Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity

Journal of Medicinal Chemistry

Volumn 44, Issue 23, 2001, Pages 3965-3977

  Boschelli, D H ^a   Ye, F ^a   Wang, Y D ^a   Dutia, M ^a   Johnson, S L ^a   Wu, B ^a   Miller, K ^a   Powell, D W ^a   Yaczko, D ^b   Young, M ^b   Tischler, M ^b   Arndt, K ^a   Discafani, C ^a   Etienne, C ^a   Gibbons, J ^a   Grod, J ^a   Lucas, J ^a   Weber, J M ^a   Boschelli, F ^a  

^a PFIZER INC   (United States)

^b DARTMOUTH COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(2,4 DICHLORO 5 METHOXYPHENYL)AMINO] 6 METHOXY 7 [3 (4 MORPHOLINYL)PROPOXY] 3 QUINOLINECARBONITRILE; BOSUTINIB; PROTEIN TYROSINE KINASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG POTENCY; ENZYME ASSAY; FEMALE; HUMAN; HUMAN CELL; IC 50; MOUSE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE, TRANSFORMED; ENZYME INHIBITORS; FEMALE; FIBROBLASTS; HUMANS; IMMUNOBLOTTING; MICE; MICE, INBRED BALB C; MICE, NUDE; NITRILES; PHOSPHORYLATION; PIPERAZINES; QUINOLINES; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; TYROSINE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035829463     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0102250     Document Type: Article

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