A distant upstream promoter of the HNF-4α gene connects the transcription factors involved in maturity-onset diabetes of the young

Human Molecular Genetics

Volumn 10, Issue 19, 2001, Pages 2089-2097

  Thomas, Heike ^a   Jaschkowitz, Karin ^a   Bulman, Mike ^b   Frayling, Timothy M ^b   Mitchell, Simon M S ^b   Roosen, Simone ^a   Lingott Frieg, Anja ^a   Tack, Cees J ^c   Ellard, Sian ^b   Ryffel, Gerhart U ^a   Hattersley, Andrew T ^b  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTE NUCLEAR FACTOR 4 ALPHA; INSULIN; NUCLEAR FACTOR I ALPHA; NUCLEAR FACTOR I BETA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IPF 1; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INSULIN RELEASE; LIVER CELL; MATURITY ONSET DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SPECIFICITY;

ADULT; ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; HEPATOCYTE NUCLEAR FACTOR 4; HOMEODOMAIN PROTEINS; HUMANS; ISLETS OF LANGERHANS; LUCIFERASES; MALE; MICE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; PEDIGREE; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0034777911     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Maturity-onset diabetes of the young: Clinical heterogeneity explained by genetic heterogeneity
2. Molecular and genetic bases for maturity onset diabetes of youth
3. Molecular genetics of maturity-onset diabetes of the young
4. Linkage of type 2 diabetes to the glucokinase gene
5. Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: Implications for structure/function relationships
6. Mutations in the glucokinase gene of the fetus result in reduced birth weight
7. Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)
8. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
9. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
10. Mutation in hepatocyte nuclear factor-1β gene (TCF2) associated with MODY
11. Hepatocyte nuclear factor 4α regulates the expression of pancreatic β-cell genes implicated in glucose metabolism and nutrient-induced insulin secretion
12. Molecular targets of a human HNF1 α mutation responsible for pancreatic β-cell dysfunction
13. IPF1, a homeodomain-containing transactivator of the insulin gene
14. Insulin-promoter-factor 1 is required for pancreas development in mice
15. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
16. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
17. Mutations in the human genes encoding the transcription factors of the HNF1 and HNF4 families: Functional and pathological consequences
18. Liver-enriched transcription factors and hepatocyte differentiation
19. Hepatocyte nuclear factor 4α
20. Hepatocyte nuclear factor 4 (HNF4)
21. Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4
22. A transcriptional hierarchy involved in mammalian cell-type specification
23. Mammalian hepatocyte differentiation requires the transcription factor HNF-4α
24. Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4α binding site in the promoter of the hepatocyte nuclear factor-1α gene
25. Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression
26. Phenotypic effects of the forced expression of HNF4 and HNF1α are conditioned by properties of the recipient cell
27. HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors
28. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily
29. A novel isoform of rat hepatocyte nuclear factor 4 (HNF-4)
30. Identification of two splice isoforms of mRNA for mouse hepatocyte nuclear factor 4 (HNF-4)
31. Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes
32. Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver
33. Organization and partial sequence of the hepatocyte nuclear factor-4α/MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODY
34. An alternative splice variant of the tissue specific transcription factor HNF4α predominates in undifferentiated murine cell types
35. Liver cell specific gene transcription in vitro: The promoter elements HP1 and TATA box are necessary and sufficient to generate a liver-specific promoter
36. Mutations in hepatocyte nuclear factor 1β are not a common cause of maturity-onset diabetes of the young in the U.K
37. A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q
38. Homeodomain determinants of major groove recognition
39. Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex
40. The insulin gene contains multiple transcriptional elements that respond to glucose
41. Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic α- and β-cells
42. The human glucokinase gene β-cell-type promoter: An essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells
43. Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis
44. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
45. Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2
46. The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes
47. A physical map of the 20q12-q13.1 region associated with type 2 diabetes
48. Type 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs
49. Analysis of the HNF4α gene in Caucasian type II diabetic nephropathic patients
50. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
51. The mutated human gene encoding hepatocyte nuclear factor 1β inhibits kidney formation in developing Xenopus embryos
52. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3β in the developing murine liver and pancreas
53. Interaction between the homeodomain proteins cdx2 and HNF1α mediates expression of the lactase-phlorizin hydrolase gene
54. Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter
55. GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo
56. Hepatocyte-specific promoter element HP1 of the Xenopus albumin gene interacts with transcriptional factors of mammalian hepatocytes