 149:443-454.
2. Menza MA, Robertson-Hoffmann DE, Bonapace AS. Parkinson's disease and anxiety: comorbidity with depression. Biol Psychiatry 1993; 34:465-470.
3. Mayeux R, Williams Y. Clinical and biochemical features of depression in Parkinson's disease. Am J Psychiatry 1986; 143:756-759.
4. Kostic VS, Djuricic BM, Covickovic-Sternic N, et al. Depression and Parkinson's disease: possible role of serotonergic mechanisms. J Neurol 1987; 234:94-96.
5. Kendler KS, Walters EE, Truett KR, et al. Sources of individual differences in depression symptoms: analysis of two samples of twins and their families. Am J Psychiatry 1994; 151:1605-1614.
6. Kendler KS, Walters EE, Truett KR, et al. A twin-family study of self-report symptoms of panic-phobia and somatization. Behav Genet 1995; 25:499-515.
7. Plomin R, Owen MJ, McGuffin P. The genetic basis of complex human behaviors. Science 1994; 264:1733-1739.
8. Ricketts MH, Hamer RM, Sage JI, et al. Association of a serotonin transporter gene promoter polymorphism with harm avoidance behavior in an elderly population. Psychiatr Genet 1998; 8:41-44.
9. Lesch KP, Aulakh CS, Wolozin BL, et al. Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants. Mol Brain Res 1993; 17:31-35.
10. Heils A, Teufel A, Petri S, et al. Allelic variation of human serotonin gene expression. J Neurochem 1996; 66:2621-2624.
11. Lesch KP, Bengal D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274:1527-1531.
12. Collier DA, Stober G, Li T, et al. A novel functional polymorphism within the promoter of the serotonin transporter gene -possible role in susceptibility to affective disorders. Mol Psychiatry 1996; 1:453-460.
13. Ball D, Hill L, Freeman B, et al. The serotonin transporter gene and peer-rated neuroticism. Neuroreport 1997; 8:1301-1304.
14. Ebstein RP, Gritsenko I, Nemanov L, et al. No association between the serotonin transporter gene regulatory region polymorphism and the tridimensional personality questionnaire (TPQ) temperament of harm avoidance. Mol Psychiatry 1997; 2:224-226.
15. Fahn S, Elton RL. The UPDRS Development Committee. Recent developments in Parkinson's disease. Vol 2. Florham Park, NJ: MacMillan, 1987:153-163.
16. Linn MW, Linn BS. Rapid Disability Rating Scale-2. J Am Geriatr Soc 1982; 30:378-382.
17. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967; 6:278-296.
18. Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol 1959; 32:50-55.
19. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. Psychiatry Res 1975; 12:189-198.
20. SAS Institute Inc. SAS procedure guide for personal computers, release 6.03 Edition. Cary, NC: SAS Institute, 1988.
21. Sobell JL, Heston LL, Sommer SS. Delineation of genetic predisposition to multifactorial disease: a general approach on the threshold of feasibility. Genomics 1992; 12:1-6.
22. Goldman D. High anxiety. Science 1996; 274:1483.
23. Hensler JG, Ferry RC, Labow DM, Kovachich GB, Frazer A. Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus. Synapse 1994; 17:1-15.
24. Griebel G. 5-hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol Ther 1995; 65:319-395.
25. Handley SL. 5-hydroxytryptamine pathways in anxiety and its treatment. Pharmacol Ther 1995; 66:103-148.
26. Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 1994; 40:288-295.
27. Perry E, Marshall E, Blessed G, Tomlinson B, Perry R. Decreased imipramine binding in the brains of patients with depressive illness. Br J Psychiatry 1983; 142:188-192.
28. Cloninger RC. A systematic method for clinical description and classification of personality variants. Arch Gen Psychiatry 1987; 44:573-588.
29. Khan A. Neurochemistry of schizophrenia and depression. Clovis, CA: A.J. Publisher, 1998:225-235.
30. McGeer PL, McGeer EG. Enzymes associated with the metabolism of catecholamines, acetylcholine and GABA in human controls and patients with Parkinson's disease and Huntington's chorea. J Neurochem 1976; 26:65-76.
31. Lupien S, Lecours AR, Schwartz G, et al. Longitudinal study of basal cortisol levels in healthy elderly subjects: evidence for subgroups. Neurobiol Aging 1996; 17:95-105.
32. McEwen BS. Re-examination of the glucocorticoid hypothesis of stress and aging. Prog Brain Res 1992; 93:365-381.
33. Slotkin TA, McCook EC, Ritchie JC, Carroll BJ, Seidler FJ. Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects. Biol Psychiatry 1997; 41:172-183.