Varied tropism of HIV-1 isolates derived from different regions of adult brain cortex discriminate between patients with and without AIDS dementia complex (ADC): Evidence for neurotropic HIV variants

Virology

Volumn 279, Issue 2, 2001, Pages 509-526

  Smit, Theresa K ^a   Wang, Bin ^a   Ng, Thomas ^b   Osborne, Robert ^b   Brew, Bruce ^c   Saksena, Nitin K ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WESTMEAD HOSPITAL   (Australia)

^c ST VINCENT S HOSPITAL   (Australia)

Author keywords

AIDS dementia; Coreceptors; HIV; Macrophages; Monocytes

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; BRAIN CELL; BRAIN CORTEX; BRAIN REGION; BRAIN TISSUE; CASE REPORT; CELL CULTURE; CELL TYPE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FRONTAL LOBE; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MACROPHAGE; MALE; MONOCYTE; NEUROPATHOLOGY; NUCLEOTIDE SEQUENCE; OCCIPITAL LOBE; PARIETAL LOBE; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; VIRAL GENETICS; VIRUS ISOLATION; VIRUS STRAIN;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0035864287     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0681     Document Type: Article

References (53)

1. HIV-1 infection of brain
2. Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif: Flexibility in aphthovirus receptor usage
3. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes
4. Unique HIV type 1 V3 region sequences derived from six different regions of brain: Region-specific evolution within host-determined quasispecies
5. Macrophage tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell tropic isolates: Definition of critical amino acids involved in cell tropism
6. Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression
7. Early viral brain invasion in iatrogenic human immunodeficiency virus infection
8. Minimal requirements for the HIV-1 V3 domain to support the syncytium-inducing phenotype: Analysis by single amino acid substitution
9. Genetic subtyping of human immunodeficiency virus using a heteroduplex mobility assay
10. HIV type 1 V3 sequences and the development of dementia during AIDS
11. Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus
12. In vivo distribution and cytopathology of variants of human immunodeficiency virus type 1 showing restricted sequence variability in the V3 loop
13. HIV-1 V3 domain variation in brain and spleen of children with AIDS: Tissue-specific evolution within host determined quasispecies
14. PHYLIP-Phylogenetic Inference Package (version 3.2)
15. Evidence for a functional interaction between the V1/V2 and C4 domains of human immunodeficiency virus type 1 envelope glycoprotein gp120
16. Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule
17. Chemokine receptors in HIV-1 infection of the central nervous system
18. Role of the β-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia
19. Dementia and pancytopenia in a patient who died of AIDS within one year after primary human immunodeficiency virus infection was diagnosed
20. Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1
21. Genetic determinants of Dengue type 4 virus neurovirulence for mice
22. V3 sequences of paired HIV-1 isolates from blood and cerebrospinal fluid cluster according to host and show variation related to the clinical stage of disease
23. A simple model for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences
24. Genetic differences between blood and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: Evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences
25. CXCR-4 (fusin), a coreceptor for the type 1 human immunodeficiency virus (HW-1), is expressed in the human brain in a variety of cell types, including microglia and neurons
26. Dementia in AIDS patients: Incidence and risk factors
27. Change in tropism upon immune escape by human immunodeficiency virus
28. Microglia in the giant cell encephalitis of acquired immune deficiency syndrome: Proliferation, infection and fusion
29. Astrocytes and the AIDS dementia complex
30. Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences
31. The brain in AIDS: Central nervous system HIV-1 infection and AIDS dementia complex
32. Early penetration of the blood-brain-barrier by HIV
33. Molecular and biological mechanisms in the development of AIDS dementia complex (ADC)
34. Cellular receptors for viruses: Links to tropism and pathogenesis
35. Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: Progression of disease is associated with a shift from monocytotropic to T-cell tropic virus population
36. HTLV-III infection in brains of children and adults with AIDS encephalopathy
37. Chemokine receptor utilization by human immuno-deficiency virus type 1 isolates that replicate in microglia
38. A naturally occurring single base amino acid substitution in the V3 region of the human immunodeficiency virus type 1 env protein alters the cellular host range and antigenic structure of the virus
39. Infection of primary human microglia and monocyte-derived macrophages with human immunodeficiency virus type 1 isolates: Evidence of differential tropism
40. Site-directed mutagenesis of the codon for IIe-25 in gPr80env alters the neuro-virulence of ts1, a mutant of Moloney murine leukemia virus TB
41. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
42. Viral determinants of age-dependent virulence of Sindbis virus for mice
43. Virus entry: Two receptors are better than one
44. Localization of HIV-1 coreceptors CCR5 and CXCR4 in the brain of children with AIDS
45. Selection of HIV-1 genotypes by cultivation in different primary cells
46. Gene defects clustered at the C-terminus of the vpr gene of HIV-1 in long term nonprogressing mother and child pair: In vivo evolution of vpr quasispecies in blood and plasma
47. Specific tropism of HIV-1 for microglial cells in primary human brain cultures
48. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients
49. In vivo compartmentalization of human immunodeficiency virus: Evidence from the examination of pol sequences from autopsy tissues
50. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1 in vitro
51. The HIV-1 envelope glycoproteins, fusogens, antigens and immunogens
52. CCR5 coreceptor usage of non-syncytium-inducing primary HIV-1 is independent of phylogenetically distinct global HIV-1 isolates: Delineation of consensus motif in the V3 domain that predicts CCR-5 usage
53. Intracellular CXCR4 signaling, neuronal apoptosis, and the neuropathogenic mechanisms for HIV-1 associated dementia