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Volumn 7, Issue 3, 2006, Pages 297-308

Statistical methods in genetics

Author keywords

Association studies; Data mining; Epistasis; Gene mapping; Linkage disequilibrium

Indexed keywords

DISEASE PREDISPOSITION; GENE INTERACTION; GENETIC VARIABILITY; GENETICS; GENOTYPE; HUMAN; INFORMATION PROCESSING; METHODOLOGY; POPULATION; REVIEW; STATISTICAL ANALYSIS;

EID: 33748803319     PISSN: 14675463     EISSN: 14774054     Source Type: Journal    
DOI: 10.1093/bib/bbl028     Document Type: Review
Times cited : (16)

References (115)
  • 1
    • 25844510235 scopus 로고    scopus 로고
    • Shaking the tree: Mapping complex disease genes with linkage disequilibrium
    • Palmer LJ, Cardon LR. Shaking the tree: Mapping complex disease genes with linkage disequilibrium. Lancet 2005;366: 1223-34.
    • (2005) Lancet , vol.366 , pp. 1223-1234
    • Palmer, L.J.1    Cardon, L.R.2
  • 2
    • 0029130796 scopus 로고
    • Maximum-hkelihood estimation of molecular haplotype frequencies in a diploid population
    • Excoffier L, Slatkin M. Maximum-hkelihood estimation of molecular haplotype frequencies in a diploid population. Moll Biol Evol 1995;12:921-27.
    • (1995) Moll Biol Evol , vol.12 , pp. 921-927
    • Excoffier, L.1    Slatkin, M.2
  • 3
    • 10044232695 scopus 로고    scopus 로고
    • Algorithms for inferring haplotypes
    • Niu T. Algorithms for inferring haplotypes. Genet Epidemiol 2004;27:334-47.
    • (2004) Genet Epidemiol , vol.27 , pp. 334-347
    • Niu, T.1
  • 4
    • 0033794938 scopus 로고    scopus 로고
    • Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data
    • Fallin D, Schork M. Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data. Am J Hum Genet 2000;67:947-59.
    • (2000) Am J Hum Genet , vol.67 , pp. 947-959
    • Fallin, D.1    Schork, M.2
  • 5
    • 33748806621 scopus 로고    scopus 로고
    • A fast and flexible statistical model for large-scale population structure in genetic association studies
    • Scheet P, Stephens M. A fast and flexible statistical model for large-scale population structure in genetic association studies. Genome Res 2006:16:290-6.
    • (2006) Genome Res , vol.16 , pp. 290-296
    • Scheet, P.1    Stephens, M.2
  • 7
    • 0030807876 scopus 로고    scopus 로고
    • Linkage disequilibrium measures for fine-scale mapping: A comparison
    • Guo SW. Linkage disequilibrium measures for fine-scale mapping: A comparison. Hum Hered 1997;47:301-14.
    • (1997) Hum Hered , vol.47 , pp. 301-314
    • Guo, S.W.1
  • 8
    • 0029150074 scopus 로고
    • A comparison of linkage disequilibrium measures for fine-scale mapping
    • Devlin B, Risch N. A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 1995;29:311-22.
    • (1995) Genomics , vol.29 , pp. 311-322
    • Devlin, B.1    Risch, N.2
  • 9
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996;273:1516-7.
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 10
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • The International HapMap Consortium
    • The International HapMap Consortium. The International HapMap Project. Nature 2003;426:789-96.
    • (2003) Nature , vol.426 , pp. 789-796
  • 11
    • 0034969437 scopus 로고    scopus 로고
    • Are rare variants responsible for susceptibility to complex diseases?
    • Pritchard JK. Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet 2001;69:124-37.
    • (2001) Am J Hum Genet , vol.69 , pp. 124-137
    • Pritchard, J.K.1
  • 12
    • 0036799545 scopus 로고    scopus 로고
    • The allelic architecture of human disease genes: Common disease-common variant... or not?
    • Pritchard JK, Cox NJ. The allelic architecture of human disease genes: common disease-common variant... or not? Hum Mol Genet 2002;11:2417-23.
    • (2002) Hum Mol Genet , vol.11 , pp. 2417-2423
    • Pritchard, J.K.1    Cox, N.J.2
  • 13
    • 0035451780 scopus 로고    scopus 로고
    • On the allelic spectrum of human disease
    • Reich DE, Lander ES. On the allelic spectrum of human disease. Trends Genet 2001;17:502-10.
    • (2001) Trends Genet , vol.17 , pp. 502-510
    • Reich, D.E.1    Lander, E.S.2
  • 15
    • 0031466983 scopus 로고    scopus 로고
    • From genotypes to genes: Doubling the sample size
    • Sasieni PD. From genotypes to genes: Doubling the sample size. Biometrics 1997;53:1253-61.
    • (1997) Biometrics , vol.53 , pp. 1253-1261
    • Sasieni, P.D.1
  • 16
    • 0032471913 scopus 로고    scopus 로고
    • Genome screens using linkage disequilibrium tests: Optimal marker characteristics and feasibility
    • Chapman NH, Wijsman EM. Genome screens using linkage disequilibrium tests: Optimal marker characteristics and feasibility. Am J Hum Genet 1998;63:1872-85.
    • (1998) Am J Hum Genet , vol.63 , pp. 1872-1885
    • Chapman, N.H.1    Wijsman, E.M.2
  • 17
    • 0000937686 scopus 로고
    • Tests for linear trends in proportions and frequencies
    • Armitage P. Tests for linear trends in proportions and frequencies. Biometrics 1955;11:375-86.
    • (1955) Biometrics , vol.11 , pp. 375-386
    • Armitage, P.1
  • 18
    • 0036364293 scopus 로고    scopus 로고
    • Trend tests for case-control studies of genetic markers: Power, sample size and robustness
    • Freidlin B, Zheng G, Li Z, et al. Trend tests for case-control studies of genetic markers: Power, sample size and robustness. Hum Hered 2002;53:146-52.
    • (2002) Hum Hered , vol.53 , pp. 146-152
    • Freidlin, B.1    Zheng, G.2    Li, Z.3
  • 19
    • 0032231375 scopus 로고    scopus 로고
    • Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus
    • Nielsen DM, Ehm MG, Weir BS. Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus. Am J Hum Genet 1998;63:1531-40.
    • (1998) Am J Hum Genet , vol.63 , pp. 1531-1540
    • Nielsen, D.M.1    Ehm, M.G.2    Weir, B.S.3
  • 20
    • 0035015534 scopus 로고    scopus 로고
    • Fine-scale mapping using Hardy-Weinberg disequilibrium
    • Jiang R, Dong J, Wang D, et al. Fine-scale mapping using Hardy-Weinberg disequilibrium. Ann Hum Genet 2001;65: 207-19.
    • (2001) Ann Hum Genet , vol.65 , pp. 207-219
    • Jiang, R.1    Dong, J.2    Wang, D.3
  • 21
    • 30344443252 scopus 로고    scopus 로고
    • Fine-mapping using the weighted average method for a case-control study
    • Song K, Orloff M, Lu Q, et al. Fine-mapping using the weighted average method for a case-control study. BMC Genet-2005;6(Suppl 1):S67.
    • (2005) BMC Genet , vol.6 , Issue.SUPPL. 1
    • Song, K.1    Orloff, M.2    Lu, Q.3
  • 22
    • 31344435414 scopus 로고    scopus 로고
    • A powerful method of combining measures of association and Hardy-Weinberg disequilibrium for fine-mapping in case-control studies
    • Song K, Elston RC. A powerful method of combining measures of association and Hardy-Weinberg disequilibrium for fine-mapping in case-control studies. Stat Med 2006;25: 105-26.
    • (2006) Stat Med , vol.25 , pp. 105-126
    • Song, K.1    Elston, R.C.2
  • 23
    • 0035884417 scopus 로고    scopus 로고
    • Computational tools for exact conditional, logistic regression
    • Corcoran C, Mehta C, Patel N, et al. Computational tools for exact conditional, logistic regression. Stat Med 2001;20: 2723-39.
    • (2001) Stat Med , vol.20 , pp. 2723-2739
    • Corcoran, C.1    Mehta, C.2    Patel, N.3
  • 24
    • 17644378739 scopus 로고    scopus 로고
    • Nonparametric tests of association of multiple genes with human disease
    • Schaid DJ, Kk McDonnell S, Hebbring SJ, et al. Nonparametric tests of association of multiple genes with human disease. Am J Hum Genet 2005;76:780-93.
    • (2005) Am J Hum Genet , vol.76 , pp. 780-793
    • Schaid, D.J.1    McDonnell, K.K.S.2    Hebbring, S.J.3
  • 25
    • 27244436454 scopus 로고    scopus 로고
    • A constrained-likehhood approach to marker-trait association studies
    • Wang K, Sheffield CC. A constrained-likehhood approach to marker-trait association studies. Am J Hum Genet 2005;77: 768-80.
    • (2005) Am J Hum Genet , vol.77 , pp. 768-780
    • Wang, K.1    Sheffield, C.C.2
  • 26
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
    • Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52:506-16.
    • (1993) Am J Hum Genet , vol.52 , pp. 506-516
    • Spielman, R.S.1    McGinnis, R.E.2    Ewens, W.J.3
  • 27
    • 0032714352 scopus 로고    scopus 로고
    • Genomic control for association studies
    • Devlin B, Roeder K. Genomic control for association studies. Biometrics 1999;55:997-1004.
    • (1999) Biometrics , vol.55 , pp. 997-1004
    • Devlin, B.1    Roeder, K.2
  • 28
    • 0035528928 scopus 로고    scopus 로고
    • Case-control studies of association in structured or admixed populations
    • Pritchard JK, Donnelly P. Case-control studies of association in structured or admixed populations. Theor Popul Biol 2001;60:227-37.
    • (2001) Theor Popul Biol , vol.60 , pp. 227-237
    • Pritchard, J.K.1    Donnelly, P.2
  • 29
    • 18444396148 scopus 로고    scopus 로고
    • Properties of structured association approaches to detecting population stratification
    • Purcell S, Sham P. Properties of structured association approaches to detecting population stratification. Hum Hered 2004;58:93-107.
    • (2004) Hum Hered , vol.58 , pp. 93-107
    • Purcell, S.1    Sham, P.2
  • 30
    • 0037648359 scopus 로고    scopus 로고
    • Control of confounding of genetic associations in stratified populations
    • Hoggart CJ, Parra EJ, Shriver MD, et al. Control of confounding of genetic associations in stratified populations. Am J Hum Genet 2003;72:1492-504.
    • (2003) Am J Hum Genet , vol.72 , pp. 1492-1504
    • Hoggart, C.J.1    Parra, E.J.2    Shriver, M.D.3
  • 31
    • 0035121797 scopus 로고    scopus 로고
    • Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model
    • Satten GA, Flanders WD, Yang Q. Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model. Am J Hum Genet 2001;68:466-77.
    • (2001) Am J Hum Genet , vol.68 , pp. 466-477
    • Satten, G.A.1    Flanders, W.D.2    Yang, Q.3
  • 33
    • 0034118493 scopus 로고    scopus 로고
    • Inference of population structure using multilocus genotype data
    • Pritchard JK, Stephens M, Donnelly P. Inference of population structure using multilocus genotype data. Genetics 2000;155:945-59.
    • (2000) Genetics , vol.155 , pp. 945-959
    • Pritchard, J.K.1    Stephens, M.2    Donnelly, P.3
  • 34
    • 0034918729 scopus 로고    scopus 로고
    • Estimation of admixture proportions: A likelibood-based approach using Markov chain Monte Carlo
    • Chikhi L, Bruford MW, Beaumont MA. Estimation of admixture proportions: a likelibood-based approach using Markov chain Monte Carlo. Genetics 2001;158: 1347-62.
    • (2001) Genetics , vol.158 , pp. 1347-1362
    • Chikhi, L.1    Bruford, M.W.2    Beaumont, M.A.3
  • 35
    • 27644566838 scopus 로고    scopus 로고
    • Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignment
    • Yang B, Zhao H, Kranzler HR, Gelernter J. Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignment. BMC Genet 2005;6:50.
    • (2005) BMC Genet , vol.6 , pp. 50
    • Yang, B.1    Zhao, H.2    Kranzler, H.R.3    Gelernter, J.4
  • 36
    • 33644824316 scopus 로고    scopus 로고
    • Case-control association tests correcting for population stratification
    • Kohler K, Bickeboller H. Case-control association tests correcting for population stratification. Ann Hum Genet 2006;70:98-115.
    • (2006) Ann Hum Genet , vol.70 , pp. 98-115
    • Kohler, K.1    Bickeboller, H.2
  • 37
    • 0347362518 scopus 로고    scopus 로고
    • Informativeness of genetic markers for inference of ancestry
    • Rosenberg NA, Li LM, Ward R, Pritchard JK. Informativeness of genetic markers for inference of ancestry. Am J Hum Genet 2003;73:1402-22.
    • (2003) Am J Hum Genet , vol.73 , pp. 1402-1422
    • Rosenberg, N.A.1    Li, L.M.2    Ward, R.3    Pritchard, J.K.4
  • 38
    • 13144265739 scopus 로고    scopus 로고
    • Genome-wide association studies: Theoretical and practical concerns
    • Wang WYS, Barratt BJ, Clayton DG, et al. Genome-wide association studies: Theoretical and practical concerns. Nat Rev Genet 2005;6:109-18.
    • (2005) Nat Rev Genet , vol.6 , pp. 109-118
    • Wang, W.Y.S.1    Barratt, B.J.2    Clayton, D.G.3
  • 39
    • 32044443597 scopus 로고    scopus 로고
    • Logistic regression protects against population structure in genetic association studies
    • Setakis E, Stimadel H, Balding DJ. Logistic regression protects against population structure in genetic association studies. Genome Res 2006;16:290-6.
    • (2006) Genome Res , vol.16 , pp. 290-296
    • Setakis, E.1    Stimadel, H.2    Balding, D.J.3
  • 40
    • 33646694298 scopus 로고    scopus 로고
    • Confounding from cryptic relatedness in case-control association studies
    • Voight BF, Pritchard JK. Confounding from cryptic relatedness in case-control association studies. PLoS Genet 2005;1:e32.
    • (2005) PLoS Genet , vol.1
    • Voight, B.F.1    Pritchard, J.K.2
  • 41
    • 16644401078 scopus 로고    scopus 로고
    • False positive rates in association studies as a function of degree of stratification
    • Koller DL, Peacock M, Lai D, et al. False positive rates in association studies as a function of degree of stratification. J Bone Miner Res 2004;19:1291-5.
    • (2004) J Bone Miner Res , vol.19 , pp. 1291-1295
    • Koller, D.L.1    Peacock, M.2    Lai, D.3
  • 42
    • 2442585696 scopus 로고    scopus 로고
    • The effects of human population structure on large genetic association studies
    • Marchini J, Cardon LR, Phillips MS, et al. The effects of human population structure on large genetic association studies. Nat Genet 2004;36:512-7.
    • (2004) Nat Genet , vol.36 , pp. 512-517
    • Marchini, J.1    Cardon, L.R.2    Phillips, M.S.3
  • 43
    • 12144285594 scopus 로고    scopus 로고
    • Assessing the impact of population stratification on genetic association studies
    • Freedman ML, Reich D, Penney KL, et al. Assessing the impact of population stratification on genetic association studies. Nat Genet 2004;36:388-93.
    • (2004) Nat Genet , vol.36 , pp. 388-393
    • Freedman, M.L.1    Reich, D.2    Penney, K.L.3
  • 44
    • 11244279011 scopus 로고    scopus 로고
    • An Icelandic example of the impact of population structure on association studies
    • Helgason I A, Yngvadóttir I B, Hrafnkelsson B, et al. An Icelandic example of the impact of population structure on association studies. Nat Genet 2005;37:90-95.
    • (2005) Nat Genet , vol.37 , pp. 90-95
    • Helgason, I.A.1    Yngvadóttir, I.B.2    Hrafnkelsson, B.3
  • 45
    • 33645762226 scopus 로고
    • A sharper bonferroni procedure for multiple tests of significance
    • Hochberg Y. A sharper bonferroni procedure for multiple tests of significance. Biometrika 1988;75:800-02.
    • (1988) Biometrika , vol.75 , pp. 800-802
    • Hochberg, Y.1
  • 46
    • 0001677717 scopus 로고
    • Controlling the false discovery rate - A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J Royal Stat Soc B Methodolog 1995;57:289-300.
    • (1995) J Royal Stat Soc B Methodolog , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 48
    • 26444610029 scopus 로고    scopus 로고
    • Adaptive designs based on the truncated product method
    • Neuhauser M, Bretz F. Adaptive designs based on the truncated product method. BMC Med Res Methodol 2005;5:30.
    • (2005) BMC Med Res Methodol , vol.5 , pp. 30
    • Neuhauser, M.1    Bretz, F.2
  • 49
    • 0344826563 scopus 로고    scopus 로고
    • Rank truncated product of P-values, with application to genomewide association scans
    • Dudbridge F, Koeleman BPC. Rank truncated product of P-values, with application to genomewide association scans. Genet Epidemiol 2003;25:360-66.
    • (2003) Genet Epidemiol , vol.25 , pp. 360-366
    • Dudbridge, F.1    Koeleman, B.P.C.2
  • 50
    • 1842539516 scopus 로고    scopus 로고
    • A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other
    • Nyholt DR. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 2004;74:765-9.
    • (2004) Am J Hum Genet , vol.74 , pp. 765-769
    • Nyholt, D.R.1
  • 51
    • 0036720233 scopus 로고    scopus 로고
    • Testing for candidate gene linkage disequilibrium using a dense array of single nucleotide polymorphisms in case-parents studies
    • Wen-Chung Lee. Testing for candidate gene linkage disequilibrium using a dense array of single nucleotide polymorphisms in case-parents studies. Epidemiology 2002; 13:545-51.
    • (2002) Epidemiology , vol.13 , pp. 545-551
    • Lee, W.-C.1
  • 52
    • 0028151261 scopus 로고
    • Empirical threshold values for quantitative trait mapping
    • Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics 1994;138:963-71.
    • (1994) Genetics , vol.138 , pp. 963-971
    • Churchill, G.A.1    Doerge, R.W.2
  • 53
    • 4143076901 scopus 로고    scopus 로고
    • Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies
    • Dudbridge F, Koeleman BPC. Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies. Am J Hum Genet 2004;75:424-35.
    • (2004) Am J Hum Genet , vol.75 , pp. 424-435
    • Dudbridge, F.1    Koeleman, B.P.C.2
  • 54
    • 0345689434 scopus 로고    scopus 로고
    • Sum statistics for the joint detection of multiple disease loci in case-control association studies with SNP markers
    • Wille A, Hoh J, Ott J. Sum statistics for the joint detection of multiple disease loci in case-control association studies with SNP markers. Genet Epidemiol 2003;25:350-9.
    • (2003) Genet Epidemiol , vol.25 , pp. 350-359
    • Wille, A.1    Hoh, J.2    Ott, J.3
  • 55
    • 0031939968 scopus 로고    scopus 로고
    • Linkage disequilibrium and gene mapping: An empirical least-squares approach
    • Lazzeroni LC. Linkage disequilibrium and gene mapping: An empirical least-squares approach. Am J Hum Genet 1998; 62:159-70.
    • (1998) Am J Hum Genet , vol.62 , pp. 159-170
    • Lazzeroni, L.C.1
  • 56
    • 0032714314 scopus 로고    scopus 로고
    • Fieller's theorem and linkage disequilibrium mapping
    • Cordell HJ, Elston RC. Fieller's theorem and linkage disequilibrium mapping. Genet Epidemiol 1999;17:237-52.
    • (1999) Genet Epidemiol , vol.17 , pp. 237-252
    • Cordell, H.J.1    Elston, R.C.2
  • 57
    • 15544376156 scopus 로고    scopus 로고
    • Integration of association statistics over genomic regions using bayesian adaptive regression splines
    • Zhang X, Roeder K, Wallstrom G, Devlin B. Integration of association statistics over genomic regions using bayesian adaptive regression splines. Hum Genomics 2003;1:20-9.
    • (2003) Hum Genomics , vol.1 , pp. 20-29
    • Zhang, X.1    Roeder, K.2    Wallstrom, G.3    Devlin, B.4
  • 58
    • 15544379620 scopus 로고    scopus 로고
    • Analysis of single-locus tests to detect gene/disease associations
    • Roeder K, Bacanu S, Sonpar V, Zhang X, Devlin B. Analysis of single-locus tests to detect gene/disease associations. Genet Epidemiol 2005;28:207-19.
    • (2005) Genet Epidemiol , vol.28 , pp. 207-219
    • Roeder, K.1    Bacanu, S.2    Sonpar, V.3    Zhang, X.4    Devlin, B.5
  • 59
    • 0037320526 scopus 로고    scopus 로고
    • Hierarchical modeling of linkage disequilibrium: Genetic structure and spatial relations
    • Conti DV, Witte JS. Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations. Am J Hum Genet 2003;72:351-63.
    • (2003) Am J Hum Genet , vol.72 , pp. 351-363
    • Conti, D.V.1    Witte, J.S.2
  • 60
    • 0035214299 scopus 로고    scopus 로고
    • Trimming, weighting, and grouping SNPs in human case-control association studies
    • Hoh J, Wille A, Ott J. Trimming, weighting, and grouping SNPs in human case-control association studies. Genome Res 2001;11:2115-19.
    • (2001) Genome Res , vol.11 , pp. 2115-2119
    • Hoh, J.1    Wille, A.2    Ott, J.3
  • 61
    • 34248681251 scopus 로고    scopus 로고
    • Detecting susceptibility genes in case-control studies using set association
    • Kim S, Zhang K, Sun F. Detecting susceptibility genes in case-control studies using set association. BMC Genet 2003; 4(Suppl. 1):S9.
    • (2003) BMC Genet , vol.4 , Issue.SUPPL. 1
    • Kim, S.1    Zhang, K.2    Sun, F.3
  • 62
    • 0034796715 scopus 로고    scopus 로고
    • Predicting quantitative trait levels by modeling SNP interaction
    • Fijal BA, Kim LL, Buxbaum SG, et al. Predicting quantitative trait levels by modeling SNP interaction. Genet Epidemiol 2001;21(Suppl. 1):S608-13.
    • (2001) Genet Epidemiol , vol.21 , Issue.SUPPL. 1
    • Fijal, B.A.1    Kim, L.L.2    Buxbaum, S.G.3
  • 63
    • 0035154452 scopus 로고    scopus 로고
    • Genetic analysis of case/control data using estimated haplotype frequencies: Application to APOE locus variation and Alzheimer's disease
    • Fallin D, Cohen A, Essioux L, et al. Genetic analysis of case/control data using estimated haplotype frequencies: Application to APOE locus variation and Alzheimer's disease. Genome Res 2001;11:143-51.
    • (2001) Genome Res , vol.11 , pp. 143-151
    • Fallin, D.1    Cohen, A.2    Essioux, L.3
  • 64
    • 0033990339 scopus 로고    scopus 로고
    • Model-free analysis and permutation tests for allelic associations
    • Zhao JH, Curtis D, Sham PC. Model-free analysis and permutation tests for allelic associations. Hum Hered 2000;50: 133-9.
    • (2000) Hum Hered , vol.50 , pp. 133-139
    • Zhao, J.H.1    Curtis, D.2    Sham, P.C.3
  • 65
    • 0036155283 scopus 로고    scopus 로고
    • Score tests for association between traits and haplotypes when linkage phase is ambiguous
    • Schaid DJ, Rowland CM, Tines DE, et al. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002;70:425-34.
    • (2002) Am J Hum Genet , vol.70 , pp. 425-434
    • Schaid, D.J.1    Rowland, C.M.2    Tines, D.E.3
  • 66
    • 0036284203 scopus 로고    scopus 로고
    • Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals
    • Zaykin DV, Westfall PH, Young SS, et al. Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered 2002;53:79-91.
    • (2002) Hum Hered , vol.53 , pp. 79-91
    • Zaykin, D.V.1    Westfall, P.H.2    Young, S.S.3
  • 67
    • 0344410771 scopus 로고    scopus 로고
    • Inference on haplotype effects in case-control studies using unphased genotype data
    • Epstein MP, Satten GA. Inference on haplotype effects in case-control studies using unphased genotype data. Am J Hum Genet 2003;73:1316-29.
    • (2003) Am J Hum Genet , vol.73 , pp. 1316-1329
    • Epstein, M.P.1    Satten, G.A.2
  • 68
    • 33645465693 scopus 로고    scopus 로고
    • Estimation and testing of genotype and haplotype effects in case-control studies: Comparison of weighted regression and multiple imputation procedures
    • Cordell HJ. Estimation and testing of genotype and haplotype effects in case-control studies: Comparison of weighted regression and multiple imputation procedures. Genet Epidemiol 2006;30:259-75.
    • (2006) Genet Epidemiol , vol.30 , pp. 259-275
    • Cordell, H.J.1
  • 69
    • 0942298156 scopus 로고    scopus 로고
    • Power of direct vs. indirect haplotyping in association studies
    • Thomas S, Porteous D, Visscher PM. Power of direct vs. indirect haplotyping in association studies. Genet Epidemiol 2004;26:116-24.
    • (2004) Genet Epidemiol , vol.26 , pp. 116-124
    • Thomas, S.1    Porteous, D.2    Visscher, P.M.3
  • 70
    • 2342642816 scopus 로고    scopus 로고
    • Little loss of information due to unknown phase for fine-scale linkage-disequilibrium mapping with single-nucleotide-polymorphism genotype data
    • Morris AP, Whittaker JC, Balding DJ. Little loss of information due to unknown phase for fine-scale linkage-disequilibrium mapping with single-nucleotide-polymorphism genotype data. Am J Hum Genet 2004;74: 945-53.
    • (2004) Am J Hum Genet , vol.74 , pp. 945-953
    • Morris, A.P.1    Whittaker, J.C.2    Balding, D.J.3
  • 71
    • 0033926169 scopus 로고    scopus 로고
    • Data mining applied to linkage disequilibrium mapping
    • Toivonen HT, Onkamo P, Vasko K, et al. Data mining applied to linkage disequilibrium mapping. Am J Hum Genet 2000;67:133-45.
    • (2000) Am J Hum Genet , vol.67 , pp. 133-145
    • Toivonen, H.T.1    Onkamo, P.2    Vasko, K.3
  • 73
    • 0037386186 scopus 로고    scopus 로고
    • Genome association studies of complex diseases by case-control designs
    • Fan R, Knapp M. Genome association studies of complex diseases by case-control designs. Am J Hum Genet 2003;72: 850-68.
    • (2003) Am J Hum Genet , vol.72 , pp. 850-868
    • Fan, R.1    Knapp, M.2
  • 74
    • 0345269986 scopus 로고    scopus 로고
    • On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit
    • Tzeng JT, Devlin B, Wasserman L, et al. On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit. Am J Hum Genet 2003;72:891-902.
    • (2003) Am J Hum Genet , vol.72 , pp. 891-902
    • Tzeng, J.T.1    Devlin, B.2    Wasserman, L.3
  • 75
    • 3042591234 scopus 로고    scopus 로고
    • Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes
    • Durrant C, Zondervan KT, Cardon LR, et al. Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes. Am J Hum Genet 2004;75:35-43.
    • (2004) Am J Hum Genet , vol.75 , pp. 35-43
    • Durrant, C.1    Zondervan, K.T.2    Cardon, L.R.3
  • 76
    • 30344443530 scopus 로고    scopus 로고
    • Linkage disequilibrium mapping via cladistic analysis of phase-unknown genotypes and inferred haplotypes in the Genetic Analysis Workshop 14 simulated data
    • Durrant C, Morris AP. Linkage disequilibrium mapping via cladistic analysis of phase-unknown genotypes and inferred haplotypes in the Genetic Analysis Workshop 14 simulated data. BMC Genet 2005;6(Suppl 1):S100.
    • (2005) BMC Genet , vol.6 , Issue.SUPPL. 1
    • Durrant, C.1    Morris, A.P.2
  • 77
    • 28944432280 scopus 로고    scopus 로고
    • Haplotype-based linkage disequilibrium mapping via direct data mining
    • Li J, Jiang T. Haplotype-based linkage disequilibrium mapping via direct data mining. Bioinformatics 2005;21: 4384-93.
    • (2005) Bioinformatics , vol.21 , pp. 4384-4393
    • Li, J.1    Jiang, T.2
  • 78
    • 0346101493 scopus 로고    scopus 로고
    • Fine-scale mapping of disease genes with multiple mutations via spatial clustering techniques
    • Molitor J, Marjoram P, Thomas D. Fine-scale mapping of disease genes with multiple mutations via spatial clustering techniques. Am J Hum Genet 2003;73: 1368-84.
    • (2003) Am J Hum Genet , vol.73 , pp. 1368-1384
    • Molitor, J.1    Marjoram, P.2    Thomas, D.3
  • 80
    • 24944519425 scopus 로고    scopus 로고
    • Using tree-based recursive partitioning methods to group haplotypes for increased power in association studies
    • Yu K, Xu J, Rao DC, Province M. Using tree-based recursive partitioning methods to group haplotypes for increased power in association studies. Ann Hum Genet 2005;69:577-89.
    • (2005) Ann Hum Genet , vol.69 , pp. 577-589
    • Yu, K.1    Xu, J.2    Rao, D.C.3    Province, M.4
  • 81
    • 7444235478 scopus 로고    scopus 로고
    • Classifying disease chromosomes arising from multiple founders, with application to fine-scale haplotype mapping
    • Yu K, Martin RB, Whittemore AS. Classifying disease chromosomes arising from multiple founders, with application to fine-scale haplotype mapping. Genet Epidemiol 2004;27:173-81.
    • (2004) Genet Epidemiol , vol.27 , pp. 173-181
    • Yu, K.1    Martin, R.B.2    Whittemore, A.S.3
  • 82
    • 7444256665 scopus 로고    scopus 로고
    • Genetic association mapping under founder heterogeneity via weighted haplotype similarity analysis in candidate genes
    • Yu K, Gu CC, Province M, Xiong CJ, Rao DC. Genetic association mapping under founder heterogeneity via weighted haplotype similarity analysis in candidate genes. Genet Epidemiol 2004;27:182-91.
    • (2004) Genet Epidemiol , vol.27 , pp. 182-191
    • Yu, K.1    Gu, C.C.2    Province, M.3    Xiong, C.J.4    Rao, D.C.5
  • 83
    • 0024209791 scopus 로고
    • Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci
    • Chakraborty R, Weiss KM. Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci. Proc Natl Acad Sci USA 1988;85:9119-23.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9119-9123
    • Chakraborty, R.1    Weiss, K.M.2
  • 84
    • 0041817568 scopus 로고    scopus 로고
    • Inference of population structure using multilocus genotype data: Linked loci and correlated allele frequencies
    • Falush D, Stephens M, Pritchard JK. Inference of population structure using multilocus genotype data: Linked loci and correlated allele frequencies. Genetics 2003;164:1567-87.
    • (2003) Genetics , vol.164 , pp. 1567-1587
    • Falush, D.1    Stephens, M.2    Pritchard, J.K.3
  • 85
    • 2342622086 scopus 로고    scopus 로고
    • Methods for high-density admixture mapping of disease genes
    • Patterson N, Hattangadi N, Lane B, et al. Methods for high-density admixture mapping of disease genes. Am J Hum Genet 2004;74:979-1000.
    • (2004) Am J Hum Genet , vol.74 , pp. 979-1000
    • Patterson, N.1    Hattangadi, N.2    Lane, B.3
  • 86
    • 6344244729 scopus 로고    scopus 로고
    • Statistical tests for admixture mapping with case-control and cases-only data
    • Montana G, Pritchard JK. Statistical tests for admixture mapping with case-control and cases-only data. Am J Hum Genet 2004;75:771-89.
    • (2004) Am J Hum Genet , vol.75 , pp. 771-789
    • Montana, G.1    Pritchard, J.K.2
  • 87
    • 2342544848 scopus 로고    scopus 로고
    • Design and analysis of admixture mapping studies
    • Hoggart CJ, Shriver MD, Kittles RA, et al. Design and analysis of admixture mapping studies. Am J Hum Genet 2004;74:965-78.
    • (2004) Am J Hum Genet , vol.74 , pp. 965-978
    • Hoggart, C.J.1    Shriver, M.D.2    Kittles, R.A.3
  • 88
    • 11144296825 scopus 로고    scopus 로고
    • Prospects for admixture mapping of complex traits
    • McKeigue PM. Prospects for admixture mapping of complex traits. Am J Hum Genet 2005;76:1-7.
    • (2005) Am J Hum Genet , vol.76 , pp. 1-7
    • McKeigue, P.M.1
  • 89
    • 2342497705 scopus 로고    scopus 로고
    • Tree and spline based association analysis of gene-gene interaction models for ischemic stroke
    • Cook NR, Zee RYL, Ridker PM. Tree and spline based association analysis of gene-gene interaction models for ischemic stroke. Stat Med 2004;23:1439-53.
    • (2004) Stat Med , vol.23 , pp. 1439-1453
    • Cook, N.R.1    Zee, R.Y.L.2    Ridker, P.M.3
  • 90
    • 1842435248 scopus 로고    scopus 로고
    • Novel analytical methods applied to type 1 diabetes genome-scan data
    • Pociot F, Karlsen AE, Pedersen CB, et al. Novel analytical methods applied to type 1 diabetes genome-scan data. Am J Hum Genet 2004;74:647-60.
    • (2004) Am J Hum Genet , vol.74 , pp. 647-660
    • Pociot, F.1    Karlsen, A.E.2    Pedersen, C.B.3
  • 91
    • 0033680875 scopus 로고    scopus 로고
    • Use of classification trees for association studies
    • Zhang H, Bonney G. Use of classification trees for association studies. Genet Epidemiol 2000;19:323-32.
    • (2000) Genet Epidemiol , vol.19 , pp. 323-332
    • Zhang, H.1    Bonney, G.2
  • 92
    • 3242677689 scopus 로고    scopus 로고
    • Tree-structured supervised learning and the genetics of hypertension
    • Huang J, Lin A, Narasimhan B, et al. Tree-structured supervised learning and the genetics of hypertension. Proc Natl Acad Sci USA 2004;101:10529-54.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10529-10554
    • Huang, J.1    Lin, A.2    Narasimhan, B.3
  • 93
    • 25444453244 scopus 로고    scopus 로고
    • Screening large-scale association study data: Exploiting interactions using random forests
    • Lunetta KL, Hayward LB, Segal J, et al. Screening large-scale association study data: Exploiting interactions using random forests. BMC Genet 2004;5:32.
    • (2004) BMC Genet , vol.5 , pp. 32
    • Lunetta, K.L.1    Hayward, L.B.2    Segal, J.3
  • 94
    • 12744259874 scopus 로고    scopus 로고
    • Identifying SNPs predictive of phenotype using random forests
    • Bureau A, Dupuis J, Falls K, et al. Identifying SNPs predictive of phenotype using random forests. Genet Epidemiol 2005;28:171-182.
    • (2005) Genet Epidemiol , vol.28 , pp. 171-182
    • Bureau, A.1    Dupuis, J.2    Falls, K.3
  • 95
    • 30344439983 scopus 로고    scopus 로고
    • A genome-wide tree-and forest-based association analysis of comorbidity of alcoholism and smoking
    • Ye Y, Zhong X, Zhang H. A genome-wide tree-and forest-based association analysis of comorbidity of alcoholism and smoking. BMC Genet 2005;6(Suppl. 1):S135.
    • (2005) BMC Genet , vol.6 , Issue.SUPPL. 1
    • Ye, Y.1    Zhong, X.2    Zhang, H.3
  • 96
    • 13544256549 scopus 로고    scopus 로고
    • Recursive partitioning analysis of complex disease pharmacogenetic studies. I. Motivation and overview
    • Young SS, Ge N. Recursive partitioning analysis of complex disease pharmacogenetic studies. I. Motivation and overview. Pharmacogenomics 2005;6:65-75.
    • (2005) Pharmacogenomics , vol.6 , pp. 65-75
    • Young, S.S.1    Ge, N.2
  • 97
    • 13544266486 scopus 로고    scopus 로고
    • Large recursive partitioning analysis of complex disease pharmacogenetic studies. II. Statistical considerations
    • Zaykin DV, Young SS. Large recursive partitioning analysis of complex disease pharmacogenetic studies. II. Statistical considerations. Pharmacogenomics 2005;6:77-89.
    • (2005) Pharmacogenomics , vol.6 , pp. 77-89
    • Zaykin, D.V.1    Young, S.S.2
  • 98
    • 2342658449 scopus 로고    scopus 로고
    • Combining genotype groups and recursive partitioning: An application to hiv-1 genetics data
    • Foulkes AS, DeGruttola V, Hertogs K. Combining genotype groups and recursive partitioning: An application to hiv-1 genetics data. J Royal Stat So C, Part 2, 2004;53: 311-23.
    • (2004) J Royal Stat So C, Part 2 , vol.53 , pp. 311-323
    • Foulkes, A.S.1    DeGruttola, V.2    Hertogs, K.3
  • 99
    • 0034798155 scopus 로고    scopus 로고
    • Common disease analysis using multivariate adaptive regression splines (MARS): Genetic analysis workshop 12 simulated sequence data
    • York TP, Eaves L.J. Common disease analysis using multivariate adaptive regression splines (MARS): Genetic analysis workshop 12 simulated sequence data. Genet Epidemiol 2001;21(Suppl. 1):S649-54.
    • (2001) Genet Epidemiol , vol.21 , Issue.SUPPL. 1
    • York, T.P.1    Eaves, L.J.2
  • 101
    • 16844366786 scopus 로고    scopus 로고
    • Genome-wide strategies for detecting multiple loci that influence complex diseases
    • Marchini J, Donnelly P, Cardon LR. Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet 2005;37:413-7.
    • (2005) Nat Genet , vol.37 , pp. 413-417
    • Marchini, J.1    Donnelly, P.2    Cardon, L.R.3
  • 102
    • 12744269194 scopus 로고    scopus 로고
    • Identifying interacting SNPs using Monte Carlo logic regression
    • Kooperberg C, Ruczinski I. Identifying interacting SNPs using Monte Carlo logic regression. Genet Epidemiol 2005; 28:157-70.
    • (2005) Genet Epidemiol , vol.28 , pp. 157-170
    • Kooperberg, C.1    Ruczinski, I.2
  • 103
    • 27544508518 scopus 로고    scopus 로고
    • Finding associations in dense genetic maps: A genetic algorithm approach
    • Clark TG, De Iorio M, Griffiths RC, et al. Finding associations in dense genetic maps: A genetic algorithm approach. Hum Hered 2005;60:97-108.
    • (2005) Hum Hered , vol.60 , pp. 97-108
    • Clark, T.G.1    De Iorio, M.2    Griffiths, R.C.3
  • 104
    • 33748794572 scopus 로고    scopus 로고
    • Bayesian method for finding interactions in genomic studies
    • Technical report, The University of Michigan Department of Biostatistics
    • Wei C, Debashis G, Trivellore ER, Kardia S. Bayesian method for finding interactions in genomic studies. Technical report, The University of Michigan Department of Biostatistics, 2004.
    • (2004)
    • Wei, C.1    Debashis, G.2    Trivellore, E.R.3    Kardia, S.4
  • 105
    • 84893179575 scopus 로고
    • Variable selection via gibbs sampling
    • George EI, McCulloch RE. Variable selection via gibbs sampling. J Am Stat Assoc 1993;88:881-89.
    • (1993) J Am Stat Assoc , vol.88 , pp. 881-889
    • George, E.I.1    McCulloch, R.E.2
  • 106
    • 0042208380 scopus 로고    scopus 로고
    • Stochastic search variable selection for identifying multiple quantitative trait loci
    • Yi N, George V, Allison DB. Stochastic search variable selection for identifying multiple quantitative trait loci. Genetics 2003;164:1129-38.
    • (2003) Genetics , vol.164 , pp. 1129-1138
    • Yi, N.1    George, V.2    Allison, D.B.3
  • 107
    • 0038449175 scopus 로고    scopus 로고
    • Analysis of multilocus models of association
    • Devlin B, Roeder K, Wasserman L. Analysis of multilocus models of association. Genet Epidemiol 2003;25:36-47.
    • (2003) Genet Epidemiol , vol.25 , pp. 36-47
    • Devlin, B.1    Roeder, K.2    Wasserman, L.3
  • 108
    • 0035084663 scopus 로고    scopus 로고
    • A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation
    • Nelson MR, Kardia SL, Ferrell RE, et al. A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation. Genome Res 2001;11:458-70.
    • (2001) Genome Res , vol.11 , pp. 458-470
    • Nelson, M.R.1    Kardia, S.L.2    Ferrell, R.E.3
  • 109
    • 0034973569 scopus 로고    scopus 로고
    • Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer
    • Ritchie MD, Hahn LW, Roodi N, et al. Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet 2001;69:138-47.
    • (2001) Am J Hum Genet , vol.69 , pp. 138-147
    • Ritchie, M.D.1    Hahn, L.W.2    Roodi, N.3
  • 110
    • 0037433052 scopus 로고    scopus 로고
    • Multifactor dimensionality reduction software for detecting gene-gene and gene-enviromnent interactions
    • Hahn LW, Ritchie MD, Moore JH. Multifactor dimensionality reduction software for detecting gene-gene and gene-enviromnent interactions. Bioinformatics 2003;19: 376-82.
    • (2003) Bioinformatics , vol.19 , pp. 376-382
    • Hahn, L.W.1    Ritchie, M.D.2    Moore, J.H.3
  • 111
    • 0037310257 scopus 로고    scopus 로고
    • Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity
    • Ritchie MD, Hahn LW, Moore JH. Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol 2003;24:150-7.
    • (2003) Genet Epidemiol , vol.24 , pp. 150-157
    • Ritchie, M.D.1    Hahn, L.W.2    Moore, J.H.3
  • 112
    • 18444417980 scopus 로고    scopus 로고
    • MDR and PRP: A comparison of methods for high-order genotype-phenotype associations
    • Bastone L, Reilly M, Rader DJ, et al. MDR and PRP: A comparison of methods for high-order genotype-phenotype associations. Hum Hered 2004;58:82-92.
    • (2004) Hum Hered , vol.58 , pp. 82-92
    • Bastone, L.1    Reilly, M.2    Rader, D.J.3
  • 113
    • 2942517830 scopus 로고    scopus 로고
    • An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: The importance of model validation
    • Coffey CS, Hebert PR, Ritchie MD, et al. An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: The importance of model validation. BMC Bioinformatics 2004;5:49.
    • (2004) BMC Bioinformatics , vol.5 , pp. 49
    • Coffey, C.S.1    Hebert, P.R.2    Ritchie, M.D.3
  • 114
    • 2342475667 scopus 로고    scopus 로고
    • Multilocus analysis of hypertension: A hierarchical approach
    • Williams SM, Ritchie MD, Phillips JA, et al. Multilocus analysis of hypertension: A hierarchical approach. Hum Hered 2004;57:28-38.
    • (2004) Hum Hered , vol.57 , pp. 28-38
    • Williams, S.M.1    Ritchie, M.D.2    Phillips, J.A.3
  • 115
    • 27644439141 scopus 로고    scopus 로고
    • Efficiency and power in genetic association studies
    • deBakker PIW, Yelensky R, Pe'er I, et al. Efficiency and power in genetic association studies. Nat Genet 2005;37: 1217-23.
    • (2005) Nat Genet , vol.37 , pp. 1217-1223
    • deBakker, P.I.W.1    Yelensky, R.2    Pe'er, I.3


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