Transcriptional activity of blood-and cerebrospinal fluid-derived nef/long-terminal repeat sequences isolated from a slow progressor infected with nef-deleted human immunodeficiency virus type 1 (HIV-1) who developed HIV-associated dementia

Journal of NeuroVirology

Volumn 12, Issue 3, 2006, Pages 219-228

  Churchill, Melissa J ^a   Figueiredo, Anna ^a,b   Cowley, Daniel ^a,g   Gray, Lachlan ^a,c   Purcell, Damian F J ^c   Sullivan, John S ^d,e   McPhee, Dale A ^b,c,f   Wesselingh, Steven L ^a,g   Brew, Bruce J ^h   Gorry, Paul R ^a,c,g  

^a MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d AUSTRALIAN RED CROSS BLOOD SERVICE   (Australia)

^e University of Sydney   (Australia)

^f ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^g MONASH UNIVERSITY   (Australia)

^h ST VINCENT S HOSPITAL   (Australia)

Author keywords

HIV 1; Nef; Neurotropism; NF KB; Sp 1

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEF PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; TRANSACTIVATOR PROTEIN; VIRUS RNA;

ARTICLE; BINDING SITE; BLOOD SAMPLING; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID LEVEL; CONTROLLED STUDY; DEMENTIA; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONG TERMINAL REPEAT; MOLECULAR CLONING; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; VIRUS LOAD; VIRUS REPLICATION; VIRUS VIRULENCE;

AIDS DEMENTIA COMPLEX; GENE DELETION; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, NEF; GENE PRODUCTS, TAT; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; TRANS-ACTIVATION (GENETICS); VIRAL LOAD; VIRULENCE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33750035813     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280600827369     Document Type: Article

References (59)

1. Albright, A and Shieh, J and Itoh, T and Lee, B and Pleasure, D and O'Connor, M and Doms, R and Gonzalez-Scarano, F. (1999) Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolateJ Virol, 73, pp. 205-213. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=9847323&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+73%5BVolume%5D+AND+205%5BPage+ Number%5D+AND+1999%5BPublication+Date%5D+AND+Albright%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=73&iss=&firstpage=205
2. Alexander, L and Illyinskii, P and Lang, S and Means, R and Lifson, J and Mansfield, K and Desrosiers, R. (2003) Determinants of increased replicative capacity of serially passaged simian immunodeficiency virus with nef deleted in rhesus monkeys J Virol, 77, pp. 6823-6835. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=12768002&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+77%5BVolume%5D+AND+6823%5BPage+ Number%5D+AND+2003%5BPublication+Date%5D+AND+Alexander%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=77&iss=&firstpage=6823 http://dx.doi.org/10.1128%2FJVI.77.12.6823-6835.2003
3. Burdo, T and Gartner, S and Mauger, D and Wigdahl, B. (2004a) Region-specific distribution of human immunodeficiency virus type 1 long terminal repeats containing specific configurations of CCAAT/ enhancer-binding protein site II in brains derived from demented and nondemented patients J NeuroVirol, 10(Suppl 1), pp. 7-14. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=14982733&Session=&searchQuery=J+ NeuroVirol%5BJournal+Name%5D+AND+10%5BVolume%5D+AND+7%5BPage+ Number%5D+AND+2004%5BPublication+Date%5D+AND+Burdo%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1355-0284&vol=10&iss=Suppl+1&firstpage=7 http://dx.doi.org/10.1080%2F13550280490270789
4. Burdo, T and Nonnemacher, M and Irish, B and Choi, C and Krebs, F and Gartner, S and Wigdahl, B. (2004b) High-affinity interaction between HIV-1 Vpr and specific sequences that span the C/EBP and adjacent NF-kappaB sites within the HIV-1 LTR correlate with HIV-1-associated dementia DNA Cell Biol, 23, pp. 261-269. http://www4.infotrieve.com/ newmedline/detail.asp?NameID=15142383&Session=&searchQuery= DNA+Cell+Biol%5BJournal+Name%5D+AND+23%5BVolume%5D+AND+261%5BPage+ Number%5D+AND+2004%5BPublication+Date%5D+AND+Burdo%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1044-5498&vol=23&iss=&firstpage=261 http://dx.doi.org/10.1089%2F104454904773819842
5. Chakrabarti, L and Baptiste, V and Khatissian, E and Cumont, M and Aubertin, A and Montagnier, L and Hurtrel, B. (1995) Limited viral spread and rapid immune response in lymph nodes of macaques inoculated with attenuated simian immunodeficiency virus Virology, 213, pp. 535-548. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=7491778&Session=&searchQuery= Virology%5BJournal+Name%5D+AND+213%5BVolume%5D+AND+535%5BPage+ Number%5D+AND+1995%5BPublication+Date%5D+AND+Chakrabarti%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0042-6822&vol=213&iss=&firstpage=535 http://dx.doi.org/10.1006%2Fviro.1995.0026
6. Churchill, M and Rhodes, D and Learmont, J and Sullivan, J and Wesselingh, S and Cooke, I and Deacon, N and Gorry, P. (2006) Longitudinal analysis of human immunodeficiency virus type 1 nef/long terminal repeat sequences in a cohort of long-term survivors infected from a single source J Virol, 80, pp. 1047-1052. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=16379007&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+80%5BVolume%5D+AND+1047%5BPage+Number%5D+ AND+2006%5BPublication+Date%5D+AND+Churchill%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=80&iss=&firstpage=1047 http://dx.doi.org/10.1128%2FJVI.80.2.1047-1052.2006
7. Churchill, M and Sterjovski, J and Gray, L and Cowley, D and Chatfield, C and Learmont, J and Sullivan, J and Crowe, S and Mills, J and Brew, B and Wesselingh, S and McPhee, D and Gorry, P. (2004) Longitudinal analysis of nef/long terminal repeat-deleted HIV-1 in blood and cerebrospinal fluid of a long-term survivor who developed HIV-associated dementia J Infect Dis, 190, pp. 2181-2186. http://www4.infotrieve.com/ newmedline/detail.asp?NameID=15551218&Session=&searchQuery=J+ Infect+Dis%5BJournal+Name%5D+AND+190%5BVolume%5D+AND+2181%5BPage+ Number%5D+AND+2004%5BPublication+Date%5D+AND+Churchill%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1344-6304&vol=190&iss=&firstpage=2181 http://dx.doi.org/10.1086%2F425585
8. Crowe, S and Ho, D and Marriott, D and Brew, B and Gorry, P and Sullivan, J and Learmont, J and Mills, J. (2005) In vivo replication kinetics of a nef-deleted strain of HIV-1 AIDS, 19, pp. 842-843. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=15867504&Session=&searchQuery=AIDS%5BJournal+ Name%5D+AND+19%5BVolume%5D+AND+842%5BPage+Number%5D+AND+ 2005%5BPublication+Date%5D+AND+Crowe%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=0856-3969&vol= 19&iss=&firstpage=842 http://dx.doi.org/ 10.1097%2F01.aids.0000168984.05209.f1
9. Deacon, N and Tsykin, A and Solomon, A and Smith, K and Ludford-Menting, M and Hooker, D and McPhee, D and Greenway, A and Ellett, A and Chatfield, C and (1995) Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients Science, 270, pp. 988-991. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=7481804&Session=&searchQuery=Science%5BJournal+ Name%5D+AND+270%5BVolume%5D+AND+988%5BPage+Number%5D+AND+ 1995%5BPublication+Date%5D+AND+Deacon%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=0294-0337&vol= 270&iss=&firstpage=988
10. Desrosiers, R and Lifson, J and Gibbs, J and Czajak, S and Howe, A and Arthur, L and Johnson, R. (1998) Identification of highly attenuated mutants of simian immunodeficiency virus J Virol, 72, pp. 1431-1437. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=9445045&Session=&searchQuery=J+Virol%5BJournal+ Name%5D+AND+72%5BVolume%5D+AND+1431%5BPage+Number%5D+AND+ 1998%5BPublication+Date%5D+AND+Desrosiers%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=0022-538X&vol= 72&iss=&firstpage=1431
11. Dunfee, R and Thomas, E and Gorry, P and Wang, J and Ancuta, P and Gabuzda, D. (2006) Mechanisms of HIV-1 Neurotropism Curr HIV Res, 4, pp. 267-278. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=16842080&Session=&searchQuery=Curr+HIV+ Res%5BJournal+Name%5D+AND+4%5BVolume%5D+AND+267%5BPage+Number%5D+ AND+2006%5BPublication+Date%5D+AND+Dunfee%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=1570-162X&vol= 4&iss=&firstpage=267 http://dx.doi.org/ 10.2174%2F157016206777709500
12. Gabuzda, D and Wang, J. (2000) Chemokine receptors and mechanisms of cell death in HIV neuropathogenesis J NeuroVirol, 6(Suppl 1), pp. S24-S32. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=10871762&Session=&searchQuery=J+ NeuroVirol%5BJournal+Name%5D+AND+6%5BVolume%5D+AND+S24%5BPage+ Number%5D+AND+2000%5BPublication+Date%5D+AND+Gabuzda%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1355-0284&vol=6&iss=Suppl+1&firstpage=S24
13. Gabuzda, D and Wang, J and Gorry, P.(2002) HIV-1-associated dementia. In Universes in delicate balance: Chemokines and the nervous system. (pp. 345-360). Amsterdam: Elsevier Science.
14. Gonzalez-Scarano, F and Martin-Garcia, J. (2005) The neuropathogenesis of AIDS Nat Rev Immunol, 5, pp. 69-81. http://www4.infotrieve.com/ newmedline/detail.asp?NameID=15630430&Session=&searchQuery= Nat+Rev+Immunol%5BJournal+Name%5D+AND+5%5BVolume%5D+AND+69%5BPage+ Number%5D+AND+2005%5BPublication+Date%5D+AND+ Gonzalez%2DScarano%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=1474-1733&vol= 5&iss=&firstpage=69 http://dx.doi.org/10.1038%2Fnri1527
15. Gorry, P and Purcell, D and Howard, J and McPhee, D. (1998) Restricted HIV-1 infection of human astrocytes: Potential role of nef in the regulation of virus replication J NeuroVirol, 4, pp. 377-386. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=9718129&Session=&searchQuery=J+ NeuroVirol%5BJournal+Name%5D+AND+4%5BVolume%5D+AND+377%5BPage+ Number%5D+AND+1998%5BPublication+Date%5D+AND+Gorry%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1355-0284&vol=4&iss=&firstpage=377
16. Gorry, P and Bristol, G and Zack, J and Ritola, K and Swanstrom, R and Birch, C and Bell, J and Bannert, N and Crawford, K and Wang, H and Schols, D and De Clercq, E and Kunstman, K and Wolinsky, S and Gabuzda, D. (2001) Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity J Virol, 75, pp. 10073-10089. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=11581376&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+75%5BVolume%5D+AND+10073%5BPage+ Number%5D+AND+2001%5BPublication+Date%5D+AND+Gorry%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=75&iss=&firstpage=10073 http://dx.doi.org/10.1128%2FJVI.75.21.10073-10089.2001
17. Gorry, P and Taylor, J and Holm, G and Mehle, A and Morgan, T and Cayabyab, M and Farzan, M and Wang, H and Bell, J and Kunstman, K and Moore, J and Wolinsky, S and Gabuzda, D. (2002) Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate J Virol, 76, pp. 6277-6292. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=12021361&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+76%5BVolume%5D+AND+6277%5BPage+ Number%5D+AND+2002%5BPublication+Date%5D+AND+Gorry%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=76&iss=&firstpage=6277 http://dx.doi.org/10.1128%2FJVI.76.12.6277-6292.2002
18. Gray, L and Sterjovski, J and Churchill, M and Ellery, P and Nasr, N and Lewin, S and Crowe, S and Wesselingh, S and Cunningham, A and Gorry, P. (2005) Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome Virology, 337, pp. 384-398. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=15916792&Session=&searchQuery= Virology%5BJournal+Name%5D+AND+337%5BVolume%5D+AND+384%5BPage+ Number%5D+AND+2005%5BPublication+Date%5D+AND+Gray%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0042-6822&vol=337&iss=&firstpage=384 http://dx.doi.org/10.1016%2Fj.virol.2005.04.034
19. He, J and Chen, Y and Farzan, M and Choe, H and Ohagen, A and Gartner, S and Busciglio, J and Yang, X and Hofmann, W and Newman, W and Mackay, C and Sodroski, J and Gabuzda, D. (1997) CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia Nature, 385, pp. 645-649. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=9024664&Session=&searchQuery= Nature%5BJournal+Name%5D+AND+385%5BVolume%5D+AND+645%5BPage+ Number%5D+AND+1997%5BPublication+Date%5D+AND+He%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0028-0887&vol=385&iss=&firstpage=645 http://dx.doi.org/10.1038%2F385645a0
20. Hofmann-Lehmann, R and Vlasak, J and Williams, A and Chenine, A and McClure, H and Anderson, D and O'Neil, S and Ruprecht, R. (2003) Live attenuated, nef-deleted SIV is pathogenic in most adult macaques after prolonged observation AIDS, 17, pp. 157-166. http://www4.infotrieve.com/ newmedline/detail.asp?NameID=12545074&Session=&searchQuery= AIDS%5BJournal+Name%5D+AND+17%5BVolume%5D+AND+157%5BPage+ Number%5D+AND+2003%5BPublication+Date%5D+AND+Hofmann%2DLehmann%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0856-3969&vol=17&iss=&firstpage=157 http://dx.doi.org/10.1097%2F00002030-200301240-00004
21. Hogan, T and Stauff, D and Krebs, F and Gartner, S and Quiterio, S and Wigdahl, B. (2003) Structural and functional evolution of human immunodeficiency virus type 1 long terminal repeat CCAAT/enhancer binding protein sites and their use as molecular markers for central nervous system disease progression J NeuroVirol, 9, pp. 55-68. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=12587069&Session=&searchQuery=J+ NeuroVirol%5BJournal+Name%5D+AND+9%5BVolume%5D+AND+55%5BPage+ Number%5D+AND+2003%5BPublication+Date%5D+AND+Hogan%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1355-0284&vol=9&iss=&firstpage=55
22. Iafrate, A and Carl, S and Bronson, S and Stahl-Hennig, C and Swigut, T and Skowronski, J and Kirchhoff, F. (2000) Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo J Virol, 74, pp. 9836-9844. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=11024110&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+74%5BVolume%5D+AND+9836%5BPage+ Number%5D+AND+2000%5BPublication+Date%5D+AND+Iafrate%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=74&iss=&firstpage=9836 http://dx.doi.org/10.1128%2FJVI.74.21.9836-9844.2000
23. Jeeninga, R and Hoogenkamp, M and Armand-Ugon, M and de Baar, M and Verhoef, K and Berkhout, B. (2000) Functional differences between the long terminal repeat transcriptional promoters of human immunodeficiency virus type 1 subtypes A through G J Virol, 74, pp. 3740-3751. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=10729149&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+74%5BVolume%5D+AND+3740%5BPage+ Number%5D+AND+2000%5BPublication+Date%5D+AND+Jeeninga%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=74&iss=&firstpage=3740 http://dx.doi.org/10.1128%2FJVI.74.8.3740-3751.2000
24. Joag, S and Stephens, E and Galbreath, D and Zhu, G and Li, Z and Foresman, L and Zhao, L and Pinson, D and Narayan, O. (1995) Simian immunodeficiency virus SIVmac chimeric virus whose env gene was derived from SIV-encephalitic brain is macrophage-tropic but not neurovirulent J Virol, 69, pp. 1367-1369. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=7815523&Session=&searchQuery=J+Virol%5BJournal+ Name%5D+AND+69%5BVolume%5D+AND+1367%5BPage+Number%5D+AND+ 1995%5BPublication+Date%5D+AND+Joag%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=0022-538X&vol= 69&iss=&firstpage=1367
25. Kestler, H, 3rd and Ringler, D and Mori, K and Panicali, D and Sehgal, P and Daniel, M and Desrosiers, R. (1991) Importance of the nef gene for maintenance of high virus loads and for development of AIDS Cell, 65, pp. 651-662. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=2032289&Session=&searchQuery=Cell%5BJournal+ Name%5D+AND+65%5BVolume%5D+AND+651%5BPage+Number%5D+AND+ 1991%5BPublication+Date%5D+AND+Kestler%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=0576-9787&vol= 65&iss=&firstpage=651 http://dx.doi.org/ 10.1016%2F0092-8674%2891%2990097-I
26. Kirchhoff, F and Greenough, T and Brettler, D and Sullivan, J and Desrosiers, R. (1995) Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection N Engl J Med, 332, pp. 228-232. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=7808489&Session=&searchQuery=N+Engl+J+ Med%5BJournal+Name%5D+AND+332%5BVolume%5D+AND+228%5BPage+Number%5D+ AND+1995%5BPublication+Date%5D+AND+Kirchhoff%5BAuthor+Name%5D& count=1 http://www.csa.com/htbin/linkabst.cgi?issn=0028-4793&vol= 332&iss=&firstpage=228 http://dx.doi.org/ 10.1056%2FNEJM199501263320405
27. Kondo, M and Shima, T and Nishizawa, M and Sudo, K and Iwamuro, S and Okabe, T and Takebe, Y and Imai, M. (2005) Identification of attenuatedvariants of HIV-1 circulating recombinant form 01Æ that are associated with slow disease progression due to gross genetic alterations in the nef/long terminal repeat sequences J Infect Dis, 192, pp. 56-61. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=15942894&Session=&searchQuery=J+Infect+ Dis%5BJournal+Name%5D+AND+192%5BVolume%5D+AND+56%5BPage+Number%5D+ AND+2005%5BPublication+Date%5D+AND+Kondo%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=1344-6304&vol=192&iss= &firstpage=56 http://dx.doi.org/10.1086%2F430739
28. Korber, B and MacInnes, K and Smith, R and Myers, G. (1994) Mutational trends in V3 loop protein sequences observed in different genetic lineages of human immunodeficiency virus type 1 J Virol, 68, pp. 6730-6744. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=8084005&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+68%5BVolume%5D+AND+6730%5BPage+ Number%5D+AND+1994%5BPublication+Date%5D+AND+Korber%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=68&iss=&firstpage=6730
29. Learmont, J and Tindall, B and Evans, L and Cunningham, A and Cunningham, P and Wells, J and Penny, R and Kaldor, J and Cooper, D. (1992) Long-term symptomless HIV-1 infection in recipients of blood products from a single donor Lancet, 340, pp. 863-867. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=1357294&Session=&searchQuery= Lancet%5BJournal+Name%5D+AND+340%5BVolume%5D+AND+863%5BPage+ Number%5D+AND+1992%5BPublication+Date%5D+AND+Learmont%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1474-4422&vol=340&iss=&firstpage=863 http://dx.doi.org/10.1016%2F0140-6736%2892%2993281-Q
30. Learmont, J and Geczy, A and Mills, J and Ashton, L and Raynes-Greenow, C and Garsia, R and Dyer, W and McIntyre, L and Oelrichs, R and Rhodes, D and Deacon, N and Sullivan, J. (1999) Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort N Engl J Med, 340, pp. 1715-1722. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=10352163&Session=&searchQuery=N+Engl+J+ Med%5BJournal+Name%5D+AND+340%5BVolume%5D+AND+1715%5BPage+Number%5D+ AND+1999%5BPublication+Date%5D+AND+Learmont%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0028-4793&vol=340&iss=&firstpage=1715 http://dx.doi.org/10.1056%2FNEJM199906033402203
31. Li, S and Juarez, J and Alali, M and Dwyer, D and Collman, R and Cunningham, A and Naif, H. (1999) Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates J Virol, 73, pp. 9741-9755. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=10559284&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+73%5BVolume%5D+AND+9741%5BPage+ Number%5D+AND+1999%5BPublication+Date%5D+AND+Li%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=73&iss=&firstpage=9741
32. Li, Y and Hui, H and Burgess, C and Price, R and Sharp, P and Hahn, B and Shaw, G. (1992) Complete nucleotide sequence, genome organization, and biological properties of human immunodeficiency virus type 1 in vivo: Evidence for limited defectiveness and complementation J Virol, 66, pp. 6587-6600. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=1404605&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+66%5BVolume%5D+AND+6587%5BPage+ Number%5D+AND+1992%5BPublication+Date%5D+AND+Li%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=66&iss=&firstpage=6587
33. Li, Y and Kappes, J and Conway, J and Price, R and Shaw, G and Hahn, B. (1991) Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: Identification of replication-competent and -defective viral genomes J Virol, 65, pp. 3973-3985. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=1830110&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+65%5BVolume%5D+AND+3973%5BPage+ Number%5D+AND+1991%5BPublication+Date%5D+AND+Li%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=65&iss=&firstpage=3973
34. Mankowski, J and Flaherty, M and Spelman, J and Hauer, D and Didier, P and Amedee, A and Murphey-Corb, M and Kirstein, L and Munoz, A and Clements, J and Zink, M. (1997) Pathogenesis of simian immunodeficiency virus encephalitis: Viral determinants of neurovirulence J Virol, 71, pp. 6055-6060. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=9223498&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+71%5BVolume%5D+AND+6055%5BPage+ Number%5D+AND+1997%5BPublication+Date%5D+AND+Mankowski%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=71&iss=&firstpage=6055
35. Mariani, R and Kirchhoff, F and Greenough, T and Sullivan, J and Desrosiers, R and Skowronski, J. (1996) High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection J Virol, 70, pp. 7752-7764. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=8892896&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+70%5BVolume%5D+AND+7752%5BPage+ Number%5D+AND+1996%5BPublication+Date%5D+AND+Mariani%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=70&iss=&firstpage=7752
36. Martin-Garcia, J and Cao, W and Varela-Rohena, A and Plassmeyer, M and Gonzalez-Scarano, F. (2006) HIV-1 tropism for the central nervous system: Brain-derived envelope glycoproteins with lower CD4 dependence and reduced sensitivity to a fusion inhibitor Virology, 346, pp. 169-179. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=16309726&Session=&searchQuery= Virology%5BJournal+Name%5D+AND+346%5BVolume%5D+AND+169%5BPage+ Number%5D+AND+2006%5BPublication+Date%5D+AND+Martin%2DGarcia%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0042-6822&vol=346&iss=&firstpage=169 http://dx.doi.org/10.1016%2Fj.virol.2005.10.031
37. Martin-Garcia, J and Cocklin, S and Chaiken, I and Gonzalez-Scarano, F. (2005) Interaction with CD4 and antibodies to CD4-induced epitopes of the envelope gp120 from a microglial cell-adapted human immunodeficiency virus type 1 isolate J Virol, 79, pp. 6703-6713. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=15890908&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+79%5BVolume%5D+AND+6703%5BPage+ Number%5D+AND+2005%5BPublication+Date%5D+AND+Martin%2DGarcia%5BAuthor+ Name%5Dcount=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=79&iss=&firstpage=6703 http://dx.doi.org/10.1128%2FJVI.79.11.6703-6713.2005
38. Messmer, D and Ignatius, R and Santisteban, C and Steinman, R and Pope, M. (2000) The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cellsand T cells J Virol, 74, pp. 2406-2413. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=10666271&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+74%5BVolume%5D+AND+2406%5BPage+ Number%5D+AND+2000%5BPublication+Date%5D+AND+Messmer%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=74&iss=&firstpage=2406 http://dx.doi.org/10.1128%2FJVI.74.5.2406-2413.2000
39. Miller, M and Warmerdam, M and Gaston, I and Greene, W and Feinberg, M. (1994) The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages J Exp Med, 179, pp. 101-113. http://www4.infotrieve.com/ newmedline/detail.asp?NameID=8270859&Session=&searchQuery=J+Exp+ Med%5BJournal+Name%5D+AND+179%5BVolume%5D+AND+101%5BPage+Number%5D+ AND+1994%5BPublication+Date%5D+AND+Miller%5BAuthor+Name%5D&count=1 http://www.csa.com/htbin/linkabst.cgi?issn=0021-5031&vol= 179&iss=&firstpage=101 http://dx.doi.org/ 10.1084%2Fjem.179.1.101
40. Millhouse, S and Krebs, F and Yao, J and McAllister, J and Conner, J and Ross, H and Wigdahl, B. (1998) Sp1 and related factors fail to interact with the NF-kappaB-proximal G/C box in the LTR of a replication competent, brain-derived strain of HIV-1 (YU-2) J NeuroVirol, 4, pp. 312-323. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=9639074&Session=&searchQuery=J+ NeuroVirol%5BJournal+Name%5D+AND+4%5BVolume%5D+AND+312%5BPage+ Number%5D+AND+1998%5BPublication+Date%5D+AND+Millhouse%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1355-0284&vol=4&iss=&firstpage=312
41. O'Brien, W and Koyanagi, Y and Namazie, A and Zhao, J and Diagne, A and Idler, K and Zack, J and Chen, I. (1990) HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain Nature, 348, pp. 69-73. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=2172833&Session=&searchQuery= Nature%5BJournal+Name%5D+AND+348%5BVolume%5D+AND+69%5BPage+Number%5D+ AND+1990%5BPublication+Date%5D+AND+O%27Brien%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0028-0887&vol=348&iss=&firstpage=69 http://dx.doi.org/10.1038%2F348069a0
42. Ohagen, A and Devitt, A and Kunstman, K and Gorry, P and Rose, P and Korber, B and Taylor, J and Levy, R and Murphy, R and Wolinsky, S and Gabuzda, D. (2003) Genetic and functional analysis of full-length human immunodeficiency virus type 1 env genes derived from brain and blood of patients with AIDS J Virol, 77, pp. 12336-12345. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=14581570&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+77%5BVolume%5D+AND+12336%5BPage+ Number%5D+AND+2003%5BPublication+Date%5D+AND+Ohagen%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=77&iss=&firstpage=12336 http://dx.doi.org/10.1128%2FJVI.77.22.12336-12345.2003
43. Peters, P and Bhattacharya, J and Hibbitts, S and Dittmar, M and Simmons, G and Bell, J and Simmonds, P and Clapham, P. (2004) Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages J Virol, 78, pp. 6915-6926. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=15194768&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+78%5BVolume%5D+AND+6915%5BPage+ Number%5D+AND+2004%5BPublication+Date%5D+AND+Peters%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=78&iss=&firstpage=6915 http://dx.doi.org/10.1128%2FJVI.78.13.6915-6926.2004
44. Power, C and McArthur, J and Johnson, R and Griffin, D and Glass, J and Perryman, S and Chesebro, B. (1994) Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences J Virol, 68, pp. 4643-4649. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=8207838&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+68%5BVolume%5D+AND+4643%5BPage+ Number%5D+AND+1994%5BPublication+Date%5D+AND+Power%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=68&iss=&firstpage=4643
45. Rhodes, D and Ashton, L and Solomon, A and Carr, A and Cooper, D and Kaldor, J and Deacon, N. (2000) Characterization of three nef-defective human immunodeficiency virus type 1 strains associated with long-term nonprogression. Australian Long-Term Nonprogressor Study Group J Virol, 74, pp. 10581-10588. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=11044102&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+74%5BVolume%5D+AND+10581%5BPage+ Number%5D+AND+2000%5BPublication+Date%5D+AND+Rhodes%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=74&iss=&firstpage=10581 http://dx.doi.org/10.1128%2FJVI.74.22.10581-10588.2000
46. Ross, H and Gartner, S and McArthur, J and Corboy, J and McAllister, J and Millhouse, S and Wigdahl, B. (2001a) HIV-1 LTR C/EBP binding site sequence configurations preferentially encountered in brain lead to enhanced C/EBP factor binding and increased LTR-specific activity J NeuroVirol, 7, pp. 235-249. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=11517398&Session=&searchQuery=J+ NeuroVirol%5BJournal+Name%5D+AND+7%5BVolume%5D+AND+235%5BPage+ Number%5D+AND+2001%5BPublication+Date%5D+AND+Ross%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1355-0284&vol=7&iss=&firstpage=235 http://dx.doi.org/10.1080%2F13550280152403281
47. Ross, H and Nonnemacher, M and Hogan, T and Quiterio, S and Henderson, A and McAllister, J and Krebs, F and Wigdahl, B. (2001b) Interaction between CCAAT/enhancer binding protein and cyclic AMP response element binding protein 1 regulates human immunodeficiency virus type 1 transcription in cells of the monocyte/macrophage lineag J Virol, 75, pp. 1842-1856. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=11160683&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+75%5BVolume%5D+AND+1842%5BPage+ Number%5D+AND+2001%5BPublication+Date%5D+AND+Ross%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=75&iss=&firstpage=1842 http://dx.doi.org/10.1128%2FJVI.75.4.1842-1856.2001
48. Ryan-Graham, M and Peden, K. (1995) Both virus and host components are important for the manifestation of a Nef-phenotype in HIV-1 and HIV-2 Virology, 213, pp. 158-168. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=7483259&Session=&searchQuery= Virology%5BJournal+Name%5D+AND+213%5BVolume%5D+AND+158%5BPage+ Number%5D+AND+1995%5BPublication+Date%5D+AND+Ryan%2DGraham%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0042-6822&vol=213&iss=&firstpage=158 http://dx.doi.org/10.1006%2Fviro.1995.1556
49. Sacktor, N and McDermott, M and Marder, K and Schifitto, G and Selnes, O and McArthur, J and Stern, Y and Albert, S and Palumbo, D and Kieburtz, K and De Marcaida, J and Cohen, B and Epstein, L. (2002) HIV-associated cognitive impairment before and after the advent of combination therapy J NeuroVirol, 8, pp. 136-142. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=11935465&Session=&searchQuery=J+ NeuroVirol%5BJournal+Name%5D+AND+8%5BVolume%5D+AND+136%5BPage+ Number%5D+AND+2002%5BPublication+Date%5D+AND+Sacktor%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1355-0284&vol=8&iss=&firstpage=136
50. Schwartz, C and Catez, P and Rohr, O and Lecestre, D and Aunis, D and Schaeffer, E. (2000) Functional interactions between C/EBP, Sp1, and COUP-TF regulate human immunodeficiency virus type 1 gene transcription in human brain cells J Virol, 74, pp. 65-73. http://www4.infotrieve.com/ newmedline/detail.asp?NameID=10590092&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+74%5BVolume%5D+AND+65%5BPage+ Number%5D+AND+2000%5BPublication+Date%5D+AND+Schwartz%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=74&iss=&firstpage=65
51. Shieh, J and Albright, A and Sharron, M and Gartner, S and Strizki, J and Doms, R and Gonzalez-Scarano, F. (1998) Chemokine receptor utilization by human immunodeficiency virus type 1 isolates that replicate in microglia J Virol, 72, pp. 4243-4249. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=10590092&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+74%5BVolume%5D+AND+65%5BPage+ Number%5D+AND+2000%5BPublication+Date%5D+AND+Schwartz%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=72&iss=&firstpage=4243
52. Shieh, J and Martin, J and Baltuch, G and Malim, M and Gonzalez-Scarano, F. (2000) Determinants of syncytium formation in microglia by human immunodeficiency virus type 1: Role of the V1/V2 domains J Virol, 74, pp. 693-701. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=10623731&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+74%5BVolume%5D+AND+693%5BPage+ Number%5D+AND+2000%5BPublication+Date%5D+AND+Shieh%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=74&iss=&firstpage=693
53. Singh, D and McCormick, C and Pacyniak, E and Griffin, D and Pinson, D and Sun, F and Berman, N and Stephens, E. (2002) Pathogenic and nef-interrupted simian-human immunodeficiency viruses traffic to the macaque CNS and cause astrocytosis early after inoculation Virology, 296, pp. 39-51. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=12036316&Session=&searchQuery= Virology%5BJournal+Name%5D+AND+296%5BVolume%5D+AND+39%5BPage+ Number%5D+AND+2002%5BPublication+Date%5D+AND+Singh%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0042-6822&vol=296&iss=&firstpage=39
54. Smit, T and Brew, B and Tourtellotte, W and Morgello, S and Gelman, B and Saksena, N. (2004) Independent evolution of human immunodeficiency virus (HIV) drug resistance mutations in diverse areas of the brain in HIV-infected patients, with and without dementia, on antiretroviral treatment J Virol, 78, pp. 10133-10148. http://www4.infotrieve.com/ newmedline/detail.asp?NameID=15331746&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+78%5BVolume%5D+AND+10133%5BPage+ Number%5D+AND+2004%5BPublication+Date%5D+AND+Smit%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=78&iss=&firstpage=10133 http://dx.doi.org/10.1128%2FJVI.78.18.10133-10148.2004
55. Smit, T and Wang, B and Ng, T and Osborne, R and Brew, B and Saksena, N. (2001) Varied tropism of HIV-1 isolates derived from different regions of adult brain cortex discriminate between patients with and without AIDS dementia complex (ADC): Evidence for neurotropic HIV variants Virology, 279, pp. 509-526. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=11162807&Session=&searchQuery= Virology%5BJournal+Name%5D+AND+279%5BVolume%5D+AND+509%5BPage+ Number%5D+AND+2001%5BPublication+Date%5D+AND+Smit%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0042-6822&vol=279&iss=&firstpage=509 http://dx.doi.org/10.1006%2Fviro.2000.0681
56. Strain, M and Letendre, S and Pillai, S and Russell, T and Ignacio, C and Gunthard, H and Good, B and Smith, D and Wolinsky, S and Furtado, M and Marquie-Beck, J and Durelle, J and Grant, I and Richman, D and Marcotte, T and McCutchan, J and Ellis, R and Wong, J. (2005) Genetic composition of human immunodeficiency virus type 1 in cerebrospinal fluid and blood without treatment and during failing antiretroviral therapy J Virol, 79, pp. 1772-1788. http://www4.infotrieve.com/ newmedline/detail.asp?NameID=15650202&Session=&searchQuery=J+ Virol%5BJournal+Name%5D+AND+79%5BVolume%5D+AND+1772%5BPage+ Number%5D+AND+2005%5BPublication+Date%5D+AND+Strain%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0022-538X&vol=79&iss=&firstpage=1772 http://dx.doi.org/10.1128%2FJVI.79.3.1772-1788.2005
57. Thompson, K and Kent, S and Gahan, M and Purcell, D and McLean, C and Preiss, S and Dale, C and Wesselingh, S. (2003) Decreased neurotropism of nef long terminal repeat (nef/LTR)-deleted simian immunodeficiency virus J NeuroVirol, 9, pp. 442-451. http://www4.infotrieve.com/ newmedline/detail.asp?NameID=12907389&Session=&searchQuery=J+ NeuroVirol%5BJournal+Name%5D+AND+9%5BVolume%5D+AND+442%5BPage+ Number%5D+AND+2003%5BPublication+Date%5D+AND+Thompson%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1355-0284&vol=9&iss=&firstpage=442
58. van Marle, G and Power, C. (2005) Human immunodeficiency virus type 1 genetic diversity in the nervous system: Evolutionary epiphenomenon or disease determinant? J NeuroVirol, 11, pp. 107-128. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=16036790&Session=&searchQuery=J+ NeuroVirol%5BJournal+Name%5D+AND+11%5BVolume%5D+AND+107%5BPage+ Number%5D+AND+2005%5BPublication+Date%5D+AND+van+Marle%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=1355-0284&vol=11&iss=&firstpage=107 http://dx.doi.org/10.1080%2F13550280590922838
59. Wesselingh, S and Power, C and Glass, J and Tyor, W and McArthur, J and Farber, J and Griffin, J and Griffin, D. (1993) Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia Ann Neurol, 33, pp. 576-582. http://www4.infotrieve.com/newmedline/ detail.asp?NameID=8498837&Session=&searchQuery=Ann+ Neurol%5BJournal+Name%5D+AND+33%5BVolume%5D+AND+576%5BPage+ Number%5D+AND+1993%5BPublication+Date%5D+AND+Wesselingh%5BAuthor+ Name%5D&count=1 http://www.csa.com/htbin/ linkabst.cgi?issn=0364-5134&vol=33&iss=&firstpage=57 http://dx.doi.org/10.1002%2Fana.410330604