Point mutations in either subunit of the GABAB receptor confer constitutive activity to the heterodimer

Molecular Pharmacology

Volumn 70, Issue 4, 2006, Pages 1406-1413

  Mukherjee, Richa S ^a   McBride, Edward W ^a   Beinborn, Martin ^a   Dunlap, Kathleen ^b   Kopin, Alan S ^a,b,c  

^a TUFTS MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; BACLOFEN; G PROTEIN COUPLED RECEPTOR; HETERODIMER; T 290K; UNCLASSIFIED DRUG; Y 690K;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; EMBRYO; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; BACLOFEN; CELL LINE; CERCOPITHECUS AETHIOPS; CLONING, MOLECULAR; COS CELLS; GABA AGONISTS; GABA-B RECEPTOR ANTAGONISTS; HUMANS; MICE; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; POINT MUTATION; PROTEIN ISOFORMS; RADIOLIGAND ASSAY; RECEPTORS, GABA-B; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 33748927491     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.024463     Document Type: Article

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