A pragmatic test of a simple calorimetric method for determining the fragility of some amorphous pharmaceutical materials

Pharmaceutical Research

Volumn 15, Issue 5, 1998, Pages 762-767

  Hancock, Bruno C ^a   Dalton, Chad R ^a   Pikal, Michael J ^b   Shamblin, Sheri L ^b  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Activation energy; Amorphous; Fragility; Glass transition temperature; Molecular mobility

Indexed keywords

CITRIC ACID; DRUG ADDITIVE; INDOMETACIN; LACTOSE; PLASDONE K 120; POVIDONE; RAFFINOSE; SUCROSE; TREHALOSE; UNCLASSIFIED DRUG;

ARTICLE; COOLING; DIFFERENTIAL SCANNING CALORIMETRY; DRUG STABILITY; ENTROPY; HEATING; MATERIAL STATE; MECHANICAL STRESS; MOLECULAR INTERACTION; PHASE TRANSITION; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE;

CALORIMETRY; ENERGY TRANSFER; MATHEMATICS; PHARMACEUTICAL PREPARATIONS;

EID: 0031749397     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011931305755     Document Type: Article

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