Serotonin transporter gene promoter (5-HTTLPR) and intron 2 (VNTR) polymorphisms in Croatian suicide victims

Biological Psychiatry

Volumn 54, Issue 9, 2003, Pages 884-889

  Hranilovic, Dubravka ^a   Stefulj, Jasminka ^a   Furac, Ivana ^b   Kubat, Milovan ^b   Balija, Melita ^c   Jernej, Branimir ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c CROATIAN INSTITUTE OF TRANSFUSION MEDICINE   (Croatia)

Author keywords

5 HT transporter; Intron; Promoter; Slavic population; Suicidal behavior

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; AGED; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; CROATIA; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; SAMPLE; SUICIDE; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 0142188615     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(03)00179-3     Document Type: Article

References (35)

1. Alvarez J.C., Cremniter D., Lesieur P., Gregoire A., Gilton A., Macquin-Mavier I., et al. Low blood cholesterol and low platelet serotonin levels in violent suicide attempters. Biol Psychiatry. 45:1999;1066-1069.
2. Asberg M., Forslund K. Neurobiological aspects of suicidal behavior. Int Rev Psychiatry. 12:2000;62-74.
3. Baca-Garcia E., Vaquero C., Diaz-Sastre C., Saiz-Ruiz J., Fernandez-Piqueras J., De Leon J. A gender-specific association between the serotonin transporter gene and suicide attempts. Neuropsychopharmacology. 26:2002;692-695.
4. Bellivier F., Henry C., Szoke A., Schurhoff F., Nostenbertrand M., Feingold J., et al. Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression. Neurosci Lett. 255:1998;143-146.
5. Bellivier F., Szoeke A., Henry C., Lacoste J., Bottos C., Nosten-Bertrand M., et al. Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders. Biol Psychiatry. 48:2000;319-322.
6. Bondy B., Erfurth A., De Jonge S., Krueger M., Meyer H. Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide. Mol Psychiatry. 5:2000;193-195.
7. Chong S.A., Lee W.L., Tan C.H., Tay A.H.N., Chan A.O.M., Tan E.C. Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia. Psychiatry Res. 97:2000;101-106.
8. Courtet P., Baud P., Abbar M., Boulenger J.P., Castelnau D., Mouthon D., et al. Association between violent suicidal behavior and the low activity allele of the serotonin transporter gene. Mol Psychiatry. 6:2001;338-341.
9. Du L., Faludi G., Palkovits M., Demeter E., Bakish D., Lapierre Y.D., et al. Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims. Biol Psychiatry. 46:1999;196-201.
10. Fiskerstrand C.E., Lovejoy E.A., Quinn J.P. An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. FEBS Lett. 458:1999;171-174.
11. Fitch D., Lesage A., Seguin M., Tousignant M., Benkelfat C., Rouleau G.A., Turecki G. Suicide and the serotonin transporter gene. Mol Psychiatry. 6:2000;127-128.
12. Geijer T., Frisch A., Persson M.L., Wasserman D., Rockah R., Michaelovsky E., et al. Search for association between suicide attempt and serotonergic polymporphisms. Psychiatry Genet. 10:2000;19-26.
13. Gelenter J., Kranzler H., Cubells J.F. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet. 101:1997;243-246.
14. Gorwood P., Batel P., Ades J., Hamon M., Boni C. Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior. Biol Psychiatry. 48:2000;259-264.
15. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., Lesch K.P. Allelic variation of human serotonin transporter gene expression. J Neurochem. 66:1996;1-4.
16. Hranilovic D., Schwab S.G., Jernej B., Knapp M., Lerer B., Albus M., et al. Serotonin transporter gene and schizophrenia: Evidence for association/linkage disequilibrium in families with affected siblings. Mol Psychiatry. 5:2000;91-95.
17. Lesch K.P., Balling U., Gross J., Strauss K., Wolozin B.L., Murphy D.L., Riederer P. Organization of the human serotonin transporter gene. J Neural Transm. 95:1994;157-162.
18. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 274:1996;1527-1531.
19. Lesch K.P., Moessner R. Genetically driven variation in serotonin uptake Is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biol Psychiatry. 44:1998;179-192.
20. Lichtermann D., Hranilovic D., Trixler M., Franke P., Jernej B., Delmo C.D., et al. Support for alleic association of a polymorphic site in the promoter region of the serotonin transporter gene with risk for alcoholic dependence. Am J Psychiatry. 157:2000;2045-2047.
21. MacKenzie A., Quinn J. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci U S A. 96:1999;15251-15255.
22. Mann J.J., Brent D., Arango V. The neurobiology and genetics of suicide and attempted suicide A focus on serotonergic system . Neuropsychopharmacol. 24:2001;467-477.
23. Mann J.J., Huang Z.Z., Underwood M.D., Kassir S.A., Oppenheim S., Kelly T.M., et al. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry. 57:2000;729-738.
24. Michaelovsky E., Firsch A., Rockah R., Peleg L., Magal N., Shohat M., Weizman R. A novel allele in the promoter region of the human serotonin transporter gene. Mol Psychiatry. 4:1999;97-99.
25. Oquendo M.A., Mann J.J. Neuroimaging findings in major depression, suicidal behavior and aggression. Clin Neurosci Res. 1:2001;377-380.
26. Prenger T.V. What's wrong with Bonferroni adjustments. BMJ. 316:1998;1236-1238.
27. Preuss U.W., Koller G., Soyka M., Bondy B. Association between suicide attempts and 5-HTTLPR-S-allele in alcohol-dependent and control subjects Further evidence from a German alcohol-dependent inpatient sample . Biol Psychiatry. 50:2001;636-639.
28. Rammamoorthy S., Bauman A.L., Moore K.R., Han H., Yang-Feng T., Chang A.S., et al. Antidepressant- and cocaine-sensitive human serotonin transporter Molecular cloning, expression, and chromosomal localization . Proc Natl Acad Sci U S A. 90:1993;2542-2546.
29. Roy A. Suicidal behavior in depression Relationship to platelet serotonin transporter . Neuropsychobiol. 39:1999;71-75.
30. Roy A. Genetic influence on suicide risk. Clin Neurosci Res. 1:2001;324-330.
31. Russ M.J., Lachmann H.M., Kashdan T., Saito T., Bajmakovic-Kacila S. Analysis of cathecol-O-methyltransferase and 5-hydrpxytryptamine transporter polymorphisms in patients at risk for suicide. Psychiatry Res. 93:2000;73-78.
32. Sander T., Harms H., Dufeu P., Kuhn S., Hoehe M., Lesch K.P., et al. Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. Biol Psichiatry. 43:1998;908-912.
33. Spreux-Varoquaux O., Alvarez J.C., Berlin I., Batista G., Despierre P.G., Gilton A., Cremniter D. Differential abnormalities in plasma 5-HIAA and platelet serotonin concentrations in violent suicide attempters. Relationships with impulsivity and depression. Life Sci. 69:2001;647-657.
34. Turecki G. Suicidal behavior Is there a genetic predisposition? Bipolar Disorders. 3:2001;335-349.
35. Zalsman G., Frisch A., Bromberg M., Gelernter J., Michaelovsky E., Campino A., et al. Family-based association study of serotonin transporter promoter in suicidal adolescents No association with suicidality but possible role in violence traits . Am J Med Genet. 105:2001;239-245.