Phosphatidylinositol 3-kinase and the control of endosome dynamics: New players defined by structural motifs

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Volumn 2, Issue 12, 2001, Pages 859-866

  Corvera, S ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

FYVE; Membrane traffic; PH domain; Phox; Signal transduction

Indexed keywords

GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,5 BIPHOSPHATE; UNCLASSIFIED DRUG;

CELL ACTIVITY; CELL FUNCTION; CELL SURFACE; CELL SURVIVAL; CELL TRANSPORT; COMPLEX FORMATION; CONTROLLED STUDY; DYNAMICS; ENDOSOME; ENZYME ACTIVITY; MAMMAL CELL; MEMBRANE TRANSPORT; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BINDING SITES; BLOOD PROTEINS; ENDOSOMES; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOPROTEINS; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 0035184743     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2001.21201.x     Document Type: Review

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16. Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast
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19. Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain
20. Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking
21. Endocytosis and vesicular trafficking of immune complexes and activation of phospholipase D by the human high-affinity IgG receptor requires distinct phosphoinositide 3-kinase activities
22. Phosphatidylinositol 3′-kinase, but not p70 ribosomal S6 kinase, is involved in membrane protein recycling wortmannin inhibits glucose transport and downregulates cell-surface transferrin receptor numbers effect on fluid-phase endocytosis in fibroblasts
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26. Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmannin
27. Trafficking kinetics of the insulin-regulated membrane aminopeptidase in 3T3-L1 adipocytes
28. Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
29. + exchanger NHE3 isoform is regulated by the phosphatidylinositol 3-kinase pathway
30. Wortmannin inhibits transcytosis of dimeric IgA by the polymeric immunoglobulin receptor
31. Wortmannin, an inhibitor of phosphoinositide 3-kinase, inhibits transcytosis in polarized epithelial cells
32. Bidirectional transcytosis of IgG by the rat neonatal Fc receptor expressed in a rat kidney cell line: A system to study protein transport across epithelia
33. Evidence for apical endocytosis in polarized hepatic cells: Phosphoinositide 3-kinase inhibitors lead to the lysosomal accumulation of resident apical plasma membrane proteins
34. Morphological effects of wortmannin on the endosomal system and GLUT4- containing compartments in rat adipose cells
35. Multivesicular body morphogenesis requires phosphatidyl-inositol 3-kinase activity
36. Phosphoinositide signaling and turnover: Ptdlns (3) P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities
37. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
38. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger
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40. Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p
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42. FYVE fingers bind Ptdlns(3)P
43. A functional Ptdlns(3)P-binding motif
44. EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine 'fingers' and contains a calmodulin-binding IQ motif
45. The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization
46. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
47. The Rab5 effector EEA1 interacts directly with syntaxin-6
48. Relationships between EEA1 binding partners and their role in endosome fusion
49. Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain
50. A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic
51. +-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells
52. Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast
53. Fab1p Ptdlns(3)P 5-kinase function essential for protein sorting in the multivesicular body
54. Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5′-kinase PIKfyve
55. PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin
56. Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15
57. Early endosomal localization of hrs requires a sequence within the proline- and glutamine-rich region but not the FYVE finger
58. Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate
59. Neutrophil signal transduction and activation of the respiratory burst
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62. SNX3 regulates endosomal function through its PX-domain-mediated interaction with Ptdlns(3)P
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68. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases
69. Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking
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74. Inaugural article: Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate
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