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Volumn 8, Issue 2, 1998, Pages 219-225

Centromeres: The missing link in the development of human artificial chromosomes

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SATELLITE DNA;

EID: 0032055381     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(98)80144-5     Document Type: Article
Times cited : (73)

References (49)
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    • Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites
    • of outstanding interest. This very important paper examines the molecular requirements for targeting CENP-A for assembly at centromeres. Targeting requires three distinct regions within CENP-A and further requires that synthesis of CENP-A is uncoupled from histone H3 during S phase. This finding implicates an assembly pathway late in S phase when centromeric DNA typically replicates.
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