Assessment of an LC-MS method for plasma quantification of the new immunosuppressant FK778 through comparison with HPLC-UV

Transplantation Proceedings

Volumn 37, Issue 6, 2005, Pages 2722-2727

  Molinaro, M ^a   Carazzone, C ^a,b   Barbano, D ^a   Abbiati, F ^a,b   Alessiani, M ^a,b   Regazzi, M ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 3 HYDROXY N [4 (TRIFLUOROMETHYL)PHENYL] 6 HEPTYNAMIDE; ACETONITRILE; AMMONIUM ACETATE;

ACCURACY; ANALYTIC METHOD; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NORMAL HUMAN; OBSERVER VARIATION; PRECIPITATION; PRIORITY JOURNAL; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

EID: 25144475111     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2005.06.069     Document Type: Article

References (13)

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2. H.T. Silva, R.E. Morris Leflunomide and malononitriloamides Exp Opin Investig Drugs 6 1997 51
3. S.D. Slauson, H.T. Silva, S.W. Sherwood Flow cytometric analysis of the molecular mechanism of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide analogues in a novel whole blood assay Immunol Lett 67 1999 79
4. K. Bilolo, J. Ouyang, X. Wang Synergistic effects of molononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat Transplantation 75 2003 1881
5. S. Qi, S. Zhu, D. Xu Significant prolongation of renal allograft survival by delayed combination therapy of FK778 with tacrolimus in non-human primates Transplantation 75 2003 1124
6. J. Savikko, E. Von Willabrand, P. Häyry Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effects potential applications for restenosis and chronic rejection Transplantation 76 2003 455
7. H.U. Schorlemmer, E. Ruuth, R. Kurrle Malononitrilamides synergistically prevent acute and treat ongoing skin allograft rejection with cyclosporine Transpl Int 11 1998 S340
8. Z. Qi, H. Ekberg Malononitrilamides 715 and 279 prolong rat cardiac allograft survival, reverse ongoing rejection inhibit allospecific antibody production and interact positively with cyclosporine Scan J Immunol 48 1998 379
9. Y. Vanrenterghem, J.P. Van Hooff, M. Klinger The effects of FK778 in combination with tacrolimus and steroids a phase II multicenter study in renal transplant patients Transplantation 78 2004 9
10. W.J. Waldman, D.A. Knight, N.S. Lurain Novel mechanism of inhibition of CMV by the experimental immunosuppressive agent leflunomide Transplantation 68 1999 814
11. F. Pan, A. Ebbs, C. Wynn FK778, a powerful new immunosoppressant, effectively reduces functional and histologic changes of chronic rejection in rat renal allografts Transplantation 75 2003 1110
12. T. Birsan, C. Dambrin, J. Klupp In vivo pharmacokinetic and pharmacodynamic evaluation of the malononitrilamide FK778 in non-human primates Transpl Int 16 2003 354
13. Y. Vanrenterghem, J. van Hoof, M. Klinger The effect of FK778 in combination with tacrolimus and steroid a phase II multicenter study in renal transplant patients Transplantation 78 2004 9