메뉴 건너뛰기




Volumn 66, Issue 13, 2006, Pages 1665-1684

Immunotherapy for de novo renal transplantation: What's in the pipeline?

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXYSPERGUALIN; 2 CYANO 3 HYDROXY N [4 (TRIFLUOROMETHYL)PHENYL] 6 HEPTYNAMIDE; 4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; ABATACEPT; ABE 071; AEB 071; ALEMTUZUMAB; ANISPERIMUS; BASILIXIMAB; BELATACEPT; CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOSPORIN; DACLIZUMAB; EFALIZUMAB; EVEROLIMUS; FINGOLIMOD; GLUCOCORTICOID; IMMUNOSUPPRESSIVE AGENT; JANUS KINASE 3 INHIBITOR; LF 15 0195; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; POLYCLONAL ANTIBODY; RAPAMYCIN; RITUXIMAB; TACROLIMUS; TERIFLUNOMIDE; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG; UNINDEXED DRUG; VISILIZUMAB;

EID: 33748903363     PISSN: 00126667     EISSN: 00126667     Source Type: Journal    
DOI: 10.2165/00003495-200666130-00002     Document Type: Review
Times cited : (17)

References (146)
  • 1
    • 1442338509 scopus 로고    scopus 로고
    • Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era
    • Mar
    • Meier-Kriesche HU, Shold JD, Srinivas TR, et al. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant 2004 Mar; 4 (3): 378-83
    • (2004) Am J Transplant , vol.4 , Issue.3 , pp. 378-383
    • Meier-Kriesche, H.U.1    Shold, J.D.2    Srinivas, T.R.3
  • 2
    • 16544384099 scopus 로고    scopus 로고
    • Kidney transplantation in the hyperimmunized patient
    • Gloor J. Kidney transplantation in the hyperimmunized patient. Contrib Nephrol 2005; 146: 11-21
    • (2005) Contrib Nephrol , vol.146 , pp. 11-21
    • Gloor, J.1
  • 3
    • 0036080242 scopus 로고    scopus 로고
    • African Americans and renal transplantation: Disproportionate need, limited access, and impaired outcomes
    • Feb
    • Young CJ, Gaston RS. African Americans and renal transplantation: disproportionate need, limited access, and impaired outcomes. Am J Med Sci 2002 Feb; 323 (2): 94-9
    • (2002) Am J Med Sci , vol.323 , Issue.2 , pp. 94-99
    • Young, C.J.1    Gaston, R.S.2
  • 4
    • 10244229090 scopus 로고    scopus 로고
    • Delayed graft function in renal transplantation
    • Dec
    • Peeters P, Terryn W, Vanholder R, et al. Delayed graft function in renal transplantation. Curr Opin Crit Care 2004 Dec; 10 (6): 489-98
    • (2004) Curr Opin Crit Care , vol.10 , Issue.6 , pp. 489-498
    • Peeters, P.1    Terryn, W.2    Vanholder, R.3
  • 5
    • 21344469284 scopus 로고    scopus 로고
    • Workshop on late renal allograft dys-function
    • Jul
    • Meyers CM, Kirk AD. Workshop on late renal allograft dys-function. Am J Transplant 2005 Jul; 5 (7): 1600-5
    • (2005) Am J Transplant , vol.5 , Issue.7 , pp. 1600-1605
    • Meyers, C.M.1    Kirk, A.D.2
  • 6
    • 0035997307 scopus 로고    scopus 로고
    • Cardiovascular risk reduction in renal transplantation: Strategies for success
    • Jun
    • Kiberd BA. Cardiovascular risk reduction in renal transplantation: strategies for success. Minerva Urol Nefrol 2002 Jun; 54 (2): 51-63
    • (2002) Minerva Urol Nefrol , vol.54 , Issue.2 , pp. 51-63
    • Kiberd, B.A.1
  • 7
    • 0031931923 scopus 로고    scopus 로고
    • Infectious complications following renal transplantation
    • Feb
    • Sia IG, Paya CV. Infectious complications following renal transplantation. Surg Clin North Am 1998 Feb; 78 (1): 95-112
    • (1998) Surg Clin North Am , vol.78 , Issue.1 , pp. 95-112
    • Sia, I.G.1    Paya, C.V.2
  • 8
    • 2542504501 scopus 로고    scopus 로고
    • Malignancy in renal transplantation
    • Jun
    • Morath C, Mueller M, Goldschmidt H, et al. Malignancy in renal transplantation. J Am Soc Nephrol 2004 Jun; 15 (6): 1582-8
    • (2004) J Am Soc Nephrol , vol.15 , Issue.6 , pp. 1582-1588
    • Morath, C.1    Mueller, M.2    Goldschmidt, H.3
  • 9
    • 0347132155 scopus 로고    scopus 로고
    • Noncompliance after kidney transplantation: A systematic review
    • published erratum appears in Transplant Proc 2004 Mar; 36 (2): 409 Dec
    • Jindal RM, Joseph JT, Morris MC, et al. Noncompliance after kidney transplantation: a systematic review [published erratum appears in Transplant Proc 2004 Mar; 36 (2): 409]. Transplant Proc 2003 Dec; 35 (8): 2868-72
    • (2003) Transplant Proc , vol.35 , Issue.8 , pp. 2868-2872
    • Jindal, R.M.1    Joseph, J.T.2    Morris, M.C.3
  • 10
    • 1642327515 scopus 로고    scopus 로고
    • Frequency and impact of nonadherence to immunosuppressants after renal transplantation: A systematic review
    • Mar 15
    • Butler JA, Roderick P, Mulle M, et al. Frequency and impact of nonadherence to immunosuppressants after renal transplantation: a systematic review. Transplantation 2004 Mar 15; 77 (5): 769-76
    • (2004) Transplantation , vol.77 , Issue.5 , pp. 769-776
    • Butler, J.A.1    Roderick, P.2    Mulle, M.3
  • 11
    • 2442705238 scopus 로고    scopus 로고
    • New drugs to improve transplant outcomes
    • May 15
    • First MR, Fitzsimmons WE. New drugs to improve transplant outcomes. Transplantation 2004 May 15; 77 (9 Suppl.): S88-92
    • (2004) Transplantation , vol.77 , Issue.9 SUPPL.
    • First, M.R.1    Fitzsimmons, W.E.2
  • 12
    • 12344292602 scopus 로고    scopus 로고
    • Modified release tacrolimus
    • Dec 31
    • First MR, Fitzsimmons WE. Modified release tacrolimus. Yonsei Med J 2004 Dec 31; 45 (6): 1127-31
    • (2004) Yonsei Med J , vol.45 , Issue.6 , pp. 1127-1131
    • First, M.R.1    Fitzsimmons, W.E.2
  • 13
    • 17844396683 scopus 로고    scopus 로고
    • Conversion of stable liver transplant recipients from a twice-daily Prograf-based regimen to a once-daily modified release tacrolimus-based regimen
    • Mar
    • Florman S, Alloway R, Kalayoglu M, et al. Conversion of stable liver transplant recipients from a twice-daily Prograf-based regimen to a once-daily modified release tacrolimus-based regimen. Transplant Proc 2005 Mar; 37 (2): 1211-3
    • (2005) Transplant Proc , vol.37 , Issue.2 , pp. 1211-1213
    • Florman, S.1    Alloway, R.2    Kalayoglu, M.3
  • 14
    • 17844363738 scopus 로고    scopus 로고
    • Conversion of stable kidney transplant recipients from a twice daily Prograf-based regimen to a once daily modified release tacrolimus-based regimen
    • Mar
    • Alloway R, Steinberg S, Khalil K, et al. Conversion of stable kidney transplant recipients from a twice daily Prograf-based regimen to a once daily modified release tacrolimus-based regimen. Transplant Proc 2005 Mar; 37 (2): 867-70
    • (2005) Transplant Proc , vol.37 , Issue.2 , pp. 867-870
    • Alloway, R.1    Steinberg, S.2    Khalil, K.3
  • 15
    • 33748883602 scopus 로고    scopus 로고
    • A phase III, randomized, open-label, comparative, multi-center study to assess the safety and efficacy of Prograf® (tacrolimus)/MMF, modified release (MR) tacrolimus/MMF and Neoral® (cyclosporine)/MMF in de novo kidney transplant recipients: 12-Month results
    • abstract no. 748
    • Silva Jr HT, for the Modified Release De Novo Kidney Study Group. A phase III, randomized, open-label, comparative, multi-center study to assess the safety and efficacy of Prograf® (tacrolimus)/MMF, modified release (MR) tacrolimus/MMF and Neoral® (cyclosporine)/MMF in de novo kidney transplant recipients: 12-month results [abstract no. 748]. Am J Transplant 2006; Suppl.: 318
    • (2006) Am J Transplant , Issue.SUPPL. , pp. 318
    • Silva Jr., H.T.1
  • 16
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    • Salomon B, Bluestone JA. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol 2001; 19: 225-52
    • (2001) Annu Rev Immunol , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.A.2
  • 17
    • 23944491219 scopus 로고    scopus 로고
    • Immunosuppression-the promise of specificity
    • Aug 25
    • Ingelfinger JR, Schawartz RS. Immunosuppression-the promise of specificity. N Engl J Med 2005 Aug 25; 353 (8): 836-9
    • (2005) N Engl J Med , vol.353 , Issue.8 , pp. 836-839
    • Ingelfinger, J.R.1    Schawartz, R.S.2
  • 18
    • 0025830902 scopus 로고
    • CTLA-4 is a second receptor for the B cell activation antigen B7
    • Sep 1
    • Linsley PS, Brady W, Urnes M, et al. CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 1991 Sep 1; 174 (3): 561-9
    • (1991) J Exp Med , vol.174 , Issue.3 , pp. 561-569
    • Linsley, P.S.1    Brady, W.2    Urnes, M.3
  • 19
    • 0031307384 scopus 로고    scopus 로고
    • Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation
    • Dec 1
    • Levisetti MG, Padrid PA, Szot GL, et al. Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation. J Immunol 1997 Dec 1; 159 (11): 5187-91
    • (1997) J Immunol , vol.159 , Issue.11 , pp. 5187-5191
    • Levisetti, M.G.1    Padrid, P.A.2    Szot, G.L.3
  • 20
    • 0242574700 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig
    • Nov 13
    • Kremer JM, Westhovens R, Leon M, et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med 2003 Nov 13; 349 (20): 1907-15
    • (2003) N Engl J Med , vol.349 , Issue.20 , pp. 1907-1915
    • Kremer, J.M.1    Westhovens, R.2    Leon, M.3
  • 21
    • 20044386299 scopus 로고    scopus 로고
    • Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties
    • Mar
    • Larsen CP, Pearson TC, Adams AB, et al. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant 2005 Mar; 5 (3): 443-53
    • (2005) Am J Transplant , vol.5 , Issue.3 , pp. 443-453
    • Larsen, C.P.1    Pearson, T.C.2    Adams, A.B.3
  • 22
    • 25444508245 scopus 로고    scopus 로고
    • T-cell costimulatory pathways in allograft rejection and tolerance
    • Sep 15
    • Clarkson MR, Sayegh MH. T-cell costimulatory pathways in allograft rejection and tolerance. Transplantation 2005 Sep 15; 80 (5): 555-63
    • (2005) Transplantation , vol.80 , Issue.5 , pp. 555-563
    • Clarkson, M.R.1    Sayegh, M.H.2
  • 23
    • 12644262358 scopus 로고    scopus 로고
    • CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
    • Aug 5
    • Kirk AD, Harlan DM, Armstrong NN, et al. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci U S A 1997 Aug 5; 94 (16): 8789-94
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.16 , pp. 8789-8794
    • Kirk, A.D.1    Harlan, D.M.2    Armstrong, N.N.3
  • 24
    • 0036275436 scopus 로고    scopus 로고
    • Costimulatory blockade in patients with rheumatoid arthritis: A pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion
    • Jun
    • Moreland LW, Alten R, Van den Bosch F, et al. Costimulatory blockade in patients with rheumatoid arthritis: a pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion. Arthritis Rheum 2002 Jun; 46 (6): 1470-9
    • (2002) Arthritis Rheum , vol.46 , Issue.6 , pp. 1470-1479
    • Moreland, L.W.1    Alten, R.2    Van Den Bosch, F.3
  • 25
    • 23944502334 scopus 로고    scopus 로고
    • Costimulation blockade with belatacept in renal transplantation
    • Aug 25
    • Vincenti F, Larsen C, Durrbach A, et al. Costimulation blockade with belatacept in renal transplantation. N Engl J Med 2005 Aug 25; 353 (8): 770-81
    • (2005) N Engl J Med , vol.353 , Issue.8 , pp. 770-781
    • Vincenti, F.1    Larsen, C.2    Durrbach, A.3
  • 26
    • 33748891438 scopus 로고    scopus 로고
    • Belatacept (LEA29Y) as part of a CNI-FREE regimen in recipients of renal allografts with higher risk of poor long-term function and graft loss
    • abstract no. 946
    • Griyno AJ, Halloran P, Vanrenterghem Y, et al. Belatacept (LEA29Y) as part of a CNI-FREE regimen in recipients of renal allografts with higher risk of poor long-term function and graft loss [abstract no. 946]. Am J Transplant 2005; 5 Suppl. 11: 397
    • (2005) Am J Transplant , vol.5 , Issue.11 SUPPL. , pp. 397
    • Griyno, A.J.1    Halloran, P.2    Vanrenterghem, Y.3
  • 28
    • 9944248665 scopus 로고    scopus 로고
    • Janus kinase-3 (JAK3) inhibition: A novel immunosuppressive option for allogeneic transplantation
    • Oct; Epub 2004 Sep 11
    • Säemann MD, Zeyda M, Stulnig TM, et al. Janus kinase-3 (JAK3) inhibition: a novel immunosuppressive option for allogeneic transplantation. Transpl Int 2004 Oct; 17 (9): 481-9. Epub 2004 Sep 11
    • (2004) Transpl Int , vol.17 , Issue.9 , pp. 481-489
    • Säemann, M.D.1    Zeyda, M.2    Stulnig, T.M.3
  • 29
    • 0141923796 scopus 로고    scopus 로고
    • Specific inhibition of Stat5a/b promotes apoptosis of IL-2R-responsive primary and tumor-derived lymphoid cells
    • Behbod F, Nagy ZS, Stepkowski SM, et al. Specific inhibition of Stat5a/b promotes apoptosis of IL-2R-responsive primary and tumor-derived lymphoid cells. J Immunol 2003; 171: 3919-27
    • (2003) J Immunol , vol.171 , pp. 3919-3927
    • Behbod, F.1    Nagy, Z.S.2    Stepkowski, S.M.3
  • 30
    • 0035816692 scopus 로고    scopus 로고
    • Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex
    • Jul 6
    • Tomita K, Saijo K, Yamasaki S, et al. Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex. J Biol Chem 2001 Jul 6; 276 (27): 25378-85
    • (2001) J Biol Chem , vol.276 , Issue.27 , pp. 25378-25385
    • Tomita, K.1    Saijo, K.2    Yamasaki, S.3
  • 31
    • 0037708570 scopus 로고    scopus 로고
    • Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154
    • Jun 15
    • Säemann MD, Zeyda M, Diakos C, et al. Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154. Transplantation 2003 Jun 15; 75 (11): 1864-72
    • (2003) Transplantation , vol.75 , Issue.11 , pp. 1864-1872
    • Säemann, M.D.1    Zeyda, M.2    Diakos, C.3
  • 32
    • 0005618532 scopus 로고    scopus 로고
    • Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival
    • Feb 1
    • Li XC, Ima A, Li Y, et al. Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival. J Immunol 2000 Feb 1; 164 (3): 1193-9
    • (2000) J Immunol , vol.164 , Issue.3 , pp. 1193-1199
    • Li, X.C.1    Ima, A.2    Li, Y.3
  • 33
    • 0037079735 scopus 로고    scopus 로고
    • Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin
    • Jan 15
    • Stepkowski SM, Erwin-Cohen RA, Behbod F, et al. Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin. Blood 2002 Jan 15; 99 (2): 680-9
    • (2002) Blood , vol.99 , Issue.2 , pp. 680-689
    • Stepkowski, S.M.1    Erwin-Cohen, R.A.2    Behbod, F.3
  • 34
    • 0035869505 scopus 로고    scopus 로고
    • Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts
    • Mar 15
    • Behbod F, Erwin-Cohen RA, Wang ME, et al. Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts. J Immunol 2001 Mar 15; 166 (6): 3724-32
    • (2001) J Immunol , vol.166 , Issue.6 , pp. 3724-3732
    • Behbod, F.1    Erwin-Cohen, R.A.2    Wang, M.E.3
  • 35
    • 0242332186 scopus 로고    scopus 로고
    • Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor
    • Oct 31
    • Changelian PS, Flanagan ME, Ball DJ, et al. Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science 2003 Oct 31; 302 (5646): 875-8
    • (2003) Science , vol.302 , Issue.5646 , pp. 875-878
    • Changelian, P.S.1    Flanagan, M.E.2    Ball, D.J.3
  • 36
    • 0742318929 scopus 로고    scopus 로고
    • The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models
    • Jan
    • Kudlacz E, Perry B, Sawyer P, et al. The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models. Am J Transplant 2004 Jan; 4 (1): 51-7
    • (2004) Am J Transplant , vol.4 , Issue.1 , pp. 51-57
    • Kudlacz, E.1    Perry, B.2    Sawyer, P.3
  • 37
    • 20244368823 scopus 로고    scopus 로고
    • Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates
    • Apr 15
    • Borie DC, Changelian PS, Larson MJ, et al. Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates. Transplantation 2005 Apr 15; 79 (7): 791-801
    • (2005) Transplantation , vol.79 , Issue.7 , pp. 791-801
    • Borie, D.C.1    Changelian, P.S.2    Larson, M.J.3
  • 38
    • 11144343254 scopus 로고    scopus 로고
    • Janus kinase 3: A novel target for selective transplant immunosupression
    • Dec
    • Podder H, Kahan BD. Janus kinase 3: a novel target for selective transplant immunosupression. Expert Opin Ther Targets 2004 Dec; 8 (6): 613-29
    • (2004) Expert Opin Ther Targets , vol.8 , Issue.6 , pp. 613-629
    • Podder, H.1    Kahan, B.D.2
  • 39
    • 25444525392 scopus 로고    scopus 로고
    • The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities
    • Oct 1
    • Stepkowski SM, Kao J, Wang ME, et al. The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities. J Immunol 2005 Oct 1; 175 (7): 4236-46
    • (2005) J Immunol , vol.175 , Issue.7 , pp. 4236-4246
    • Stepkowski, S.M.1    Kao, J.2    Wang, M.E.3
  • 40
    • 33748896444 scopus 로고    scopus 로고
    • Dose-dependent reduction in psoriasis severity as evidence of immunosuppressive activity of an oral Jak3 inhibitor in humans
    • abstract no. 60
    • Chan G, Wang C, Boy M, et al. Dose-dependent reduction in psoriasis severity as evidence of immunosuppressive activity of an oral Jak3 inhibitor in humans [abstract no. 60]. Am J Transplant 2006; 6 Suppl. 2: 87
    • (2006) Am J Transplant , vol.6 , Issue.2 SUPPL. , pp. 87
    • Chan, G.1    Wang, C.2    Boy, M.3
  • 41
    • 33748912697 scopus 로고    scopus 로고
    • Phase I evaluation of the safety of a JAK3 inhibitor, Cp-690,550 in stable kidney transplant recipients
    • A3921007 Study Group. abstract no. 58
    • Weimar W, Gaston R, Brennan D, et al. A3921007 Study Group. Phase I evaluation of the safety of a JAK3 inhibitor, Cp-690,550 in stable kidney transplant recipients [abstract no. 58]. Am J Transplant 2006; 6 Suppl. 2: 86
    • (2006) Am J Transplant , vol.6 , Issue.2 SUPPL. , pp. 86
    • Weimar, W.1    Gaston, R.2    Brennan, D.3
  • 42
    • 33748884359 scopus 로고    scopus 로고
    • Multiple dose pharmacokinetics of Cp-690,550 in stable renal allograft recipients dosed with Cp-690,550 in combination with other immunosuppressive agents
    • A3921007 Study Group. abstract no. 2549
    • Weimar W, Duplin M, Gaston R, et al. A3921007 Study Group. Multiple dose pharmacokinetics of Cp-690,550 in stable renal allograft recipients dosed with Cp-690,550 in combination with other immunosuppressive agents [abstract no. 2549]. American J Transplant 2006; 6 Suppl. 2: 900
    • (2006) American J Transplant , vol.6 , Issue.2 SUPPL. , pp. 900
    • Weimar, W.1    Duplin, M.2    Gaston, R.3
  • 43
    • 33748912185 scopus 로고    scopus 로고
    • Changes in peripheral blood lymphocyte subsets, IFN-γ production capacity and gene expression following treatment with the JAK-3 inhibitor Cp-690,550 in stable renal allograft recipients
    • abstract no. 59
    • Baan CC, Schoordijk-Verschoor W, Korevaar SS, et al. Changes in peripheral blood lymphocyte subsets, IFN-γ production capacity and gene expression following treatment with the JAK-3 inhibitor Cp-690,550 in stable renal allograft recipients [abstract no. 59]. Am J Transplant 2006; 6 Suppl. 2: 86
    • (2006) Am J Transplant , vol.6 , Issue.2 SUPPL. , pp. 86
    • Baan, C.C.1    Schoordijk-Verschoor, W.2    Korevaar, S.S.3
  • 45
  • 46
    • 0031804660 scopus 로고    scopus 로고
    • Comparative effects of malononitriloamide analogs of leflunomide on whole blood lymphocyte stimulation in humans, rhesus macaques, cats, dogs, and rats
    • Jun
    • Gregory CR, Silva HT, Patz JD, et al. Comparative effects of malononitriloamide analogs of leflunomide on whole blood lymphocyte stimulation in humans, rhesus macaques, cats, dogs, and rats. Transplant Proc 1998 Jun; 30 (4): 1047-8
    • (1998) Transplant Proc , vol.30 , Issue.4 , pp. 1047-1048
    • Gregory, C.R.1    Silva, H.T.2    Patz, J.D.3
  • 47
    • 0036076671 scopus 로고    scopus 로고
    • A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs
    • Jul
    • Jin MB, Nakayama M, Ogata T, et al. A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs. Surgery 2002 Jul; 132 (1): 72-9
    • (2002) Surgery , vol.132 , Issue.1 , pp. 72-79
    • Jin, M.B.1    Nakayama, M.2    Ogata, T.3
  • 48
    • 12344314265 scopus 로고    scopus 로고
    • FK778, a synthetic malononitrilamide
    • Dec 31
    • Fitzsimmons WE, First MR. FK778, a synthetic malononitrilamide. Yonsei Med J 2004 Dec 31; 45 (6): 1132-5
    • (2004) Yonsei Med J , vol.45 , Issue.6 , pp. 1132-1135
    • Fitzsimmons, W.E.1    First, M.R.2
  • 49
    • 0031179645 scopus 로고    scopus 로고
    • The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms
    • Jul 1
    • Elder RT, Xu X, Williams JW, et al. The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms. J Immunol 1997 Jul 1; 159 (1): 22-7
    • (1997) J Immunol , vol.159 , Issue.1 , pp. 22-27
    • Elder, R.T.1    Xu, X.2    Williams, J.W.3
  • 50
    • 0032374063 scopus 로고    scopus 로고
    • Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide
    • Dec 1
    • Bruneau JM, Yea CM, Spinella-Jaegle S, et al. Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide. Biochem J 1998 Dec 1; 336 (Pt 2): 299-303
    • (1998) Biochem J , vol.336 , Issue.2 PART , pp. 299-303
    • Bruneau, J.M.1    Yea, C.M.2    Spinella-Jaegle, S.3
  • 51
    • 0032519992 scopus 로고    scopus 로고
    • Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production
    • Feb 15
    • Siemasko K, Chong AS, Jack HM, et al. Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production. J Immunol 1998 Feb 15; 160 (4): 1581-8
    • (1998) J Immunol , vol.160 , Issue.4 , pp. 1581-1588
    • Siemasko, K.1    Chong, A.S.2    Jack, H.M.3
  • 52
    • 0033560704 scopus 로고    scopus 로고
    • Flow cytometric analysis of the molecular mechanisms of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide analogues in a novel whole blood assay
    • Slauson SD, Silva HT, Sherwood SW, et al. Flow cytometric analysis of the molecular mechanisms of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide analogues in a novel whole blood assay. Immunol Lett 1999; 67: 179-83
    • (1999) Immunol Lett , vol.67 , pp. 179-183
    • Slauson, S.D.1    Silva, H.T.2    Sherwood, S.W.3
  • 53
    • 20344377174 scopus 로고    scopus 로고
    • The novel immunosuppressant FK778 inhibits formation of the immunologic Synapse
    • May
    • Zeyda M, Geyeregger R, Poglitsch M, et al. The novel immunosuppressant FK778 inhibits formation of the immunologic Synapse. Transplant Proc 2005 May; 37 (4): 1970-1
    • (2005) Transplant Proc , vol.37 , Issue.4 , pp. 1970-1971
    • Zeyda, M.1    Geyeregger, R.2    Poglitsch, M.3
  • 54
    • 20344403537 scopus 로고    scopus 로고
    • The malononitrilamide FK778 inhibits activation of NF-kappaB in human dendritic cells
    • May
    • Zeyda M, Stuhlmeier KM, Kirsch B, et al. The malononitrilamide FK778 inhibits activation of NF-kappaB in human dendritic cells. Transplant Proc 2005 May; 37 (4): 1968-9
    • (2005) Transplant Proc , vol.37 , Issue.4 , pp. 1968-1969
    • Zeyda, M.1    Stuhlmeier, K.M.2    Kirsch, B.3
  • 55
    • 3142668958 scopus 로고    scopus 로고
    • FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: In vivo and in vitro studies
    • Jul 15
    • Deuse T, Schrepfer S, Schafer H, et al. FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies. Transplantation 2004 Jul 15; 78 (1): 71-7
    • (2004) Transplantation , vol.78 , Issue.1 , pp. 71-77
    • Deuse, T.1    Schrepfer, S.2    Schafer, H.3
  • 56
    • 18144376604 scopus 로고    scopus 로고
    • FK778, a novel immunosuppressive agent, reduces early adhesion molecule upregulation and prolongs cardiac allograft survival
    • Feb
    • Schrepfer S, Deuse T, Schafer H, et al. FK778, a novel immunosuppressive agent, reduces early adhesion molecule upregulation and prolongs cardiac allograft survival. Transpl Int 2005 Feb; 18 (2): 215-20
    • (2005) Transpl Int , vol.18 , Issue.2 , pp. 215-220
    • Schrepfer, S.1    Deuse, T.2    Schafer, H.3
  • 57
    • 20344390044 scopus 로고    scopus 로고
    • Down-regulation of TGF-beta and VCAM-1 is associated with successful treatment of chronic rejection in rats
    • May
    • Crews GM, Erickson L, Pan F, et al. Down-regulation of TGF-beta and VCAM-1 is associated with successful treatment of chronic rejection in rats. Transplant Proc 2005 May; 37 (4): 1926-8
    • (2005) Transplant Proc , vol.37 , Issue.4 , pp. 1926-1928
    • Crews, G.M.1    Erickson, L.2    Pan, F.3
  • 58
    • 0037708567 scopus 로고    scopus 로고
    • Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat
    • Jun 15
    • Bilolo KK, Ouyang J, Wang X, et al. Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat. Transplantation 2003 Jun 15; 75 (11): 1881-7
    • (2003) Transplantation , vol.75 , Issue.11 , pp. 1881-1887
    • Bilolo, K.K.1    Ouyang, J.2    Wang, X.3
  • 59
    • 0013241476 scopus 로고    scopus 로고
    • Combination therapy of malononitrilamide FK778 with tacrolimus on cell proliferation assays and in rats receiving renal allografts
    • May 15
    • Vu MD, Qi S, Wang X, et al. Combination therapy of malononitrilamide FK778 with tacrolimus on cell proliferation assays and in rats receiving renal allografts. Transplantation 2003 May 15; 75 (9): 1455-9
    • (2003) Transplantation , vol.75 , Issue.9 , pp. 1455-1459
    • Vu, M.D.1    Qi, S.2    Wang, X.3
  • 60
    • 12344318112 scopus 로고    scopus 로고
    • Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats
    • Jan 15
    • Zeng H, Waldman WJ, Yin DP, et al. Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats. Transplantation 2005 Jan 15; 79 (1): 17-22
    • (2005) Transplantation , vol.79 , Issue.1 , pp. 17-22
    • Zeng, H.1    Waldman, W.J.2    Yin, D.P.3
  • 61
    • 16244382061 scopus 로고    scopus 로고
    • FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506
    • Jan-Feb
    • Yamamoto S, Okuda T, Yamasaki K, et al. FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506. Transplant Proc 2005 Jan-Feb; 37 (1): 126-9
    • (2005) Transplant Proc , vol.37 , Issue.1 , pp. 126-129
    • Yamamoto, S.1    Okuda, T.2    Yamasaki, K.3
  • 62
    • 10644249817 scopus 로고    scopus 로고
    • FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation
    • Dec 15
    • Yamamoto S, Okuda T, Yamasaki K, et al. FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation. Transplantation 2004 Dec 15; 78 (11): 1618-25
    • (2004) Transplantation , vol.78 , Issue.11 , pp. 1618-1625
    • Yamamoto, S.1    Okuda, T.2    Yamasaki, K.3
  • 63
    • 0037469015 scopus 로고    scopus 로고
    • Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs
    • Apr 27
    • Kyles AE, Gregory CR, Griffey SM, et al. Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs. Transplantation 2003 Apr 27; 75 (8): 1128-33
    • (2003) Transplantation , vol.75 , Issue.8 , pp. 1128-1133
    • Kyles, A.E.1    Gregory, C.R.2    Griffey, S.M.3
  • 64
    • 25144508991 scopus 로고    scopus 로고
    • Efficacy of Malononitrilamide FK778 in a preclinical model of small bowel transplantation
    • Jul-Aug
    • Alessiani M, Zonta S, Abbiati F, et al. Efficacy of Malononitrilamide FK778 in a preclinical model of small bowel transplantation. Transplant Proc 2005 Jul-Aug; 37 (6): 2719-21
    • (2005) Transplant Proc , vol.37 , Issue.6 , pp. 2719-2721
    • Alessiani, M.1    Zonta, S.2    Abbiati, F.3
  • 65
    • 0037469065 scopus 로고    scopus 로고
    • Significant prolongation of renal allograft survival by delayed combination therapy of FK778 with tacrolimus in nonhuman primates
    • Apr 27
    • Qi S, Zhu S, Xu D, et al. Significant prolongation of renal allograft survival by delayed combination therapy of FK778 with tacrolimus in nonhuman primates. Transplantation 2003 Apr 27; 75 (8): 1124-8
    • (2003) Transplantation , vol.75 , Issue.8 , pp. 1124-1128
    • Qi, S.1    Zhu, S.2    Xu, D.3
  • 66
    • 0346218088 scopus 로고    scopus 로고
    • Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model
    • Dec 15
    • Deuse T, Schrepfer S, Reichenspurner H. Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. Transplantation 2003 Dec 15; 76 (11): 1627-9
    • (2003) Transplantation , vol.76 , Issue.11 , pp. 1627-1629
    • Deuse, T.1    Schrepfer, S.2    Reichenspurner, H.3
  • 67
    • 1442360358 scopus 로고    scopus 로고
    • The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent
    • Feb 27
    • Deuse T, Schrepfer S, Reichenspurner H. The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent. Transplantation 2004 Feb 27; 77 (4): 509-13
    • (2004) Transplantation , vol.77 , Issue.4 , pp. 509-513
    • Deuse, T.1    Schrepfer, S.2    Reichenspurner, H.3
  • 68
    • 0037469022 scopus 로고    scopus 로고
    • FK778, a powerful new immunosuppressant, effectively reduces functional and histologic changes of chronic rejection in rat renal allografts
    • Apr 27
    • Pan F, Ebbs A, Wynn C, et al. FK778, a powerful new immunosuppressant, effectively reduces functional and histologic changes of chronic rejection in rat renal allografts. Transplantation 2003 Apr 27; 75 (8): 1110-4
    • (2003) Transplantation , vol.75 , Issue.8 , pp. 1110-1114
    • Pan, F.1    Ebbs, A.2    Wynn, C.3
  • 69
    • 0042467489 scopus 로고    scopus 로고
    • Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: Potential applications for restenosis and chronic rejection
    • Aug 15
    • Savikko J, Von Willebrand E, Hayry P. Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection. Transplantation 2003 Aug 15; 76 (3): 455-8
    • (2003) Transplantation , vol.76 , Issue.3 , pp. 455-458
    • Savikko, J.1    Von Willebrand, E.2    Hayry, P.3
  • 70
    • 0036819728 scopus 로고    scopus 로고
    • Prospective, pilot, open-label, short-term study of conversion to leflunomide reverses chronic renal allograft dysfunction
    • Oct
    • Hardinger KL, Wang CD, Schnitzler MA, et al. Prospective, pilot, open-label, short-term study of conversion to leflunomide reverses chronic renal allograft dysfunction. Am J Transplant 2002 Oct; 2 (9): 867-71
    • (2002) Am J Transplant , vol.2 , Issue.9 , pp. 867-871
    • Hardinger, K.L.1    Wang, C.D.2    Schnitzler, M.A.3
  • 71
    • 0035862995 scopus 로고    scopus 로고
    • Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide
    • Jan 15
    • Knight DA, Hejmanowski AQ, Dierksheide JE, et al. Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide. Transplantation 2001 Jan 15; 71 (1): 170-4
    • (2001) Transplantation , vol.71 , Issue.1 , pp. 170-174
    • Knight, D.A.1    Hejmanowski, A.Q.2    Dierksheide, J.E.3
  • 72
    • 0033610251 scopus 로고    scopus 로고
    • Novel mechanism of inhibition of cytomegalovirus by the experimental immunosuppressive agent leflunomide
    • Sep 27
    • Waldman WJ, Knight DA, Lurain NS, et al. Novel mechanism of inhibition of cytomegalovirus by the experimental immunosuppressive agent leflunomide. Transplantation 1999 Sep 27; 68 (6): 814-25
    • (1999) Transplantation , vol.68 , Issue.6 , pp. 814-825
    • Waldman, W.J.1    Knight, D.A.2    Lurain, N.S.3
  • 73
    • 2442717552 scopus 로고    scopus 로고
    • Leflunomide therapy for cytomegalovirus disease in renal allograft recepients
    • May 15
    • John GT, Manivannan J, Chandy S, et al. Leflunomide therapy for cytomegalovirus disease in renal allograft recepients. Transplantation 2004 May 15; 77 (9): 1460-1
    • (2004) Transplantation , vol.77 , Issue.9 , pp. 1460-1461
    • John, G.T.1    Manivannan, J.2    Chandy, S.3
  • 74
    • 11844269965 scopus 로고    scopus 로고
    • Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778
    • Jan
    • Evers DL, Wang X, Huong SM, et al. Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778. Antiviral Res 2005 Jan; 65 (1): 1-12
    • (2005) Antiviral Res , vol.65 , Issue.1 , pp. 1-12
    • Evers, D.L.1    Wang, X.2    Huong, S.M.3
  • 75
    • 20144366719 scopus 로고    scopus 로고
    • Leflunomide for polyomavirus type BK nephropathy
    • Mar 17
    • Williams JW, Javaid B, Kadambi PV, et al. Leflunomide for polyomavirus type BK nephropathy. N Engl J Med 2005 Mar 17; 352 (11): 1157-8
    • (2005) N Engl J Med , vol.352 , Issue.11 , pp. 1157-1158
    • Williams, J.W.1    Javaid, B.2    Kadambi, P.V.3
  • 76
    • 12344300330 scopus 로고    scopus 로고
    • Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture system
    • Jan 15
    • Farasati NA, Shapiro R, Vats A, et al. Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture system. Transplantation 2005 Jan 15; 79 (1): 116-8
    • (2005) Transplantation , vol.79 , Issue.1 , pp. 116-118
    • Farasati, N.A.1    Shapiro, R.2    Vats, A.3
  • 77
    • 25144475111 scopus 로고    scopus 로고
    • Assessment of an LC-MS method for plasma quantification of the new immunosuppressant FK778 through comparison with HPLC-UV
    • Jul-Aug
    • Molinaro M, Carazzone C, Barbano D, et al. Assessment of an LC-MS method for plasma quantification of the new immunosuppressant FK778 through comparison with HPLC-UV. Transplant Proc 2005 Jul-Aug; 37 (6): 2722-7
    • (2005) Transplant Proc , vol.37 , Issue.6 , pp. 2722-2727
    • Molinaro, M.1    Carazzone, C.2    Barbano, D.3
  • 78
    • 0038037898 scopus 로고    scopus 로고
    • Effects of the malononitrilamide FK778 on immune functions in vitro in whole blood from non-human primates and healthy human volunteers
    • Apr-Jun
    • Birsan T, Dambrin C, Klupp J, et al. Effects of the malononitrilamide FK778 on immune functions in vitro in whole blood from non-human primates and healthy human volunteers. Transpl Immunol 2003 Apr-Jun; 11 (2): 163-7
    • (2003) Transpl Immunol , vol.11 , Issue.2 , pp. 163-167
    • Birsan, T.1    Dambrin, C.2    Klupp, J.3
  • 79
    • 0038748017 scopus 로고    scopus 로고
    • In vivo pharmacokinetic and pharmacodynamic evaluation of the malononitrilamide FK778 in non-human primates
    • May
    • Birsan T, Dambrin C, Klupp J, et al. In vivo pharmacokinetic and pharmacodynamic evaluation of the malononitrilamide FK778 in non-human primates. Transpl Int 2003 May; 16 (5): 354-60
    • (2003) Transpl Int , vol.16 , Issue.5 , pp. 354-360
    • Birsan, T.1    Dambrin, C.2    Klupp, J.3
  • 80
    • 3142734960 scopus 로고    scopus 로고
    • The effects of FK778 in combination with tacrolimus and steroids: A phase II multicenter study in renal transplant patients
    • Jul 15
    • Vanrenterghem Y, Van Hooff JP, Klinger M, et al. The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients. Transplantation 2004 Jul 15; 78 (1): 9-14
    • (2004) Transplantation , vol.78 , Issue.1 , pp. 9-14
    • Vanrenterghem, Y.1    Van Hooff, J.P.2    Klinger, M.3
  • 81
    • 4143082819 scopus 로고    scopus 로고
    • FK778: A powerful immunosuppressive, but will it really be good for you?
    • Jul 15
    • Fawcett J, Johnson DW. FK778: a powerful immunosuppressive, but will it really be good for you? Transplantation 2004 Jul 15; 78 (1): 7-8
    • (2004) Transplantation , vol.78 , Issue.1 , pp. 7-8
    • Fawcett, J.1    Johnson, D.W.2
  • 84
    • 17644365138 scopus 로고    scopus 로고
    • Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
    • Cyster JG. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu Rev Immunol 2005; 23: 127-59
    • (2005) Annu Rev Immunol , vol.23 , pp. 127-159
    • Cyster, J.G.1
  • 85
    • 3042743990 scopus 로고    scopus 로고
    • FTY720: Sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function
    • Jul
    • Brinkmann V, Cyster JG, Hla T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant 2004 Jul; 4 (7): 1019-25
    • (2004) Am J Transplant , vol.4 , Issue.7 , pp. 1019-1025
    • Brinkmann, V.1    Cyster, J.G.2    Hla, T.3
  • 86
    • 0037373333 scopus 로고    scopus 로고
    • FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes
    • Mar
    • Honing SM, Fu S, Mao X, et al. FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. J Clin Invest 2003 Mar; 111 (5): 627-37
    • (2003) J Clin Invest , vol.111 , Issue.5 , pp. 627-637
    • Honing, S.M.1    Fu, S.2    Mao, X.3
  • 87
    • 3142709457 scopus 로고    scopus 로고
    • FTY720-enhanced T cell homing is dependent on CCR2, CCR5, CCR7, and CXCR4: Evidence for distinct chemokine compartments
    • Jul 15
    • Yopp AC, Fu S, Honing SM, et al. FTY720-enhanced T cell homing is dependent on CCR2, CCR5, CCR7, and CXCR4: evidence for distinct chemokine compartments. J Immunol 2004 Jul 15; 173 (2): 855-65
    • (2004) J Immunol , vol.173 , Issue.2 , pp. 855-865
    • Yopp, A.C.1    Fu, S.2    Honing, S.M.3
  • 88
    • 14044271525 scopus 로고    scopus 로고
    • Novel mediators of FTY720 in human lymphocytes
    • Feb 27
    • Bohler T, Budde K, Neumayer HH, et al. Novel mediators of FTY720 in human lymphocytes. Transplantation 2005 Feb 27; 79 (4): 492-5
    • (2005) Transplantation , vol.79 , Issue.4 , pp. 492-495
    • Bohler, T.1    Budde, K.2    Neumayer, H.H.3
  • 89
    • 0034120178 scopus 로고    scopus 로고
    • FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory
    • Jun 1
    • Pinschewer DD, Ochsenbein AF, Odermatt B, et al. FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. J Immunol 2000 Jun 1; 164 (11): 5761-70
    • (2000) J Immunol , vol.164 , Issue.11 , pp. 5761-5770
    • Pinschewer, D.D.1    Ochsenbein, A.F.2    Odermatt, B.3
  • 90
    • 1342322649 scopus 로고    scopus 로고
    • FTY720-induced lymphocyte homing modulates post-transplant preservation/reperfusion injury
    • Mar
    • Dragun D, Böhler T, Nieminen-Kelhä N, et al. FTY720-induced lymphocyte homing modulates post-transplant preservation/reperfusion injury. Kidney Int 2004 Mar; 65 (3): 1076-83
    • (2004) Kidney Int , vol.65 , Issue.3 , pp. 1076-1083
    • Dragun, D.1    Böhler, T.2    Nieminen-Kelhä, N.3
  • 91
    • 2342634478 scopus 로고    scopus 로고
    • Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects
    • May
    • Kovarik JM, Schmouder R, Barilla D, et al. Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects. Br J Clin Pharmacol 2004 May; 57 (5): 586-91
    • (2004) Br J Clin Pharmacol , vol.57 , Issue.5 , pp. 586-591
    • Kovarik, J.M.1    Schmouder, R.2    Barilla, D.3
  • 92
    • 1942508223 scopus 로고    scopus 로고
    • Multiple-dose FTY720: Tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects
    • May
    • Kovarik JM, Schmouder R, Barilla D, et al. Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects. J Clin Pharmacol 2004 May; 44 (5): 532-7
    • (2004) J Clin Pharmacol , vol.44 , Issue.5 , pp. 532-537
    • Kovarik, J.M.1    Schmouder, R.2    Barilla, D.3
  • 93
    • 33748917460 scopus 로고    scopus 로고
    • Pharmacokinetics are predictable and linear over an extended exposure range
    • abstract no. 266
    • Kovarik JM, Slade A, Riviere GJ, et al. Pharmacokinetics are predictable and linear over an extended exposure range [abstract no. 266]. Am J Transplant 2004; 4 Suppl. 8: 231
    • (2004) Am J Transplant , vol.4 , Issue.8 SUPPL. , pp. 231
    • Kovarik, J.M.1    Slade, A.2    Riviere, G.J.3
  • 94
    • 3042694259 scopus 로고    scopus 로고
    • FTY720 and cyclosporine: Evaluation for a pharmacokinetic interaction
    • Jul-Aug; Epub 2004 May 11
    • Kovarik JM, Schmouder R, Barilla D, et al. FTY720 and cyclosporine: evaluation for a pharmacokinetic interaction. Ann Pharmacother 2004 Jul-Aug; 38 (7-8): 1153-8. Epub 2004 May 11
    • (2004) Ann Pharmacother , vol.38 , Issue.7-8 , pp. 1153-1158
    • Kovarik, J.M.1    Schmouder, R.2    Barilla, D.3
  • 95
    • 0036205659 scopus 로고    scopus 로고
    • First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients
    • Apr
    • Budde K, Schmouder RL, Brunkhorst R, et al. First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients. J Am Soc Nephrol 2002 Apr; 13 (4): 1073-83
    • (2002) J Am Soc Nephrol , vol.13 , Issue.4 , pp. 1073-1083
    • Budde, K.1    Schmouder, R.L.2    Brunkhorst, R.3
  • 96
    • 0142040141 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: A multicenter, randomized, placebo-controlled, phase I study
    • Oct 15
    • Kahan BD, Karlix JL, Ferguson RM, et al. Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study. Transplantation 2003 Oct 15; 76 (7): 1079-84
    • (2003) Transplantation , vol.76 , Issue.7 , pp. 1079-1084
    • Kahan, B.D.1    Karlix, J.L.2    Ferguson, R.M.3
  • 97
    • 27244457788 scopus 로고    scopus 로고
    • FTY720, a novel immunomodulator in de novo kidney transplant patients: Pharmacokinetics and exposure-response relationship
    • Nov
    • Skerjanec A, Tedesco H, Neumayer HH, et al. FTY720, a novel immunomodulator in de novo kidney transplant patients: pharmacokinetics and exposure-response relationship. J Clin Pharmacol 2005 Nov; 45 (11): 1268-78
    • (2005) J Clin Pharmacol , vol.45 , Issue.11 , pp. 1268-1278
    • Skerjanec, A.1    Tedesco, H.2    Neumayer, H.H.3
  • 98
    • 33748888013 scopus 로고    scopus 로고
    • FTY720 pharmacokinetics are similar across ethnic-racial groups
    • abstract no. 264
    • Kovarik JM, Slade A, Sugita Y, et al. FTY720 pharmacokinetics are similar across ethnic-racial groups [abstract no. 264]. Am J Transplant 2004; 4 Suppl. 8: 230
    • (2004) Am J Transplant , vol.4 , Issue.8 SUPPL. , pp. 230
    • Kovarik, J.M.1    Slade, A.2    Sugita, Y.3
  • 99
    • 16844364903 scopus 로고    scopus 로고
    • FTY720 pharmacokinetics in mild to moderate hepatic impairment
    • Apr
    • Kovarik JM, Schmouder RL, Serra D, et al. FTY720 pharmacokinetics in mild to moderate hepatic impairment. J Clin Pharmacol 2005 Apr; 45 (4): 446-52
    • (2005) J Clin Pharmacol , vol.45 , Issue.4 , pp. 446-452
    • Kovarik, J.M.1    Schmouder, R.L.2    Serra, D.3
  • 100
    • 10744230053 scopus 로고    scopus 로고
    • Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients
    • Jul
    • Budde K, Schmouder R, Nashan B, et al. Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients. Am J Transplant 2003 Jul; 3 (7): 846-54
    • (2003) Am J Transplant , vol.3 , Issue.7 , pp. 846-854
    • Budde, K.1    Schmouder, R.2    Nashan, B.3
  • 101
    • 17644431534 scopus 로고    scopus 로고
    • Pharmacodynamics of FTY720, the first member of a new class of immune-modulating therapeutics in transplantation medicine
    • Oct
    • Bohler T, Waiser J, Schutz M, et al. Pharmacodynamics of FTY720, the first member of a new class of immune-modulating therapeutics in transplantation medicine. Int J Clin Pharmacol Ther 2003 Oct; 41 (10): 482-7
    • (2003) Int J Clin Pharmacol Ther , vol.41 , Issue.10 , pp. 482-487
    • Bohler, T.1    Waiser, J.2    Schutz, M.3
  • 102
    • 9644262393 scopus 로고    scopus 로고
    • Overview of FTY720 clinical pharmacokinetics and pharmacology
    • Dec
    • Kovarik JM, Schmouder RL, Slade AJ. Overview of FTY720 clinical pharmacokinetics and pharmacology. Ther Drug Monit 2004 Dec; 26 (6): 585-7
    • (2004) Ther Drug Monit , vol.26 , Issue.6 , pp. 585-587
    • Kovarik, J.M.1    Schmouder, R.L.2    Slade, A.J.3
  • 103
    • 20944435136 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients
    • May
    • Park SI, Felipe CR, Machado PG, et al. Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients. Braz J Med Biol Res 2005 May; 38 (5): 683-94
    • (2005) Braz J Med Biol Res , vol.38 , Issue.5 , pp. 683-694
    • Park, S.I.1    Felipe, C.R.2    Machado, P.G.3
  • 104
    • 17044403903 scopus 로고    scopus 로고
    • FTY720 high dose: Lymphocyte response at single doses up to 40mg
    • abstract no. 293
    • Slade A, Kovarik JM, Hunt TL, et al. FTY720 high dose: Lymphocyte response at single doses up to 40mg [abstract no. 293]. Am J Transplant 2004; 4 Suppl. 8: 238
    • (2004) Am J Transplant , vol.4 , Issue.8 SUPPL. , pp. 238
    • Slade, A.1    Kovarik, J.M.2    Hunt, T.L.3
  • 105
    • 31344464240 scopus 로고    scopus 로고
    • Insights into FTY720 use in transplantation from human exposure-lymphocyte mechanistic model based on clinical data
    • abstract no. 134
    • Kovarik JM, Schmidli H, Men G, et al. Insights into FTY720 use in transplantation from human exposure-lymphocyte mechanistic model based on clinical data [abstract no. 134]. Am J Transplant 2005; 5 Suppl. 11: 190
    • (2005) Am J Transplant , vol.5 , Issue.11 SUPPL. , pp. 190
    • Kovarik, J.M.1    Schmidli, H.2    Men, G.3
  • 106
    • 20544456156 scopus 로고    scopus 로고
    • FTY720, a novel immunomodulator: Efficacy and safety results from the first phase 2A study in de novo renal transplantation
    • Jun 15
    • Tedesco-Silva H, Mourad G, Kahan BD, et al. FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation. Transplantation 2005 Jun 15; 79 (11): 1553-60
    • (2005) Transplantation , vol.79 , Issue.11 , pp. 1553-1560
    • Tedesco-Silva, H.1    Mourad, G.2    Kahan, B.D.3
  • 107
    • 2342577326 scopus 로고    scopus 로고
    • FTY720 in combination with everolimus: A novel CNI-free regimen effective in patients at high risk for DGF
    • abstract no. 1572
    • Lorber M, Kahan B, Tedesco-Silva H, et al. FTY720 in combination with everolimus: a novel CNI-free regimen effective in patients at high risk for DGF [abstract no. 1572]. Am J Transplant 2003; 5 Suppl. 3: 555
    • (2003) Am J Transplant , vol.5 , Issue.3 SUPPL. , pp. 555
    • Lorber, M.1    Kahan, B.2    Tedesco-Silva, H.3
  • 108
    • 33745800873 scopus 로고    scopus 로고
    • FTY720/cyclosporine regimens in de novo renal transplantation: A 1-year dose-finding study
    • Mulgaonkar S, Tedesco H, Oppenheimer F, et al. FTY720/cyclosporine regimens in de novo renal transplantation: a 1-year dose-finding study. Am J Transplant. 2006; 6: 1848-1857
    • (2006) Am J Transplant , vol.6 , pp. 1848-1857
    • Mulgaonkar, S.1    Tedesco, H.2    Oppenheimer, F.3
  • 109
    • 2442647649 scopus 로고    scopus 로고
    • FYT: Not just a homely drug
    • May 15
    • Calne SR. FYT: not just a homely drug. Transplantation 2004 May 15; 77 (9): 1327
    • (2004) Transplantation , vol.77 , Issue.9 , pp. 1327
    • Calne, S.R.1
  • 110
    • 33748897346 scopus 로고    scopus 로고
    • A one year randomized controlled efficacy and safety trial of FTY720, versus mycophenolate mofetil with cyclosporine and corticosteroids in de novo renal transplantation
    • abstract no. 52
    • Mark Pescovitz, the FTY720 0125 Study Group. A one year randomized controlled efficacy and safety trial of FTY720, versus mycophenolate mofetil with cyclosporine and corticosteroids in de novo renal transplantation [abstract no. 52]. American J Transplant 2006; Suppl.: 84
    • (2006) American J Transplant , Issue.SUPPL. , pp. 84
    • Pescovitz, M.1
  • 111
    • 33748884914 scopus 로고    scopus 로고
    • FTY720 a novel immunomodulator, vs. mycophenolate mofetil with cyclosporine micro-emulsion in de novo renal transplantation, a one-year randomized controlled trial in 668 patients from Europe and Australia
    • abstract no. 829
    • Salvadori M, Budde K, Charpentier B, et al. FTY720 a novel immunomodulator, vs. mycophenolate mofetil with cyclosporine micro-emulsion in de novo renal transplantation, a one-year randomized controlled trial in 668 patients from Europe and Australia [abstract no. 829.]. Am J Transplant 2006; Suppl.: 346
    • (2006) Am J Transplant , Issue.SUPPL. , pp. 346
    • Salvadori, M.1    Budde, K.2    Charpentier, B.3
  • 112
    • 33846011160 scopus 로고    scopus 로고
    • FTY720 vs. MMF in de novo renal transplant patients on full-dose neoral: 6-Month results of a double-blind study
    • abstract no. 51
    • Tedesco H, Szakaly P, Shoker A, et al. FTY720 vs. MMF in de novo renal transplant patients on full-dose neoral: 6-month results of a double-blind study [abstract no. 51]. Am J Transplant 2006; Suppl.: 83
    • (2006) Am J Transplant , Issue.SUPPL. , pp. 83
    • Tedesco, H.1    Szakaly, P.2    Shoker, A.3
  • 113
    • 3042750654 scopus 로고    scopus 로고
    • Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: Clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging
    • Jul
    • Rausch M, Hiestand P, Foster CA, et al. Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging. J Magn Reson Imaging 2004 Jul; 20 (1): 16-24
    • (2004) J Magn Reson Imaging , vol.20 , Issue.1 , pp. 16-24
    • Rausch, M.1    Hiestand, P.2    Foster, C.A.3
  • 114
    • 0029786784 scopus 로고    scopus 로고
    • 15-Deoxyspergualin: A newly developed immunosuppressive agent and its mechanism of action and clinical effect: a review
    • Japan Collaborative Transplant Study Group for NKT-01. Aug
    • Amemiya H. 15-Deoxyspergualin: a newly developed immunosuppressive agent and its mechanism of action and clinical effect: a review. Japan Collaborative Transplant Study Group for NKT-01. Artif Organs 1996 Aug; 20 (8): 832-5
    • (1996) Artif Organs , vol.20 , Issue.8 , pp. 832-835
    • Amemiya, H.1
  • 115
    • 2942568020 scopus 로고    scopus 로고
    • Rituximab as treatment for refractory kidney transplant rejection
    • Jun
    • Becker YT, Becker BN, Pirsch JD, et al. Rituximab as treatment for refractory kidney transplant rejection. Am J Transplant 2004 Jun; 4 (6): 996-1001
    • (2004) Am J Transplant , vol.4 , Issue.6 , pp. 996-1001
    • Becker, Y.T.1    Becker, B.N.2    Pirsch, J.D.3
  • 116
    • 0036871663 scopus 로고    scopus 로고
    • What's in the pipeline? New immunosuppressive drugs in transplantation
    • Nov
    • Vincenti F. What's in the pipeline? New immunosuppressive drugs in transplantation. Am J Transplant 2002 Nov; 2 (10): 898-903
    • (2002) Am J Transplant , vol.2 , Issue.10 , pp. 898-903
    • Vincenti, F.1
  • 117
    • 0037773336 scopus 로고    scopus 로고
    • New monoclonal antibodies in renal transplantation
    • Mar
    • Vicenti F. New monoclonal antibodies in renal transplantation. Minerva Urol Nefrol 2003 Mar; 55 (1): 57-66
    • (2003) Minerva Urol Nefrol , vol.55 , Issue.1 , pp. 57-66
    • Vicenti, F.1
  • 118
    • 0036899589 scopus 로고    scopus 로고
    • Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: A randomized, double-blind, placebo-controlled trial
    • Kalunian KC, Davis Jr JC, Merrill JT, et al. Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2002; 46 (12): 3251-8
    • (2002) Arthritis Rheum , vol.46 , Issue.12 , pp. 3251-3258
    • Kalunian, K.C.1    Davis Jr., J.C.2    Merrill, J.T.3
  • 119
    • 0036591183 scopus 로고    scopus 로고
    • IDEC-131: IDEC/Eisai
    • Dumont FJ. IDEC-131: IDEC/Eisai. Curr Opin Investig Drugs 2002; 3 (5): 725-34
    • (2002) Curr Opin Investig Drugs , vol.3 , Issue.5 , pp. 725-734
    • Dumont, F.J.1
  • 120
    • 0842264044 scopus 로고    scopus 로고
    • Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura
    • Kuwana M, Nomura S, Fujimura K, et al. Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura. Blood 2004; 103 (4): 1229-36
    • (2004) Blood , vol.103 , Issue.4 , pp. 1229-1236
    • Kuwana, M.1    Nomura, S.2    Fujimura, K.3
  • 121
    • 0034722921 scopus 로고    scopus 로고
    • Phase I trial of HuM291, a humanized anti-CD3 antibody, in patients receiving renal allografts from living donors
    • Norman DJ, Vincenti F, de Mattos AM, et al. Phase I trial of HuM291, a humanized anti-CD3 antibody, in patients receiving renal allografts from living donors. Transplantation 2000; 70 (12): 1707-12
    • (2000) Transplantation , vol.70 , Issue.12 , pp. 1707-1712
    • Norman, D.J.1    Vincenti, F.2    De Mattos, A.M.3
  • 122
    • 19944415907 scopus 로고    scopus 로고
    • A phase II multicenter study of visilizumab, humanized anti-CD3 antibody, to treat steroid-refractory acute graft-versus-host disease
    • Carpenter PA, Lowder J, Johnston L, et al. A phase II multicenter study of visilizumab, humanized anti-CD3 antibody, to treat steroid-refractory acute graft-versus-host disease. Biol Blood Marrow Transplant 2005; 11 (6): 465-71
    • (2005) Biol Blood Marrow Transplant , vol.11 , Issue.6 , pp. 465-471
    • Carpenter, P.A.1    Lowder, J.2    Johnston, L.3
  • 123
    • 0037469068 scopus 로고    scopus 로고
    • Monotherapy with LF 15-0195, an analogue of 15-deoxyspergualin, significantly prolongs renal allograft survival in monkeys
    • Apr 27
    • Yang H, Chen G, Kanai N, et al. Monotherapy with LF 15-0195, an analogue of 15-deoxyspergualin, significantly prolongs renal allograft survival in monkeys. Transplantation 2003 Apr 27; 75 (8): 1166-71
    • (2003) Transplantation , vol.75 , Issue.8 , pp. 1166-1171
    • Yang, H.1    Chen, G.2    Kanai, N.3
  • 124
    • 0037469019 scopus 로고    scopus 로고
    • Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells
    • Apr 27
    • Min WP, Zhou D, Ichim TE, et al. Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells. Transplantation 2003 Apr 27; 75 (8): 1160-5
    • (2003) Transplantation , vol.75 , Issue.8 , pp. 1160-1165
    • Min, W.P.1    Zhou, D.2    Ichim, T.E.3
  • 125
    • 33746876350 scopus 로고    scopus 로고
    • Prolongation of allograft survival by administration of anti-CD45RB monoclonal antibody is due to alteration of CD45RB: CD45RB T-cell proportions
    • Epub 2006 Jul 6
    • Luke PP, Deng JP, Lian D, et al. Prolongation of allograft survival by administration of anti-CD45RB monoclonal antibody is due to alteration of CD45RB: CD45RB T-cell proportions. Am J Transplant. Epub 2006 Jul 6
    • Am J Transplant
    • Luke, P.P.1    Deng, J.P.2    Lian, D.3
  • 126
    • 33748909915 scopus 로고    scopus 로고
    • Long-term limb allograft survival using a short course of anti-C45RB monoclonal antibody, LF15-0195 and rapamycin in a mouse model
    • abstract no. 969
    • Zhong T, Liu Y, Jiang J, et al. Long-term limb allograft survival using a short course of anti-C45RB monoclonal antibody, LF15-0195 and rapamycin in a mouse model [abstract no. 969]. American J Transplant 2006; 6 Suppl. 2: 393
    • (2006) American J Transplant , vol.6 , Issue.2 SUPPL. , pp. 393
    • Zhong, T.1    Liu, Y.2    Jiang, J.3
  • 127
    • 0347986633 scopus 로고    scopus 로고
    • Emerging and diverse roles of protein kinase C in immune cell signaling
    • Tan S-L, Parker PJ. Emerging and diverse roles of protein kinase C in immune cell signaling. Biochem J 2003; 376: 545-52
    • (2003) Biochem J , vol.376 , pp. 545-552
    • Tan, S.-L.1    Parker, P.J.2
  • 128
    • 33748892465 scopus 로고    scopus 로고
    • NVP-AEB071: Human pharmacodynamics in combination with mycophenolic acid
    • abstract no. 396
    • Slade, AV, Agyemang A, Sieberling M, et al. NVP-AEB071: human pharmacodynamics in combination with mycophenolic acid [abstract no. 396]. Am J Transplantation 2006; 6 Suppl. 2: 99
    • (2006) Am J Transplantation , vol.6 , Issue.2 SUPPL. , pp. 99
    • Slade, A.V.1    Agyemang, A.2    Sieberling, M.3
  • 129
    • 33748894877 scopus 로고    scopus 로고
    • NVP-AEB071: Pharmacokinetics and pharmacodynamic activity of a novel T-cell activation inhibitor under multiple-dose conditions
    • abstract no. 392
    • Slade A, Hijazi Y, Wagner J, et al. NVP-AEB071: pharmacokinetics and pharmacodynamic activity of a novel T-cell activation inhibitor under multiple-dose conditions [abstract no. 392]. American J Transplant 2006; 6 Suppl. 2: 198
    • (2006) American J Transplant , vol.6 , Issue.2 SUPPL. , pp. 198
    • Slade, A.1    Hijazi, Y.2    Wagner, J.3
  • 130
    • 33748917008 scopus 로고    scopus 로고
    • NVP-AEB071 pharmacokinetics: Combination with everolimus does not result in clinically relevant interaction
    • abstract no. 2435
    • Slade A, Bartlett M, van Marle S, et al. NVP-AEB071 pharmacokinetics: combination with everolimus does not result in clinically relevant interaction [abstract no. 2435]. Am J Transplant 2006; 6 Suppl. 2: 865
    • (2006) Am J Transplant , vol.6 , Issue.2 SUPPL. , pp. 865
    • Slade, A.1    Bartlett, M.2    Van Marle, S.3
  • 131
    • 33748893806 scopus 로고    scopus 로고
    • NVP-AEB071 pharmacokinetics: Combination with mycophenolate mofetil (Cellcept®) is safe and does not result in an interaction
    • abstract no. 2436
    • Slade A, Pfrunder A, Koelle EU, et al. NVP-AEB071 pharmacokinetics: combination with mycophenolate mofetil (Cellcept®) is safe and does not result in an interaction [abstract no. 2436]. Am J Transplant 2006; 6 Suppl. 2: 866
    • (2006) Am J Transplant , vol.6 , Issue.2 SUPPL. , pp. 866
    • Slade, A.1    Pfrunder, A.2    Koelle, E.U.3
  • 132
    • 0032490341 scopus 로고    scopus 로고
    • Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients
    • plubished erratum appears in Lancet 1998 Aug 1; 352 (9125): 408
    • Calne R, Friend P, Moffatt S, et al. Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients [plubished erratum appears in Lancet 1998 Aug 1; 352 (9125): 408]. Lancet 1998; 351 (9117): 1701-2
    • (1998) Lancet , vol.351 , Issue.9117 , pp. 1701-1702
    • Calne, R.1    Friend, P.2    Moffatt, S.3
  • 134
    • 0038638396 scopus 로고    scopus 로고
    • Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H)
    • Kirk AD, Hale DA, Mannon RB, et al. Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H). Transplantation 2003; 76 (1): 120-9
    • (2003) Transplantation , vol.76 , Issue.1 , pp. 120-129
    • Kirk, A.D.1    Hale, D.A.2    Mannon, R.B.3
  • 135
    • 33744920975 scopus 로고    scopus 로고
    • Bloodstream infections in organ transplant recipients receiving alemtuzumab: No evidence of occurrence of organisms typically associated with profound T cell depletion
    • Epub 2006 Jan 2
    • Silveira FP, Marcos A, Kwak EJ, et al. Bloodstream infections in organ transplant recipients receiving alemtuzumab: no evidence of occurrence of organisms typically associated with profound T cell depletion. J Infect. Epub 2006 Jan 2
    • J Infect
    • Silveira, F.P.1    Marcos, A.2    Kwak, E.J.3
  • 136
    • 20044380331 scopus 로고    scopus 로고
    • Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion
    • Pearl JP, Parris J, Hale DA, et al. Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion. Am J Transplant 2005; 5 (3): 465-74
    • (2005) Am J Transplant , vol.5 , Issue.3 , pp. 465-474
    • Pearl, J.P.1    Parris, J.2    Hale, D.A.3
  • 137
    • 4744354630 scopus 로고    scopus 로고
    • Campath-1H in renal transplantation: The University of Wisconsin experience
    • Knechtle SJ, Fernandez LA, Pirsch JD, et al. Campath-1H in renal transplantation: the University of Wisconsin experience. Surgery 2004; 136 (4): 754-60
    • (2004) Surgery , vol.136 , Issue.4 , pp. 754-760
    • Knechtle, S.J.1    Fernandez, L.A.2    Pirsch, J.D.3
  • 138
    • 20044391391 scopus 로고    scopus 로고
    • Acute cellular rejection predominated by monocytes is a severe form of rejection in human renal recipients with or without campath-1H (alemtuzumab) induction therapy
    • Zhang PL, Malek SK, Prichard JW, et al. Acute cellular rejection predominated by monocytes is a severe form of rejection in human renal recipients with or without campath-1H (alemtuzumab) induction therapy. Am J Transplant 2005; 5 (3): 604-7
    • (2005) Am J Transplant , vol.5 , Issue.3 , pp. 604-607
    • Zhang, P.L.1    Malek, S.K.2    Prichard, J.W.3
  • 139
    • 20544458513 scopus 로고    scopus 로고
    • Alemtuzumab (CAMPATH 1H) induction therapy in cadaveric kidney transplantation: Efficacy and safety at five years
    • Watson CJ, Bradley JA, Friend PJ, et al. Alemtuzumab (CAMPATH 1H) induction therapy in cadaveric kidney transplantation: efficacy and safety at five years. Am J Transplant 2005; 5 (6): 1347-53
    • (2005) Am J Transplant , vol.5 , Issue.6 , pp. 1347-1353
    • Watson, C.J.1    Bradley, J.A.2    Friend, P.J.3
  • 140
    • 27744481221 scopus 로고    scopus 로고
    • Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin
    • Kirk AD, Mannon RB, Kleiner DE, et al. Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin. Transplantation 2005; 80 (8): 1051-9
    • (2005) Transplantation , vol.80 , Issue.8 , pp. 1051-1059
    • Kirk, A.D.1    Mannon, R.B.2    Kleiner, D.E.3
  • 141
    • 0038805159 scopus 로고    scopus 로고
    • Campath-1H induction plus rapamycin monotherapy for renal transplantation: Results of a pilot study
    • Knechtle SJ, Pirsch JD, Fechner JJ, et al. Campath-1H induction plus rapamycin monotherapy for renal transplantation: results of a pilot study. Am J Transplant 2003; 3 (6): 722-30
    • (2003) Am J Transplant , vol.3 , Issue.6 , pp. 722-730
    • Knechtle, S.J.1    Pirsch, J.D.2    Fechner, J.J.3
  • 142
    • 26644457880 scopus 로고    scopus 로고
    • Randomized trial of alemtuzumab for prevention of graft rejection and preservation of renal function after kidney transplantation
    • Sep 27
    • Vatshala A, Ona ET, Tan SY, et al. Randomized trial of alemtuzumab for prevention of graft rejection and preservation of renal function after kidney transplantation. Transplantation 2005 Sep 27; 80 (6): 765-74
    • (2005) Transplantation , vol.80 , Issue.6 , pp. 765-774
    • Vatshala, A.1    Ona, E.T.2    Tan, S.Y.3
  • 143
    • 29544432261 scopus 로고    scopus 로고
    • Steroid-free tacrolimus monotherapy after pretransplantation thymoglobulin or campath and laparoscopy in living donor renal transplantation
    • Tan HP, Kaczorowski D, Basu A, et al. Steroid-free tacrolimus monotherapy after pretransplantation thymoglobulin or campath and laparoscopy in living donor renal transplantation. Transplant Proc 2005; 37 (10): 4235-40
    • (2005) Transplant Proc , vol.37 , Issue.10 , pp. 4235-4240
    • Tan, H.P.1    Kaczorowski, D.2    Basu, A.3
  • 144
    • 20144389244 scopus 로고    scopus 로고
    • Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with thymoglobulin or campath
    • Apr
    • Shapiro R, Basu A, Tan H, et al. Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with thymoglobulin or campath. J Am Coll Surg 2005 Apr; 200 (4): 505-15
    • (2005) J Am Coll Surg , vol.200 , Issue.4 , pp. 505-515
    • Shapiro, R.1    Basu, A.2    Tan, H.3
  • 145
    • 3042819498 scopus 로고    scopus 로고
    • Surrogate markers for long-term renal allograft survival
    • Jul
    • Hariharan S, Kasiske B, Matas A, et al. Surrogate markers for long-term renal allograft survival. Am J Transplant 2004 Jul; 4 (7): 1179-83
    • (2004) Am J Transplant , vol.4 , Issue.7 , pp. 1179-1183
    • Hariharan, S.1    Kasiske, B.2    Matas, A.3
  • 146
    • 18144399975 scopus 로고    scopus 로고
    • Clinical pharmacogenetics of immunosuppressive drugs in organ transplantation
    • Mar
    • Szekeres T, Haushofer A. Clinical pharmacogenetics of immunosuppressive drugs in organ transplantation. Pharmacogenomics 2005 Mar; 6 (2): 163-8
    • (2005) Pharmacogenomics , vol.6 , Issue.2 , pp. 163-168
    • Szekeres, T.1    Haushofer, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.