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Volumn 20, Issue 8, 1996, Pages 832-835

15-Deoxyspergualin: A newly developed immunosuppressive agent and its mechanism of action and clinical effect: A review

Author keywords

15 Deoxyspergualin; Clinical trial; Immunosuppressive agent

Indexed keywords

MEDICAL APPLICATIONS;

EID: 0029786784     PISSN: 0160564X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1525-1594.1996.tb04555.x     Document Type: Article
Times cited : (23)

References (21)
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    • Fujii H, Takeda T, Nemoto K, Abe F, Fujii A, Talmadge JE, Takeuchi T. Deoxyspergualin, a novel immunosuppressant, markedly inhibits human mixed lymphocyte reaction and cytotoxic T-lymphocyte activity in vitro. Int J Immunopharm 1992;14:731-7.
    • (1992) Int J Immunopharm , vol.14 , pp. 731-737
    • Fujii, H.1    Takeda, T.2    Nemoto, K.3    Abe, F.4    Fujii, A.5    Talmadge, J.E.6    Takeuchi, T.7
  • 3
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    • Cytostatic effect of deoxyspergualin on a murine leukemia cell line L 1210
    • Hiratsuka M, Kuramochi H, Takahashi K. Cytostatic effect of deoxyspergualin on a murine leukemia cell line L 1210. Jpn J Cancer Res 1991;82:1065-8.
    • (1991) Jpn J Cancer Res , vol.82 , pp. 1065-1068
    • Hiratsuka, M.1    Kuramochi, H.2    Takahashi, K.3
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    • Interaction of the immunosuppressant deoxyspergualin with a member of the Hsp 70 family of heat shock proteins
    • Nadler SG, Tepper MA, Schacter B, Mazzucco CE. Interaction of the immunosuppressant deoxyspergualin with a member of the Hsp 70 family of heat shock proteins. Science 1992;258:484-6.
    • (1992) Science , vol.258 , pp. 484-486
    • Nadler, S.G.1    Tepper, M.A.2    Schacter, B.3    Mazzucco, C.E.4
  • 6
    • 0023371309 scopus 로고
    • Blastogenic responses and the release of interleukins 1 and 2 by spleen cells obtained from rat skin allograft recipients administered with 15-deoxyspergualin
    • Nemoto K, Abe F, Nakamtira T, Ishizuka M, Takeuchi T, Umezawa H. Blastogenic responses and the release of interleukins 1 and 2 by spleen cells obtained from rat skin allograft recipients administered with 15-deoxyspergualin. J Antibiot 1987;40:1062-4.
    • (1987) J Antibiot , vol.40 , pp. 1062-1064
    • Nemoto, K.1    Abe, F.2    Nakamtira, T.3    Ishizuka, M.4    Takeuchi, T.5    Umezawa, H.6
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    • In vitro immunosuppressive properties of spergualins to murine T cell response
    • Fujii H, Takada T, Nemoto K, Abe F, Fujii A, Takeuchi T. In vitro immunosuppressive properties of spergualins to murine T cell response. J Antibiot 1989;42:788-94.
    • (1989) J Antibiot , vol.42 , pp. 788-794
    • Fujii, H.1    Takada, T.2    Nemoto, K.3    Abe, F.4    Fujii, A.5    Takeuchi, T.6
  • 8
    • 0024413085 scopus 로고
    • Mechanism of action of 15-deoxyspergualin. 1. Suppressive effect on the induction of alloreactive secondary cytotoxic T lymphocytes in vivo and in vitro
    • Nishimura K, Tokunaga T. Mechanism of action of 15-deoxyspergualin. 1. Suppressive effect on the induction of alloreactive secondary cytotoxic T lymphocytes in vivo and in vitro. Immunology 1989;68:66-71.
    • (1989) Immunology , vol.68 , pp. 66-71
    • Nishimura, K.1    Tokunaga, T.2
  • 10
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    • Therapeutic effect of 15-deoxyspergualin on acute graft rejection detected by 31P nuclear magnetic resonance spectrography, and its effect on rat heart transplantation
    • Suzuki S, Kanashiro M, Watanabe H, Amemiya H. Therapeutic effect of 15-deoxyspergualin on acute graft rejection detected by 31P nuclear magnetic resonance spectrography, and its effect on rat heart transplantation. Transplantation 1988;46:669-72.
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    • Suzuki, S.1    Kanashiro, M.2    Watanabe, H.3    Amemiya, H.4
  • 12
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    • Markedly enhanced therapeutic effect of deoxyspergualin on acute rejection when combined with methylprednisolone in kidney recipient
    • Amemiya H, Dohi K, Otsubo O, Endo T, Nagano S, Ishibashi M, Hirano T, Sato K, Kurita T. Markedly enhanced therapeutic effect of deoxyspergualin on acute rejection when combined with methylprednisolone in kidney recipient. Transplant Proc 1991;23:1087-9.
    • (1991) Transplant Proc , vol.23 , pp. 1087-1089
    • Amemiya, H.1    Dohi, K.2    Otsubo, O.3    Endo, T.4    Nagano, S.5    Ishibashi, M.6    Hirano, T.7    Sato, K.8    Kurita, T.9
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    • Suzuki S. Deoxyspergualin: Mode of action and effects on graft rejection. In: Thomson AW, Starzl TE, eds. Immunosuppressive drugs: Developments in anti-rejection therapy. London: Edward Arnold, 1994;187-202.
    • (1994) Immunosuppressive Drugs: Developments in Anti-rejection Therapy , pp. 187-202
    • Suzuki, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.