A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation

Genome Research

Volumn 11, Issue 3, 2001, Pages 458-470

  Nelson, M R ^a,d   Kardia, S L R ^b   Ferrell, R E ^c   Sing, C F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d Esperion Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRIACYLGLYCEROL;

ADULT; ALLELE; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; GENE LOCUS; GENETIC MODEL; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HEALTH STATUS; HUMAN; ISCHEMIC HEART DISEASE; MALE; POPULATION; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE TRAIT; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTATIONAL BIOLOGY; GENETIC MARKERS; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MODELS, GENETIC; MULTIGENE FAMILY; PHENOTYPE; QUANTITATIVE TRAIT, HERITABLE; REPRODUCIBILITY OF RESULTS; VARIATION (GENETICS);

EID: 0035084663     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.172901     Document Type: Article

References (52)

1. Genetic linkage between the antigenic group (Ag) and the apolipoprotein B gene: Assignment of the Ag locus
2. A three codon insertion/deletion polymorphism in the signal peptide region of the human apolipoprotein B (ApoB) gene directly typed by the polymerase chain reaction
3. Bias of the contribution of single-locus effects to the variance of a quantitative trait
4. Haplotype structure and population genetic inferences from nucleotide sequence variation in human lipoprotein lipase
5. Influence of dietary fat apolipoprotein E phenotype, and sex on plasma lipoprotein levels
6. Polymorphisms in the apolipoprotein AI-CIII gene complex
7. Improvements on cross-validation: The 632+ bootstrap method
8. The correlations between relatives on the supposition of Mendelian inheritance
9. Is the gene the unit of selection?
10. A BstNI (EcoRII) RFLP in the lipoprotein lipase gene (LPL)
11. RFLP for the human lipoprotein lipase (LPL) gene: HindIII
12. AvaII polymorphism in the human LDL receptor gene
13. Comparing partitions
14. The molecular basis of the human serum paraoxonase activity polymorphism
15. Evidence that the apolipoprotein E-genotype effects on lipid levels can change with age in males: A longitudinal analysis
16. A study of polymorphisms around the human apolipoprotein AI gene in hyperlipidaemic and normal individuals
17. Optimization by simulated annealing
18. The art of computer programming
19. A study of cross-validation and bootstrap for accuracy estimation and model selection
20. A DNA polymorphism in the human low-density lipoprotein receptor gene
21. Human LDL receptor gene: Two ApaLI RFLPs
22. Genotype and phenotype
23. PvuII RFLP at the human lipoprotein lipase(LPL) gene
24. Sources of variation in plasma lipid and lipoprotein traits in a sample selected for health
25. Influence of apolipoprotein E genotype variation on the means, variances, and correlations of plasma lipids and apolipoproteins in children
26. RFLP for the human apolipoprotein B gene. IV. MspI
27. Human apolipoprotein E: The complete amino acid sequence
28. DNA polymerphism adjacent to human apoprotein A-1 gene: Relation to hypertriglyceridaemia
29. The gender-specific apolipoprotein E genotype influence on the distribution of lipids and apolipoproteins in the population of Rochester, MN. I. Pleiotropic effects on means and variances
30. The gender-specific apolipoprotein E genotype influence on the distribution of lipids and apolipoproteins in the population of Rochester, MN. II. Regression relationships with concomitants
31. The future of genetic studies of complex human diseases
32. Molecular cloning of human LDL apolipoprotein B cDNA
33. Genetic architecture of common multifactorial diseases
34. Cross-validation: A review
35. The effect of physical activity on serum total and low-density lipoprotein cholesterol concentrations varies with apolipoprotein E phenotype in male children and young adults: The Cardiovascular Risk in Young Finns Study
36. Epistasis and complex traits
37. The unit of selection in Drosophila mercatorum. I. The interaction of selection and meiosis in parthenogenetic strains
38. Linkage disequilibrium mapping of complex disease: Fantasy or reality?
39. Distribution of sodium-lithium counter-transport and blood pressure in Caucasians five to eighty-nine years of age
40. On estimating the proportion of variance attributable to a measured locus
41. The roles of mutation, inbreeding, crossbreeding, and selection in evolution
42. TaqIpolymorphism in the human LDL receptor gene
43. Genotype-environment interaction: Apolipoprotein E (ApoE) gene effects and age as an index of time and spatial context in the human
44. Genetic structure of five susceptibility gene regions for coronary artery disease: Disequilibria within and among regions
45. Complex adaptive systems and human health: The influence of common genotypes of the apolipoprotein E (ApoE) gene polymorphism and age on the relational order within a field of lipid metabolism traits