Structural and dynamic properties of crystalline and amorphous phases in raffinose-water mixtures

Pharmaceutical Research

Volumn 16, Issue 9, 1999, Pages 1441-1448

  Kajiwara, Kazuhito ^a   Franks, Felix ^b   Echlin, Patrick ^c   Greer, A Lindsay ^c  

^a TEIKYO UNIVERSITY OF SCIENCE   (Japan)

^b BioUpdate Foundation   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Dehydration; Excipient; Raffinose pentahydrate; Stabilisation; Vitrification

Indexed keywords

DRUG VEHICLE; RAFFINOSE;

ARTICLE; CRYSTAL STRUCTURE; DEHYDRATION; DRUG MIXTURE; DRUG STRUCTURE; PRIORITY JOURNAL; STRUCTURE ANALYSIS; THERMODYNAMICS; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLOGRAPHY, X-RAY; DESICCATION; EXCIPIENTS; HEAT; HYDROGEN BONDING; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, POLARIZATION; RAFFINOSE; THERMOGRAVIMETRY; WATER;

EID: 0032861291     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018915512289     Document Type: Article

References (27)

1. F. Franks, R. H. M. Hatley, and S. F. Mathias. Materials science and the production of shelf-stable biologicals. Pharm. Technol. Int. 3:24-34 (1991).
2. J. L. Green and C. A. Angell. Phase relations and vitrification in saccharide-water solutions and the trehalose anomaly. J. Phys. Chem. 93:2880-2882 (1989).
3. K. B. Storey. Biochemical adaptation for cold hardiness in insects. Phil. Trans. Roy. Soc. B326:635-654 (1990).
4. A. Sakai and W. Larcher. Frost survival of plants: Responses and adaptation to freezing stress. Ecological Studies 62; Springer, Berlin, 1987.
5. A. P. MacKenzie. Non-equilibrium freezing behaviour of aqueous systems. Phil. Trans. Roy. Soc. B278:167-188 (1977).
6. L. Slade and H. Levine. Beyond water activity: Recent advances based on an alternative approach to the assessment of food quality and safety. Crit. Rev. Food Sci. Nutrition 30:115-360 (1991).
7. L. Streefland, A. D. Auffret, and F. Franks. Bond cleavage reactions in solid aqueous carbohydrate solutions. Pharm. Res. 15:843-849 (1998).
8. C. T. Moynihan. Structural relaxation and the glass transition. Revs. Mineralogy 32:1 - 19 (1995).
9. B. J. Aldous, A. D. Auffret, and F. Franks. The crystallisation of hydrates from amorphous carbohydrates. Cryo-Letters 16:181-186 (1995).
10. A. Saleki-Gerhardt, J. G. Stowell, S. R. Byrn, and G. Zografi. Hydration and dehydration of crystalline and amorphous forms of raffinose. J. Pharm. Sci. 84:318-323 (1995).
11. S.-P. Ding, J. Fan, J. L. Green, Q. Lu, E. Sanchez, and C. A. Angell. Vitrification of trehalose by water toss from its crystalline dihydrate. J. Thermal Anal. 47:1391-1405 (1996).
12. C. J. Roberts and F. Franks. Crystalline and amorphous phases in the binary system water-β, β-trehalose. J. Chem. Soc. Faraday Trans. 92:1337-1343 (1996).
13. F. Shafizader and R. A. Sussot. Crystalline transitions of carbohydrates. J. Org. Chem. 38:3710-3715 (1973).
14. F. Sussich, R. Urbani, F. Princivalle, and A. Césaro. Polymorphic amorphous and crystalline forms of trehalose. J. Amer. Chem. Soc. 120:7893-7899 (1998).
15. K. Kajiwara and F. Franks. Crystalline and amorphous phases in the binary system water-raffinose. J. Chem. Soc. Faraday Trans. 93:1779-1783 (1997).
16. R. H. M. Hatley, F. Franks, and M. Green. A novel data acquisition, retention and examination system (DARES) for differential scanning calorimetry. Thermochim Acta 156:247-257 (1989).
17. L. Finegold, F. Franks, and R. H. M. Hatley. Glass/rubber transitions and heat capacities of binary sugar blends. J. Chem. Soc. 85:2945-2951 (1989).
18. T. Wakabayashi and F. Franks. Heat capacities of undercooled aqueous solutions of polyvinyl pyrrolidone. Z. phys. Chem. N.F. 155:171-180 (1987).
19. A. Fransson and G. Bäckström. Isothermal enthalpy relaxation of glycerol. Int. J. Thermophysics 8:351-362 (1987).
20. G. A. Jeffrey and D. Huang. The hydrogen bonding in the crystal structure of raffinose pentahydrate. Carbohydrate Res. 206:173-182 (1990).
21. C. A. Angell. Formation of glasses from liquids and biopolymers. Science 267:1924-1935 (1995).
22. W. Kauzmann. The nature of the glassy state and the behavior of liquids at low temperatures. Chem. Rev. 43:219-256 (1948).
23. C. T. Moynihan, S.-K. Lee, M. Tatsumisago, and T. Minami. Estimation of activation energies for structural relaxation and viscous flow from DTA and DSC experiments. Thermochim. Acta 280/281:153-162 (1996).
24. B. C. Hancock, S. L. Shamblin, and G. Zografi. Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures. Pharm. Res. 12:799-806 (1995).
25. M. J. Pikal, D. R. Rigsbee, and M. L. Roy. The relationship between glass transition temperature and stability of freeze-dried human growth hormone. Symp. Abstract, 10th AAPS Annual Meeting, November 5-9, 1995.
26. R. H. M. Hatley. Glass fragility and the stability of pharmaceutical preparations-excipient selection. Pharm. Dev. Technol. 2:257-264 (1997).
27. R. H. Tromp, R. Parker, and S. G. Ring. A neutron scattering study of the structure of amorphous glucose. J. Chem. Phys. 107:6038-6049 (1997).