Rapid assessment of the structural relaxation behavior of amorphous pharmaceutical solids: Effect of residual water on molecular mobility

Pharmaceutical Research

Volumn 23, Issue 10, 2006, Pages 2291-2305

  Miller, Danforth P ^a   Lechuga Ballesteros, David ^a  

^a NEKTAR THERAPEUTICS   (United States)

Author keywords

Amorphous; Enthalpy relaxation; Glass transition temperature; Hydration limit; Microcalorimetry; MITAT; Structural relaxation

Indexed keywords

RAFFINOSE; WATER;

ARTICLE; CALORIMETRY; CHEMICAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; ENTHALPY; GRAVIMETRY; HUMIDITY; ISOTHERM; LABORATORY; MATHEMATICAL MODEL; MEASUREMENT; MICROCALORIMETRY; MOISTURE; MOLECULAR INTERACTION; MOLECULE; MORPHOLOGY; PARTICLE SIZE; PERFUSION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SIMULATION; SOLID; STORAGE TEMPERATURE; THERMOGRAVIMETRY; VAPOR; WATER VAPOR; X RAY POWDER DIFFRACTION;

ADSORPTION; ALGORITHMS; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG STORAGE; FREEZE DRYING; HUMIDITY; MICROSCOPY, ELECTRON, SCANNING; MODELS, STATISTICAL; PHARMACEUTICAL PREPARATIONS; POWDERS; RAFFINOSE; TEMPERATURE; THERMOGRAVIMETRY; WATER; X-RAY DIFFRACTION;

EID: 33749447868     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9095-1     Document Type: Article

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