FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506

Transplantation Proceedings

Volumn 37, Issue 1, 2005, Pages 126-129

  Yamamoto, S ^a,c   Okuda, T ^a   Yamasaki, K ^a   Tanaka, H ^a   Takemura, S ^a   Minamiyama, Y ^b   Ikeda, K ^a   Hirohashi, K ^a   Suehiro, S ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 3 HYDROXY N [4 (TRIFLUOROMETHYL)PHENYL] 6 HEPTYNAMIDE; ALANINE AMINOTRANSFERASE; CEFTRIAXONE; CREATININE; IMMUNOGLOBULIN M; PLASMA PROTEIN; TACROLIMUS;

ACUTE GRAFT REJECTION; ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BLOOD CHEMISTRY; BODY WEIGHT; CONFERENCE PAPER; CONTROLLED STUDY; DONOR; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG POTENTIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; INFECTION; INTERMETHOD COMPARISON; LIVER GRAFT; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MALE; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RECIPIENT; TIME SERIES ANALYSIS;

EID: 16244382061     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2005.02.016     Document Type: Conference Paper

References (7)

1. B. Rozman Clinical pharmacokinetics of leflunomide Clin Pharmacokinet 41 2002 421
2. X. Xu, J.W. Williams, H. Gong Two activities of the immunosuppressive metabolite of leflunomide, A77 1726 Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation Biochem Pharmacol 52 1996 527
3. A.J. Demetris, S.G. Qian, H. Sun Liver allograft rejection: an overview of morphologic findings Am J Surg Pathol 14 Suppl 1 1990 49
4. M.B. Jin, M. Nakayama, T. Ogata A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs Surgery 132 2002 72
5. S. Qi, S. Zhu, D. Xu Significant prolongation of renal allograft survival by delayed combination therapy of FK778 with tacrolimus in nonhuman primates Transplantation 75 2003 1124
6. T. Deuse, S. Schrepfer, H. Reichenspurner The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent Transplantation 77 2004 509
7. K.K. Bilolo, J. Ouyang, X. Wang Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat Transplantation 75 2003 1881