Stability prediction of amorphous benzodiazepines by calculation of the mean relaxation time constant using the Williams-Watts decay function

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 48, Issue 1, 1999, Pages 43-48

  Van Den Mooter, G ^a   Augustijns, P ^a   Kinget, R ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Amorphous drugs; Benzodiazepines; Enthalpy relaxation; Glass transition temperature; Molecular mobility

Indexed keywords

BENZODIAZEPINE DERIVATIVE; DIAZEPAM; GLASS; TEMAZEPAM; TRIAZOLAM;

AGING; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; ENTHALPY; MATHEMATICAL MODEL; PHASE TRANSITION; PREDICTION; RELAXATION TIME; TEMPERATURE; THERMODYNAMICS;

BENZODIAZEPINES; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHYSICAL; CRYSTALLIZATION; DIAZEPAM; DRUG STABILITY; TEMAZEPAM; THERMODYNAMICS; TIME FACTORS; TRIAZOLAM;

EID: 0032990865     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(99)00013-2     Document Type: Article

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