Efficacy of malononitrilamide FK778 in a preclinical model of small bowel transplantation

Transplantation Proceedings

Volumn 37, Issue 6, 2005, Pages 2719-2721

  Alessiani, M ^a,b   Zonta, S ^a   Abbiati, F ^a   Cobianchi, L ^a   Bardone, M ^a   Zitelli, E ^a   Doni, M ^a   Vigano J ^a   Mazzilli, M ^a   Lovisetto, F ^a   Dominioni, T ^a   Dionigi, B ^a   Lusona, B ^a   Morbini, P ^a   Molinaro, M D ^a   Dionigi, P ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 3 HYDROXY N [4 (TRIFLUOROMETHYL)PHENYL] 6 HEPTYNAMIDE; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; BACTERIAL INFECTION; CAUSE OF DEATH; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; FOLLOW UP; GRAFT REJECTION; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE TRANSPLANTATION; NONHUMAN; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; SURVIVAL RATE; SURVIVAL TIME; SWINE; TREATMENT OUTCOME;

EID: 25144508991     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2005.06.105     Document Type: Article

References (17)

1. K. Abu-Elmagd, J. Reyes, G. Bond Clinical intestinal transplantation a decade of experience at a single center Ann Surg 234 2001 404
2. The Intestinal Transplant Registry: Current results 2002. Available at: http://www.intestinal-transplant.org. Accessed October 31, 2004
3. A.R. Muelle, A. Pascher, P. Platz Immunosuppression following intestinal transplantation Transplant Proc 36 2004 325
4. M. Alessiani, M. Spada, M. Merli Different models of intestinal transplantation in pigs technical aspects Transplant Proc 28 1996 2698
5. T. Wu, K. Abu-Elmagd, J. Bonf A schema for histologic grading of small intestine allograft acute rejection Transplantation 75 2003 1241
6. M. Alessiani, M. Spada, P. Dionigi Combined immunosuppressive therapy with tacrolimus and mycophenolate mofetil for small bowel transplantation in pigs Transplantation 62 1996 563
7. M. Alessiani, F. De Ponti, F. Fayer The influence of surgery, immunosuppressive drugs, and rejection, on graft function after small bowel transplantation a large animal study Transplant Int 16 2003 327
8. M.B. Jin, M. Nakayama, T. Ogata A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs Surgery 132 2002 72
9. X. Xu, J.W. Williams, H. Gong Two activities of the immunosuppressive metabolite of leflunomide, A77 1726 Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation Biochem Pharmacol 52 1996 527
10. A.S.F. Chong, K. Rezai, H. Gebel Effect of leflunomide and other immunosuppressive agents on T cell proliferation in vitro Transplantation 61 1996 140
11. K.F. Seimasko, A.S.F. Chong, J.W. Williams Regulation of B cell function by immunosuppressive agent leflunomide Transplantation 61 1996 636
12. T. Birsan, C. Dambin, J. Klupp Effects of the malononitrilamide FK778 on immune functions in vitro in whole blood non-human primates and healty human volunteers Transplant Immunol 11 2003 163
13. F. Pan, A. Ebbs, C. Wynn FK778, a powerful new immunosuppressant, effectively reduces functional and histologic changes of chronic rejection in rat renal allografts Transplantation 75 2003 1110
14. A.E. Kyles, C.R. Gragory, S.M. Griffey Immunosuppression with a combination of the luflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs Transplantation 75 2003 1128
15. S. Qi, S. Zhu, D. Xu Significant prolongation of renal allograft survival by delayed combination therapy of FK778 with tacrolimus in nonhuman primates Transplantation 75 2003 1124
16. K.K. Bilolo, J. Ouyang, X. Wang Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat Transplantation 75 2003 1881
17. Y. Vanrenterghem, J.P. van Hooff, M. Klinger The effects of FK778 in combination with tacrolimus and steroids a phase II multicenter study in renal transplant patients Transplantation 78 2004 9